• Asian Pacific Journal of Cancer Prevention
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• v.16 no.9
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• pp.3759-3765
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• 2015

Background: Approaches in disruption of MDM2-p53 interactions have now emerged as an important therapeutic strategy in resurrecting wild type p53 functional status. The present study highlights virtual screening strategies in identification of high affinity small molecule non-peptidic inhibitors. Nutlin3A and RG7112 belonging to compound class of Cis-imidazoline, MI219 of Spiro-oxindole class and Benzodiazepine derived TDP 665759 served as query small molecules for similarity search with a threshold of 95%. The query molecules and the similar molecules corresponding to each query were docked at the transactivation binding cleft of MDM2 protein. Aided by MolDock algorithm, high affinity compound against MDM2 was retrieved. Patch Dock supervised Protein-Protein interactions were established between MDM2 and ligand (query and similar) bound and free states of p53. Compounds with PubCid 68870345, 77819398, 71132874, and 11952782 respectively structurally similar to Nutlin3A, RG7112, Mi219 and TDP 665759 demonstrated higher affinity to MDM2 in comparison to their parent compounds. Evident from the protein-protein interaction studies, all the similar compounds except for 77819398 (similar to RG 7112) showed appreciable inhibitory potential. Of particular relevance, compound 68870345 akin to Nutlin 3A had highest inhibitory potential that respectively showed 1.3, 1.2, 1.16 and 1.26 folds higher inhibitory potential than Nutilin 3A, MI 219, RG 7112 and TDP 1665759. Compound 68870345 was further mapped for structure based pharamacophoric features. In the study, we report Cis-imidazoline derivative compound; Pubcid: 68870345 to have highest inhibitory potential in blocking MDM2-p53 interactions hitherto discovered.

• Journal of the Korea Convergence Society
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• v.13 no.5
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• pp.155-164
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• 2022

Considerable interest has been directed toward utilizing virtual environment-based simulations for teacher education which provide authentic experience of classroom environment and repetitive training. Emotional Interaction should be considered for more advanced simulation learning performance. Since emotion is important factors in creative thinking, inspiration, concentration, and learning motivation, identifying learners' emotional interactions and applying these results to teaching simulation is essential activities. In this context, this study aims to identify the objective data for the empathetic response through the movement of the learner's EEG (Electroencephalogram) and eye-tracking, and to provide clues for designing emotional teaching simulation. The results of this study indicated that intended empathetic response was provided and in terms of valence (positive and negative) states and situational interest played an important role in determining areas of interest. The results of this study are expected to provide guidelines for the design of emotional interactions in simulations for teacher education as follow; (a) the development of avatars capable of expressing sophisticated emotions and (b) the development of scenarios suitable for situations that cause emotional reactions.

• Structural Engineering and Mechanics
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• v.11 no.2
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• pp.185-197
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• 2001

This paper presents the effect of axial stretching on large amplitude free vibration of an extensible suspended cable supported at the same level. The model formulation developed in this study is based on the virtual work-energy functional of cables which involves strain energy due to axial stretching and work done by external forces. The difference in the Euler equations between equilibrium and motion states is considered. The resulting equations govern the horizontal and vertical motion of the cables, and are coupled and highly nonlinear. The solution for the nonlinear static equilibrium configuration is determined by the shooting method while the solution for the large amplitude free vibration is obtained by using the second-order central finite difference scheme with time integration. Numerical examples are given to demonstrate the vibration behaviour of extensible suspended cables.

• International Journal of Human Ecology
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• v.15 no.1
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• pp.51-63
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• 2014

Services for self-designing, or adaptive customization services, have become dominant in virtual marketplaces and are believed to create additional values both for the company as well as for the customer. While most research focused on the value from the services' outputs, this research attempts to address the customer-perceived value deriving from the process of the services, and focuses on the self-fulfillment effect of the involved mental processing. An online survey was administered with 313 U.S. shoppers. In the results, participants using adaptive customization services reported higher self-fulfillment perceptions, than did those not using the services. Furthermore, both the self-fulfillment perceptions (i.e., autonomy and competence) significantly increased perceived design utility. The results suggest that the process of adaptive customization services should be strategically managed to improve the customers' positive mental states that subsequently improve the perceived value of the output designs. Implications and suggestions for future studies are dsicussed.

• Journal of the Korean Society for Precision Engineering
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• v.32 no.6
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• pp.553-562
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• 2015

This paper presents a strategy and an algorithm for levitation control of an over-actuated passive maglev tray system. The passive maglev tray system has more actuators than its degrees of freedom. The actuators of the system are switching when the tray travels longitudinally. Furthermore, the levitation forces of the actuators are non-homogeneous because the actuation devices are not in the moving platform. These characteristics make a limit in using conventional control approaches for levitation. For smooth actuator switching, the actuator force generation should be dependent on longitudinal positions of the tray. To enable constant pose tracking, this research introduces a control strategy and a control algorithm based on integral controllers on virtual variables. The states of the tray are estimated using a Kalman filter and fed to the proposed controller. The performances of the proposed control strategy and the algorithm are validated through tests.

• International Union of Geodesy and Geophysics Korean Journal of Geophysical Research
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• v.25 no.1
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• pp.47-56
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• 1997

We present a theoretical study on how the plasmasphere responses to the sudden impulses in the magnetosphere. A mechanism on how Pi 2 pulsations are excited in the magnetosphere is also proposed. When impulsive disturbances associated with the substorm onset are assumed in the magnetotail, their propagation toward the sunward direction is investigated with a wave equation. The propagation speed undergoes serious variations owing to the existence of the plasmasphere, which results in various reflection and tunneling of traveling disturbances at the plasmapause. In order to examine the effect of the plasmapause on initial impulsive disturbances, we analytically solve the wave equation based on the model of reasonable Alfven speed profile. The exact solution shows that virtual resonant states exist inside the plasmaspheric cavity. We obtain the result that these unique modes strongly persist for arbitrary incoming impulses from the source in the magnetotail, which quantitatively corresponds to the signature of PI 2 pulsations.

• The Transactions of the Korea Information Processing Society
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• v.6 no.1
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• pp.49-56
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• 1999

Distributed object Computing, owing to the development of distributed computing, has improved the performance of distributed processing conducted between homogeneous and heterogeneous systems in network. However, it has failed to solve fundamental problems such as network overload and enormous requests demands by servers and clients. In this paper, we propose to design and implement an Object Migration system that uses the java language to tackle the mentioned problems. As the first step of the implementation of the system, we justify the characteristics of t도 mobile object model that keeps codes and states of an object. Implemented Object Migration System would accept objects being migrated to a specific node and support the virtual place in which objects could be executed automatically. Therefore, the Object Migration system we suggest could not only solve problems imposed to traditional distributed computing but also offer transparency of object migration between homogeneous and heterogeneous systems.

• Transactions of The Korea Fluid Power Systems Society
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• v.1 no.2
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• pp.1-7
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• 2004

In-process diagnosis is essential to achieve predictive maintenance in industrial plants. An in- process diagnosis method was proposed for hydraulic servo systems, which was based upon leakage flow measurement. Leakage due to servovalve wear was analysed and modeled mathematically far computer simulation work. The key idea of diagnosis algorithm is that when monitoring signals, such as servovalve input and load displacement are in steady states, the return-line flow of hydraulic servo systems can be regarded as null-leakage of servovalve. Virtual experiments were performed to ensure effectiveness of the proposed diagnosis method.

• The Journal of the Korea institute of electronic communication sciences
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• v.5 no.5
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• pp.421-427
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• 2010

In order to visualize the transfer of sound waves, we performed real-time processing with the fast operating system of GPU, the Graphics Processing Unit. Simulation by using the method of the discrete Huygens' model was also implemented. The sound waves were visualized by varying the real-time processing, the reflecting surfaces within the two-dimensional virtual sound field, and the states of the sound source. Experimental results have shown that reflection and diffraction patterns for the sound waves were identified at the reflecting objects.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2018.11a
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• pp.256-257
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• 2018

This paper deals with the path-following control for marine surface vehicles with underactuated characteristics. In consideration of practical limitations of actuators, an improved DVS(dynamic virtual ship) guidance algorithm is proposed with the multi-level DVS optionally selected to be tracked. To address the output-feedback control issue, an adaptive FLS(fuzzy logical systems) is devised to online approximate the kinematic states. Based on that observing framework, the path-following control law is thereafter derived. Simulations testify effectiveness of the proposed scheme