• 전자공학회논문지C
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• 제35C권2호
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• pp.29-35
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• 1998

This paper describes architectures and design of a SIMD type parallel image processing chip called SliM-II. The chiphas a linear array of 64 processing elements (PEs), operates at 30 MHz in the worst case simulation and gives at least 1.92 GIPS. In contrast to existing array processors, such as IMAP, MGAP-2, VIP, etc., each PE has a multiplier that is quite effective for convolution, template matching, etc. The instruction set can execute an ALU operation, data I/O, and inter-PE communication simulataneously in a single instruction cycle. In addition, during the ALU/multiplier operation, SliM-II provides parallel move between the register file and on-chip memory as in DSP chips, SliM-II can greatly reduce the inter-PE communication overhead, due to the idea a sliding, which is a technique of overlapping inter-PE communication with computation. Moreover, the bandwidth of data I/O and inter-PE communication increases due to bit-parallel data paths. We used the COMPASS$^{TM}$ 3.3 V 0.6.$\mu$m standrd cell library (v8r4.10). The total number of transistors is about 1.5 muillions, the core size is 13.2 * 13.0 mm$^{2}$ and the package type is 208 pin PQ2 (Power Quad 2). The performance evaluation shows that, compared to a existing array processors, a proposed architeture gives a significant improvement for algorithms requiring multiplications.s.

• Asian-Australasian Journal of Animal Sciences
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• 제29권4호
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• pp.487-499
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• 2016

The aim of the present study was to examine the effects of testosterone (T) and estradiol-$17{\beta}$ ($E_2$) on the production of progesterone ($P_4$) by granulosa cells, and of the $E_2$ on the production of $P_4$ and T by theca internal cells. In the first experiment, granulosa cells isolated from the largest ($F_1$) and third largest ($F_3$) preovulatory follicle were incubated for 4 h in short-term culture system, $P_4$ production by granulosa cells of both $F_1$ and $F_3$ was increased in a dose-dependent manner by ovine luteinizing hormone (oLH), but not T or $E_2$. In the second experiment, $F_1$ and $F_3$ granulosa cells cultured for 48 h in the developed monolayer culture system were recultured for an additional 48 h with increasing doses of various physiological active substances existing in the ovary, including T and $E_2$. Basal $P_4$ production for 48 h during 48 to 96 h of the cultured was about nine fold greater by $F_1$ granulosa cells than by $F_3$ granulosa cells. In substances examined oLH, chicken vasoactive intestinal polypeptide (cVIP) and T, but not $E_2$, stimulated in a dose-dependent manner $P_4$ production in both $F_1$ and $F_3$ granulosa cells. In addition, when the time course of $P_4$ production by $F_1$ granulosa cells in response to oLH, cVIP, T and $E_2$ was examined for 48 h during 48 to 96 h of culture, although $E_2$ had no effect on $P_4$ production by granulosa cells of $F_1$ during the period from 48 to 96 h of culture, $P_4$ production with oLH was found to be increased at 4 h of the culture, with a maximal 9.14 fold level at 6 h. By contrast, $P_4$ production with cVIP and T increased significantly (p<0.05) from 8 and 12 h of the culture, respectively, with maximal 6.50 fold response at 12 h and 6, 48 fold responses at 36 h. Furthermore, when $F_1$ granulosa cells were precultured with $E_2$ for various times before 4 h culture with oLH at 96 h of culture, the increase in $P_4$ production in response to oLH with a dose-related manner was only found at a pretreatment time of more than 12 h. In the third experiment, theca internal cells of $F_1$, $F_2$ and the largest third to fifth preovulatory follicles ($F_{3-5}$) were incubated for 4 h in short-term culture system with increasing doses of $E_2$. The production of $P_4$ and T by theca internal cells were increased with the addition of $E_2$ of $10^{-6}M$. These increases were greater in smaller follicles. These results indicate that, in granulosa cells of the hen, T may have a direct stimulatory action in the long term on $P_4$ production, and on $E_2$ in long-term action which may enhance the sensitivity to LH for $P_4$ production, and thus, in theca internal cells, $E_2$ in short term action may stimulate the production of $P_4$ and T.

• Asian Pacific Journal of Cancer Prevention
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• 제15권6호
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• pp.2917-2922
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• 2014

Background: The p53-binding protein 1 (TP53BP1) gene may be involved in the development of cancer through disrupting DNA repair. However, investigation of associations between TP53BP1 rs2602141 A/C polymorphism and cancer have yielded contradictory and inconclusive outcomes. We therefore performed a meta-analysis to evaluate the association between the TP53BP1 rs2602141 A/C polymorphism and cancer susceptibility. Materials and Methods: Published literature from PubMed, Medline, the Cochrane Library, EMbase, Web of Science, Google (scholar), CBMDisc, Chongqing VIP database, and CNKI database were retrieved. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using fixed or random-effects models. Publication bias was estimated using funnel plots, Begg's and Egger's test. Results: A total of seven studies (3,018 cases and 5,548 controls) were included in the meta-analysis. Our results showed that the genotype distribution of TP53BP1 rs2602141 A/C was not associated with cancer risk overall. However, on subgroup analysis, we found that TP53BP1 rs2602141 A/C was associated with cancer risk within an allele model (A vs C, OR=1.14, 95%CI: 1.01-1.29) and a codominant model (AA vs CC, OR=1.36, 95%CI: 1.06-1.74) in Asians rather than in Caucasians. Subgroup analysis by cancer type, genotype, and with or without adjustment for controls showed no significant association. Conclusions: The findings suggested an association between rs2602141 A/C polymorphism in TP53BP1 gene and increased risk of cancer in Asians.

• 한국축산식품학회지
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• 제34권5호
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• pp.700-708
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• 2014

The volatile composition of veal has yet to be reported and is one of the important factors determining meat character and quality. To identify the most important aroma compounds in veal from Holstein bull calves fed one of three diets, samples were subjected to solid-phase microextraction (SPME) combined with gas chromatography-quadrupole mass spectrometry (GC-MS). Most of the important odorants were aldehydes and alcohols. For group A (veal calves fed entirely on milk for 90 d before slaughter), the most abundant compound class was the aldehydes (52.231%), while that was alcohols (26.260%) in group C (veal calves fed starter diet for at least 60 d before slaughter). In both classes the absolute percentages of the volatile compounds in veal were different indicating that the veal diet significantly (p<0.05) affected headspace volatile composition in veal as determined by principal component analysis (PCA). Twenty three volatile compounds showed significance by using a partial least-squared discriminate analysis (PLS-DA) (VIP>1). The establishment of the global volatile signature of veal may be a useful tool to define the beef diet that improves the organoleptic characteristics of the meat and consequently impacts both its taste and economic value.

• 한국미생물·생명공학회지
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• 제51권4호
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• pp.535-537
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• 2023

We report the draft genome sequence of Bacillus thuringiensis serovar aizawai AS23, an insecticidal strain targeting lepidopteran pests, which was isolated from the rhizosphere of Korean melon (Cucumis melo L.). The genome of strain AS23 comprising 6,846,584 bp with a G + C content of 34.83% was assembled to 11 contigs obtained using hybrid assembly. Additionally, we mined the genome for pesticidal genes, identifying several insecticidal genes, including Cry1Aa3, Cry1Ca9, Cry1Da2, Cry1Ia44, Cry2Ab41, Cry9Ea9, Spp1Aa1, and Vip3Aa86.

• 한국조리학회지
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• 제8권1호
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• pp.55-69
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• 2002

1. 본 연구는 우리나라의 나물류중 돌나물을 이용한 건강음료를 개발하기 위하여 기초성분을 조사하고, 채취시기에 따른 성분의 변화를 조사하여 천연식품재료로서 가치를 높이고자 일반성분, 무기성분, Ascorbic acid, Chlorophyll Polyphenol류와 향기성분에 대하여 조사하였다. 2. 돌나물의 일반성분은 3월과 5월 각각의 채취시기에 따른 성분의 변화는 거의 없었으나, 조지방은 3월 채취시료에서 약간 높았으며, 다른 나물류에 비해 수분함량이 많은 것으로 나타났다. 3. 무기성분의 함량은 칼슘, 마그네슘, 인, 칼륨, 나트륨순으로 함유되어 있으며 철, 구리, 아연 등은 미량 함유된 것으로 나타났다. 4. Ascorbic acid의 함량은 3월 시료에 비해 5월 시료에서 높게 나타났으나, 다른 엽채류에 비하여 적은 량 함유되어 있다. 5. Chlorophyll1의 함량은 3월 시료와 5월 시료를 실온에서 방치하며 측정한 결과 7일 후 각각 최초함량의 37.8%와 37.6% 정도가 감소되었는데, 외관상 큰 차이를 느끼지 못했다. 6. Polyphenol류 함량은 적은 량 함유되었고, 3월과 5월 시료 모두 5일 경과후 까지는 미량 감소하는 것으로 나타났다. 7. 향기성분은 3월 시료에서 9종, 5월 시료에서 11종을 각각 확인하였는데, 3월과 5월 시료에 모두 들어있는 성분은 7-Octen-4-ol, Nonanal, 2-Penta-decanone,6,10, 14-trimethy1, Decane,2,3,7-trimethy1이었다. 이와 같은 결과로 우리나라에서 예로부터 약용과 식용으로 이용되어왔던 돌나물이 식용 및 건강식품으로서의 가치가 높은 영양성분과 기호성분을 가지고 있으며, 이를 이용한 건강음료를 개발하므로서 농가의 소득증대 및 기타 다양한 봄나물들을 이용한 건강음료의 개발이 가능할 것으로 나타났다.achi, Japan)을 이용하여 관찰하였다. 실험결과의 통계분석은 95% 수준의 one-way ANOVA/Tukey's test를 이용하여 결과를 얻었다. 실험에 이용된 2종류 복합레진의 굴곡강도와 탄성계수는 C-factor치 증가에 따라 감소하였으며, 파단면 또한 C-factor의 증가에 따라 더 불규칙해지는 양상을 나타내었다. 본 실험의 결과 hybrid형 복합레진이 micro-hybrid형 복합레진에 비해 C-factor의 영향을 더 많이 받는 것으로 나타났으며, 와동의 C-factor증가가 굴곡강도나 탄성계수와 같은 복합레진의 물리적 성질을 저하시킨다는 것을 의미하였다.중합수축. 중합도 및 미세경도 측정치는 one-way ANO-VA와 Duncan's multiple range test를, 변연누출 정도는 chi-square test를 이용, 통계처리하여 다음의 결과를 얻었다. . 중합수축의 정도는 VIP$^{TM}$(Bisco) 사용군에서 전체 조사광도가 높을수록 큰 경향을 보여 600mW/$\textrm{cm}^2$군에서 가장 크게 나타났고, 그 다음으로 Pulse-delay군, 400mW/$\textrm{cm}^2$군, 200 mW/$\textrm{cm}^2$군 순이었고, Optilux 501$^{TM}$(Demetron/Kerr) 사용군에서는 Continuous 방식이 Ramp 방식 보다 크게 나타났다. . 중합도와 미세경도 값은 공히, 전체 조사광도가 높을수록 높게 나타났으며 , 최종 중합도는 44.77~54.98%의 범위를, 미세경도 값은 34.10~56.30의 범위를 보였다. . 미세누출은 전반적으로 상아질 변연이 법랑질 변연에 비해 많았고, VIP$^{TM}$(Bisco) 사용 군에서는

• The Korean Journal of Physiology and Pharmacology
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• 제2권4호
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• pp.521-527
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• 1998

An important property of the intestine is the ability to secrete fluid. The intestinal secretion is regulated by a number of substances including vasoactive intestinal peptide (VIP), ATP and different inflammatory mediators. One of the most important secretagogues is adenosine during inflammation. However, the controversy concerning the underlying mechanism of adenosine-stimulated $Cl^-$ secretion in intestinal epithelial cells still continues. To investigate the effect of adenosine on $Cl^-$ secretion and its underlying mechanism in the rabbit colon mucosa, we measured short circuit current ($I_{SC}$) under automatic voltage clamp with DVC-1000 in a modified Ussing chamber. Adenosine, when added to the basolateral side of the muocsa, increased $I_{SC}$ in a dose-dependent manner. The adenosine-stimulated $I_{SC}$ response was abolished when $Cl^-$ in the bath solution was replaced completely with gluconate. In addition, the $I_{SC}$ response was inhibited by a basolateral Na-K-Cl cotransporter blocker, bumetanide, and by apical $Cl^-$ channel blockers, dephenylamine-2-carboxylate (DPC), 5-nitro-2-(3-phenyl-propylamino)-benzoate (NPPB), glibenclamide. Amiloride, an epithelial $Na^+$ channel blocker, and 4,4-diisothiocyanato-stilbene-2,2-disulphonate (DIDS), a $Ca^{2+}-activated$ $Cl^-$ channel blocker, had no effect. In the mucosa pre-stimulated with forskolin, adenosine did not show any additive effect, whereas carbachol resulted in a synergistic potentiation of the $I_{SC}$ response. The adenosine response was inhibited by 10 ${\mu}M$ H-89, an inhibitor of protein kinase A. These results suggest that the adenosine-stimulated $I_{SC}$ response is mediated by basolateral to apical $Cl^-$ secretion through a cAMP-dependent $Cl^-$ channel. The rank order of potencies of adenosine receptor agonists was $5'-(N-ethylcarboxamino)adenosine(NECA)＞N^6-(R-phenylisopropyl)adenosine(R-$ PIA)＞2-[p-(2-carbonylethyl)-phenyl-ethylamino]-5'-N-ethylcarboxaminoadenosine(CGS21680). From the above results, it can be concluded that adenosine interacts with the $A_{2b}$ adenosine receptor in the rabbit colon mucosa and a cAMP-dependent signalling mechanism underlies the stimulation of $Cl^-$ secretion.

• Journal of Biosystems Engineering
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• 제43권3호
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• pp.219-228
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• 2018

Purpose: This study evaluated the feasibility of a near-infrared spectroscopy technique for the rancidity prediction of soybean oil. Methods: A near-infrared spectroscopy technique was used to evaluate the rancidity of soybean oils which were artificially deteriorated. A soybean oil sample was collected, and the acid values were measured using titrimetric analysis. In addition, the transmission spectra of the samples were obtained for whole test periods. The prediction model for the acid value was constructed by using a partial least-squares regression (PLSR) technique and the appropriate spectrum preprocessing methods. Furthermore, optimal wavelength selection methods such as variable importance in projection (VIP) and bootstrap of beta coefficients were applied to select the most appropriate variables from the preprocessed spectra. Results: There were significantly different increases in the acid values from the sixth days onwards during the 14-day test period. In addition, it was observed that the NIR spectra that exhibited intense absorption at 1,195 nm and 1,410 nm could indicate the degradation of soybean oil. The PLSR model developed using the Savitzky-Golay $2^{nd}$ order derivative method for preprocessing exhibited the highest performance in predicting the acid value of soybean oil samples. onclusions: The study helped establish the feasibility of predicting the rancidity of the soybean oil (using its acid value) by means of a NIR spectroscopy together with optimal variable selection methods successfully. The experimental results suggested that the wavelengths of 1,150 nm and 1,450 nm, which were highly correlated with the largest absorption by the second and first overtone of the C-H, O-H stretch vibrational transition, were caused by the deterioration of soybean oil.

• Korean Journal of Acupuncture
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• 제36권2호
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• pp.93-103
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• 2019

Objectives : The aim of this study is to review the current trends in experimental studies on the acupuncture moxibustion treatment for visceral hypersensitivity. Methods : PubMed was searched for experimental studies about visceral hypersensitivity and acupuncture/moxibustion. Data were extracted and tabulated from the selected articles about experimental method, intervention, result and mechanism. Results : Total 23 articles were reviewed. Chronic visceral hypersensitivity animal model was applied in 17 studies (74%). Visceral hypersensitivity was measured by abdominal withdrawal reflex scoring or/and abdominal electromyogram. Acupoints like ST25, ST36, ST37, BL25, LI11, BL32 and PC6 were treated by electroacupuncture or moxibustion. All articles reported that electroacupuncture or moxibustion treatment is significantly effective in reducing visceral hypersensitivity. Treatment mechanisms were studied, related to mast cell, serotonin (5-HT) and receptor (5-HT3R and 5-HT4R), substance P (SP), vasoactive intestinal polypeptide (VIP), c-fos positive cell, corticotropin-releasing hormone (CRH), purinergic 2X (P2X)2, P2X3, P2X4, P2X7, N-methyl-D-aspartate (NMDA) receptor (NR1 and NR2B), prokinectin (PK) 1 and PK2. Conclusions : Evidences on acupuncture/moxibustion treatment for visceral hypersensitivity in animal studies warrant more research on effective acupoins, electro-acupuncture methods and treatment durations.

• 대한원격탐사학회지
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• 제33권5_1호
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• pp.559-570
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• 2017

본 연구에서는 야외에서 자료 취득이 가능하며 한 번에 다량의 사과를 촬영할 수 있는 지상용 초분광 스캐너를 활용하여 사과의 분광정보와 당도와의 부분최소제곱회귀분석(PLSR, Partial Least Square Regression)을 수행하였으며, 최적의 예측모델을 구축하기 위한 다양한 전처리기법의 적용가능성을 평가하고 VIP(Variable Importance in Projection)점수를 통한 최적밴드를 산출하였다. 이를 위하여 360-1019 nm영역에서 촬영된 515밴드의 초분광 영상에서 70개의 분광곡선을 취득하였으며, 디지털광도계를 이용하여 당도($^{\circ}Brix$)를 측정하였다. 사과의 분광특성과 당도사이의 회귀모델을 구축하였으며, 최적의 예측모델은 모델 예측치와 실측치간의 결정계수($r_p^2$, coefficient of determination of prediction)와 RMSECV(Root Mean Square Error of Cross Validation), RMSEP(Root Mean Square Error of Prediction)등을 고려하여 선정하였다. 그 결과 산란보정 기법의 대표적인 MSC(Multiplicative Scatter Correction)의 기반의 전처리기법이 가장 효과적이었으며, MSC와 SNV(Standard Normal Variate)를 조합한 경우 RMSECV와 RMSEP가 각각 0.8551과 0.8561로 가장 낮았고, $r_c^2$와 $r_p^2$은 각각 0.8533과 0.6546으로 가장 높았다, 또한 360-380, 546-690, 760, 915, 931-939, 942, 953, 971, 978, 981, 988, 992-1019 nm 등이 당도 측정을 위한 가장 영향력 있는 파장영역으로 나타났다. 해당 영역의 분광값을 가지고 PLSR을 수행한 결과, 전파장대를 사용할 때보다 RMSEP가 0.6841로 감소하고 $r_p^2$는 0.7795로 증가하는 것을 확인하였다. 본 연구를 통하여 사과의 당도측정에 있어 야외에서 취득한 초분광 영상자료의 활용 가능성을 확인하였으며, 이는 필드자료 및 센서 활용분야의 확장가능성을 보여준다.