• Asian-Australasian Journal of Animal Sciences
• /
• 제30권8호
• /
• pp.1099-1104
• /
• 2017

Objective: This work was to find the correlation of alcohol dehydrogenase 1C (ADH1C) genotype with vitamin A reduction and carcass traits during the vitamin A restriction period. Methods: In study 1, 60 Korean native steers were fed a diet (890 IU/kg) with 8,000 IU and 0 IU of supplemental premix vitamin A/kg of dry matter (DM) for control and treatment group, respectively. The levels of serum vitamin A were analyzed through high preparative performance liquid chromatography, and the ADH1C genotype was analyzed based on polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP; 78.1% TT type, 21.9% TC type); however, CC type was not found. Then, the interaction between ADH1C and carcass traits on the vitamin A restriction was investigated in study 2. A total of 136 Korean native steers were fed a diet that included 930 IU/kg vitamin A of DM. Results: Serum vitamin A in treatment was reduced to 112.4 IU/dL in steers with TT type of ADH1C, while for steers with TC type the concentration of serum vitamin A was dropped to 79.5 IU/dL (p<0.1) in study 1. This showed that TC type had the potential to lower serum vitamin A concentration during vitamin A restriction compared to TT type. In study 2 we found that eye muscle area, marbling and carcass weight in Korean native steers with TC type were higher than in steers with TT type (p<0.05). Conclusion: The interaction between vitamin A restriction and TC type of ADH1C gene could have the potential of increasing the marbling in Korean native steers. These results indicated that steers with TC type of the ADH1C gene were more sensitive to the change of serum vitamin A than TT types. Furthermore, this finding has the potential to enable a higher marbling score under the condition of vitamin A restriction in Korean native steers.

• Clinical and Experimental Reproductive Medicine
• /
• 제41권2호
• /
• pp.80-85
• /
• 2014

Objective: To investigate: the prevalence of vitamin D deficiency in Korean women with polycystic ovary syndrome (PCOS), and the relationship between vitamin D status and clinical or metabolic features in this group. Methods: We recruited 38 women with PCOS using the Rotterdam criteria. A total of 109 premenopausal control women were matched with patients based on age and body mass index. Serum 25-hydroxy vitamin D concentrations less than 20 ng/mL were classified as frank vitamin D deficiency. Since vitamin D may play a significant role in metabolic disturbances in women with PCOS, correlations between clinical or metabolic parameters and vitamin D status were analyzed separately in patients and controls. Results: Women with PCOS showed no differences in the level of 25-hydroxy vitamin D ($19.6{\pm}6.6ng/mL$ in patients vs. $20.1{\pm}7.4ng/mL$ in controls, respectively, p=0.696) or prevalence of vitamin D deficiency (57.9% in patients vs. 56.5% in controls, respectively, p=0.880). In addition, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles in either PCOS patients or controls. Conclusion: Our study found no differences in the absolute level of serum vitamin D between PCOS patients and matched controls. Prevalence of vitamin D deficiency was equally common among both patients and controls. Additionally, we did not find any correlations between serum vitamin D level and clinical or metabolic profiles, suggesting that the role of vitamin D in the pathogenesis of PCOS is not yet clear.

• Journal of Hospice and Palliative Care
• /
• 제18권2호
• /
• pp.120-127
• /
• 2015

목적: 국내 말기암환자를 대상으로 혈중 vitamin D 농도를 측정하고, 생존기간과의 관련성에 대하여 확인해 본다. 방법: 2012년 5월부터 15개월 동안, 국내 일개 병원의 말기암환자 96명을 대상으로 후향적 의무기록 조사를 시행하였다. Vitamin D 결핍에 영향을 미치는 요인들을 파악하기 위해 단순 로지스틱 회귀분석과 다중 로지스틱 회귀분석을 실시하였고, vitamin D가 생존기간에 미치는 영향을 파악하기 위해 다변수 분석으로 Cox's proportional hazard regression analysis를 실시하였다. 결과: 대상자의 평균 연령은 $67.06{\pm}13.77$세였고, 모든 대상자가 ECOG PS 3점 이상이었으며 혈중25(OH)D 농도는 평균 $8.60{\pm}7.16ng/ml$였다. 3명(3.1%)만이 vitamin D 충분상태(혈중 25(OH)D 농도${\geq}30ng/ml$)였으며, 5명은 vitamin D 상대적결핍상태(혈중 25(OH) 농도 20~30 ng/ml)였고, 13명(13.5%)은 vitamin D 결핍(혈중 25(OH)D 농도 10~20 ng/ml), 75명(78.1%)은 vitamin D 중증결핍상태(혈중 25(OH)D<10 ng/ml) 였다. 혈중 빌리루빈 농도가 1.2 mg/dl 이상인 경우 vitamin D 중증결핍과 관련이 있었다(Odds ratio, OR=5.041; P=0.039). 혈중 빌리루빈 농도가 높을수록 혈중 vitamin D 농도가 낮았으며, 고빌리루빈혈증인 환자는 vitamin D 중증결핍에 속할 위험이 더 크고(OR=18.476, P<0.05), 중앙생존기간도 유의하게 짧았다. Vitamin D 중증결핍인 경우 추정된 중앙생존기간은 짧았으나 통계적 유의성은 없었다. 다변량 분석결과에서 vitamin D 중증결핍은 사망의 위험인자가 아니었다. 결론: 말기암환자에서 혈중 vitamin D 결핍은 매우 심각하였으나, vitamin D 중증결핍이 생존기간에 영향을 미치지는 않았다.

• 대한치과교정학회지
• /
• 제28권4호
• /
• pp.627-640
• /
• 1998

골 성장 및 개조에 관여하는 전신적 조절인자인 $1,25-(OH)_2D_3$와 국소적 조절인자인 $TGF-{\beta}$가 사람의 치주인대세포 기능에 미치는 영향을 관찰하고자 그 인자들을 단독 혹은 복합적으로 치주인대세포에 가하여 그 활성 변화를 측정하여 다음과 같은 결과를 얻었다. 1. 10ng/m1 농도의 vitamin $D_3$를 치주인대세포에 가한 후 배양 1, 2, 3일째의 활성은 대조군과 차이가 없었으나, 50ng/ml 농도로 가한 후 배양 3째일에는 대조군에 비해 유의하게 증가하였으며, 100ng/m1 농도에서는 배양 1, 2, 3일째에 유의하게 증가하였다. 2. 0.1ng/ml 농도의 $TGF-{\beta}$를 치주인대세포에 가한 후 배양 1, 2, 3일째의 활성은 대조군과 유의한 차이가 없었으나, 1ng/ml나 5ng/ml농도의 $TGF-{\beta}$를 가한 경우 배양 3일째에 유의하게 증가되었으며 10ng/ml농도의 경우에는 배양 2, 3일째에 유의하게 증가하였다. 3. 1ng/ml 농도의 $TGF-{\beta}$와 다양한 농도의 vitamin $D_3$를 혼합투여한 경우, 100ng/m1 농도의 vitamin $D_3$로 배양 3일째에 유의한 활성 증가를 볼 수 있었다. 4. 5ng/ml 농도의 $TGF-{\beta}$와 다양한 농도의 vitamin $D_3$를 혼합투여한 경우, 10, 50, 100ng/m1의 vitamin $D_3$에서 공히 배양 2일째부터 유의한 활성 증가를 보였으나 10ng/ml에서는 배양 3일째에 그 활성이 유지되지 못하였다. 5. 10ng/ml농도의 $TGF-{\beta}$와 다양한 농도의 vitamin $D_3$를 혼합투여한 경우, 50ng/ml의 vitamin $D_3$에서는 배양 2일째부터 100ng/m1의 vitamin $D_3$에서는 1일째부터 유의한 활성 증가를 보였다.

• Clinical and Experimental Reproductive Medicine
• /
• 제47권2호
• /
• pp.101-107
• /
• 2020

Objective: The present study investigated sperm chromatin quality and testosterone levels in acrylamide-treated mice and the possible protective effects of vitamin E on the fertility potential of spermatozoa. Methods: Thirty-two adult male mice were divided equally into four groups. Group 1 was the control, group 2 received acrylamide (10 mg/kg, water solution), group 3 received vitamin E (100 mg/kg, intraperitoneal), and group 4 received both acrylamide and vitamin E. After 35 days, spermatozoa from the right cauda epididymis were analyzed in terms of count, motility, morphology, and viability. Sperm DNA integrity and chromatin condensation were assessed by acridine orange (AO), aniline blue (AB), toluidine blue (TB), and chromomycin A3 (CMA3) staining. Results: In acrylamide-treated mice, significantly lower sperm concentration, viability, motility, and testosterone levels were found in comparison with the control and acrylamide+vitamin E groups (p< 0.05). In the vitamin E group, significantly more favorable sperm parameters and testosterone levels were found than in the other groups (p< 0.05). There were also significantly more spermatozoa with less condensed chromatin in the acrylamide-treated mice than in the other groups. Moreover, significantly more spermatozoa with mature nuclei (assessed by AB, CMA3, AO, and TB staining) were present in the vitamin E group than in the control and acrylamide+vitamin E groups. Conclusion: This study revealed the deleterious effects of acrylamide on sperm parameters and sperm chromatin quality. Vitamin E can not only compensate for the toxic effects of acrylamide, but also improve sperm chromatin quality in mice.

• Journal of Animal Science and Technology
• /
• 제47권2호
• /
• pp.233-242
• /
• 2005

Effects of supplemental charcoal powder and vitamin A on growth performance, serum profile and carcass characteristics with 24 Hanwoo steers were inves$\ell$ated. The Hanwoo steers were randomly assigned to one of the three dietary treatments: 1) Control(commercial feed), 2) Tl(commercial feed supplemented with 2% charcoal powder and 0.2 % vitamin A), 3) T2(commercial feed with 2 % charcoal powder). In the age 26 month, body weight of control Tl and T2 were 633.8 kg, 621.0 kg, 619.4 kg, respectively, with not significantly different(P> 0.05). The daily weight gain of control was the highest followed by Tl and T2. The contents of vitamin A(retinol) and total cholesterol in the blood of Tl was higher Tl(56.32 $\ell$ / dt, 163.83 mg/ dz) than the other treatment groups(P < 0.05). The average of WBC value in the blood was 6.86-" 9.83 k / ${\mu}\ell$, RBC value was 7.98 - 11.26 k / ${\mu}\ell$ and blood platelet was 236.7 - 287.0 k / ${\mu}\ell$. But The serum profile in blood was not significantly different between control and treatment groups. The carcass grade and characteristics of all treatments in Hanwoo steers were not significantly different except the texture.

• Asian-Australasian Journal of Animal Sciences
• /
• 제20권2호
• /
• pp.252-256
• /
• 2007

This study was carried out to determine the effect of vitamin E and vitamin C on the performance of Japanese quails (Coturnix coturnix japonica) reared under heat stress during the growth and egg production period. A total of 810 seven-day-old Japanese quails were used in the trial. The birds received a diet with either three levels of vitamin E (DL-${\alpha}$Tocopheryl acetate) (60, 120 and 240 mg/kg of diet) and vitamin C (ROVIMIX STAY-C 35) (60, 120 and 240 mg/kg of diet). Live weight on day 35 and weight gain were the lowest in the group of chicks on a combination of 60 mg of vitamin E and 60 mg of vitamin C, whereas the highest live weight was demonstrated in chicks on a combination of 240 mg of vitamin E and 240 mg of vitamin C (p<0.01). The effects of treatments on cumulative feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found to be significant (p<0.01). The highest feed consumption, feed conversion ratio, age at 5% lay, sexual maturity weight, rate of lay and mean egg weight values were found in the group on a combination of 240 mg of vitamin E and 240 mg of vitamin C. The effect of treatments on the mortality ratio was found to be insignificant (p>0.01). The cost of supplementing diets with vitamin E and vitamin C is very low. Therefore such a combination of supplement can offer a potential protective management practice in preventing heat stress related losses in performance of Japanese quails.

• Nutritional Sciences
• /
• 제4권2호
• /
• pp.104-111
• /
• 2001

The Purpose of this study was to investigate the dietary intake of nutrients and the use of vitamin and mineral supplements by Korean college students attending Web class and the socioeconomic, dietary and health-related factors involved. The subjects were 137 male and 115 female students amending a health and nutrition-related Web class at a cycler university. This cross-sectional survey was conducted by self-administered questionnaire and the data were analyzed by SAS and SPSS PC package programs. Nutrient intake data collected using three-day recall method were analyzed by the Computer Aided Nutritional Analysis Program. Average intake by male students of most nutrients except energy, vitamin B$_2$ and calcium and intake by female students of those except energy, vitamin $B_2$, calcium and iron was higher than Korean RDA. Nutrient intake of male students was significantly influenced by the mother s job, skipping meals, exercise, vitamin and mineral supplement use, flood supplement use and self-evaluated anemia. Skipping meals and flood supplement use significantly influenced the nutrient intake of female students. A total of 47.4% of male students and 53.9% of female students were vitamin and mineral supplement users. In female students, socioeconomic characteristics such as the father s education level and household income were significantly different between vitamin and mineral supplement users and non-users. In both male and female students, there were significant differences in cross analysis between vitamin and mineral supplement use and flood supplement use. As for the self-reported health status of male and female students, vitamin and mineral supplement users perceived their health status to be worse compared to non-users. Therefore, nutrition education via the Internet is necessary in order to encourage college students to practice optimal nutrition strategies, including maintaining well-balanced diets by choosing various floods wisely.

• 생약학회지
• /
• 제6권4호
• /
• pp.205-209
• /
• 1975

Ginseng, Vitamin, and both were given to six-year-old children for three months to know effects of the drugs on the physical growth of the children. 1. Frequency of children's sickness was in order of vitamin plus ginseng, ginseng, vitamin alone and control groups. 2. Height, circumference of chest and weight of children were increased in order of vitamin plus ginseng, ginseng, vitamin, and control groups. 3. Ginseng, as compared with vitamin increased the children's growth, especially their weight and the circumference of chest.

• Journal of Nutrition and Health
• /
• 제18권2호
• /
• pp.147-154
• /
• 1985

본 실험을 통해 뚜렷한 경향을 보여주는 몇가지 결과를 요약하면 다음과 같다. 식이vitamin E의 과량 첨가는 쥐의 혈청에 반영되어 나타났으며, 식이중의 cholesterol은 이 증가 효과를 감소시키는 경향을 보여주었다. 식이 cholesterol첨가로 인해 쥐의 혈청 cholesterol농도는 영향을 받지 않은 반면, 간의 cholesterol농도는 증가되었다. 과량 vitamin E와 cholesterol 두가지를 식이에 첨가하였을 경우 (IV-ECh IV'-ECh) 간의 cholesterol농도는 식이에 cholesterol만을 첨가한 경우 (III-Ch, III'-Ch)보다 더욱 높게 나타났다. 그리고 vitamin E만을 첨가한 II-E와 II'-E군에서는 간의 cholesterol농도를 낮추어주는 경향을 보였다. 간의 vitamin A 농도는 쥐가 성장함에 따라 감소하였으며 각 실험군 간에는 유의적인 차이를 보이지 않았으나, B군의 경우 과량 vitamin E 식이는 간 vitamin A농도를 감소시키는 경향으로 나타났다. Vitamin E, vitamin A, cholesterol 및 다른 여러 요소들간의 복잡한 상호관계를 알아내기 위해, age가 다른 그리고 여러 species의 동물을 이용한, 장기간의 단계적이고도 체계적인 많은 연구가 요구되어진다.