• Journal of Animal Science and Technology
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• 제46권3호
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• pp.387-396
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• 2004

본 시험은 vitamin C와 E 급여가 한우 거세우의 도체등급, 성분 함량 및 지방산 조성에 미치는 영향을 규명하기 위하여 실시하였다. 시험구는 대조구(비타민 C 비급여 및 비타민 E 20 IU/kg feed), 비타민 C 급여구(비타민 C 0.1%/kg feed 및 비타민 E 20 IU/kg feed), 비타민 E 급여구(비타민 E 220 IU/kg feed) 및 비타민 C와 E 혼합 급여구(비타민 C 0.1%/kg fed 및 비타민 E 220 IU/kg feed)의 네 처리구로 나누어 출하 전 90일 동안 사양시험을 실시하였고, 도체등급, 배최장근의 비타민 C와 E 함량 및 지방산 조성을 조사하였다. 육량등급은 비타민 C와 E 혼합 급여구가 다른 구보다 좋았고, 육질등급은 대조구와 비타민 급여구간에 유의적인 차이는 없엇다. 배최장근 중의 일반성분 함량은 대조구와 비타민 급여구간에 뚜렷한 차이는 나타나지 않았고, 배최장근 중의 비타민 C 함량은 비타민 C 급여구 및 비타민 C와 E 혼합 급여구가 높았으며, 비타민 E 함량은 비타민 E 급여구 및 비타민 C 와 E 혼합 급여구가 높았다. 배최장근 중의 지방ㅅ나 조성 중 myristic acid, palmitic acid, palmitoleic acid 및 oleic acid는 비타민 C 급여구가 높았고, linoleic acid는 비타민 E 급여구가 높았으며, 총 포화지방산과 총 불포화지방산은 처리구간에 유의적인(P<0.05) 차이는 없었다.

• Journal of Nutrition and Health
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• 제33권5호
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• pp.507-516
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• 2000

The purpose of this study was to investigate the effect of vitamin C and vitamin E supplementation on the iron contents and oxidative stress of the rats. Rats were fed 18g ascorbic acid and 300IU $\alpha$-tocopherol/kg diet, respectively. Rats were sacrificed at 1, 3, 5 and 7 month of age. The blood, liver and brain were selected for the quantitation of iron and malondialdehyde(MDA) contents, glutathione peroxidase(GSHPx), superoxided dismutase(SOD) and catalase(CAT) activity. Iron and MDA contents and GSHPx activities were increased with aging. Vitamin C and Vitamin E supplementation increased iron contents of the plasma. Vitamin C raised iron contents, but vitamin E decreased iron contents of the liver. In the brain vitamin C and vitamin E did not affect the iron level. MDA levels were decreased with vitamin C and vitamin E supplementation in the erythrocyte and liver, and vitamin C supplementation elevated MDA levels in the brain. GSHPx activity was increased with vitamin C and vitamin E supplementation. SOD activities of erythroucyte and brain were not affected with age, but in the liver, SOD activity was raised with age and vitamin C supplementation. Vitamin C and vitamin E supplementation promoted CAT activity of erythroucyte and liver, and CAT activity of brain was eleveated with vitamin addition but was decreaed with vitamin E addition. Vitamin C and vitamin E decreased iron contents of blood plasma, MDA contents of plasma and liver, and CAT activity of erythrocyte. Above results indicated that iron contents and biomarkers of oxidative stress were more affected by age than antioxidant action of vitamin C and vitamin E.

• Journal of Nutrition and Health
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• 제20권1호
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• pp.38-45
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• 1987

This study was performed to investigate the effect of dietary vitamin E supplement and kinds of lipid on the vitamin E concentration and lipid composition in serum of the rats fed fro seven weeks. Supplemented vitamin E was 300mg/kg diet as DL-α-tocopherol acetate, and 15% of corn oil or beef tallow was added to standard diet. The results were as follows ; 1) Body weight and feed efficiency ratio were significantly increased by supplement with vitamin E, corn oil and beef tallow. 2) Serum vitamin E concentration increased significantly by supplement of vitamin E and beef tallow on the diets, while one of corn oil fed group decreased significantly . 3) The contents of triglyceride, total cholesterol, phospholipid in serum were significantly increased in the beef tallow group, and the vitamin E only -supplemented group showed significantly lower serum cholesterol in serum increased significantly in the vitamin E only -fed group and vitamin E plus corn oil-fed group. 4) The content of HDL-cholesterol in serum increased significantly in the vitamin E only -fed group and vitmain e plus corn oil -fed group. 5) The ratio of VLDL, LDL-cholesterol content to HDL-cholesterol one in serum was significantly low in the vitamin E only-supplemented group and corn oil group, and was significantly higher in the beef tallow group than in the corn oil group.

• 한국식품영양과학회지
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• 제19권3호
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• pp.207-214
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• 1990

Amish 집단(미국 오하이오주 홈스카운터 거주)의 vitamin E 영양상태를 24시간 회상법, 영양보충제의 사용량 조사 colorimetric법에 의한 혈장 vitamin E의 분석으로 평가하였다 평균식이 섭취 vitamin E는 7.4mg a-tocopherol equivalent였으며 평균 181.4 IU는 영양보충제로 섭취했다 전체 vitamin E의 67.7% 는 식이를 통해 섭취했으며 32.4%는 영양보충제를 복용함으로 섭취했다 평균 혈장 vitamin E 농도는 13.4mg/ml였다 혈장 vitamin E와 영양제로 복용한 vitamin E 사이에는 유의적인 상관과계가(r=0.489 p=0.0001)를 보여주었고 혈장 vitamin E와 연령과도 상관관계(r-0.216, p=0.0017)가 있었다 Amish 집단의 vitamin E 영양상태는 충분했으며 이집단 중의 어떤 자들은 고단위의 다량의 vitamin E 영양제를 복용하고 있어 vitamin E에 대한 올바른 정보를 알려주고 효율적인 영양교육을 시킬 필요성이 요청되었다.

• Journal of Pharmaceutical Investigation
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• 제21권1호
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• pp.51-55
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• 1991

Porous spheres composed of natural waxes and inorganic materials containing vitamin E acetate as a drug were prepared by impregnation method. Furthermore, the amount of vitamin E acetate entrapped in the spheres and the release rate of vitamin E acetate from the spheres were studied. The impregnation of vitamin E acetate was carried out by dipping the spheres in vitamin E acetate solutions. Entrapment mechanism of vitamin E acetate could be expressed in terms of Langmuir's adsorption isotherm. The amount of vitamin E acetate entrapped in porous spheres was influenced by the structure and concentration of the polymer used in vitamin E acetate solutions, and the concentration of vitamin E acetate. Release characteristics of vitamin E acetate from the spheres were investigated by withdrawing samples periodically and analyzing them by spectrophotomer.

• Journal of Nutrition and Health
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• 제43권3호
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• pp.304-314
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• 2010

Vitamin E has been a generic term for all tocopherol and tocotrienol derivatives. The most active form of vitamin E isoforms in vivo is regarded to be $\alpha$-tocopherol which is the only form defined as vitamin E in the US Food and Nutrition Board, causing controversy over setting dietary reference intake (DRI) of vitamin E. However, most of the countries other than the US maintain the original concept that all isoforms are accepted as vitamin E but with different biopotency. The roles of the isoforms of vitamin E other than $\alpha$-tocopherol have received continuous attention. Among them those of $\gamma$-tocopherol and $\alpha$-tocotrienol have been most studied in comparison with $\alpha$-tocopherol, since $\gamma$-tocopherol comprises major form of vitamin E in many plant seeds and those of the both vitamin E have been implicated in unique physiological functions. This review summarizes findings that have led a better understanding of vitamin E absorption, transport, tissue storage and various functions common and specific to vitamin E isoforms focusing $\alpha$- and $\gamma$-tocopherol as well as tocotrienols. It is expected to help redefining vitamin E and setting its DRI for Koreans.

• Journal of Nutrition and Health
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• 제32권3호
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• pp.239-247
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• 1999

With the increasing elderly population in Korea, dementia has become a mojor health problem in Korea. Several studies have been conducted on the association between dementia and dietary intake, especially vitamin E and vitamin C. The purpose of this study was to investigate the effect of vitamin E and vitamin C supplementation on the decrease in cognitive function induced by scopolamine(300mg/kg) in rats. Rats were divided into three groups : control, vitamin C, and vitamin E supplementation(2.4g Vit C or Vit E /100g diet) and fed the diets for 6 weeks. There were significant decreases in active avoidance response and brain acetylcholinesterase activity in the control group, but no significant differences were observed in the vitamin E and C groups after scopolamine treatment. Brain dopamine concentration of vitamin E and C groups was significantly higher than those of control group after scopolamine injection. The concentrations of brain norepinephrine also showed similar tendence, even though it was not statistically significant. These results indicate that vitamin E and vitamin C may protect against the cognitive function decrease induced by scopolamine. However, it is still unclear how vitamin E and C influence brain neurotransmitters and improve cognitive function. Further study is need to elucidate the role of vitamin E and C supplementation in the prevention of dementia.

• Journal of Nutrition and Health
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• 제28권10호
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• pp.967-975
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• 1995

To investigate effects of dietary fish oil and vitamin E level on the tissue levels of vitamin E and vitamin A and to see which tissue is sensitive to lipid peroxidizability, male Sprague-Dawley rats were fed experimental diets composed of either menhaden oil or soybean oil nad either low(equivalent to 17 mg $\alpha$-tocopherol) or high (equivalent to 140mg $\alpha$-tocopherol) vitamin E level for 4 weeks. Palsma TBARS per mg lipid was significantly elevated in rats fed fish oil with low vitamin E level compared to soybean oil-fed rats. TBARS levels of liver, heart, kidney and liver microsomes were also increased by feeding fish oil with low vitamin E level. Plasma TBARS level was significantly correlated with TBARS levels of liver, heart, kidney and liver microsome. Plasma vitamin E level of groups with vitamin E supplementation was elevated significantly as compared to the those without vitamin E supplementation, whereas vitamin E levels of liver, heart and kidney were not changed significantly. Plasma TBARS was negatively correlated with plasma vitamin E(r=0.5763, P<0.001) and A(r=-0.4523, P<0.01) and seems to be a good indicator of in vivo lipid peroxidative stress.

• 한국식품위생안전성학회지
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• 제1권2호
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• pp.143-149
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• 1986

Paraquat의 만성독성에 대한 vitamin E 급여의 효과를 조사하기 위하여 랫드에 paraquat를 50 ppm의 농도로 희석한 물을 음수 대신 투여하면서 vitamin E 함유 사료를 급여하여 paraquat에 대한 vitamin E의 방어 효과를 측정하였는 바 다음과 같은 결과를 얻었다. 1.혈장 vitamin E 농도는 사료 kg 당 10 mg까지의 vitamin E 함유 사료의 급여로 약 150$\mu\textrm{g}$/100ml까지 급격히 상승하였으며 그 후 급여량의 증가에도 비교적 안정된 혈중 농도를 유지하였고, 또한 paraquat 투여는 vitamin E 급여량에 관계없이 혈중 vitamin E 농도의 감소를 가져왔다. 2. 간저장 vitamin E 농도는 혈장 vitamin E 농도와 달리 급여량의 증가에 따라 비례하여 증가하는 경향을 보였으며 paraquat 투여에 의한 영향이 적었다. 3. Paraquat 투여는 적혈구 용혈율을 크게 증가시켰음 (95%), 100$\mu\textrm{g}$/100ml 이상의 vitamin E 혈장 농도에서는 안정된 적혈구 용혈율 (10% 이하)을 나타내었다. 4. Paraquat 투여는 혈장 trypsin inhibitor capacity를 크게 증가시켰으며, vitamin E 급여에 의하여 다소 회복되는 경향을 보였으나 정상에 이르지 못하였다. 5. 혈장 및 적혈구 glutathione peroxidase 활성은 paraquat 투여에 의하여 영향을 받지 않았다. 6. paraquat 투여 후의 lipid peroxide는 vitamin E의 급여로 감소되었다.

• Journal of Nutrition and Health
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• 제18권2호
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• pp.147-154
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• 1985

본 실험을 통해 뚜렷한 경향을 보여주는 몇가지 결과를 요약하면 다음과 같다. 식이vitamin E의 과량 첨가는 쥐의 혈청에 반영되어 나타났으며, 식이중의 cholesterol은 이 증가 효과를 감소시키는 경향을 보여주었다. 식이 cholesterol첨가로 인해 쥐의 혈청 cholesterol농도는 영향을 받지 않은 반면, 간의 cholesterol농도는 증가되었다. 과량 vitamin E와 cholesterol 두가지를 식이에 첨가하였을 경우 (IV-ECh IV'-ECh) 간의 cholesterol농도는 식이에 cholesterol만을 첨가한 경우 (III-Ch, III'-Ch)보다 더욱 높게 나타났다. 그리고 vitamin E만을 첨가한 II-E와 II'-E군에서는 간의 cholesterol농도를 낮추어주는 경향을 보였다. 간의 vitamin A 농도는 쥐가 성장함에 따라 감소하였으며 각 실험군 간에는 유의적인 차이를 보이지 않았으나, B군의 경우 과량 vitamin E 식이는 간 vitamin A농도를 감소시키는 경향으로 나타났다. Vitamin E, vitamin A, cholesterol 및 다른 여러 요소들간의 복잡한 상호관계를 알아내기 위해, age가 다른 그리고 여러 species의 동물을 이용한, 장기간의 단계적이고도 체계적인 많은 연구가 요구되어진다.