• Asian Pacific Journal of Cancer Prevention
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• 제17권11호
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• pp.4935-4937
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• 2016

Objective: To compare dosimetric parameters of 3 dimensional conformal radiotherapy (3 DCRT) and intensity modulated radiotherapy (IMRT) in terms of target coverage and doses to organs at risk (OAR) in the management of rectal carcinoma. Methods: In this prospective study, conducted between August 2014 and March 2016, all patients underwent CT simulation along with a bladder protocol and target contouring according to the Radiation Therapy Oncology Group (RTOG) guidelines. Two plans were made for each patient (3 DCRT and IMRT) for comparison of target coverage and OAR. Result: A total of 43 patients were recruited into this study. While there were no significant differences in mean Planning Target Volume (PTV) D95% and mean PTV D98% between 3 DCRT and IMRT, mean PTV D2% and mean PTV D50% were significantly higher in 3 DCRT plans. Compared to IMRT, 3 DCRT resulted in significantly higher volumes of hot spots, lower volumes of cold spots, and higher doses to the entire OAR. Conclusion: This study demonstrated that IMRT achieves superior normal tissue avoidance (bladder and bowel) compared to 3 DCRT, with comparable target dose coverage.

• 한국임상수의학회지
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• 제32권1호
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• pp.115-119
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• 2015

An 11-year-old spayed female maltese was presented for abdominal distention, dysuria and dyschezia. Panting and heart murmur was found and abdominal palpation was difficult due to increased abdominal pressure. A soft tissue mass, $6{\times}3cm$ in size, was identified radiographically in pelvic canal, displacing the descending colon to the medioventral direction and the urinary bladder cranially. On ultrasonography, the mass consisted of homogeneous hypoechoic parenchyma containing the focal hyperechoic region ($1.6{\times}1.5cm$). The mass had distinct margin and no connection with adjacent organs. It was considered as a mass originating from the retroperitoneal cavity. Additional diagnostic procedures were not advanced because of the owner's request, and only a surgical excision of the mass was performed to alleviate the dysuria and dyschezia. Histopathologic examination and immunohistochemistry determined the mass as a soft tissue sarcoma and excluded hemangiosarcoma and osteosarcoma, both are the most common types of the retroperitoneal tumors. This report described non-vascular soft tissue sarcoma originating from the retroperitoneal cavity in a maltese dog.

• 한국임상수의학회지
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• 제27권4호
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• pp.407-410
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• 2010

Bovine abdominal fat necrosis (lipomatosis) is relatively common disorder in adult Korean indigenous cattle. Thirteen Korean indigenous cattle with bovine lipomatosis and five clinically healthy cattle were selected and serum biochemical profiles were analyzed. Serum free fatty acids level was significantly high, while total cholesterol, serum albumin and total calcium levels were significantly low in bovine lipomatosis group. In a case of necropsy, saponificated adipose masses surrounding colon was observed and hepatic fatty degeneration and fat deposition in the renal tubules were found in a histopathologic examination. These findings indicate that affected cattle have a predisposition to deposit more fat into adipose tissue than normal cattle. Such abnormalities might lead to the development of abdominal fat necrosis with fibroplasia and possibly compress the intestines and urinary organs.

• Biomolecules & Therapeutics
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• 제4권3호
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• pp.265-270
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• 1996

The purpose of this study was to determine pharmacokinetic parameters and tissue distribution patters of urinary trypsin inhibitor(UTI) in Sprague-Dawley rats. $Na^{125}$I was conjugated to UTI to make $^{125}I-UTI$ and the concentrations were determined by $\gamma$-counter. With the aid of nonlinear least-square regression analysis for i.v bolus injection of 1,000 unit UTI including $^{125}I-UTI$, the temporal concentration curves were best fitted by 2-compartment open model. The distribution phase half-life was 0.39$\pm$0.02 hours whereas the elimination half-life was 12.99$\pm$1.05 hours in male rats. The volume of distribution and total body clearance in male rats were 0.28$\pm$0.01 1/kg and 83.16$\pm$1.15 ml/kg/h, respectively. We could not find any difference of pharmacokinetic parameters of UTI between male and female rats. UTI were distributed widely in rat organs. In both male and female rats, the kidney was the highest distributed organ. Amount of UTI in 24 hour cumulative urine in male rats was 36.22$\pm$8.74% and that in 48 hours was 43.32$\pm$10.55%. Excretion via feces was very scanty, with the 24 hours cumulative amount being only 2.76$\pm$0.97%. This data suggest the main excretion route of UTI is urine.

• Journal of Ginseng Research
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• 제2권1호
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• pp.17-33
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• 1977

1. 인삼증에 함유된 danlmarane계 glycoside 성분들 중의 한 성분인 panax saponin A(ginsenoside Rgl)(약자 : PSA)에 $^{14}C$ 또는 $^{3}H$를 도입한 방사능 표지 사포닌을 합성하였다. 2. $^{3}H$-PSA의 방사능을 생체내 에서 추적한 결과 PSA는 위장관내에서 쉽게 흡수되어 생체 내 전장기에 골고루 분포된다. 3. 각 장기에 분포된 PSA는 세포 내에 섭취되며 세포 내에 섭취 되는 양은 일정한 포화점이 있다. 4. 포화점을 초과하여 섭취된 PSA는 즉시 뇨를 통하여 배설되며 섭취된 PSA는 세포 내에 장기간 잔유한다.

• 대한한방부인과학회지
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• 제18권4호
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• pp.230-241
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• 2005

Uterine myoma is benign tumor formed from muscular and connective tissues, which is one of the most common tumors found in women's reproductive organs. Uterine myoma is the most common pelvic tumor and they are diagnosed in up to15 to 20% of women in pubertal period. Although myoma is generally considered to be a slowly growing tumor, in 20-40% of women at the age of 35 and more have uterine myoma of significant sizes with severe clinical symptoms. The most common symptoms include abdominal pain or discomfort, low abdominal pressure sensation, hypermenorrhea and urinary symptoms. The treatment of uterine myoma is just observation, operation and hormone replacement therapy. We treated 6 outpatients who has uterine myoma and visited Kyungwon InCheon Oriental Hospital with Herb-medication and acupuncture. So we have gotten good result from them. After 6 outpatients had taken Guichulpazing-tang(歸朮破?湯), the symptoms were　improved and the size of the uterine myoma was reduced significantly, It proves　that oriental medical treatment is effective on the patients with uterine myoma, but　continuous studies are needed.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2018년도 춘계학술발표회
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• pp.90-90
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• 2018

Kochiae Fructus is a medicinal plant used as medicine of the urinary organs, skin disease and inflammation. In this study, anti-inflammatory activity of Kochiae Fructus extract and its possible mechanisms of action were examined. The anti-inflammatory activity was investigated by inhibition of lipopolysaccharide (LPS) induced nitric oxide (NO), pro-inflammatory cytokine production and matrix metalloprotease-9 (MMP-9) in murine macrophage-like cell line Raw 264.7 cells. The measurement of the induced pro-inflammatory cytokine levels were carried out by ELISA. The phosphorylation of ERK1/2, JNK and MAPK and the nuclear expression of nuclear factor $NF-{\kappa}B$ p65 were investigated by Wesern blot analysis. The extract suppressed the phosphorylation of ERK1/2, JNK, and p38 MAPK, and the nuclear translocation of $NF-{\kappa}B$ p65 in activated cells. As a result, we suggest that the extract of Kochiae Fructus decreased the production of pro-inflammatory cytokines ($TNF-{\alpha}$, IL-6), nitric oxide, MMP-9 in LPS-induced Raw264.7 cells. Kochiae Fructus has possibility to be used as therapeutic benefits against inflammatory diseases.

• 한국환경보건학회지
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• 제19권4호
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• pp.67-82
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• 1993

This study was performed to investigate the preventive effect of KDD against lead toxicity. KDD of 133, 266, 532 and 1,064 mg/kg were administered twice to the rats of Sprague-Dawley strain and then 300 mg/kg lead acetate was given to times, respectively. 1. The accumulation effects of KDD against to lead showed the changes of lead concentration by time variation. But, no statistical significance were showed on 8 and 10 weeks for kidney, spleen, 8 weeks for liver, and 4, 6 and 8 weeks for duodenum. In the femur, statistical significance existed during the whole experimental period. The relatively high concentration of lead detected in the feces of the experimental group means that KDD facilitated excretion of lead. 2. The histopathological effect of KDD against lead showed cytomegaly, karyomegaly, inclusion body, urinary cast and hemosiderin of kidney in the experimental group I (Pb 300 mg/kg). Recovery of KDD administrated group was inclined to increase by KDD concentration. But, spleen's histopathological recovery of KDD aginst to lead did not show as much as kidney. In conclusion, this study revealed the preventive effect of KDD against lead toxicity and its mechanism inferred to facilitate lead excretion in feces following hinderance of lead absorption in the gastric-intestine and organs.

• 한국식품위생안전성학회지
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• 제5권1호
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• pp.7-12
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• 1990

Radiolabeled Brazilin(^3H-Brazilin)을 웅성 Wistar Rats에 투여하여 plasma concentration-time profile, urine 및 bile로의 배설, 조직분포 및 plasma protein에 대한 결합률을 살펴보았다. 1. Pharmacokinetic parameters는 다음과 같았다. $t_{1/2}$은 13.7 hr, AUC는 $\53.38\;\mu\textrm{g}{\cdot}hr/ml$, AUMC는 $1013.4\;\mu\textrm{g}{\cdot}hr^2/ml$ MRT는 18.95hr, Vss 17.778l/kg 그리고 CL은 936.77ml/hr.kg였다. 2. Plasma concentration-time profile에서 enterohepaic circulation을 시사하여 2nd peak가 발견되었고. 담즙배설 실험으로 확증할 수가 있었다. 결구투여 후 담즙 배설은 투여량의 64.4%가 10시간에 걸쳐 배설되었고, 3시간째 그 배설속도는 maximum을 이뤘다. 3. Vss는 17.8 l/kg으로 큰 값을 나타냈고, 따라서 뇌를 제외한 대부분의 조직에 Brazilin은 분포하였고 특히 liver와 kidney, epididymus 그리고 testis에 고농도 분포함을 알 수 있었다. 4. 경구투여량의 44.1%가 , 정맥주사 후 투여량의 62.9%가 urine을 통해 배설되었다. Urine을 통해 배설되는 양의 대부분(80%)은 24시간 내에 배설되었다. 5. Plasma protein에 대한 결합율을 한외여과법으로 측정한 결과 $40{\pm}4%$가 결합하는 것으로 나타났다.

• 사상체질의학회지
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• 제11권1호
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• pp.119-135
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• 1999

본 연구(硏究)는 1996.3월(月)에서 1998.11월(月)사이에 동의대학교(東義大學校) 한의과대학(韓醫科大學) 부속한방병원(附屬韓方病院)에 내원(來院) 가료중(加療中) 환자(患者) 196명을 대상(對象)으로 하였으며 사상체질(四象體質)의 판별(判別)은 사상변증내용(四象辨證內容) 설문조사지(設問調査紙)(I)과 사상체질분류검사(象體質分類檢査)(QSCCII)를 중심으로 하였다. 본 결과는 사상체질(四象體質)과 질병(疾病) 및 증상유형(症狀類形)에 대한 설문지(說問紙)를 비교하여 얻은 것이다. 1. 태음인(太陰인)은 체중증가(體重增加), 땀이 많이 난다. 몸이 붓는다. 허리가 아프다는 증상(症狀)과 기름진 음식(飮食)을 잘 먹으며 음식(飮食)을 짜게 먹는 편이 다른 체질(體質)에 비하여 더욱 유발(頻發)하였다. 2. 소음인(少陰인)은 안색이 나쁘다. 목의 이물감, 수면장애(睡眠障碍) 식욕감퇴(食慾減退), 쉽게 피로(疲勞)해짐, 식사(食事)와 무관한 위(胃)의 통증(痛症), 두통(頭痛), 생리통증상(生理痛症狀)과 기름진 음식(飮食)을 잘 안 먹는다. 음식(飮食)을 싱겁게 먹는 편이 다른 체질(體質)에 비하여 더욱 유발(頻發)하였다. 3. 통계적(統計的)으로 유의성(有意性)을 가지지는 못하였지만, 소양인(少陽人)은 호흡기계질환(呼吸器系疾患)에서 단순한 기침증상(症狀) 근골격계질환(筋骨格系疾患)에서 관절(關節)의 운동장애(運動障碍), 부인과계(歸人科系)에서 월경(月經)의 조기(調期)와 양(量)의 변화(變化)와 생식기(生殖器) 소양증(搔痒症), 피부계(皮膚系)에서 가려움증과 부스럼증 등은 다른 체질(體質)에 비하여 비교적 많았고 심혈관계질환(心血管系疾患), 혈액계질환(血液系疾患)은 비교적 적었다. 소음인(少陰人)은 전반적(全般的)인 소화기계질환(消化器系疾患), 호흡기계질환(呼吸器系疾患)에서 인흡(咽吸)의 이물감 통증, 심혈관계질환(心血管系疾患), 혈액계질환(血液系疾患), 근골격계질환(筋骨格系疾患)에서 통증(痛症)이나 비증(痺症), 정신신경계질환(精神神經系疾患)에서 정신계질환(精神系疾患), 부인과계(婦人科系)에서 월경통(月經痛)을 비롯한 유방(乳房)의 몽우리 냉증(冷症), 피부계(皮膚系)에서 발진(發疹)이나 두드러기, 시각계질환(視覺系疾患)과 청각계질환(聽覺系疾患)등이 다른 체질(體質)에 비해 많았다. 태음인(太陰人) 호흡기계질환(呼吸器系疾患)에서 목이 잘 쉬는 증상, 근골격계질환(筋骨格系疾患)에서 요통(腰痛), 정신신경계질환(精神神經系疾患)에서 신경계질환(神經系疾患), 피부계(皮膚系)에서 발진(發疹)이나 두드러기등이 다른 체질(體質)에 비하여 다소 많았으며 부인과계질환(婦人科系疾患)은 적었다.