• Journal of the Korea Computer Graphics Society
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• v.24 no.1
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• pp.9-16
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• 2018

In this paper, we introduce a visualization framework for cell image data obtained from optical diffraction tomography (ODT), including a method for representing cell morphology in 3D virtual environment and a color mapping protocol. Unlike commonly known volume data sets, such as CT images of human organ or industrial machinery, that have solid structural information, the cell image data have rather vague information with much morphological variations on the boundaries. Therefore, it is difficult to come up with consistent representation of cell structure for visualization results. To obtain desired visual representation of cellular structures, we propose an interactive visualization technique for the ODT data. In visualization of 3D shape of the cell, we adopt a volume rendering technique which is generally applied to volume data visualization and improve the quality of volume rendering result by using empty space jittering method. Furthermore, we provide a layer-based independent rendering method for multiple transfer functions to represent two or more cellular structures in unified render window. In the experiment, we examined effectiveness of proposed method by visualizing various type of the cell obtained from the microscope which can capture ODT image and fluorescence image together.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.30 no.12A
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• pp.1161-1167
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• 2005

In this Paper, a concept of virtual smart antenna (SA) is introduced for orthogonal Sequency division multiplexing (OFDM)-based cellular systems with a frequency reuse factor equal to 1. The OFDM-based cellular system is robust to multipath channels but has a disadvantage that the intercell interference (ICI) caused by adjacent base stations is large at the edge of a cell. In this paper, after deriving the symbol timing offset estimation scheme for the OFDM signal received from multiple base stations in a quasi-static fading channel, the ICI cancellation method based on virtual smart antenna is proposed using the steering vector formed by the symbol timing offset of the desired signal and interference signals.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.48 no.10
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• pp.1303-1310
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• 1999

In this paper, the Timed Petri-Nets(TPN) modeling of Modular Cell Manufacturing Systems(MCMS) was investigated to overcome the limit of batch mode operation, which has been one of the most popular manufacturing types to produce an extensive industrial output and to be able to adopt to suitable and quickly changing manufacturing environments. A model of the MCMS was developed in reference to the actual TFT-LCD manufacturing system. TFT-LCD manufacturing system is not mass-productive in batch mode, but it operates in the form of MCMS which consists of a sequence of several cells with four processes of operation, including those of color filter(C/F), TFT, cell, and module. The cell process is further regrouped in those of Front-End and Back-End. For the Back-End cell process, it is reconstructed into a virtual model, consisting of three cells. The TPN modeling encompasses those properties, such as states and operations of machines, the number of buffers, and the processing time. The performance of the modeling was further examined in terms of scheduling system. The productivity in each cells was examined with respect to the change of failure rate of the cell machines and Automatic Guided Vehicles(AGV) using simulation by TPN.

• 제어로봇시스템학회:학술대회논문집
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• 1995.10a
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• pp.39-42
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• 1995

A new methodology for representing the interaction between machines and the interlock signals required in FMCs has been developed. Object-Oriented Philosophies (OOPs) lend themselves to the development of such a scheme. A methodology developed here regards the tasks to be performed by the cell or any of its constituent machines for being primal. Sensory signals indicating the changes of state pf machines are used to trigger or initiate tasks. A task may be simple and require a relatively short time to execute, or may be complex and lengthy. This methodology may be depicated by a set of diagrams called Task Initiation Diagram (TID) and their accompanying rules.

• Journal of Mechanical Science and Technology
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• v.20 no.3
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• pp.297-309
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• 2006

This paper deals with a novel structure for single-cell characterization which makes use of bimorph micro thermal actuators combined with electrical sensor device and integrated microfluidic channel. The goal for this device is to capture and characterize individual biocell. Quantitative and qualitative characteristics of bimorph thermal actuator were analyzed with finite element analysis methods. Furthermore, optimization for the dimension of cantilevers and integrated parallel probe systems with microfluidic channels is able to be realized through the virtual simulation for actuation and the practical fabrication of prototype of probes. The experimental value of probe deflection was in accordance with the simulated one.

• Bulletin of the Korean Chemical Society
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• v.32 no.3
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• pp.821-828
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• 2011

Design and synthesis of new 3,4-diarylpyrazole-1-carboxamide derivatives are described. Their antiproliferative activity against A375 human melanoma cell line was tested and the effect of substituents on the diarylpyrazole scaffold was investigated. The pharmacological results indicated that most of the synthesized compounds showed moderate activity against A375, compared with Sorafenib. On the other hand, compounds Ia, Ie, IIb, and IIh were more potent than Sorafenib. In addition, compound IIa was equipotent to Sorafenib. Among all of these derivatives, compound IIb which has diethylamino and phenolic moieties showed the most potent antiproliferative activity against A375 human melanoma cell line. Virtual screening was carried out through docking of the most potent compound IIb into the domain of V600E-b-Raf and the binding mode was studied.

• Journal of Integrative Natural Science
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• v.15 no.4
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• pp.171-177
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• 2022

ROS1 (c-ros oncogene) is one of the gene with mutation in NSCLC (non-small cell lung cancer). The increased expression of ROS1 is leading to the increase proliferation of cell, cell migration and survival. Crizotinib and Entrectinib are the drugs that have been approved by FDA against ROS1 protein, but recently patients started to develop resistance against Crizotinib and there is a need of new drug that could act as an effective drug against ROS1 for NSCLC. In this study, we have performed virtual screening, where compounds are taken from Zinc 15 dataset and molecular docking was performed. The top compounds were taken based upon their binding affinity and their interactions with the residues. The compounds stability and chemical reactivity was also studied through Density Functional theory and their properties. Further study of these compounds could reveal the required information of ROS1-inhibitor complex and in the discovery of potent inhibitors.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.33A no.2
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• pp.23-31
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• 1996

This paper proposes a new UPC(usage parameter control) mechanism that varies the token generation rate of leaky bucket by observing virtual buffer, thus achieving an improvement of performance. An acceptance of a call in B-ISDN is determined by call admission control. A UPC that polices the agreed traffic parameters of a call and takes appropriate actions to prevent congestion in networks. The cell loss probability of conventional UPC is far from that of ideal UPC. The proposed mechanism has a better policing ability and response time for nonconforming call. The proposed mechanism uses ON-OFF model as input traffic. The results of simulation show the efficiency of the proposed mechanism.

• Proceedings of the KIPE Conference
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• 2003.07b
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• pp.929-932
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• 2003

Recently, energy Problem has become more important thing than that of past years. Therefore, researchers in many countries are trying to find the solution for removing energy Problem. One of all is the power generation with using the photovoltaic system. Because this system has some advantage, like purity and infinity. However, there are some problems to generate electrical power with using photovoltaic system. That problems, taking up a very big space and taking financial worries, come into existence. So it is inevitable to make the visual implement equipment for doing repetition experiment and solving this problems. In this paper, Boost converter are analyzed and simulated to make high power PV virtual implement system as input source instead of using transformer.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2002.10a
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• pp.772-775
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• 2002

The remote handling and maintenance devices in the nuclear hot ceil should be checked prior to the hot operation in view of reliability and operability. In this study, the digital mock-up is implemented to analyze and define the process equipment maintenance processes instead of real mock-up, which is very expensive and time consuming. To do this, the parts of equipment and maintenance devices are modeled in 3-D graphics, assembled, and kinematics is assigned. Also, the virtual workcell of the spent fuel management process is implemented in the graphical environment which is the same as the real environment. This simulator has the several functions for verification such as analyses for the manipulator's working area, the collision detection, the path planning and graphic simulation of the processes etc. This graphic simulator of the maintenance devices can be effectively used in designing of the maintenance processes for the hot cell equipment and enhance the reliability of the spent fuel management.