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In Vitro Virucidal Effect of Mouthrinse Containing C31G on Seasonal Influenza Viruses

  • Lee, Dong-Hun;Youn, Ha-Na;Park, Jae-Keun;Kang, Byung-Hwa;Kang, Jae-Hoon;Lee, Joong-Bok;Park, Seung-Yong;Choi, In-Soo;Lee, Sang-Won;Song, Chang-Seon
    • Journal of Microbiology and Biotechnology
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    • v.24 no.7
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    • pp.921-924
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    • 2014
  • C31G is a potent antimicrobial agent and can disrupt the microbial membrane by the alkyl portion of the molecule. The objective of this study was to evaluate the virucidal effectiveness of C31G and mouthrinse containing C31G (Sense-Time) on seasonal influenza viruses. Evaluation of the virucidal activity against influenza viruses was performed with end-point titration in 10-day-old chicken embryos and Madin-Darby canine kidney cells. In vitro studies demonstrated that C31G and Sense-Time inhibited the growth of seasonal influenza viruses even in the presence of 5% organic material. Gargling with C31G or Sense-Time would enhance oropharyngeal hygiene, which would be helpful for reducing influenza transmission.

Lipoxygenase Inhibitory Constituents from Indigofera oblongifolia

  • Sharif, Ahsan;Ahmed, Ejaz;Malik, Abdul;Riaz, Naheed;Afza, Nighat;Nawaz, Sarfraz Ahmad;Arshad, Muhammad;Shah, Muhammad Raza;Chaudhary, Muhammad Iqbal
    • Archives of Pharmacal Research
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    • v.28 no.7
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    • pp.761-764
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    • 2005
  • Indigin, alkylated xanthene (1) and indigoferic acid (2) have been isolated from the chloroform soluble fraction of Indigofera oblongifolia, along with $\beta$-sitosterol (3) and 3-hydroxybenzoic acid (4), which are reported for the first time from this species. Their structures were determined through spectroscopic techniques. Both the new compounds 1 and 2 showed significant activity against enzyme lipoxygenase, while 2 further showed moderate inhibition against BChE.

An Efficient Synthesis of 2-Alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides

  • Zia ur Rehman, Muhammad;Choudary, Jamil Anwar;Ahmad, Saeed
    • Bulletin of the Korean Chemical Society
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    • v.26 no.11
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    • pp.1771-1775
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    • 2005
  • An efficient and environment friendly method has been described for the synthesis of various 2-alkyl-4-hydroxy-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxides starting from N-alkylation of sodium obenzosulfimide in an ionic liquid for the first time. Ring cleavage and ring closure of the resulting product were achieved in a single step in a cost effective solvent (methanol) followed by N-alkylation of resulting alkyl 4-hydroxy-2H-1,2-benzothiazine-3-carboxylate in ionic liquid while boron triflouride was used as a catalyst along with molecular sieves in carboxamide formation step.

ALLOY STRUCTURE AND ANODIC FILM GROWTH ON RAPIDLY SOLIDIFIED AL-SI-BASED ALLOYS

  • Kim, H.S.;Thompson, G.E.;Wood, G.C.;Wright, I.G.;Maringer, R.E.
    • Journal of Surface Science and Engineering
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    • v.17 no.2
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    • pp.29-40
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    • 1984
  • The structure of rapidly solidified Al-Si-based alloys and its relationship to subsequent anodic film growth in near neutral and acid solutions have been investigated. Solidification of the alloys proceeds via pre-dendritic nuclei, associated with rugosity of the casting surface, from which cellular-type growth, comprised of aluminium-rich material surrounded by silicon-containing material, emanates. Observation of ultramicrotomed sections of the alloys and their anodic films reveals the local oxidation of the silicon-rich phase and its incorporation into the anodic alumina film, formed in near neutral solutions. Such incorporation occurs but resultant isolation of the silicon-rich phase is not possible for anodizing in phosphoric acid, and a three-dimensional network of the oxidized silicon-containing phase, with continuing development of porous anodic alumina, is observed.

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Hardware Digital Color Enhancement for Color Vision Deficiencies

  • Chen, Yu-Chieh;Liao, Tai-Shan
    • ETRI Journal
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    • v.33 no.1
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    • pp.71-77
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    • 2011
  • Up to 10% of the global population suffers from color vision deficiency (CVD) [1], especially deuteranomaly and protanomaly, the conditions in which it is difficult to discriminate between red and green hues. For those who suffer from CVD, their career fields are restricted, and their childhood education is frustrating. There are many optical eye glasses on the market to compensate for this disability. However, although they are attractive due to their light weight, wearing these glasses will decrease visual brightness and cause problems at night. Therefore, this paper presents a supplementary device that comprises a head-mounted display and an image sensor. With the aid of the image processing technique of digital color space adjustment implemented in a high-speed field-programmable gate array device, the users can enjoy enhanced vision through the display without any decrease in brightness.

The Road to RNA Silencing is Paved with Plant-Virus Interactions

  • Palukaitis, Peter
    • The Plant Pathology Journal
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    • v.27 no.3
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    • pp.197-206
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    • 2011
  • RNA silencing has had a large impact on biology in general, as well as on our understanding of plant-pathogen interactions, especially interactions between plants and viruses. While most of what we know about the mechanism of RNA silencing was deduced in the last 12 years, many of the interactions between plants and viruses, as well as virus-virus interactions in plants, which we now know are manifestations of RNA silencing, were the subject of decades of work from numerous laboratories. These laboratories were examining the nature and extent of phenomena such as recovery from infection, the formation of dark green islands resistant to re-infection, synergy between unrelated viruses and cross-protection between related viruses, all first described in the late 1920s. In this review, the relationships between these phenomena and their place in the defense mechanism we call RNA silencing will be described, to show how they are all linked.

Peste des petits ruminants in Pakistan; past, present and future perspectives

  • Abubakar, Muhammad;Irfan, Muhammad;Manzoor, Shumaila
    • Journal of Animal Science and Technology
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    • v.57 no.11
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    • pp.32.1-32.8
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    • 2015
  • Peste des petits ruminants (PPR) is considered to be one of the main constraints to enhancing the productivity of goats and sheep in regions where it is present and becoming endemic. PPR was recognized in Pakistan in early 1990s but got importance during the Participatory Disease Surveillance (PDS) of Rinderpest Eradication Campaign. Lot of research work has been initiated during last decade towards disease epidemiology, risk factor recognition, laboratory diagnosis, vaccination and demonstration of control strategies. Although there are ongoing projects working towards the progressive control of the disease in country yet there is need to have a national level control program for PPR. Also there is need to have comprehensive social economic surveys, disease hot spot recognition and identification of role of other species in disease transmission. With combined efforts of local and national authorities and political will, there is high likelihood that this devastating disease can be controlled and eventually eradicated in near future.

An Efficient If Routing Lookup by Using Routing Interval

  • Wang, Pi-Chung;Chan, Chia-Tai;Chen, Yaw-Chung
    • Journal of Communications and Networks
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    • v.3 no.4
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    • pp.374-382
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    • 2001
  • Nowadays, the commonly used table lookup scheme for IP routing is based on the sc-called classless interdomain routing (CIDR). With CIDR, routers must find out the best matching prefix (BMP) for IP packets forwarding, this complicates the IP lookup. Currently, this process is mainly performed in software and several schemes hale been proposed for hardware implementation. Since the IP lookup performance is a major design issue for the new generation routers, in this article we investigate the properties of the routing table and present a new approach for IP lookups, our approach is not based Gn BMP and significantly reduces the complexity, thus the computation cast of existing schemes can be significantly reduced. We also propose an efficient IP lookup algorithm, with which we improve the binary search on prefixes to 30 millions of packets per second (MPPS) and 5,000 route updates/s under the same experiment setup with an even larger routing table.

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ULTRAVIOLET AND VISIBLE SPECTROSCOPIC DATABASE FOR ATOMS AND MOLECULES IN CELESTIAL OBJETS

  • Kim, Sang-J.
    • Publications of The Korean Astronomical Society
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    • v.9 no.1
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    • pp.111-166
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    • 1994
  • I have developed a UV and visible spectroscopic database (UVSD) for atoms and molecules, which are found in interstellar medium, stars, galaxies, and in the atmospheres of the earth, planets, satellites, and comets. This UV and visible database, which is machine-readable, consists of three different sub-databases depending upon the characteristics of the sub-databases: (A) atomic and molecular line listings from laboratory observations or theoretical studies; (B) absorption spectra measured in laboratories; and (C) solar UV, visible, and infrared spectral atlases. The UVSD is in a very initial stage of development compared with other well organized and established infrared and microwave databases. In order to make a good quality and complete database, substantial efforts should be made for the acquisition of scattered important data from laboratories or institutions, and then the acquired heterogeneous data should be peer-reviewed and standardized.

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Conformationally Constrained Analogues of Diacylglycerol Having a Perhydrofuro[3,4-c]furan-1,4-dione Bis-${\gamma}$-butyrolactone Skeleton

  • Lee, Jee-Woo;Nancy-E. Lewin;Peter-M. Blumberg;Victor-E. Marquez
    • Archives of Pharmacal Research
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    • v.21 no.2
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    • pp.164-167
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    • 1998
  • Bis-${\gamma}$-lactones (1,2) having a perhydrofuro[3,4-c]furan-1,4-dione skeleton were designed as conformationally constrained diacylglycerol analogues. They were synthesized from D-apiose in 11 steps, and evaluated as $PKC-{\alpha}$ ligands by measuring their ability to displace bound $^3H$]PDBU from the enzyme. The compounds showed moderate binding affinities with $K_i$ values of 13.89 (${\pm}5.67$) ${\mu}M$ and 11.47 (${\pm}0.89$) ${\mu}M$, respectively. Their similar binding affinities indicate that these two bicyclic compounds were not effectively discriminated by $PKC-{\alpha}$ in terms of the direction of the side chain as other ligands built on similar bis-${\gamma}$-lactones.

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