• 생물정신의학
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• 제15권3호
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• pp.194-203
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• 2008

Objectives : This study was aimed at evaluating the relationship between somatic symptoms, depression, anxiety and cognitive function in the patients with Mild Traumatic Brain Injury(MTBI). Methods : Thirty seven patients with MTBI were selected from those patients who had visited the Department of Neuropsychiatry of Wonkwang University Hospital from 2003 to 2007. To assess and quantify the somatic symptoms, depression and anxiety, Personality Assessment Inventory(PAI) was used. Assessment of cognitive function was carried out by using Korean Wechsler Adult Intelligence Scale(K-WAIS), Rey-Kim Memory Test, and Kims Executive Function Test. The effects of somatic symptoms, depression, and anxiety on the cognitive function were evaluated by Pearson correlation test. Results : Somatic symptoms, depression, and anxiety, all showed inverse correlation to cognitive function. Specifically, 1) an increase in somatic symptoms was associated with a decrease in attention, verbal short term memory, verbal recall and recognition, and visual memory. 2) An increase in anxiety was associated with a decrease in verbal recall and recognition. 3) An increase in depression was associated with a decrease in cognitive function that requires high attention and verbal memory. Conclusion : The patients with MTBI displayed diverse symptoms ranging from cognitive impairment to somatic symptoms, depression, and anxiety. Somatic and emotional symptoms were correlated with cognitive function(especially executive function). Importantly, this study raises the possibility of treating the cognitive impairment associated with MTBI by treating somatic symptoms, depression, and anxiety.

• Applied Biological Chemistry
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• 제21권1호
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• pp.40-50
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• 1978

Effects of Zn, P and Fe on Cd uptake and accumulations by tomato (Lycopersicum esculentum Mill) and also their interactions on the uptake of Zn, Fe, Mn, P and Cd were investigated using batch type solution culture technique. Experiment 1 was a factorial scheme with 3 levels of Zn (0, 0.5, 2.5 ppm) and 3 levels of Cd (0, 0.2, 1.0 ppm). At 1.0 ppm Cd, significant yield reduction of dry matter and visual toxicity symptoms (yellowing and necrosis) of Cd was observed for all zinc levels. At this Cd level, increasing Zn treatment from 0 to 2.5 ppm increased Cd concentration from 199 to 235 ppm in leaves and from 124 to 145 ppm in stems. Similarly, Cd treatment did not suppress Zn uptake in leaves, and rather significantly increased in stems. Fe concentrations in leaves and stems were significantly reduced due to Cd treatment while Mn were increased by both Zn and Cd treatment. The results of experiment 2 with 3 levels of P (0.5, 2.0, 4.0m Mol) and 3 levels of Cd (0, 1.0, 2.0 ppm) in a factorial scheme also showed a growth reduction and visual toxic symptons from 1.0 ppm Cd level. Increasing P treatment tend to increase Cd concentrations in leaves and stems although it was not statistically significant. Increasing P concentration due to Cd treatment could be the 'concentration' effect as a result of reduced growth, while there was significant decrease in Fe concentration due to Cd treatment in spite of possible 'concentration' effect. Mn concentration was increased at 1.0 ppm Cd level and then dropped at 2.0 ppm Cd level. Zu concentration in leaves and stems showed significant increase as Cd treatment increased as observed in experiment 1. Experiment 3 had 3 levels of Fe (0.5, 1.0, 2.0 ppm) and 3 levels of Cd (0, 0.8, 1.6 ppm) treatments in a factorial design. Significant growth reduction and visual toxic symptoms as observed in experiment 1 and 2 were also observed from 0.8 ppm Cd level. Increasing Fe treatment obviously alleviated toxic symptoms, improved growth and significantly increased dry matter yield. At 0.8 ppm Cd treatment level, increasing Fe treatment from 0.5 to 2.0 ppm significantly decreased Cd concentration from 141 to 92 ppm in leaves and from 101 to 46 ppm in stems. At 1.6 ppm Cd treatment level the decrease was from 224 to 167 ppm in leaves and from 124 to 109 ppm in stems. As in the case of experiment 1 and 2, Fe concentration in leaves and stems were reduced as Cd treatment increased to 1.6 ppm at 0.5 and 1. 0 Fe treatment levels, whereas at 2.0 ppm Fe level, Cd treatment increased Fe concentration in leaves and stems showing significant interactions of Fe and Cd on Fe uptake. Cd effect on Zn and Mn showed similar results to experiment 1 and 2 and Fe treatments reduced Zn and Mn concentrations in plant tissue. The results of 3 experiments show that P and Zn did not manifest suppressive effect on Cd uptake, Fe significantly demonstrated it. Fe also alleviated Cd toxicity symptoms significantly in terms of visual symptoms and dry matter yield. Visual toxicity symptoms were definitely related to Fe status in plant tissue as well as possible physiological effect of Cd itself, and the results suggest that Fe requirement for normal growth increase as Cd element is present in plant tissue. Zn accumulated more in stems than in leaves whereas Cd, Fe and Mn showed the opposite trend in all experiments.

• Journal of Preventive Medicine and Public Health
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• 제27권3호
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• pp.557-567
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• 1994

This study was conducted to examine the effect of chronic low dose organic solvent exposures in the industries towards then neurobehavioral functions of workers. Subjective symptoms on neurobehavioral function as well as a visual reaction time test (Flicker test) were administered to 94 exposed and 162 unexposed workers in a oil refinery and some other auto-repair shops. The results obtained were as follows : 1. Symptom complaints were higher and Flicker test values were lower in exposed workers than in unexposed workers. 2. Flicker valus were Inversely correlated with urinary Hippuric acid concentration in exposed workers(r=-0.26, p<0.05). 3. Flicker valus were inversely co..elated with Subjective symptom score(r=-0.15, p<0.05). Low Flicker value were also related with some subjetive symptoms such as 'Dimmed vision', 'Nightmare', 'Weakness on extrimity' in workers as a whole. While symptoms of 'Dimmed vision ', 'Nightmare' only observed among exposed workers.

• Journal of Korean Neurosurgical Society
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• 제58권3호
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• pp.291-293
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• 2015

Anterior communicating artery (ACoA) aneurysms sometimes present with visual symptoms when they rupture or directly compress the optic nerve. Giant or large ACoA aneurysms producing bitemporal hemianopsia are extremely rare. Here we present an unusual case of bitemporal hemianopsia caused by a large intracranial aneurysm of the ACoA. A 41-year-old woman was admitted to our neurosurgical department with a sudden-onset bursting headache and visual impairment. On admission, her vision was decreased to finger counting at 30 cm in the left eye and 50 cm in the right eye, and a severe bitemporal hemianopsia was demonstrated on visual field testing. A brain computed tomography scan revealed a subarachnoid hemorrhage at the basal cistern, and conventional cerebral catheter angiography of the left internal carotid artery demonstrated an $18{\times}8mm$ dumbbell-shaped aneurysm at the ACoA. Microscopic aneurysmal clipping was performed. An ACoA aneurysm can produce visual field defects by compressing the optic chiasm or nerves. We emphasize that it is important to diagnose an aneurysm through cerebrovascular study to prevent confusing it with pituitary apoplexy.

• 한국인터넷방송통신학회논문지
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• 제16권3호
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• pp.129-135
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• 2016

저시력인들을 위한 기존 시각 향상 장치들이 많이 있다. 이 장치는 주로 확대경 역할이 대부분이고, 고가이다. 저시력 원인으로는 다양한 증상에 기인한다. 시력 향상을 위해서는 영상의 확대, 밝기, 대비를 조절할 필요가 있다. 따라서 시력 향상 휴대용 마이크로 디스플레이 구동 드라이버 및 장치를 개발한다. 이 장치의 4가지 기본 원리는 영상 확대, 특정 색 조절, BLU로 밝기 조절, 프리즘에 의한 시축 개선이다. 제안된 HMVED 장치의 임상 실험이 실시되었다. 결과적으로 기존 장치에 비해서 수혜 효과가 돋보였으며 본 장치는 저중량, 저가, 휴대성이 용이하므로 저시력인의 삶의 질 향상에 도모한다.

• Journal of Korean Neurosurgical Society
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• 제50권4호
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• pp.281-287
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• 2011

Objective : Pituitary apoplexy is life-threatening clinical syndrome caused by the rapid enlargement of a pituitary tumor due to hemorrhage and/or infarction. The pathogenesis of pituitary apoplexy is not completely understood. We analyzed the magnetic resonance imaging (MRI) of pituitary tumors and subsequently correlated the radiological findings with the clinical presentation. Additionally, immunohistochemistry was also performed to determine whether certain biomarkers are related to radiological apoplexy. Methods : Thirty-four cases of pituitary adenoma were enrolled for retrospective analysis. In this study, the radiological apoplexy was defined as cases where hemorrhage, infarction or cysts were identified on MRI. Acute clinical presentation was defined as the presence of any of the following symptoms: severe sudden onset headache, decreased visual acuity and/or visual field deficit, and acute mental status changes. Angiogenesis was quantified by immunohistochemical expression of fetal liver kinase 1 (Flk-1), neuropilin (NRP) and vascular endothelial growth factor (VEGF) expression, while microvascular density (MVD) was assessed using Endoglin and CD31. Results : Clinically, fourteen patients presented with acute symptoms and 20 for mild or none clinical symptoms. Radiologically, fifteen patients met the criteria for radiological apoplexy. Of the fifteen patients with radiologic apoplexy, 9 patients presented acute symptoms whereas of the 19 patient without radiologic apoplexy, 5 patients presented acute symptoms. Of the five biomarkers tracked, only VEGF was found to be positively correlated with both radiological and nonradiological apoplexy. Conclusion : While pituitary apoplexy is currently defined in cases where clinical symptoms can be histologically confirmed, we contend that cases of radiologically identified pituitary hemorrhages that present with mild or no symptoms should be designated subacute or subclinical apoplexy. VEGF is believed to have a positive correlation with pituitary hemorrhage. Considering the high rate of symptomatic or asymptomatic pituitary tumor hemorrhage, additional studies are needed to detect predictors of the pituitary hemorrhage.

• Journal of Yeungnam Medical Science
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• 제33권1호
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• pp.1-7
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• 2016

The two distinctive clinical features of varicella-zoster virus (VZV) are varicella (chickenpox) by primary infection and zoster (singles) by the reactivation of latent infection. In addition to the two typical clinical symptoms mentioned above, diverse clinical manifestations have been reported as a result of VZV reactivation, including chronic radicular pain without rash, visual loss, facial palsy, dysphagia, sore throat, odynophagia, otalgia, hearing loss, dizziness, headache, hemiplegia, etc. Most of these symptoms are derived from neuropathy and vasculopathy of affected nerves and arteries. Diagnosis of VZV disease can be difficult if there is no appearance of a skin rash during development of atypical symptoms. In addition to natural infection, vaccination and anti-viral agent treatment have influenced the changes of epidemics and clinical presentations of varicella and zoster. In this article, diverse clinical manifestations caused by VZV reactivation, particular without skin rash, are reviewed.

• 대한한방내과학회지
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• 제37권6호
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• pp.1059-1068
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• 2016

Objectives: This study reports on the efficacy of treating patients with general weakness symptoms with Korean medicine. Methods: Two patients with general weakness symptoms were treated with Korean medical treatment modalities, including acupuncture, moxibustion, and herbal medicines. Blood tests, the visual analogue scale (VAS), and patients' complaints were used to assess the treatment effects. Results and Conclusions: dehydroepiandrosterone sulphate (DHEAS), DHEAS/cortisol index, VAS, and the patients' complaints improved after treatment. Korean medical treatment is effective in improving DHEAS and the DHEAS/cortisol index according to the improvements in the patients' conditions. However, more studies are required to validate its use with other patients.

• 사상체질의학회지
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• 제28권3호
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• pp.286-299
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• 2016

Objectives The purpose of this study was to report significant improvement of functional dyspepsia in 3 patients, who were diagnosed with 'Soyangin Spleen Cold-based Exterior Cold disease' and applied medication based on Sasang Constitutonal medicine.Methods The patients were treated with herbal medications, according to their own constitution. The objective outcome was measured by body composition analyzer and Gastrointestinal Symptom Rating Scale (GSRS), and the subjective sensation was assessed by using Visual Analogue Scale (VAS).Results The symptoms of functional dyspepsia improved remarkedly in all respects, without any side effects. Original symptoms also changed for the better.Conclusions This results show that it is available that functional dyspepsia is treated with medicines according to Sasang Constitutional medicine.

• 한방안이비인후피부과학회지
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• 제33권4호
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• pp.156-164
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• 2020

Objectives : This study is to report a case of tinea pedis accompanied with erythema and pruritus, treated with Korean medicine treatment. Methods : A 26-year-old female patient has suffered from erythema and pruritus on her right 3rd toe. She applied desoximetasone ointment on it for a month, but the effect didn't last long and the symptoms got worse. After disappointing application of the corticosteroid, she received Korean medicine treatment including herbal medicine and herbal external medication for 1.5 months. Results : The skin symptoms such as erythema and pruritus were remarkably improved. Also, the Visual Analogue Scale(VAS) of pruritus changed from 4 to 0. Conclusions : This case report suggests that Korean medicine may have a role in treating tinea pedis with some skin symptoms such as erythema and pruritus.