• 천문학회지
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• 제51권6호
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• pp.185-195
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• 2018

Galaxy clusters are known to host many active galaxies (AGNs) with radio jets, which could expand to form radio bubbles with relativistic electrons in the intracluster medium (ICM). It has been suggested that fossil relativistic electrons contained in remnant bubbles from extinct radio galaxies can be re-accelerated to radio-emitting energies by merger-driven shocks via diffusive shock acceleration (DSA), leading to the birth of radio relics detected in clusters. In this study we assume that such bubble consist primarily of thermal gas entrained from the surrounding medium and dynamically-insignificant amounts of relativistic electrons. We also consider several realistic models for magnetic fields in the cluster outskirts, including the ICM field that scales with the gas density as $B_{ICM}{\infty}n^{0.5}_{ICM}$. Then we perform time-dependent DSA simulations of a spherical shock that runs into a lower-density but higher-temperature bubble with the ratio $n_b/n_{ICM}{\approx}T_{ICM}/T_b{\approx}0.5$. We find that inside the bubble the shock speed increases by about 20 %, but the Mach number decreases by about 15% in the case under consideration. In this re-acceleration model, the observed properties of a radio relic such as radio flux, spectral index, and integrated spectrum would be governed mainly by the presence of seed relativistic electrons and the magnetic field profile as well as shock dynamics. Thus it is crucial to understand how fossil electrons are deposited by AGNs in the ICM and how the downstream magnetic field evolves behind the shock in detailed modeling of radio relics.

• Journal of Microbiology and Biotechnology
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• 제32권1호
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• pp.126-140
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• 2022

Stem cells can be applied usefully in basic research and clinical field due to their differentiation and self-renewal capacity. The aim of this study was to establish an effective novel therapeutic cellular source and create its molecular expression profile map to elucidate the possible therapeutic mechanism and signaling pathway. We successfully obtained a mesenchymal stem cell population from human embryonic stem cells (hESCs) cultured on chemically defined feeder-free conditions and treated with connective tissue growth factor (CTGF) and performed the expressive proteomic approach to elucidate the molecular basis. We further selected 12 differentially expressed proteins in CTGF-induced hESC-derived mesenchymal stem cells (C-hESC-MSCs), which were found to be involved in the metabolic process, immune response, cell signaling, and cell proliferation, as compared to bone marrow derived-MSCs(BM-MSCs). Moreover, these up-regulated proteins were potentially related to the Wnt/β-catenin pathway. These results suggest that C-hESC-MSCs are a highly proliferative cell population, which can interact with the Wnt/β-catenin signaling pathway; thus, due to the upregulated cell survival ability or downregulated apoptosis effects of C-hESC-MSCs, these can be used as an unlimited cellular source in the cell therapy field for a higher therapeutic potential. Overall, the study provided valuable insights into the molecular functioning of hESC derivatives as a valuable cellular source.

• 한국해양공학회지
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• 제36권2호
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• pp.125-131
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• 2022

Structural design for shipbuilding is generally divided into three stages: the basic, detailed, and production designs, of which the production design is the most frequently revised among the three design stages. The revision involved in production design department was approximately 61% of the total 4,211 revision members and approximately 56% of the total 710 revision cases in the survey on the number of design revisions for nine ships. In this study, members and drawings with a high revision rate were investigated, and related design departments were identified. In addition, the work contents of the design department were analyzed to reduce the number of design revisions and three tasks are very frequently revised were selected. A survey was conducted with engineers engaged in the production design, after which, standards were proposed for the method of aggregating bills of materials, to employ macros to calculate the length of members and that of profile input data when reviewing drawings. Via the study, it was determined that the major causes of design revision are simple mistakes by engineers or lack of understanding on structural arrangement of basic members more than intricacies of prior design and high level specification. As a result of applying the proposed standards, it was confirmed that the design revision was reduced by approximately 40%.

• Steel and Composite Structures
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• 제43권5호
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• pp.533-552
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• 2022

The current article deals with the dynamic stability, and structural improvement of vibrating electrically curved screen on the viscoelastic substrate. By considering optimum value for radius curvature of the electrically curved screen, the structure improvement of the system occurs. For modeling the electrically system, the Maxwell's' equation is developed. Hertz contact model in employed to obtain contact forces between impactor and structure. Moreover, variational methods and nonlinear von Kármán model are used to derive boundary conditions (BCs) and nonlinear governing equations of the vibrating electrically curved screen. Galerkin and Multiple scales solution approach are coupled to solve the nonlinear set of governing equations of the vibrating electrically curved screen. Along with the analytical solution, 3D finite element simulation via ABAQUS package is provided with the aid of a FE package for simulating the current system's response. The results are categorized in 3 different sections. First, effects of geometrical and material parameters on the vibrational performance and stability of the curves panel. Second, physical properties of the impactor are taken in to account and their effect on the absorbed energy and velocity profile of the impactor are presented. Finally, effect of the radius and initial velocity on the mode shapes of the current structure is demonstrated.

• 대한치과교정학회지
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• 제52권5호
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• pp.362-371
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• 2022

Orthognathic surgery is the primary treatment option for severe skeletal discrepancy. However, orthodontic camouflage should be considered as an alternative treatment option, considering the risks of surgery. A 19.5-yearold man presented with a severe prognathic mandible with a Class III molar relationship and an anterior crossbite. Orthognathic surgery could be considered because of his severe skeletal discrepancy and mandibular prognathism. However, the anesthetist for orthognathic surgery did not recommend surgery under general anesthesia because of risk factors associated with the patient's aplastic anemia, including bleeding and infections. Thus, a camouflage treatment to promote backward rotation of the mandible via orthodontic extrusion of the posterior teeth was planned. An anterior bite plate, intermaxillary elastics, and fixed orthodontic appliances were used to extrude the posterior teeth and to align the dentition. After 17 months of nonsurgical orthodontic treatment, normal occlusion was achieved, and the facial profile was dramatically improved. This case report describes the dentoskeletal and soft-tissue effects of mandibular rotation and its long-term stability.

• Applied Microscopy
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• 제50권
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• pp.17.1-17.9
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• 2020

Recent advances in fabrication have enabled radial-junction architectures for cost-effective and high-performance optoelectronic devices. Unlike a planar PN junction, a radial-junction geometry maximizes the optical interaction in the three-dimensional (3D) structures, while effectively extracting the generated carriers via the conformal PN junction. In this paper, we report characterizations of radial PN junctions that consist of p-type Si micropillars created by deep reactive-ion etching (DRIE) and an n-type layer formed by phosphorus gas diffusion. We use electron-beam induced current (EBIC) microscopy to access the 3D junction profile from the sidewall of the pillars. Our EBIC images reveal uniform PN junctions conformally constructed on the 3D pillar array. Based on Monte-Carlo simulations and EBIC modeling, we estimate local carrier separation/collection efficiency that reflects the quality of the PN junction. We find the EBIC efficiency of the pillar array increases with the incident electron beam energy, consistent with the EBIC behaviors observed in a high-quality planar PN junction. The magnitude of the EBIC efficiency of our pillar array is about 70% at 10 kV, slightly lower than that of the planar device (≈ 81%). We suggest that this reduction could be attributed to the unpassivated pillar surface and the unintended recombination centers in the pillar cores introduced during the DRIE processes. Our results support that the depth-dependent EBIC approach is ideally suitable for evaluating PN junctions formed on micro/nanostructured semiconductors with various geometry.

• 응용통계연구
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• 제35권6호
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• pp.755-764
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• 2022

본 논문에서는 금융 시계열 변동성 추정을 위한 준-모수(quasi-likelihood) 방법을 다루고 있다. 모형식에서 오차항의 분포를 미지(unknown)로 하여 준-우도 함수를 통한 모수 추정을 하는 경우 이노베이션의 지정을 멱변환을 통해 구성하였다. 고정된 멱변환에 대한 프로파일-정보 행렬을 비교하여 최대값을 제공하는 멱변환을 제안하였다. 이차원 이노베이션으로의 확장을 다루었으며 코로나 펜데믹 기간의 높은 변동성을 보이는 국내 9개 주가 자료 분석을 통해 방법론을 예시하고 있다.

• BMB Reports
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• 제56권7호
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• pp.398-403
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• 2023

Natural killer (NK) cells are an essential part of the innate immune system that helps control infections and tumors. Recent studies have shown that Vorinostat, a histone deacetylase (HDAC) inhibitor, can cause significant changes in gene expression and signaling pathways in NK cells. Since gene expression in eukaryotic cells is closely linked to the complex three-dimensional (3D) chromatin architecture, an integrative analysis of the transcriptome, histone profiling, chromatin accessibility, and 3D genome organization is needed to gain a more comprehensive understanding of how Vorinostat impacts transcription regulation of NK cells from a chromatin-based perspective. The results demonstrate that Vorinostat treatment reprograms the enhancer landscapes of the human NK-92 NK cell line while overall 3D genome organization remains largely stable. Moreover, we identified that the Vorinostat-induced RUNX3 acetylation is linked to the increased enhancer activity, leading to elevated expression of immune response-related genes via long-range enhancer-promoter chromatin interactions. In summary, these findings have important implications in the development of new therapies for cancer and immune-related diseases by shedding light on the mechanisms underlying Vorinostat's impact on transcriptional regulation in NK cells within the context of 3D enhancer network.

• Clinical Nutrition Research
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• 제12권1호
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• pp.40-53
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• 2023

Differential bitterness perception associated with genetic polymorphism in the bitter taste receptor gene taste 2 receptor member 38 (TAS2R38) may influence an individual's food preferences, nutrition consumption, and eventually chronic nutrition-related disorders including cardiovascular disease. Therefore, the effect of genetic variations on nutritional intake and clinical markers needs to be elaborated for health and disease prevention. In this study, we conducted sex-stratified analysis to examine the association between genetic variant TAS2R38 rs10246939 A > G with daily nutritional intake, blood pressure, and lipid parameters in Korean adults (males = 1,311 and females = 2,191). We used the data from the Multi Rural Communities Cohort, Korean Genome and Epidemiology Study. Findings suggested that the genetic variant TAS2R38 rs10246939 was associated with dietary intake of micronutrients including calcium (adjusted p = 0.007), phosphorous (adjusted p = 0.016), potassium (adjusted p = 0.022), vitamin C (adjusted p = 0.009), and vitamin E (adjusted p = 0.005) in females. However, this genetic variant did not influence blood glucose, lipid profile parameters, and other blood pressure markers. These may suggest that this genetic variation is associated with nutritional intake, but its clinical effect was not found. More studies are needed to explore whether TAS2R38 genotype may be a potential predictive marker for the risk of metabolic diseases via modulation of dietary intake.

• 지능정보연구
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• 제18권3호
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• pp.97-117
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• 2012

인터넷 사용자는 비디오를 보면서 소셜 네트워크 서비스를 이용하고 웹 검색을 하고, 비디오에 나타난 상품에 관심이 있을 경우 검색엔진을 통해 정보를 찾는다. 비디오와 사용자의 직접적인 상호작용을 위해 비디오 어노테이션에 대한 연구가 진행되었고, 스마트 TV 환경에서 어노테이션 된 비디오가 활용될 경우 사용자는 객체에 대한 링크를 통해 원하는 상품의 정보를 쉽게 확인할 수 있게 된다. 사용자가 상품에 대한 구매를 원할 경우 상품에 대한 정보검색 이외에 상품평이나 소셜 네트워크 친구의 의견을 통해 구매 결정을 한다. 소셜 네트워크로부터 발생되는 정보는 다른 정보에 비해 신뢰도가 높아 구매 결정에 큰 영향을 미친다. 하지만 현재 소셜 네트워크 서비스는 의견을 얻고자 할 경우 모든 소셜 네트워크 친구들에게 전달되고 많은 의견을 얻게 되어 이들로부터 유용한 정보를 파악하는 것은 쉽지 않다. 본 논문에서는 소셜 네트워크 사용자의 프로파일을 기반으로 상품에 대해 유용한 정보를 제공할 수 있는 친구를 규명하기 위한 필터링 방법을 제안한다. 사용자 프로파일은 페이스북의 사용자 정보와 페이스북 페이지의 'Like' 정보를 이용하여 구성된다. 프로파일의 상품 정보는 GoodRelations 온톨로지와 BestBuy 데이터를 이용하여 의미적으로 표현된다. 사용자가 비디오를 보면서 상품 정보를 얻고자 할 경우 어노테이션된 URI를 이용하여 정보가 전달된다. 시스템은 소셜 네트워크 친구들에 대한 사용자 프로파일과 BestBuy를 기반으로 어노테이션된 상품에 대한 의미적 유사도를 계산하고 유사도 값에 따라 순위가 결정한다. 결정된 순위는 유용한 정보를 제공할 수 있는 소셜 네트워크 상의 친구를 규명하는데 사용된다. 참가자의 동의하에 페이스북 정보를 활용하였고, 시스템에 의해 도출된 결과와 참가자 인터뷰를 통해 평가된 결과를 이용하여 타당성을 검증하였다. 비교 실험의 결과는 제안하는 시스템이 상품 구매결정을 하기 위해 유용한 정보를 획득할 수 있는 방법임을 증명한다.