• Composites Research
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• 제32권5호
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• pp.284-289
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• 2019

본 논문에서는 KIA K3 (1.6) 가솔린 자동차의 연비(km/liter)식을 동력학적 힘-모멘트 평형 방정식, 구동력 및 에너지 방정식을 구성하고 분석하여 유도하였다. 이를 통해 차량의 속도(V), 자동차 총 중량(M), 타이어-노면의 롤링저항계수($C_r$), 도로 경사각(${\theta}$)과 항력계수($C_d$), 차량의 횡단면적(A)과 같은 공기역학적 매개변수가 자동차의 연비에 미치는 영향을 분석하였다. 또한 경량금속합금, 섬유강화 플라스틱 복합재료와 같은 대체재료가 기존 자동차의 강재, 주철재를 대체하여 차량의 무게를 줄일 수 있는 가능성 등을 Ashby의 재료지수 방법으로 조사하였다. 본 연구를 통해 다음과 같은 결과를 얻었다. 고속(100km/h)에서 연비에 가장 큰 영향을 미친 매개변수는 그 크기순으로 자동차의 속도 V와 공기역학적 매개변수인 $C_d$, A, ${\rho}$ 및 동력학적 매개변수인 $C_r$, M의 순서로 조사되었다. 반면에 저속(60 km/h)에서는 동력학적 매개변수로는 V, M, $C_r$의 순서로, 공기역학적 매개변수로는 $C_d$, A, ${\rho}$ 순으로 영향을 미침을 확인하였다.

• 한국산림과학회지
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• 제109권4호
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• pp.461-467
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• 2020

본 연구는 정확도가 높은 Kozak 수간곡선모델을 이용하여 전국에 분포한 삼나무의 수간곡선식 및 입목수간재적표를 개발하고자 수행되었다. 이를 위해 전국에 분포하는 총 1,000본의 삼나무 표본목을 벌채하여 수간고별 직경을 측정하고 수간 형상을 파악할 수 있는 수간곡선식을 추정하였다. 추정한 모델의 통계적 적합도지수는 98.7%로 나타났고 편차는 -0.0142, 평균절대편차는 1.1640로 높은 적합도를 보였다. 또한 현행재적표와 신규재적표의 재적은 통계적으로 유의적인 차이를 보였다(p<0.05). 새롭게 개발된 재적표는 현실림을 반영한 것으로, 국가 및 지자체의 산림통계 정확도 향상과 목재 자원량 평가 시 발생할 수 있는 경제적 손실 방지에 기여할 것으로 판단된다.

• Tuberculosis and Respiratory Diseases
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• 제84권2호
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• pp.96-104
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• 2021

Background: Many chronic obstructive pulmonary disease (COPD) patients receiving monotherapy continue to experience symptoms, exacerbations and poor quality of life. This study aimed to assess the efficacy and safety of direct switch from once-daily tiotropium (TIO) 18 ㎍ to indacaterol/glycopyrronium (IND/GLY) 110/50 ㎍ once daily in COPD patients in Korea. Methods: This was a randomized, open-label, parallel group, 12-week trial in mild-to-moderate COPD patients who received TIO 18 ㎍ once daily for ≥12 weeks prior to study initiation. Patients aged ≥40 years, with predicted post-bronchodilator forced expiratory volume in 1 second (FEV₁) ≥50%, post-bronchodilator FEV₁/forced vital capacity <0.7 and smoking history of ≥10 pack-years were included. Eligible patients were randomized in a 1:1 ratio to either IND/GLY or TIO. The primary objective was to demonstrate superiority of IND/GLY over TIO in pre-dose trough FEV₁ at week 12. Secondary endpoints included transition dyspnea index (TDI) focal score, COPD assessment test (CAT) total score, and rescue medication use following the 12-week treatment, and safety assessment. Results: Of the 442 patients screened, 379 were randomized and 347 completed the study. IND/GLY demonstrated superiority in pre-dose trough FEV₁ versus TIO at week 12 (least squares mean treatment difference [Δ], 50 mL; p=0.013). Also, numerical improvements were observed with IND/GLY in the TDI focal score (Δ, 0.31), CAT total score (Δ, -0.81), and rescue medication use (Δ, -0.09 puffs/day). Both treatments were well tolerated by patients. Conclusion: A direct switch from TIO to IND/GLY provided improvements in lung function and other patient-reported outcomes with an acceptable safety profile in patients with mild-to-moderate airflow limitation.

• 한국환경복원기술학회지
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• 제24권4호
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• pp.15-29
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• 2021

Urban green spaces offer a variety of benefits to living things and humans. However, existing green spaces have been reduced and fragmented due to urbanization, and there is a limit to creating new large green spaces in densely developed cities. Street trees have fewer restrictions on land use, which can be a measure to secure green areas in cities. In Korea, excessive pruning is being done on some street trees for reasons such as blocking of building signboards, contact with electric wires, and restrictions on sidewalk widths. Therefore, it is necessary to quantitatively understand the relationship between the benefits provided by street trees and their structures to come up with an efficient and systematic planning and management plan for urban street trees. In this study, we quantitatively analyzed the relationship between the thermal comfort improvement by the shades of street trees and the vertical structure, planting environment, and types of street trees. To calculate the thermal comfort felt by human body, we calculated UTCI (Universal Thermal Climate Index) of each street tree. For the vertical structure of street trees, we used Terrestrial LiDAR and the point clouds of street tree's crown was sliced vertically at 1m intervals. We conducted a multiple regression analysis on the thermal comfort improvement using the variables we obtained from fields. As a result, in the case of a street tree's vertical structure, the lager the volume of tree's crown located 3-4m (β=0.298, p<.05) and 6-7m (β=0.568, p<.001) above clear length, the better the cooling effect. In addition, the thermal comfort improvement was assessed to decrease as the DBH increased (β=-0.435, p<.001). In general, the crown diameter and DBH are positively correlated, with a cooling effect occurring as crown diameter increases. In this study, the opposite result was obtained due to the small number of trees measured, so additional research is needed by increasing the number of tree samples. In the case of the planting environment, the effect of improving thermal comfort was higher in the shaded area of trees planted to the south (β=-0.541, p<.001). Since unsystematic management of street trees can deteriorate the function of them, quantitative evaluations of the vertical structure of street trees are required, which can provide specific measures for planning and management of urban street trees with thermal comfort effect.

• 대한본초학회지
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• 제28권4호
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• pp.71-76
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• 2013

Objectives : The biological activities and compound contents of herbal medicine vary depending on manufacturing processes. In this study, we compared anti-inflammatory effects and compound contents of three kinds of multi-herbal extract HT008 produced by different manufacturing processes in order to determine chemical and biological equivalence. Methods : HT008 was produced by three different manufacturing methods: 1. Freeze dried extract of Eleutherococcus senticosus, Scutellaria baicalensis and Angelica sinensis (HT008 FD), 2. Spray dried extract of E. senticosus and S. baicalensis combined with reflux extract of A. sinensis (HT008 SD), 3. Spray dried extract of E. senticosus and S. baicalensis combined with supercritial fluid extract of A. sinensis (HT008 SF). Anti-inflammatory effects were evaluated using acetic acid induced pain model and ${\lambda}$-carageenan induced paw edema model. Compound contents were evaluated by HPLC quantitative analysis of standard compounds of HT008, eleutheroside E, baicalin, z-ligustilide. Results : HT008 FD, HT008 SD and HT008 SF significantly decreased acetic acid induced pain index and ${\lambda}$-carrageenan induced paw edema volume compared with that of control group. There was no significant difference in efficacy among the HT008 FD, HT008 SD and HT008 SF. Standard compound contents of HT008 FD, HT008 SD and HT008 SF were quantified within the range of Korean pharmacopoeia or other research. Conclusions : Three different manufacturing methods of multi-herbal extracts have been developed without noticeable difference in the efficacy or compound contents. The results might be used to establish manufacturing process and industrialization of herbal extracts.

• The Journal of Advanced Prosthodontics
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• 제14권4호
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• pp.203-211
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• 2022

PURPOSE. The aim of this study was to introduce rating criteria to evaluate student performance in a newly developed, digital wax-up preclinical program for computer-aided design (CAD) of full-coverage crowns and preliminarily investigate the reliability and internal consistency of the rating system. MATERIALS AND METHODS. This study, conducted in 2017, enrolled 47 fifth-year dental students of Okayama University Dental School. Digital wax-up training included a fundamental practice using computer graphics (CG), multipurpose CAD software programs, and an advanced practice to execute a digital wax-up of the right mandibular second molar (#47). Each student's digital wax-up work (stereolithography data) was evaluated by two instructors using seven qualitative criteria. The total qualitative score (0-90) of the criteria was calculated. The total volumetric discrepancy between each student's digital wax-up work and a reference prepared by an instructor was automatically measured by the CAD software. The inter-rater reliability of each criterion was analyzed using a weighted kappa index. The relationship between the total volume discrepancy and the total qualitative score was analyzed using Spearman's correlation. RESULTS. The weighted kappa values for the seven qualitative criteria ranged from 0.62 - 0.93. The total qualitative score and the total volumetric discrepancy were negatively correlated (ρ = -0.27, P = .09, respectively); however, this was not statistically significant. CONCLUSION. The established qualitative criteria to evaluate students' work showed sufficiently high inter-rater reliability; however, the digitally measured volumetric discrepancy could not sufficiently predict the total qualitative score.

• Composites Research
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• 제20권4호
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• pp.31-41
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• 2007

시스템 요구 조건에 따른 다양한 돔 형상 설계를 위하여 외부 하중이 고려된 돔 형상 설계 식이 제시되었고, 동일 원통부와 보스 오프닝을 가지면서 다른 돔 형상을 갖는 압력 용기의 성능(파열압력*내부용적/복합재무게) 변화를 유한요소해석을 통하여 평가하였다. 해석 결과는 돔 형상이 낮아질수록 파열 압력이 저하되어 압력 용기 성능이 저하됨을 나타내었다. 특히 원통부 반경과 보스 오프닝간의 비를 나타내는 보스 오프닝 크기 비율(${\rho}\;o$)이 큰 경우는 돔 형상이 낮아짐에 따라 복합재 무게 증가율이 크게 나타남으로서 압력 용기 성능 저하의 원인이 되었고, 파열 압력 상승을 위하여 돔 부위에 추가적인 보강설계가 요구되었다. 예를 들어 ${\rho}\;o=0.35$ 이하의 돔인 경우, 돔 형상 변화가 크지 않음으로서 돔 형상 변화에 따른 압력 용기 성능 변화도 크지 않은 것으로 나타난 반면, ${\rho}\;o=0.54$ 이상의 압력 용기인 경우 낮은 돔으로 변화됨에 따라 파열 압력 감소와 복합재 무게 증가로 압력 용기 성능 저하가 비교적 크게 나타나서 압력 용기 내부 용적 증가나 스커트와 돔간의 공간 확보가 우선인 설계 조건을 제외하고는 낮은 돔 형상 설계가 바람직하지 않은 것으로 나타났다.

• 환경영향평가
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• 제32권6호
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• pp.407-418
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• 2023

본 연구는 한국의 주요 개발사업에서의 지형변화지표를 분석하고, 지형 변화 지표 사이의 상관관계를 분석하여 각 입지유형과 경사유형에 따른 기반 지형변화지표를 도출하였다. 이를 통해 미래 개발사업에 있어서 토지 이용 및 조성의 효율성을 높이며 환경에 대한 영향을 최소화하는 지속 가능한 개발 방향으로 기여하고자 한다. 또한, 연구 결과를 실제 현장에 적용하기 위해 국내 지형 관련 규정을 조사하고 해당 규정과 연구 분석 결과 간의 부합성과 활용 가능성에 대해 논의하였다. 이를 토대로, 향후 연구에 있어서 보다 정확하고 유용한 지형변화 지표의 활용을 위한 방안을 탐구하고자 한다. 결과적으로, 관광단지개발사업에서는 평지, 구릉지, 산지 순으로 지형변화가 주로 이루어지며, 구릉지와 산지에서의 지형변화도 평지에 비해 높은 것으로 분석되었다. 또한, 산업단지 조성사업에서는 급경사지(20°-30°)와 험준지(30°-40°), 도시개발 사업에서는 경사지(15°-20°), 체육시설 조성사업에서는 경사지와 급경사지, 관광단지 조성사업에서는 경사지(15°-20°)와 급경사지(20°-30°)에서의 지형변화지표 평균이 다른 경사도에 비해 높은 것으로 확인되었다. 연구 결과는 앞으로 국내 개발 사업에서 지형 훼손을 최소화하는 전략을 개발하는 데 기여할 수 있으며, 환경 영향 평가를 수행할 때 필요한 참고 자료로 활용될 수 있다.

• Korean Journal of Radiology
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• 제22권7호
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• pp.1172-1184
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• 2021

Objective: The purposes of this study were to analyze the radiation doses for pediatric abdominopelvic and chest CT examinations from university hospitals in Korea and to establish the local diagnostic reference levels (DRLs) based on the body weight and size. Materials and Methods: At seven university hospitals in Korea, 2494 CT examinations of patients aged 15 years or younger (1625 abdominopelvic and 869 chest CT examinations) between January and December 2017 were analyzed in this study. CT scans were transferred to commercial automated dose management software for the analysis after being de-identified. DRLs were calculated after grouping the patients according to the body weight and effective diameter. DRLs were set at the 75th percentile of the distribution of each institution's typical values. Results: For body weights of 5, 15, 30, 50, and 80 kg, DRLs (volume CT dose index [CTDI_vol]) were 1.4, 2.2, 2.7, 4.0, and 4.7 mGy, respectively, for abdominopelvic CT and 1.2, 1.5, 2.3, 3.7, and 5.8 mGy, respectively, for chest CT. For effective diameters of < 13 cm, 14-16 cm, 17-20 cm, 21-24 cm, and > 24 cm, DRLs (size-specific dose estimates [SSDE]) were 4.1, 5.0, 5.7, 7.1, and 7.2 mGy, respectively, for abdominopelvic CT and 2.8, 4.6, 4.3, 5.3, and 7.5 mGy, respectively, for chest CT. SSDE was greater than CTDI_vol in all age groups. Overall, the local DRL was lower than DRLs in previously conducted dose surveys and other countries. Conclusion: Our study set local DRLs in pediatric abdominopelvic and chest CT examinations for the body weight and size. Further research involving more facilities and CT examinations is required to develop national DRLs and update the current DRLs.

• Journal of Cardiovascular Imaging
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• 제31권2호
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• pp.85-95
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• 2023

BACKGROUND: The prognostic utility of follow-up transthoracic echocardiography (FU-TTE) in patients with hypertrophic cardiomyopathy (HCM) is unclear, specifically in terms of whether changes in echocardiographic parameters in routine FU-TTE parameters are associated with cardiovascular outcomes. METHODS: From 2010 to 2017, 162 patients with HCM were retrospectively enrolled in this study. Using echocardiography, HCM was diagnosed based on morphological criteria. Patients with other diseases that cause cardiac hypertrophy were excluded. TTE parameters at baseline and FU were analyzed. FU-TTE was designated as the last recorded value in patients who did not develop any cardiovascular event or the latest exam before event development. Clinical outcomes were acute heart failure, cardiac death, arrhythmia, ischemic stroke, and cardiogenic syncope. RESULTS: Median interval between the baseline TTE and FU-TTE was 3.3 years. Median clinical FU duration was 4.7 years. Septal trans-mitral velocity/mitral annular tissue Doppler velocity (E/e'), tricuspid regurgitation velocity, left ventricular ejection fraction (LVEF), and left atrial volume index (LAVI) at baseline were recorded. LVEF, LAVI, and E/e' values were associated with poor outcomes. However, no delta values predicted HCM-related cardiovascular outcomes. Logistic regression models incorporating changes in TTE parameters had no significant findings. Baseline LAVI was the best predictor of a poor prognosis. In survival analysis, an already enlarged or increased size LAVI was associated with poorer clinical outcomes. CONCLUSIONS: Changes in echocardiographic parameters extracted from TTE did not assist in predicting clinical outcomes. Cross-sectionally evaluated TTE parameters were superior to changes in TTE parameters between baseline and FU at predicting cardiovascular events.