• 약학회지
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• 제41권2호
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• pp.203-211
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• 1997

This study was conducted to investigate the subacute transdermal toxicity of Syndella gel, a new topical drug containing deproteinized dialysate of calf's blood and micronomicin sulfate in Sprague-Dawley rats. Three doses (1.97, 3.94, 7.88 g/kg) of Syndella gel was daily treated transdermally to male and female rats for 30 days. No death was occurred in either control or treated rats. No significant toxic clinical signs and body weight change were not observed at any doses in the male or female rats treated. There were no significant alterations in hematologic and biochemical parameters in both sexes, however slight increase of potassium concentration was observed in 3.94g/kg and 7.88 g/kg female groups. No significant necrotic changes were not observed in examined organs. This study showed that up to 7.88g/kg Syndella gel did not induce subacute transdermal toxicity.

• Research in Vestibular Science
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• 제17권4호
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• pp.160-166
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• 2018

Objectives: This study was conducted to assess the current management status of the vestibular function test laboratories in Korea. Methods: Questionnaire about the management status of the vestibular function test laboratories was sent by email to the entire members of the Korean Balance Society. The contents of questionnaire included situation of employees who perform the tests, the types of vestibular function tests and equipment, frequency of the test and types of dizziness related questionnaires. Results: Forty-nine hospitals and clinics responded. All the 49 respondents answered that they have videonystagmography. Spontaneous nystagmus analysis by videonystagmogrphy was the most frequently tests for patients with dizziness. Questionnaires for dizziness were used by 27 respondents (55.1%) for initial evaluation of the dizziness patients. The Korean version of dizziness handicap inventory was the most frequently used dizziness related questionnaire. Conclusions: We analyzed the current management status of vestibular function test laboratories to comprehend the present condition of the vestibular function test. We think that these results will help to provide a standard for laboratory operations and prepare for the education, focusing on high-demand tests.

• Safety and Health at Work
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• 제9권4호
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• pp.473-478
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• 2018

Background: Multiple Chemical Sensitivity (MCS) is an acquired disease which etiology remains unknown. It is characterized by the development of sensitivity to certain chemical products. Most of the hypotheses formulated to explain the syndrome associate it to a previous exposition to some kind of volatile chemical. University researchers in chemical laboratories suffer a phenomenon of multi-exposition to chemical agents at low concentration during long periods of time although in an irregular form. Many of these chemical agents have similar properties to those suspicious of causing MCS. This article studies the prevalence of MCS in laboratory researchers. Methods: The study group is university researchers in chemical laboratories. The control group was obtained from administrative personnel who work in the same universities and therefore, are not exposed to chemical products from the laboratories, but have the same exposition to the rest of environmental polluting agents from the area and from the buildings of the university. In this study, it is used the Quick Environmental Exposure and Sensitivity Inventory (QEESI) (sensitivity of 92%/specificity of 95%). Results: The results showed that the prevalence of MCS for the university researchers is not related to exposition by inhalation to multiple chemical agents, at low concentration. Conclusions: The results disagree with one of the main etiological hypotheses of MCS, which is based on the existence of hypersensitive people, who presents a response after prolonged expositions to very low concentrations during a long period of time.

• 한국임상수의학회지
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• 제30권1호
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• pp.75-79
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• 2013

Laminitis is a common horse disease that causes pain and disability. One of the major causes of laminitis is carbohydrate overload, which leads to the overgrowth of gram-positive bacteria and subsequent toxemia. This study was performed to establish an experimental model of acute phase laminitis. A horse was fed with a bolus dose of oligofructose, examined for clinical signs and blood parameters, and euthanized for necropsy and histopathology. After administration, the horse exhibited clinical signs including watery feces, inappetence, severe lameness, pyrexia and tachycardia. Complete blood count showed increased hematocrit, lymphocytosis and neutropenia. Serum chemistry revealed hyperglycemia, hyperproteinemia, high level of glutamic oxalate transaminase, creatinine, uric acid and mild hyponatremia. Histologically, the lamina tissue was edematous with mild infiltration of inflammatory cells. These findings indicate that oligofructose-induced laminitis in horse is an appropriate model for studying pathogenesis of acute phase laminitis.

• Bulletin of the Korean Chemical Society
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• 제28권3호
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• pp.373-378
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• 2007

A micro organism Agrobacterium tumifacient as an immobilized cell on a solid support was presented as a new biosorbent in a simple and sensitive spectrophotometry determination of Ni(II) in various samples using 4-hydroxy benzaldehyde-4-bromophenyl hydrazone as a color developing agent (λmax 497 nm) at pH 4.0 ± 0.2. Beer's law was obeyed over the range of 0.01-0.1 μg L-1. The molar absorptivity and Sandell's sensitivity were 1.285 × 105 L mol-1cm-1 and 0.007245 μg cm-2 respectively. Under these conditions, the preconcentration factor obtained was 82, and the detection limit achieved was 0.05 μg L-1. The detailed study of various interfering ions made the method more sensitive and selective. The recovery of Ni(II) from various samples range from 97.75 to 99.35%. The present method was successfully applied for the determination of Ni(II) in spiked, natural water and alloy samples. The proposed method was compared with reported methods in terms of Student's ‘t'-test and Variance ratio ‘f'-test which indicates that there is no significant difference between proposed and literature method at 95% confidence level.

• 한국안전학회지
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• 제33권1호
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• pp.118-127
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• 2018

The study aims present data collection on the current state of safety and safety consciousness in universities' laboratories to verify the relation between investigation factors and further draw implications. The first finding is that laboratories with high risk level do not have better safety management performance than those with lower risk level. Secondly, labs that experienced accidents has a higher level of control than those without any. Regarding to the university's acceptance of safety requirements, the group with a high level of risk awareness or accidents were concerned that their universities did not provide sufficient support in safety management. It means that safety is low on the list of priorities in Universities' overall agenda and individual labs are responsible of their own safety. Most of the causes of accidents in the labs are man-made than physical errors. It requires that continuous safety educations and measures through safe research activities are means to eliminate and reduce the individual's safety frigidity. Through the survey, it is known that current education's system and contents are too generalized to reflect the characteristics of each laboratory. Thus, it is difficult to recognize various risk situations and to actually prevent safety accidents. Therefore, it is necessary to shift to customized curriculum and system for various major fields.

• 대한안전경영과학회지
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• 제24권4호
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• pp.61-70
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• 2022

In spite of lab safety act for over 10 years, over 100 safety accidents in the laboratory have been constantly occurring. The ideal safety management system is to prevent accidents by differential classifying and managing laboratory regulatory materials according to the risk level. In order to approach this system, in-depth interviews with safety managers were first conducted to identify the current status of safety management in domestic university laboratories. And then through comparative analysis of safety management systems in domestic and foreign laboratories, a new regulatory substance classification standard based on the analysis of the hazards and the classification of risk grades, and a safety management system are proposed. From this study, it will contribute to the creation of a safe laboratory environment by differential classification and management laboratory regulatory materials based on the risk level.

• Archives of Pharmacal Research
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• 제21권6호
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• pp.753-758
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• 1998

Sixteen novel 2-substituted acetyl amino-5-alkyl-1,3,4-thiadiazol were synthesized and screened for their pharmacological activities. A few of the compounds namely 11, 12 and 16 showed anti-inflammatory activities comparable to phenylbutazone. Compound 12 also showed significan non-specific spasmolytic activity. Diuretic activity of compound 15 at a dose level of 90mg/kg p.o. was two fold higher compared to 50mg/kg p.o. of furosemide. Comparable diuresis was aso produced by compounds 9, 10, and 16.

• 대한전기학회:학술대회논문집
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• 대한전기학회 2009년도 제40회 하계학술대회
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• pp.2164.1_2165.1
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• 2009

In this study we suggest fire detection algorithm using fuzzy inference with input variables of temperature and smoke density to detect electrical fire of early stage. The algorithm consists of membership function of temperature and smoke density and fire probability. The antecedent part of the algorithm consists of temperature and smoke density, and the consequent part consists of fire possibility. The inference rules of the algorithm is estimated to input temperature and smoke density obtained by real fire. With the help of algorithms using fuzzy inference we may be diagnose electrical fire precisely.

• 한국화재소방학회:학술대회논문집
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• 한국화재소방학회 2012년도 춘계학술발표회 초록집
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• pp.389-392
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• 2012

연기감지기는 이온전류의 변화량을 감지하는 이온화식 연기감지기와 발광부와 수광부로 이루어진 챔버내에 연기에 의한 광량의 변화를 감지하는 광전식 연기감지기로 구분된다. 국내에서는 광전식 연기감지기가 더 많이 사용되고 있는데 이러한 광전식 연기감지기의 챔버내에 이물질이 침입하게 되면 비화재보를 발생시키게 된다. 본 논문은 연기감지기의 연기감지 챔버에 대한 비화재보를 감소시키기 위한 신뢰성 시험에 대하여 논한 연구이다. 광전식 연기감지기의 신뢰성을 검증하는 방법으로는 먼지에 대한 신뢰성을 검증하는 가연물 종류에 따른 연기감지 신뢰성 시험이나 분진시험이 적합한 것으로 판단되며, 이러한 시험의 반복을 통하여 광전식 연기감지기의 신뢰성을 검증하는 것이 필요한 것으로 사료된다.