• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2007년도 춘계 학술대회논문집
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• pp.83-86
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• 2007

Turbulent flow analysis is conducted around the multi-stage launch vehicle including base region and detachment motion of strap-on boosters due to resultant aerodynamic forces and gravity is simulated. Aerodynamic solution procedure is coupled with rigid body dynamics for the prediction of separation behavior. An overset mesh technique is adopted to achieve maximum efficiency in simulating relative motion of bodies and various turbulence models are implemented on the flow solver to predict the aerodynamic forces accurately. At first, some preliminary studies are conducted to show the importance of base flow for the exact prediction of detachment motion and to find the most suitable turbulence model for the simulation of launch vehicle configurations. And then, developed solver is applied to the simulation of KSR-III, a three-stage sounding rocket researched in Korea. From the analyses, after-body flow field strongly affects the separation motions of strap-on boosters. Negative pitching moment at initial stage is gradually recovered and a strap-on finally results in a safe separation, while fore-body analysis shows collision phenomena between core rocket and booster. And a slight variation of motion is observed from the comparison between inviscid and turbulent analyses. Change of separation trajectory based on viscous effects is just a few percent and therefore, inviscid analysis is sufficient for the simulation of separation motion if the study is focused only on the movement of strap-ons.

• 대한기계학회논문집B
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• 제26권1호
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• pp.159-169
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• 2002

The present study investigates in detail the combined effects of the Coriolis and centrifugal farce on the development of laminar flows in a square-sectioned U-bend rotating about an axis parallel to the center of bend curvature. When a viscous fluid flows through a rotating curved region, two types of secondary flow occur. One is caused by the Coriolis force due to the rotation of U-bend and the other by the centrifugal farce due to the curvature of U-bend. When the values of Rossby number and curvature ratio are large, the flow field in a rotating U-bend can be represented by two dimensionless parameters ; the Dean number K$\_$LC/=Re/√λ and a body ratio F=λ/Po. For positive rotation, where the rotation is in the same direction as that of the main flow, both the Coriolis force and the centrifugal force act radially outwards, the directions of the two secondary flows are the same. Therefore, the flow structure is qualitatively similar to that observed in a stationary curved duct with a larger f7c. On the other hand, in case of negative rotation, where two farces act in opposite direction, more complex flow fields can be observed depending on the relative magnitudes of the forces.

• 한국해안해양공학회지
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• 제1권1호
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• pp.71-80
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• 1989

본 연구에서는 무한요소의 개념을 선형파의 회절 및 방사문제에 적용하는 방법에 대해서 연구하였다. 유체의 동압에 의한 하중은 관성력이 중요하다고 가정하여, 점성효과는 무시하였다. 물체 주변의 내부영역은 통상적인 유한요소를 사용하여 모형화하였으며, 외부영역은 특수한 형상함수를 갖는 무한요소로 모형화하였다. 본 연구에서 개발된 무한요소의 형상함수는, 외부영역의 속도포텐셜을 보다 잘 나타내기 위하여, 외부영역의 해를 해석적 고유함수로 표시하였을 때 나타나는 진행파항과 첫번째 산란파항의 점근적인 형태를 사용하여 결정하였으며, 수치해석상의 효율성을 증가시키기 위하여, 무한요소의 시스템행렬 구성시 나타나게 되는 무한방향으로의 적분을 해석적으로 수행하였다. 본 무한요소의 효율성 및 타당성을 입증하기 위하여, 실제 많이 응용되고 있는 연직 축대칭 구조물을 대상으로 수치해석을 수행하였다. 수치해석결과, 아주 적은 수의 요소로 유체영역을 분할했음에도 불구하고, 적분방정식을 이용한 기존의 여러결과들과 아주 잘 일치함을 알 수 있었다. 또한, 해석의 효율성과 해의 정확도에 직접적으로 영향을 주는 무한요소의 위치와 유한요소의 크기에 대한 기준설정을 위한 수치실험도 수행하였다.

• Journal of Microbiology and Biotechnology
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• 제11권3호
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• pp.399-405
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• 2001

Urushiol, a natural pro-electrophilic quinone compound, has potential structural characteristics as antitumor chemotherapeutic agents. However, urushiol's use as an antitumor drug has some problems, because it is hardly miscible with an aqueous solution. Purified urushiol is highly viscous and soluble only in strong solvents. for this study, we prepared an urushiol-ethanol micro-emulsion with a unimodal size distribution by high-speed homogenization. This generated effective delivery of urushiol to its action wites, so that we could investigate its cytotoxic activity against cancer cells. Using a colony-forming assay, we were able to show that urushiol selectively inhibited the growth of the ovarian cancer cells PA-1 and 2774 at a concentration of $10^{-6}$, whereas it had only a negligible effect on normal CHO cells at the same concentration. The data suggest that urushiol may have potential as an effective antitumor agent in the treatment of ovarian cancer. In addition, we addressed the question of whether the specific cytotoxic effect of urushiol is linked to apoptosis, by DNA fragmentation and DAPI staining assays. The inhibitory effects of urushiol on the growth of ovarian cancer cells was found to be associated with DNA fragmentation and the fragmented nuclei formation, both of which represent markers for the induction of apoptosis. Therefore, the results suggested that urushiol affected its profound cytotoxicity by triggering apoptosis in ovarian cancer cells.

• Steel and Composite Structures
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• 제19권6호
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• pp.1561-1580
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• 2015

No significant improvement has been observed on the seismic performance of the ordinary steel reinforced concrete (SRC) columns compared with the reinforced concrete (RC) columns mainly because I, H or core cross-shaped steel cannot provide sufficient confinement for core concrete. Two improved SRC columns by constructing with new-type section steel were put forward on this background: a cross-shaped steel whose flanges are in contact with concrete cover by extending the geometry of webs, and a rotated cross-shaped steel whose webs coincide with diagonal line of the column's section. The advantages of new-type SRC columns have been proved theoretically and experimentally, while construction measures and seismic behavior remain unclear when the new-type columns are joined onto SRC beams. Seismic behavior of SRC joints with new-type section steel were experimentally investigated by testing 5 specimens subjected to low reversed cyclic loading, mainly including the failure patterns, hysteretic loops, skeleton curves, energy dissipation capacity, strength and stiffness degradation and ductility. Effects of steel shape, load angel and construction measures on seismic behavior of joints were also analyzed. The test results indicate that the new-type joints display shear failure pattern under seismic loading, and steel and concrete of core region could bear larger load and tend to be stable although the specimens are close to failure. The hysteretic curves of new-type joints are plumper whose equivalent viscous damping coefficients and ductility factors are over 0.38 and 3.2 respectively, and this illustrates the energy dissipation capacity and deformation ability of new-type SRC joints are better than that of ordinary ones with shear failure. Bearing capacity and ductility of new-type joints are superior when the diagonal cross-shaped steel is contained and beams are orthogonal to columns, and the two construction measures proposed have little effect on the seismic behavior of joints.

• 전산구조공학
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• 제4권4호
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• pp.135-144
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• 1991

본 논문에서는 해양구조물에 작용되는 파력을 산정하고 구조물-유동의 상호작용을 해석하기 위하여 유동장을 유한요소법으로 모형화하여 해석할 때에, 효과적으로 적용될 수 있는 유체의 3차원 무한요소를 개발하였다. 유동의 수식화는 선형파동이론에 근거하였고, 구조물의 크기가 비교적 큰 경우를 대상으로 함으로써 유동의 관성력항이 지배적이므로, 점성저항력의 영향을 무시하였다. 유동의 지배방정식이 속도포텐셜에 대한 라플라스 방정식으로 주어지고, 구조물의 표면, 수면 및 해저면을 경계로 하여, 수평방향으로는 무한대로 펼쳐진 영역에서 정의된 문제를 효과적으로 해석하기 위하여, 두 종류의 유동요소를 개발하였다. 하나는 무한원방향으로 방사되는 파를 모형화 하기 위한 무한 요소이며, 다른 하나는 심해조건에서 유용하게 적용될 수 있는 가상바닥경계요소이다. 본 연구에서 제안한 유동요소들의 유용성과 효율성은 여러가지의 부유식 해양구조물에 대한 예제해석을 통하여 입증하였다. 같은 에제에 대하여 다른 방법으로 해석한 타 문헌상의 결과와 비교할 때, 본 연구에서 개발한 유동요소를 사용한 방법이 매우 좋은 결과를 줌을 알 수 있었다.

• 대한한의학방제학회지
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• 제28권2호
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• pp.169-177
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• 2020

Objectives : This experiment was designed to assess the single oral toxicity of Ethanol Extract Inulae Flos (IF) ethanol extracts. IF is one of the important herbs to remove phlegmy which is the viscous turbid pathological product that can accumulate in the body, causing a variety of diseases. Nevertheless, there has been a lack of research on the pharmacology toxicity of IF. Methods : In this study, IF was orally administered to 5 weeks ICR mice as an oral dose of 2,000 or 3,000 or 5,000 mg/kg. The condition of the mice was observed for 14 days and their weights were measured every two days. Results : None of the mice died for 14 days. The abnormal clinical symptoms and anatomical signs of toxicity were not found in any treatment groups. The gain of net body weight was observed. There was also no significant difference in the organ weight. The serum biochemistry and hematological analysis showed a decrease in BUN, red blood cells, white blood cells and platelets although within the normal ranges. Conclusions : These results suggest that the 50% lethal dose of IF is more than 5,000 mg/kg. This could be thought that IF is a safe drug without acute toxicity and side effects. However, IF showed some weight loss and change in blood test, so it will need to be careful when using it for high doses.

• International Journal of Ocean Engineering and Technology Speciallssue:Selected Papers
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• 제5권1호
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• pp.22-28
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• 2002

A New concept for the LNG-FPSO ship, with moonpool and bilge step in bottom, is proposed. This concept is investigated with regard to motion reduction and sloshing phenomena of the cargo and operation tanks. The principal dimensions of the ship are $L\timesb B\times D\times t(design)=270.0\times51.0\times32.32\times13.7(m)$, with a total cargo capacity of 161KT; a 98% loading condition is considered for this study. The moonpools and rectangular step at the bilge have been designed for the purpose of decreasing the motion within the tank. For the motion analysis, linearized three-dimensional diffraction theory, with the simplified boundary condition was used. The six-degree of freedom coupled motion responses were calculated for the LNG-FPSO ship. Viscous effects on the roll motion responses of a vessel were taken into account in this calculation program, using an empirical formula suggested by Himeno(1981). The case study for the moonpool size has been conducted using theoretical estimation and the experimental method. For the optimization of the moonpool size and effect of the bilge step, 9 cases of its size, both with and without bilge step, were involved in the study. no motion responses, especially roll motion, for the designed LNG-FPSO ships are much lower than those of other drill ships and shuttle tankers. The limit criterions are satisfied. To check the cargo tank and operation tank sizes, we performed a sloshing analysis in the irregular waves which focuses on the pressure distribution on the tank wall and the time history of pressure and free surface for No.2 and 5 tanks of LNG-FPSO with chamfers. Finally, optimum tank sire was estimated.

• 한국세라믹학회지
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• 제44권11호
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• pp.613-617
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• 2007

The variations of physical and dielectric properties of low temperature dielectrics based on typical aluminoborosilicate glasses modified with several divalent oxides were investigated. The divalent oxides studied here included CaO, MgO, BaO, SrO and ZnO. All samples containing either 35 wt% or 45 wt% alumina filler were prepared at the same processing condition and then fired at $850^{\circ}C$ for 30 min. The resultant characteristics of fired samples depended on the choice of the divalent ion and the content of the alumina filler. Except for the ZnO modification, all other samples containing 35 wt% filler demonstrated promising densification as they exhibited reasonably high densities of 3.07-3.31 $g/cm^3$ and high shrinkages of 14.0-16.4%. Particularly, the sample containing ZnO was distinguished with large variations compared to the base sample, which can be highlighted with earlier densification and crystallization at unexpectedly low temperatures. The negative effects of the ZnO modification on densification and dielectric properties were thought to be associated with earlier crystallization potentially by influencing effective densification via viscous flow. As an optimum composition, the sample containing only CaO showed the most promising characteristics such as $k{\sim}8.05$ and $tan{\delta}{\sim}0.0018$ when 35 wt% alumina filler was used.

• 대한화학회지
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• 제40권12호
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• pp.748-755
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• 1996

물과 요소 수용액에서 Poly(ethylene oxide)(PEO)의 구조 성질에 대한 온도의 효과를 보고한다. 물과 요소/물 혼합물 (요소 농도는 각각 0.2, 1, 2 M)에서 PEO에 대한 고유점도와 Huggins 계수의 값은 점도측정 방법에 의해 얻어졌으며, 이것을 물 구조 변화 관점에서 논의했다. 낮은 온도(22.deg.C이하)에서 PEO-물간 상호작용은 우세해 사슬은 펼쳐져있는 반면, 높은 온도(24.ang.C 이상)에서는 상호작용이 우세하지 못하고 사슬은 소수성 수화에 의해 어켜있게 된다. 즉, 온도가 상승함에 따라 PEO-물 상호작용은 우세하지 못하게 된다. 요소가 계에 가해짐에 따라 PEO사슬은, 우세하지 못한 PEO-물 상호작용으로부터 유발된 구조화된 물의 동요에 의해, 더 펼쳐지거나 거대해지게 된다. 고유점도 값에 대한 온도의 효과는 Arrhenius 행동을 나타낸다. 따라서 점성 흐름에 대한 활성화 에너지를 구해 논의하였다.