• Proceedings of the KIEE Conference
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• 2004.10a
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• pp.164-168
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• 2004

A Zero-Voltage-Switching(ZVS) Three-Level Converter realizes ZVS for the switches with the use of the leakage inductance(or external resonant inductance) and the output capacitors of the switches, however; the rectifier diodes suffer from recovery which results in oscillation and voltage spike. In order to solve this problem, this paper proposes a novel ZVS Three-Level converter, which introduces two clamping diodes to the basic Three-Level converter to eliminate the oscillation and clamp the rectified voltage to the reflected input voltage.

• Proceedings of the KIEE Conference
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• 2005.04a
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• pp.183-187
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• 2005

A Zero-Voltage-Switching(ZVS) Three-Level Converter realizes ZVS for the switches with the use of the leakage inductance(or external resonant inductance) and the output capacitors of the switches, however; the rectifier diodes suffer from recovery which results in oscillation and voltage spike. In order to solve this problem, this paper proposes a novel ZVS Three-Level converter, which introduces two clamping diodes to the basic Three-Level converter to eliminate the oscillation and clamp the rectified voltage to the reflected input voltage, the proposed ZVS Three-Level converter can be simplified by removing the two freewheeling diodes.

• Proceedings of the KIEE Conference
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• 2001.10a
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• pp.205-207
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• 2001

In response to this inverter microwave oven has been developed to improve high speed cooking time & energy saving performance. The voltage resonating inverter has a defect in switching element that works at 5 or 6times higher than input voltage. Especially, it is very difficult to choose the switching device is very high for the 220 (V) commercial voltage. In this paper, it is proposed the optimum method to realize the turbo 1200(W) output power for microwave oven that is employed the 900(V) IGBT with decreasing operating voltage of the switching component by making the 220(V), 1000(W) inverter through the active clamp voltage resonating inverter.

• Journal of Power Electronics
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• v.19 no.4
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• pp.944-955
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• 2019

In this paper, the three-level T-type neutral-point-clamped indirect matrix converter topology and the relative space vector modulation methods are introduced to improve the voltage transfer ratio and output voltage performance. The presented converter topology is based on combinations of cascaded-rectifier and three-level T-type neutral-point-clamp inverter. It can overcome the limitation of voltage transfer ratio of the conventional matrix converter and the high voltage rating of power switches of conventional matrix converter. Two SVPWM strategies for proposed converter are described in this paper to achieve the advantages features such as: sinusoidal input/output currents and three-level output voltage waveforms. Results from Psim 9.0 software simulation are provided to confirm the theoretical analysis. Hence, a laboratory prototype was implemented, and the experimental results are shown to validate the simulation results and to verify the effectiveness of the proposed topology and modulation strategies.

• Proceedings of the KIPE Conference
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• 2016.07a
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• pp.335-336
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• 2016

This paper introduces a bidirectional full-bridge converter with new active damp structure. The proposed active damp circuit can damp the oscillating voltage across the rectifier diodes with a smaller voltage stress of the damping capacitor and eliminate the circulating current. In addition, the proposed converter can achieve additional advantages such as nearly ZCS switching for leading-leg switches and no recovery current for rectifier-bridge by the suitable design of the damp capacitor to resonate with leakage inductor. Since the ZVS is achieved for both leading-leg and lagging-leg switches by the magnetizing current of the transformer, it can be achieved regardless of the load variation. A 3.3 kW prototype converter is implemented for vehicle-to-grid (V2G) application and the advantages of the proposed converter are verified by the experiments. The maximum efficiencies of 98.2% and 97.6% have been achieved for the buck mode and boost mode operation, respectively.

• Proceedings of the KIEE Conference
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• 1996.07a
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• pp.521-524
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• 1996

A new zero voltage and nero current switching(ZVZCS) full bridge(FB) PWM converter b proposed to improve the performance of the previously presented ZVZCS-FB-PWM converters [7,8]. By adding a secondary active clamp and controlling the clamp switch moderately, ZVS(for leading-leg switches) are ZCS(for lagging-leg switches) are achieved without nay lossy components, the reverie avalanche break down of leading-leg IGBTs[7] or the saturable reactor in the primary[8]. Many advantages including simple circuit topology, high efficiency, and low cost mate the new converter attractive for high voltage and high power(> 10 kW) applications. The principle of operation is explained and analyzed. The features and design considerations of the new converter are also illustrated and verified on an 1.8 kW, 100 kHz IGBT based experimental circuit.

• Biomolecules & Therapeutics
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• v.12 no.4
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• pp.250-256
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• 2004

Cordyceps possesses numerous health-promoting ingredients including hypoglycemic agents. The mechanism for the reduction of circulatory sugar content, however, is still not fully understand. In this study, 4-beta acetoxyscirpendiol (ASD) was purified from the methanolic extracts from fruiting bodies of Paecilomyces tenuipes. Na+/Glucose transporter-1 (SGLT-1) was expressed in the Xenopus oocytes. The effect of ASD on the oocyte expressed SGLT-1 was analyzed utilizing the voltage clamp and 2-deoxy-D-glucose (2-DOG) uptake studies. ASD was shown to significantly inhibit SGLT-1 activity compared to the non-treated control in a dose- dependent manner. In the presense of its two derivatives (diacetoxyscirpenol or 15-acetoxyscirpendiol), SGLT-1 activity was greatly inhibited similarly as ASD. Between ASD derivatives, 15-acetoxyscirepenol showed inhibition equivalent to that of ASD while diacetoxyscirpenol did less degree of inhibition. Insummary , these results strongly indicate that ASD in P. tenuipes may serve as a functional substance in lowering blood sugar in the circulatory system. ASD and its derivatives can be utilized as inhibitors of SGLT-1.

• BMB Reports
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• v.38 no.2
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• pp.211-217
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• 2005

Cordyceps, an entomopathogenic fungus, contains many health-promoting ingredients. Recent reports indicate that the consumption of cordyceps helps reduce blood-sugar content in diabetics. However, the mechanism underlying this reduction in circulatory sugar content is not fully understood. Methanolic extracts were prepared from the fruiting bodies of Paecilomyces tenuipes, and 4-beta acetoxyscirpendiol (4-ASD) was eventually isolated and purified. $Na^+$/Glucose transporter-1 (SGLT-1) was expressed in Xenopus oocytes, and the effect of 4-ASD on SGLT-1 was analyzed utilizing a voltage clamp and by performing 2-deoxy-D-glucose (2-DOG) uptake studies. 4-ASD was shown to significantly inhibit SGLT-1 activity compared to the non-treated control in a dose-dependent manner. In the presence of the derivatives of 4-ASD (diacetoxyscirpenol or 15-acetoxyscirpendiol), SGLT-1 activity was greatly inhibited in an 4-ASD-like manner. Of these derivatives, 15-acetoxyscirepenol inhibited SGLT-1 as well as 4-ASD, whereas diacetoxyscirpenol was slightly less effective. Taken together, these results strongly indicate that 4-ASD in P. tenuipes may lower blood sugar levels in the circulatory system. We conclude that 4-ASD and its derivatives are effective SGLT-1 inhibitors.

• YAKHAK HOEJI
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• v.50 no.2
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• pp.111-117
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• 2006

Cardiac chambers serve as mechanosensory systems during the haemodynamic or mechanical disturbances. To examine a possible role of fluid pressure (FP) in the regulatien of atrial $Ca^{2+}$ signaling we investigated the effect of FP on L-type $Ca^{2+}$ current $(I_{Ca})$ in rat ventricular myocytes using whole-cell patch-clamp technique. FP $(\sim40cm\;H_2O)$ was applied to whole area of single myocytes with electronically controlled micro-jet system. FP suppressed the magnitude of peak $I_{Ca}$ by $\cong25\%$ at 0 mV without changing voltage dependence of the current-voltage relationship. FP significantly accelerated slow component in inactivation of $I_{Ca}$, but not its fast component. Analysis of steady-state inactivation curve revealed a reduction of the number of $Ca^{2+}$ channels available for activity in the presence of FP. Dialysis of myocytes with high concentration of immobile $Ca^{2+}$ buffer partially attenuated the FP-induced suppression of $I_{Ca}$. In addition, the intracellular $Ca^{2+}$ buttering abolished the FP-induced acceleration of slow component in $I_{Ca}$ inactivation. These results indicate that FP sup-presses $Ca^{2+}$ currents, in part, by increasing cytosolic $Ca^{2+}$ concentration.

• Journal of Ginseng Research
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• v.25 no.2
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• pp.74-81
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• 2001

The effect of Korean Ginseng saponins (total saponin, PD saponin and PT saponin) on the serotonin type 3 receptor, which is known to be involved in nausea and vomiting following anticancer chemotherapy or the general anesthesia, was investigated. after in vitro transcribed recombinant serotonin type 3 receptor in the Xenopus laevis oocyte, classic two electrodes voltage clamp technique was used. All of ginseng saponins inhibited the response of the agonist, serotonin, on the serotonin type 3 receptor in a dose-dependent manner. PT saponin showed to have the inhibitory effect more than 2 times as potent as PD saponin. Total saponin shifted the serotonin dose response plot to the right (EC$\_$50/, 0.70$\pm$0.17 $\mu$M into 3.57$\pm$1.42 $\mu$M, and Hill coefficient, 2.14$\pm$0.60 into 1.52$\pm$1.00). Ginseng saponin did not change the reversal potential (∼0 mV) of serotonin type 3 receptor. These results suggest that Korean ginseng saponin may have the inhibitory effect on serotonin type 3 receptor.