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Treatment Results of Multidrug Resistant Tuberculosis in a University Hospital in Korea (다제내성 결핵의 치료 성적)

  • Yum, Ho-Kee;Song, Yeong-Su;Choi, Sao-Jean;Lee, Bong-Choon;Kim, Dong-Soon
    • Tuberculosis and Respiratory Diseases
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    • v.43 no.6
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    • pp.862-870
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    • 1996
  • Background : Multidrug-resistant tuberculosis(MDR-Tb) has been increased not only in Asia but also in Western society, which may cause public health problems and reduce the efficacy of treatment of tuberculosis. In Western society HIV infection is believed to do a central role in increasing incidence of MDR tuberculosis, but MDR-Tb in Korea may be somewhat different about clinical features, underlying disorders, and prognosis. Goble et al reponed that overall treatment failure rate in MDR-Tb including resistance to isoniazid(INH) and rifampin (RFP) was 44 %. The aim of this study is to find the treatment result in Korea and the factors determining the prognosis. Methods: A retrospective study of pulmonary tuberculosis cultured M. tuberculosis from sputum or bronchial washing fluid between 1986 through 1992 was conducted in the Seoul Paik Hospital, Inje University. We reviewed clinical courses of 141 patients, who had a tuberculosis with resistance to 2 or more drugs including isoniazid(INH) and rifampin(RFP). One hundred and 4 patients of 141 patients had completed treatment and followed up for more than one year. Results: Of 104 (mean age $43.6{\pm}16.7$, M: F=63 : 41) patients with sufficient follow-up data, 73(84.6%) patients responded which is defined as negative Sputum cultures for at least 3 consecutive months. Seven patients(6.7%) had a failure in negative conversion and 9(8.7%) of the patients who initially responded relapsed. Overall treatment failure rate was 15.4%, Patients who were treated for less than 12 months had a higher relapse rate(12.3%) than 18 months(4.9%). And there was a statistically significant correlation between the relapse rate and the number of drugs to which isolates wera resistant(p<0.05). Conclusion : The treatment failure rate of MDR-Tb in Korea was lower than previous studies in western Country and the major determining factor of prognosis was the number of resistant drugs to M. tuberculosis at drug sensitivity test. For reducing the relapse rate, we recommend more than 12 months of treatment for MDR tuberculosis.

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A Case of Significant Endobronchial Injury due to Recurrent Iron Pill Aspiration

  • Kwak, Joo-Hee;Koo, Gun Woo;Chung, Sung Jun;Park, Dong Won;Kwak, Hyun Jung;Moon, Ji-Yong;Kim, Sang-Heon;Sohn, Jang Won;Yoon, Ho Joo;Shin, Dong Ho;Park, Sung Soo;Pyo, Ju Yeon;Oh, Young-Ha;Kim, Tae-Hyung
    • Tuberculosis and Respiratory Diseases
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    • v.78 no.4
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    • pp.440-444
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    • 2015
  • Gastric mucosal damage by iron pills is often reported. However, iron pill aspiration is uncommon. Oxidation of the impacted iron pill causes bronchial mucosal damage that progresses to chronic bronchial inflammation, necrosis, endobronchial stenosis and rarely, perforation. We reported a case of a 92-year-old woman with chronic productive cough and significant left-sided atelectasis. Bronchoscopy revealed substantial luminal narrowing with exudative inflammation of the left main bronchus. Bronchial washing cytology showed necroinflammatory exudate and a small amount of brown material. Mucosal biopsy showed diffuse brown pigments indicative of ferrous pigments, crystal deposition, and marked tissue degeneration. After vigorous coughing, she expectorated dark sediments and her symptoms and radiological abnormalities improved. There are a few such reports worldwide; however, this was the first case reported in Korea. Careful observation of aspiration-prone patients and early detection of iron pill aspiration may prevent iron pill-induced bronchial injury.

Functional Properties of Mungbean Protein Isolates (분리녹두단백의 식품기능적 특성에 관한 연구)

  • Kye, In-Sug;Jun, Yeong-Soo;Cheigh, Hong-Sik
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.18 no.3
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    • pp.300-306
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    • 1989
  • This study was investigated to determine the functional properties of mugbean protein isolates(MPI) from sunhwa-nogdu(SH) and conventional mungbean varieties(C). MPI were prepared from defatted mungbean flour by extraction with 0.1N NaOH, precipitation at pH 4.5, washing of dispersed precipitate with buffer solution and distilled water, and subsequent freeze-drying. Crude protein content of MPI was in the range of $88.7{\sim}91.3%$. The lowest solubility was recorded at $pH\;4{\sim}5$, whereas the best buffering action was in the range of $5.5{\sim}7.5$. On the other hand, gelation of MPI was found to depend on the protein concentration. In the cases of foamability, % volume increase and specific volume were higher for 10 min. with a good whipping ability. And also, the MPI properties of two varieties of SH and C were compared and discussed.

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Effect of Water Temperature and Packing Type on Quality of Fresh-Cut Sesame Leaf (세척 깻잎의 선도 유지에 대한 세척수 온도와 포장 형태의 영향)

  • Kim, Byeong-Sam;Chang, Min-Sun;Park, Shin-Young;Cha, Hwan-Soo;Kwon, Ki-Hyun
    • Journal of the Korean Society of Food Science and Nutrition
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    • v.37 no.2
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    • pp.231-238
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    • 2008
  • Quality attributes of fresh-cut sesame leaf (Perilla frutescens var. japonica) as affected by hydrocooling and packing were investigated in terms of weight loss, respiration, vitamin C content, total chlorophyll content, microbial load and sensory properties during storage at 4 and $10^{\circ}C$. Fresh sesame leaf was trimmed and washed with cold water (1, $5^{\circ}C$) as well as tap water ($13^{\circ}C$) for 30 sec 3 times and then packaged in PP (polypropylene) film bag and PETE (polyethylene terephthalate) tray, and stored for 9 days at 4 and $10^{\circ}C$. Weight loss was decreased by washing and packing. Respiration rate was increased slowly over the storage at $4^{\circ}C$. Vitamin C content and total chlorophyll contents of sesame leaf packaged within PETE tray decreased gradually during storage. Hydrocooling and packing within PETE tray treatments resulted in approximately $1{\sim}2\;log\;CFU/g$ reduction of microbial load.

Chromaticity Improvement of PEG Waste from Wire Sawing of Silicon Ingot (실리콘 잉곳 절삭시 발생하는 폐 PEG 색도 개선에 관한 연구)

  • Cho, Yun-Kyeong;Jung, Kyeong-Youl;Sim, Min-Seok;Lee, Gi-Ho
    • Korean Chemical Engineering Research
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    • v.50 no.2
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    • pp.310-316
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    • 2012
  • The chromaticity of polyethylene glycol (PEG) generated from the recyling of a silicone slurry waste was improved by using activated carbon powder and a carbon filter. The color change of the PEG waste was investigated by changing the amount of adsorbent, adsorption time and temperature. The surface area of activated carbon did not have a significant impact on improving the color of the PEG waste. According to the results for the APHA color variation of the PEG waste changing the amount of the carbon adsorbent, the optimal usage to achieve the low APHA value was 100~150 mg-C/g-PEG. From the investigatnion on the effect of the adsorption temperature range from $25^{\circ}C$ to $100^{\circ}C$, it was found that the optimal temperatures were $40{\sim}50^{\circ}C$ in terms of achieving the lowest APHA value. The variation of the APHA color was investigated by changing the operation condition of the activated carbon filters. The use of ACF was a good way to enhance the chromaticity of the PEG waste. As a result, the APHA value of the PEG waste (APHA=53 at the initial waste) was reduced to be 10 through the ACF purification. It was also confirmed that the performance of the used carbon adsorbent can be recovered by the washing with purified water.

Removal of Sodium Contained in Al(OH)3 Synthesized by Bayer Process (베이어법으로 합성된 Al(OH)3에 함유된 미량 Na 성분의 제거)

  • Choi, Hee-Young;Kim, Do-Hyeong;Park, No-Kuk;Lee, Tae-Jin;Kang, Mi-Sook;Lee, Won-Gun;Kim, Heun-Duk;Park, Jun-Woo
    • Clean Technology
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    • v.18 no.1
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    • pp.63-68
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    • 2012
  • In this study, aluminum hydroxide ($Al(OH)_3$) was synthesized by Bayer process and sodium contained in $Al(OH)_3$ was removed with the acid solution such as HCl and acetic acid for the synthesis of high purity alumina. The bauxite produced in Queensland of Australia was used for the production of alumina by Bayer, and was crushed to a particle size of below 10 um by attrition mill. The crushed bauxite was treated in sodium hydroxide solution of 5 N for the elution of aluminum component. The elution of aluminum from bauxite was carried out at $140^{\circ}C$ and 3.4 atm in autoclave. The sample solution was separated to the red mud and liquid solution by filter paper. The elution of aluminum from bauxite was confirmed with changing a structure and aluminum content in both bauxite and red mud analyzed by XRD and EDX. Aluminum contained in the separated solution was crystallized to $Al(OH)_3$ with the addition of aluminum hydroxide used as the seed material. $Al(OH)_3$ powder obtained during the crystallization process was purified by several times washing with distillated water. It was also confirmed that the sodium remained in $Al(OH)_3$ powder is removed with acid solution. The purity of $Al(OH)_3$ powder produced in this study was 99.3% and the content of sodium was reduced to approximately 0.009% after the acid treatment.

Analysis on the Water Footprint of Crystalline Silicon PV System (결정질 실리콘 태양광시스템의 물 발자국 산정에 대한 연구)

  • Na, Won-Cheol;Kim, Younghwan;Kim, Kyung Nam;Lee, Kwan-Young
    • Clean Technology
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    • v.20 no.4
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    • pp.449-456
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    • 2014
  • There has been increasing concerns for the problems of water security in countries, caused by the frequent occurrence of localized drought due to the climate change and uncertainty of water balance. The importance of fresh water is emphasized as considerable amount of usable fresh water is utilized for power generation sector producing electricity. PV power system, the source of renewable energy, consumes water for the every steps of life cycle: manufacturing, installation, and operation. However, it uses relatively less water than the traditional energy sources such as thermal power and nuclear power sources. In this study, to find out the use of water for the entire process of PV power system from extracting raw materials to operating the system, the footprint of water in the whole process is measured to be analyzed. Measuring the result, the PV water footprint of value chain was $0.989m^3/MWh$ and the water footprint appeared higher specially in poly-Si and solar cell process. The following two reasons explain it: poly-Si process is energy-intensive process and it consumes lots of cooling water. In solar cell process, deionized water is used considerably for washing a high-efficiency crystalline silicon. It is identified that PV system is the source using less water than traditional ones, which has a critical value in saving water. In discussing the future energy policy, it is vital to introduce the concept of water footprint as a supplementary value of renewable energy.

Enhanced Flame Retardancy of Cotton Fabric by Functionalized Graphene Oxide and Ammonium Polyphosphate (기능성화 산화 그래핀과 폴리인산암모늄을 이용한 직물 난연성 향상)

  • Ka, Dongwon;Jang, Seongon;Jung, Hyunsook;Jin, Youngho
    • Composites Research
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    • v.33 no.4
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    • pp.177-184
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    • 2020
  • Flame retardant(FR) clothes prohibit additional fire diffusion and make the personnel do their tasks without a hitch in a flammable environment. The existing FR clothes, however, are heavy and give high thermal fatigue. Therefore, it is strongly demanded to develop a light, convenient, and eco-friendly clothes. Recently, many works have been reported to make FR fabrics with phosphorus compounds, but their performance could not satisfy the specified criteria in appraisal standards of domestic and American FR clothes or combat uniforms. In this paper, two kinds of phosphorus compounds were applied to cotton fabric. Graphene oxide functionalized with a phosphorus-rich deep eutectic solvent and ammonium polyphosphate were coated on cotton fabric by eco-friendly padding procedure. The coated fabrics were analyzed with thermogravimetric analysis, vertical flame resistance test(ASTM D6413), cone calorimeter test(ISO 5660-1), and method of test for limited flame spread(ISO 15025). It was revealed that the as-made cotton with those two materials simultaneously had better flame resistance than the cottons with each one. Furthermore, an additional coating for hydrophobicity on the FR cotton was tried for better washing fastness.

Development of Air Cleaning Roll-Filter for Improving IAQ in Subway (도시철도 객실 공기질 개선을 위한 롤필터 개발연구)

  • Kwon, Soon-Bark;Park, Duck-Shin;Cho, Young-Min;Kim, Jong-Bum;NanGoong, Seok;Han, Tae-Woo;Cho, Kwan-Hyun;Kim, Tae-Sung
    • Journal of the Korean Society for Railway
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    • v.14 no.4
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    • pp.313-319
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    • 2011
  • In a modern society, various type of transportation modes are utilized, among them the subway system is the one of the main transportation mode which more than 7.21 million people ride a day in Seoul. Due to the increased interests on the indoor air quality (IAQ) of underground facilities, public concerns on IAQ of subway system are increasing also. Platform screen door (PSD) recently installed at the whole stations of Seoul subway and tunnel washing-out appeared to be effective in reducing particulate matters in the platform and tunnel. However there has not been any attempt to improve IAQ of subway cabin inside. Most technologies for removing airborne particulate matters are known to be difficult to adopt on the subway cabin due to the problem of maintenance cost. Therefore, the object of this study is a practical development of cabin air cleaning system which can reduce the concentration of airborne particles and harmful gases at the same time. In this paper, we focused on the development of particle removing system utilizing a roll-filter for increasing operating time of air filter. The prototype of system was designed and manufactured based on the numerical prediction results. For rollfilter device, 5 candidate filter materials were tested in point of particle collection efficiency and pressure drop. It was found that the electrically charged filter material showed the highest performance among them.

Effects of combined acetic acid and UV-C irradiation treatment on the microbial growth and the quality of sedum during its storage (Acetic acid와 UV-C 병합처리가 돌나물의 저장 중 미생물 성장과 품질에 미치는 영향)

  • Seong, Ki Hyun;Kang, Ji Hoon;Song, Kyung Bin
    • Food Science and Preservation
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    • v.21 no.4
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    • pp.581-586
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    • 2014
  • With the current consumer trend toward health and wellbeing, the demand for consumption of fresh cut vegetables has been increasing. As a popular vegetable with functional components, sedum (Sedum sarmentosum) is widely used in Korea as a side dish that needs no cooking. In this study, to provide a hurdle technology for postharvest sedum, the effects of combined treatment of 1% acetic acid for washing and $10kJ/m^2$ UV-C irradiation on the microbial growth and quality of sedum were examined. After the treatment, the sedum samples were stored at $10^{\circ}C$ for six days, and the results of their microbial analysis as well as their color, vitamin C content, and antioxidant activity were analyzed. The combined treatment with acetic acid and UV-C irradiation reduced the initial populations of the total aerobic bacteria and the yeast and molds in the sedum by 3.28 and 4.22 log CFU/g, respectively, compared to those in the control. The Hunter L, a, and b values of the sedum did not significantly differ across the treatments. In addition, the vitamin C content and the antioxidant activity decreased significantly during the storage, regardless of the treatment. These results suggest that the combined treatment with 1% acetic acid and $10kJ/m^2$ UV-C irradiation can be useful as a hurdle technology for retaining the microbiological safety and quality of sedum during its storage.