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Renoprotective Effect of Plantago major Against Proteinuria and Apoptosis Induced by Adriamycin in Rat

  • Yazd, Zohreh Naji Ebrahimi;Noshahr, Zahra Samadi;Hosseinian, Sara;Shafei, Mohammad Naser;Bideskan, Alireza Ebrahimzadeh;Mohebbati, Reza;Heravi, Nazanin Entezari;Shahraki, Samira;Mahzari, Somayeh;Rad, Abolfazl Khajavi
    • Journal of Pharmacopuncture
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    • v.22 no.1
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    • pp.35-40
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    • 2019
  • Objective: Adriamycin (ADR) is an important anti-cancer drug which can cause renal toxicity. Given the known anti-inflammatory and antioxidant effects of Plantago major (P. major), the aim of this study was to determine the effects of hydroalcoholic extract of P. major on ADR- induced nephropathy in rats. Methods: Fifty male Wistar albino rats were randomly divided into 5 groups including: control, ADR (5 mg/kg), ADR + P. major (600 and 1200 mg/kg) and P. major (1200 mg/kg). The animals were treated with P. major extract for 5 consecutive weeks and ADR was intravenously injected on the 7th day of the study. Urine and serum samples were collected on days 0, 14, 21, 28, and 35 for the measurement of serum cholesterol and albumin levels and urine protein excretion rate. At the end of the study, the left kidneys were removed for apoptosis assessment. Results: Administration of ADR significantly decreased serum albumin level and increased serum cholesterol and urine protein excretion rate as well as, apoptotic cell numbers compared to the control group (P < 0.001) while had no effect on glomerular filtration rate (P > 0.05). Treatment with P. major, in both 600 and 1200 mg/kg doses, increased serum albumin level and decreased serum cholesterol concentration, urine protein excretion rate and as well as the number of apoptotic cell compared to the ADR group (P < 0.001). Conclusion: Our results showed that the P. major extract effectively protects against ADR- induced nephropathy by reducing kidney apoptosis and improving renal functioning in rats.

Evaluating the Services of the Deanship of e-Learning and Distance Education at Umm Al-Qura University According to the Opinions of Beneficiaries (Students/Faculty Members)

  • Alharthi, Ahmed;Yamani, Hanaa;Elsigini, Waleed
    • International Journal of Computer Science & Network Security
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    • v.21 no.9
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    • pp.191-202
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    • 2021
  • This research was conducted with the aim to appraise the level of satisfaction of students and faculty members with the services of the Deanship of e-Learning and Distance Education at Umm Al-Qura University. In addition, it investigated any differences arising between the evaluation of students and faculty members for these services owing to their gender..To achieve these goals, a descriptive analysis methodology was used in this research. The sample comprised 1357 students (704 male and 653 female) and 372 faculty members (208 male and 164 female) from Umm Al-Qura University in the academic year 2020-2021. To collect the requisite data, the study participants were asked to complete a 5-point Likert scale questionnaire, and the validity and reliability of the data were then assessed. The findings revealed the existence of a high level of satisfaction of students and faculty members with the services of Deanship of e-Learning and Distance Education at Umm Al-Qura University. There are no statistically significant differences between the mean scores of students (male/female) at Umm Al-Qura University in evaluating the said services. Furthermore, there are no statistically significant differences between the mean scores of faculty members (male/female) at Umm Al-Qura University in evaluating these. There exist statistically significant differences between the mean scores of faculty members and students in the evaluation of the services of the Deanship for the benefit of faculty members.

Vascular ring anomaly with a right patent ductus arteriosus and a left aortic arch in a juvenile cat

  • Aki Takeuchi ;Kazumi Shimada ;Lina Hamabe ;Tomohiko Yoshida;Yusuke Ozai ;Miki Hirose ;Aimi Yokoi ;Momoko Watanabe ;Ikki Mitsui ;Ryou Tanaka
    • Journal of Veterinary Science
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    • v.24 no.4
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    • pp.50.1-50.6
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    • 2023
  • This paper reports the clinical findings and surgical treatment of feline right patent ductus arteriosus (RPDA) with a left aortic arch. A two-month-old female Maine Coon was referred for an investigation of regurgitation after weaning. RPDA with a left aortic arch was diagnosed based on the echocardiographic and computed tomography (CT) findings. A right-fourth intercostal thoracotomy was found to be an appropriate approach to the duct. Preoperative diagnosis is crucial and diagnostic imaging, including radiography, echocardiography, and cardiac CT examination, is essential for determining if the aortic arch is right or left.

Reasons and Motivations for Cigarette Smoking and Barriers against Quitting Among a Sample of Young People in Jeddah, Saudi Arabia

  • Baig, Mukhtiar;Bakarman, Marwan A;Gazzaz, Zohair J;Khabaz, Mohamad N;Ahmed, Tahir J;Qureshi, Imtiaz A;Hussain, Muhammad B;Alzahrani, Ali H;Al-Shehri, Ali A;Basendwah, Mohammad A;Altherwi, Fahd B;Al-Shehri, Fahd M
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.7
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    • pp.3483-3487
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    • 2016
  • Background: Cigarette smoking is one of the leading causes of death in the world. Tobacco consumption has grave negative consequences for health so that it is important to understand the reasons and motivations towards cigarette smoking and barriers against quitting smoking among the young generation for developing effective policies to control this widespread problem. Materials and Methods: This cross-sectional survey was carried out at the Faculty of Medicine, Rabigh, King Abdulaziz University, Jeddah, Saudi Arabia. A total of 438 young smokers participated from the University and the general population. Data were collected through anonymous, self-administered questionnaires in the Arabic language that contained questions about the reasons and motivations towards cigarette smoking and barriers against quitting smoking. The questionnaire also contained several questions regarding knowledge and attitude of the participants towards cigarette smoking. The data was analyzed on SPSS-16. Results: The mean age of the respondents was $22.9{\pm}3.48$, out of 438 subjects 87 (19.9%) were married, and 351 (80.1%) were unmarried, and 331 (75.6%) belonged to urban areas while 107 (24.5%) were from the rural areas. Responding to a question about a number of cigarettes smoked per day, 31% answered 11-20, 29% answered 21-30, and 25% answered 1-10. Questioned about smokers in the family, 34.5% responded more than one, with 19% for brother and 13% for father. About the reasons for not quitting smoking, 26% described lack of willpower, 25% had no reason, 22% said that people around me smoke, and 15.3% responded stress at home/work. The major motivation for smokers was smoker friends (42%), for 33.8% others, for 12% father/brother and 7.8% media. Conclusions: There are several avoidable and preventable reasons and barriers against quitting smoking. However, knowledge and attitude about smoking were good, and the majority of the smokers were well aware of the associated hazards. Therefore, there is a need to search out ways and means to help them to quit this addiction.

Night shift preparation, performance, and perception: are there differences between emergency medicine nurses, residents, and faculty?

  • Richards, John R.;Stayton, Taylor L.;Wells, Jason A.;Parikh, Aman K.;Laurin, Erik G.
    • Clinical and Experimental Emergency Medicine
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    • v.5 no.4
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    • pp.240-248
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    • 2018
  • Objective Determine differences between faculty, residents, and nurses regarding night shift preparation, performance, recovery, and perception of emotional and physical health effects. Methods Survey study performed at an urban university medical center emergency department with an accredited residency program in emergency medicine. Results Forty-seven faculty, 37 residents, and 90 nurses completed the survey. There was no difference in use of physical sleep aids between groups, except nurses utilized blackout curtains more (69%) than residents (60%) and faculty (45%). Bedroom temperature preference was similar. The routine use of pharmacologic sleep aids differed: nurses and residents (both 38%) compared to faculty (13%). Residents routinely used melatonin more (79%) than did faculty (33%) and nurses (38%). Faculty preferred not to eat (45%), whereas residents (24%) preferred a full meal. The majority (>72%) in all groups drank coffee before their night shift and reported feeling tired despite their routine, with 4:00 a.m. as median nadir. Faculty reported a higher rate (41%) of falling asleep while driving compared to residents (14%) and nurses (32%), but the accident rate (3% to 6%) did not differ significantly. All had similar opinions regarding night shift-associated health effects. However, faculty reported lower level of satisfaction working night shifts, whereas nurses agreed less than the other groups regarding increased risk of drug and alcohol dependence. Conclusion Faculty, residents, and nurses shared many characteristics. Faculty tended to not use pharmacologic sleep aids, not eat before their shift, fall asleep at a higher rate while driving home, and enjoy night shift work less.

Thermomechanical analysis of antisymmetric laminated reinforced composite plates using a new four variable trigonometric refined plate theory

  • Abualnour, Moussa;Chikh, Abdelbaki;Hebali, Habib;Kaci, Abdelhakim;Tounsi, Abdeldjebbar;Bousahla, Abdelmoumen Anis;Tounsi, Abdelouahed
    • Computers and Concrete
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    • v.24 no.6
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    • pp.489-498
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    • 2019
  • The thermo-mechanical bending behavior of the antisymmetric cross-ply laminates is examined using a new simple four variable trigonometric plate theory. The proposed theory utilizes a novel displacement field which introduces undetermined integral terms and needs only four variables. The validity of the present model is proved by comparison with solutions available in the literature.