• 한방안이비인후피부과학회지
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• 제21권2호
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• pp.165-175
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• 2008

Psoriasis, which is characterized by the covering of silver-white scaliness and various Sizes of redness with clear boundary, is an intractable skin disease that repeats aggravation and remission. The objective of the present clinical report is to demonstrate that oriental medical treatment after differentiation of syndromes is effective in treating psoriasis, an intractable skin disease. For this purpose, we identified the pattern of three psoriasis patients based on blood heat and viscous blood, and applied acupuncture and herbal medicine to them. The effect of treatment was evaluated using PASI (psoriasis area and severity index). In all of the three cases, the results of treatment were satisfactory. Thus, oriental medical treatment after differentiation of syndromes, which is highly effective without side effect, is considered to make a great contribution to the treatment of psoriasis in the future.

• 한국가시화정보학회지
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• 제17권2호
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• pp.10-16
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• 2019

Considering the role of viscosity in the hemorheology, the characteristics of non-Newtonian fluid are important in the pulsatile blood flows. Stenosis, with an abnormal narrowing of the vessel, contributes to block blood flows to downstream tissue and lead to plaque rupture. Therefore, systematic analysis of blood flow around stenosed vessels is crucial. In this study, non-Newtonian behaviors of blood analog fluids around the micro-stenosis with 60 % severity in diameter of $500{\mu}m$ was examined by using CFX under the pulsatile flow conditions with the period of 10 s. Viscosity information of two non-Newtonian fluids were obtained by fitting the value of normal blood and highly viscous blood. As the Newtonian fluid, the water at room temperature was used. During the pulsatile phase, wall shear stress (WSS) is highly oscillated. In addition, high viscous solution gives rise to increases the variation in the WSS around the micro-stenosis. Highly oscillating WSS enhance increasing tendency of plaque instability or rupture and damage of the tissue layer. These results, related to the influence on the damage to the endothelium or stenotic lesion, may help clinicians understand relevant mechanisms.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.695-696
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• 2002

Three-dimensional blood flow in the sac of the KTAH(Korean total artificial heart) is simulated using fluid-structure interaction model. The aim of this study is to delineate the three-dimensional unsteady-blood flow in the sac of KTAH. Incompressible viscous flow is assumed for blood using the assumption of Newtonian fluid. The numerical method employed in this study is the finite element software called ADINA. Fluid-structure interaction model between blood and sac is utilized to represent the deformation of the sac by the rigid moving actuator. Three-dimensional geometry of cactus type KTAH is chosen for numerical model with prescribed pressure boundary condition on the sac surface. Blood flow is generated by the motion of moving actuator and strongly interacts with the solid material surrounding blood. High shear stress is observed mainly near the inlet and outlet of the sac.

• 한국가시화정보학회지
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• 제16권2호
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• pp.53-58
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• 2018

This paper presents an electromagnetically driven microrobot for the enhancement of mixing performance in high viscous liquid media such as blood and bone marrow. First, an electromagnetic system was fabricated, and the magnetic flux density generated from the system was compared with the theoretical value. Second, the reciprocating motion of the microrobot was demonstrated in microchannel using electromagnetic system. As a proof of concept, the mixing performance by the electromagnetically driven microrobot in high viscous liquid was investigated using safranin solution. As a result, it was completely mixed within 140 s with the reciprocating motion of the microrobot while it took 1680 s for natural diffusion. In addition, the mixing efficiency was quantitatively evaluated through a mixing index obtained by an image analysis. The proposed method provides not only wireless actuation of a microrobot with a simple design but also high mixing performance in variety of high viscous liquid media.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.705-706
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• 2002

Hemodynamics of the TPLS(Twin Pulse Life Support System) is numerically investigated to delineate the possibility of hemolysis in blood. Computational method employing finite element algorithm is utilized to solve the blood flow of the sac squeezed by moving actuator. We assume that the blood flow interacts with the sac material which is activated by the rigid body motion of the actuator. Valve dynamics at the ends of the sac is simplified as on/off type motion. We compute the transient viscous flow in the two-dimensional geometry of the blood sac. Incompressible laminar flow is simulated on the assumption of Newtonian fluid. Blood velocity has a step gradient near the throat of the sac formed by the moving actuator. According to the decrease of the gap size of blood passage, the magnitude of shear stress in the blood is dramatically increased. Numerical solutions show that the maximum value of shear stress in the blood flow in TPLS is relatively smaller than that of the roller type ECLS.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 2000년도 춘계 학술대회논문집
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• pp.27-32
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• 2000

In this study, the three-dimensional blood flow within the sac of KTAH(Korean artificial heart) is simulated using fluid-structure interaction model. The numerical method employed in this study is the finite element commercial package ADINA. The thrombus formation is one of the most critical problems in KTAH. High fluid shear stress or stagnated flow are believed to be the main causes of these disastrous phenomenon. We solved the fluid-structure interaction between the 3D blood flow in the sac and the surrounding sac material. The sac material is assumed as linear elastic material and the blood as incompressible viscous fluid. Numerical solutions show that high shear stress region and stagnated flow are found near the upper part of the sac and near the comer of the outlet during diastole stage.

• 한국전산유체공학회:학술대회논문집
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• 한국전산유체공학회 1999년도 추계 학술대회논문집
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• pp.152-157
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• 1999

For the simulation of the blood flow in coronary artery, the system modeling of coronary hemodynamics is combined with CFD technique. The blood flow in coronary artery interacts with the global coronary circulation. Especially in case of the coronary artery with stenosis, the interaction plays an important role in the hemodynamics of the circulation. In this study we present a combined numerical approach using both the CFD technique for flow simulation and the global system model of coronary circulation. We use a lumped parameter model for the global simulation of coronary circulation whereas the finite element method is employed to compute the viscous flow field in stenosed coronary artery, The time variation of the pressure drop due to stenosis is obtained from the proposed numerical method. Numerical results shows that the flow resistance and pressure drop due to stenosis has a relatively large value in systole.

• 한국식품영양과학회지
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• 제37권1호
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• pp.35-41
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• 2008

본 연구는 청국장 점질성 중합체의 첨가식이가가 STZ로 유발된 당뇨쥐의 혈당과 지질대사에 미치는 영향을 알아보고자 하였다. 실험동물은 정상군(N), 당뇨 유발군(D) 및 청국장 점질성 중합체 첨가식이 당뇨 유발군(DCB)으로 4주간 실험식이를 공급하였다. 체중증가량과 식이효율은 D군이 N군에 비해 유의적으로 낮았다. 간무게는 D군이 N군에 비해 유의적으로 높았으나 DCB군의 간무게는 D군에 비해 유의적으로 낮았다. D군의 혈당은 4주 동안 비슷한 범위를 유지하였으나 DCB군의 혈당은 실험 4주째에 D군에 비해 유의적으로 낮았다. 혈중 중성지방은 D군이 N군에 비해 유의적으로 높았다. 그러나 DCB군은 D군에 비해 유의적으로 낮았다. DCB군의 혈중 총콜레스테롤은 DM군에 비해 낮은 경향이었으나 유의적인 차이는 없었다. 혈중 HDL-콜레스테롤은 N군과 D군이 유의적인 차이가 없었으나 DCB군은 두 군에 비해 유의적으로 높았다. 혈중 LDL-콜레스테롤은 DCB군이 D군에 비해 낮은 경향이었으나 유의적인 차이는 없었다. 간의 중성지방 함량과 콜레스테롤 함량은 D군이 N군에 비해 유의적으로 높았으나 DCB군은 D군에 비해 낮은 경향이었다. 따라서 청국장 점질성 중합체의 첨가 식이는 STZ로 유발된 당뇨쥐의 혈당을 유의적으로 감소시켰으며 당뇨의 대표적인 합병증인 지질대사 이상 중 증가된 혈중 중성지방을 유의적으로 감소시켰으며 감소된 HDL-콜레스테롤을 유의적으로 증가시켰으므로 당뇨의 혈당조절과 고지혈증 개선에 유익할 것으로 사료된다.

• 대한기계학회:학술대회논문집
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• 대한기계학회 2002년도 학술대회지
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• pp.703-704
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• 2002

The two major problems related to the blood flow in a floating type polymer valve are thrombus formation and hemolysis. It is well known that the shear stress in the fluid and flow separation around the valve are blamed for such disastrous phenomena. In this viewpoint, through study of the flow field around the valve is imperative to improve design of the valve. The aim of this study is to investigate the fluid flow around a floating type polymer valve. The numerical method employed in this study is the finite element software called ADINA. Incompressible viscous flow is assumed for blood using the assumption of Newtonian fluid. In this study, two prominent features of the axisymmetric flow around the floating type polymer valve are observed: jet-like flows observed near the gap between the conduit and the valve, and recirculating flow downstream of the valve. We also provided a detailed description of shear stress field according to the variation of flow conditions. The shear stress in fluid has its maximum value near the gap between the valve and the conduit.

• 한국산학기술학회논문지
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• 제18권3호
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• pp.545-550
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• 2017

대동맥이나 협착된 경동맥에서는 심장수축기에 간헐적으로 난류현상이 발생하고 있으며, 혈액의 점성특성으로 인해 기존 난류모델로는 정확한 해석이 어려운 실정이다. 혈류는 점탄성 유체의 성질을 가지고 있어 유체의 전단 변형률 증가에 따라 점도가 감소하는 점탄성 유체이며, 이러한 점탄성 유체는 난류 유동시 저항 감소 현상이 발생한다. 기존의 난류해석 모델들은 점성변화가 없는 뉴턴 유체에 적합한 모델들이 대부분이기 때문에, 점탄성 유체의 저항 감소 현상을 고려한 비뉴턴 유체 해석에 적합한 난류 모델개발이 필요하다. 본 논문은 난류 모델 가운데 수렴성이 좋고 해석시간이 짧은 표준 $k-{\varepsilon}$ 모델을 기반으로 저항 완충 함수를 이용하여 비뉴턴 유체의 저항감소 현상을 해석할 수 있는 수정된 난류모델을 제시하였으며, 이를 기존 난류모델들과 비교하여 제시된 난류 모델을 검증하였다. 새로 제시된 수정된 난류모델은 벽함수 및 점성저층을 고려하지 않았기 때문에 해석시간이 대폭적으로 감소하였으며, 적은 격자수를 이용하여 효율적으로 비뉴턴 유체의 난류 현상을 해석할 수 있기 때문에 향후 혈류해석 및 점탄성유체 해석에 적용할 예정이다.