• Journal of Chest Surgery
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• 제26권3호
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• pp.191-195
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• 1993

Among 25 consecutive cases having undergone mitral valve surgery between March 1991 and June 1992 in Gill General Hospital, 11 patients[44%] who had undergone mitral valve reconstruction using prosthetic rings is evaluated and presented. Patients` mean age is 43 + 19 years[range:16-72], and they are consisted with 4 males and 7 females. Mitral valve insufficiency is due to degenerative disease in 6 cases[55%] and rheumatic disease in 5 patients[45%]. Carpentier`s functional classification I is 2 cases, II is 6 cases, and III is 2 cases. Surgical techniques include prosthetic ring annuloplasty[11 patients, 100%], chorda shortening[6, 55%], leaflet mobilization[4,36%], new chorda formation[2, 18%], chorda transposition[1, 9%] commissurotomy[3, 27%], and papillary muscle splitting[3, 27%]. Average number of mitral anatomic lesions per patient are 2.7 and we used average 2.8 procedures upon mitral valve apparatus per patient. There were no surgical mortality and no late valve related admission during the mean follow up period of 17 months. The mean functional class[NYHA] is 2.81 preoperatively and improved to 1.10 postoperatively. Doppler echocardiography showed much improvement from grade II MR [1 case], grade III MR [1 case] and 9 cases of grade IV MR to 6 cases of patients showed no MR, only trace MR in 4 cases, and grade I MR was found only in one patient with NYHA functional class II postoperatively. The postoperative mean mitral valve area is $2.10+0.28cm^2$. We conclude that mitral reconstruction is a predictable and stable operation.

• Journal of Computational Design and Engineering
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• 제2권1호
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• pp.16-25
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• 2015

Since construction projects are large and complex, it is especially important to provide concurrent construction process to BIM models with construction automation. In particular, the schematic Quantity Take-Off (QTO) estimation on the BIM models is a strategy, which can be used to assist decision making in just minutes, because 70-80% of construction costs are determined by designers' decisions in the early design stage. This paper suggests a QTO process and a QTO prototype system within the building frame of Open BIM to improve the low reliability of estimation in the early design stage. The research consists of the following four steps: (1) analyzing Level of Detail (LOD) at the early design stage to apply to the QTO process and system, (2) BIM modeling for Open BIM based QTO, (3) checking the quality of the BIM model based on the checklist for applying to QTO and improving constructability, and (4) developing and verifying a QTO prototype system. The proposed QTO system is useful for improving the reliability of schematic estimation through decreasing risk factors and shortening time required.

• KIEAE Journal
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• 제14권6호
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• pp.105-110
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• 2014

The basic factors determining the amount of energy used in hospital buildings are weather conditions and building factors. But the real energy consumer is central plant equipment such as boilers and chillers that produce thermal energy for heating and cooling. Inaccurate decision of the primary equipment's size can cause a high initial-cost, an excessive equipment space, a wasted energy by low operation-efficiency and shortening of the machine's life. In this reason, the decision of optimal size for central plant equipment is very important. There are several factors for the decision such as an operation factor, a factor (equipment factor), piping losses and a simultaneous usage factor applied in the sizing process except a basic cooling load. But there is no standard method for applying those factors. Usually, factors are applied individually by an experience or custom of each engineer. In this study, the authors emphasize the meaning and the problem of those factors, examine them by analyzing factors which were applied to actual practices, and propose the recommendation value of safety, load, operation factors and application methods.

• Journal of Information Technology Applications and Management
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• 제23권2호
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• pp.263-277
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• 2016

Recently, 3D printing technology has been considered as a core applicable technology because it brings many improvements such as the development of medical technology, medical customization, and reducing production cost and shortening treatment period. This research suggests a market prediction framework for medical 3D printing business. As an immature market situation, it is important to control some uncertainty for market prediction such as a customers' conversion rate. So we adopt decision making tree (DMT) model which used to choose an optimal decision making among diverse pathway. Among medical industries this paper just focuses on dentistry business. For predicting a 5 year period trend expected market size, we identified some replaceable denture procedure by 3D printing, collected related data, controlled uncertain variables. The result shows that medical 3D printing business could be a market of 28.2 billion won at 1st year and in the end of fifth year it could become on a scale of 61.1 billion won market.

• 한국전자파학회논문지
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• 제21권10호
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• pp.1136-1142
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• 2010

본 논문에서는 조명용 LED를 광원으로 사용한 무선 광통신 시스템에서 광전 궤환을 이용한 ASK 변조 방식을 사용하여 잡음 광의 간섭을 소거하였다. 광전 궤환 회로의 발진을 이용하여 70 kHz의 반송파를 자체적으로 생성하였으며, 입력 신호를 사용하여 궤환 회로의 단락과 개방을 반복함으로써 9.6 kbps의 데이터 속도로 출력광을 ASK 변조하였다. 주변의 잡음 광이 존재하는 환경에서 광전 궤환을 이용한 ASK 변조 방식을 사용함으로써 신호대 잡음비가 약 25 dB 개선되었다.

• 대한의생명과학회지
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• 제19권3호
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• pp.188-194
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• 2013

Ulcerative colitis (UC) is an inflammatory bowel disease, which is a chronic gastrointestinal disorder. Adenophorae Radix (AR) has been used as a traditional medicine for various diseases including strengthening cardiac function, allaying a fever, and easing pain and cough. However, the regulatory effects of AR in intestinal inflammation are not yet understood. This study attempted to determine the effect of AR in dextran sulfate sodium (DSS) - induced colitis in mice. The colitis mice were induced by drinking water containing 5% DSS for 7 days. The results showed that mice treated with DSS showed remarkable clinical signs, including weight loss, and reduced colon length. Administration of AR attenuated weight loss, colon shortening and inhibited the levels of interleukin (IL) - 6 in DSS - treated colon tissues. These results provide experimental evidence that AR might be a useful therapeutic medicine for patients with UC.

• BMB Reports
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• 제51권10호
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• pp.500-507
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• 2018

Cell reprogramming has been considered a powerful technique in the regenerative medicine field. In addition to diverse its strengths, cell reprogramming technology also has several drawbacks generated during the process of reprogramming. Telomere shortening caused by the cell reprogramming process impedes the efficiency of cell reprogramming. Transcription factors used for reprogramming alter genomic contents and result in genetic mutations. Additionally, defective mitochondria functioning such as excessive mitochondrial fission leads to the limitation of pluripotency and ultimately reduces the efficiency of reprogramming. These problems including genomic instability and impaired mitochondrial dynamics should be resolved to apply cell reprograming in clinical research and to address efficiency and safety concerns. Sirtuin (NAD+-dependent histone deacetylase) has been known to control the chromatin state of the telomere and influence mitochondria function in cells. Recently, several studies reported that Sirtuins could control for genomic instability in cell reprogramming. Here, we review recent findings regarding the role of Sirtuins in cell reprogramming. And we propose that the manipulation of Sirtuins may improve defects that result from the steps of cell reprogramming.

• 대한기계학회논문집A
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• 제28권7호
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• pp.961-969
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• 2004

Most manufacturing companies are trying to develop a competitive product by increasing the quality, shortening time to market and reducing the cost of a product. Collaborators related to the development of a new product want to confirm geometric forms and dimensions during the design process, as well as to verify dimensional errors of a product during the fabrication process. Objective of this paper is the development of a collaborative design and dimension verification system on the Internet. STEP files obtained from the design process are used for the design and dimension verification. Functions of the design and dimension verification modules are constructed over the ActiveX control using the visual C/sup ++/ and OpenGL. By using mark up functions over the Internet, collaborators check geometries, interferences, dimensional errors, human factors and form errors, as well as share their design ideas and opinions with XML rapidly and remotely. The usefulness of the developed system is confirmed through case studies.

• Archives of Plastic Surgery
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• 제47권6호
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• pp.495-504
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• 2020

The primary procedural components of deviated nose correction are as follows: osteotomy to correct bony deviation, septal deviation correction, manipulation of the dorsal septum to correct upper lateral cartilage deviation, and correction of functional problems (manipulation for correction of internal valve collapse and hypertrophy of the inferior turbinate). The correction of tip and nostril asymmetry cannot be overemphasized, because if tip and nostril asymmetry is not corrected, patients are unlikely to provide favorable evaluations from an aesthetic standpoint. Tip asymmetry, deviated columella, and resulting nostril asymmetry are primarily caused by lower lateral cartilage problems, which include deviation of the medial crura, discrepancy in the height of the medial crura, and asymmetry or deformity of the lateral crura. However, caudal and dorsal septal deviation, which is a more important etiology, should also be corrected. A columellar strut graft, correction of any discrepancy in the height of the medial crura, or lateral crural correction is needed to correct lower lateral cartilage deformation depending on the type. In order to correct caudal septal deviation, caudal septal shortening, repositioning, or the cut-and-suture technique are used. Surgery to correct dorsal septal deviation is performed by combining a scoring and splinting graft, a spreader graft, and/or the clocking suture technique. Moreover, when correcting a deviated nose, correction of asymmetry of the alar rim and alar base should not be overlooked to achieve tip and nostril symmetry.

• 한국소음진동공학회논문집
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• 제15권7호
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• pp.799-805
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• 2005

This paper describes the development process of high stiffness body for ride and handling performance. High stiffness and light weight vehicle is a major target in the refinement of Passenger cars to meet customers' contradictable requirements between ride and handling performance and fuel economy This paper describes the analysis approach process for high stiffness body through the data level of body stiffness. According to the frequency band. we can suggest the design guideline about lg cornering static stiffness, torsional and lateral stiffness, body attachment stiffness. The ride and handling characteristic of a vehicle Is significantly affected by vibration transferred to the body through the chassis mounting points from front and rear suspension. It is known that body attachment stiffness is an important factor of ride and handling performance improvement. And high stiffness helps to improve the flexibility of bushing rate tuning between handling and road noise. It makes possible to design the good handling performance vehicle and save vehicles to be used in tests by using mother car at initial design stage. These improvements can lead to shortening the time needed to develop better vehicles.