• YAKHAK HOEJI
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• v.41 no.3
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• pp.328-334
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• 1997

Pharmacokinetics of DWP401, a recombinant human epidermal growth factor (rhEGF), was studied using radioimmunoassay (RIA) and $^{125}I$-DWP401 in rats. When DWP401 was adm inistered i.v. at doses of 50 and 500 mcg/kg, the plasma DWP401 disappeared biiexponentially with terminal half life of 4.7 and 92.8 min. The $C_{max}$ and $T_{max}$ after s.c. administration of ti at doses of 50 and 500 ${\mu}g$/kg were determined to be 23.6 and 17.5 ng/ml at 50 ${\mu}g$/kg, and 261.4 ng/ml and 36.8 min, respectively. Both the total urinary and biliary recoveries of intact DWP401 2343 very low (<0.4%), probably due to its extensive degradation in the body. the concentration ratio of DWP401 between the organ and plasma decreased especially in the liver and kidney as the dose and time after the dose increased. For example, the liver/plasma and kidney/plasma concentration ratio of DWP401 at 2.5 min after i.v. doses of 50 ${\mu}g$/kg were comparable and much larger than unity. But, the ratio at 2.5 min after i.v. doses of 500${\mu}g$/kg was much larger in the kidney that in than in the liver. These results suggest that the systemic administration of DWP401 might be subject to rapid and extensive clearance from circulation within several hour after main distrbution to liver and kidney.

• Journal of the Korea Computer Graphics Society
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• v.22 no.3
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• pp.43-52
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• 2016

This paper is to study techniques of a virtual reality to maximize the depth of the users' immersion based on differentiated interactive contents using korean traditional fairy tale. In order to increase more interests in korean traditional fairy tale, we produce a interactive 3D contents and propose a new approach to a system designing applying a virtual realities such as HMD, Leap motion. First, using Korean traditional fairy tale, we generate interactive contents consisting of scenes intensifying user's tensions while interaction of game process. Based on the interactive contents generated, we design scene generation using Oculus HMD, the gaze based input processes and a hand interface using Leap motion, in order to provide a multi dimensional scene transmission and an input process method to intensify the sense of the reality. We will verify through diverse tests whether the proposed virtual reality contents based on a technique of an input process will actually intensify the immersion in the virtual reality or not while minimizing the motion sickness of the users.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.96-96
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• 2022

가상현실 (Virtual Reality, VR) 기술은 3차원 가상공간 내에서의 높은 몰입감에 기반한 체험을 바탕으로 다양한 분야에서 활용되고 있다. 소방훈련이나 태풍, 지진 등 재해 대응훈련과 같이 인명피해의 위험이 있는 재해에 대한 VR 기술을 활용한 방재교육은 위험성을 동반하지 않으면서도 현장감에 기반한 높은 교육적 효과를 창출할 수 있다. 한국전자통신연구원에서는 VR 기술을 이용하여 소방훈련을 위한 실감 소방훈련 시뮬레이터를 개발한 바 있으며 목동재난체험관에서는 홍수, 태풍, 지진 등 다양한 재해에 대한 안전교육을 위한 자연재해 가상현실체험을 운영하고 있다. 이외에도 전국 지자체 및 교육청에서는 방재교육을 목적으로 VR 기술을 활용하고 있다. 그러나 기존의 VR을 활용한 수재해 방재교육은 범람의 수리학적 특성과 함께 수해지의 지형적 특성을 적절히 반영하지 못하는 단점을 가지고 있다. 이는 방재교육이나 경각심을 부각하는 데엔 효과적이나 실질적인 방재 가이드라인을 제시하는 데엔 한계가 있다. 본 연구는 몰입형 파랑해석모형인 Celeris Base를 기반으로 3차원 가상현실 시각화를 활용한 수리학적 홍수추적 모형을 개발하였다. 3차원 가상현실 시각화는 Unity3D를 이용하여 모의환경 내에 구현되었다. 강우-유출 과정의 수리학적 해석을 위해 동수역학 수치모형의 연속방정식 내에 강우와 침투에 대한 항을 추가하였다. 침투모형으로는 Horton 모형, Green-Ampt 모형과 함께 사면의 기울기를 고려한 Green-Ampt 모형을 적용하였다. 실제 유역에서의 홍수추적 모의결과는 관측값과 비교적 잘 일치함을 확인하였다. 개발된 모형은 VR 방재교육을 통해 일반인의 수재해 대응능력 향상에 기여함과 동시에 정확성 높은 홍수추적 모의결과에 기반한 홍수대책 마련에도 활용 가능할 것으로 기대된다.

• Journal of The Korean Astronomical Society
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• v.49 no.5
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• pp.193-198
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• 2016

Early-type galaxies (ETGs) are supposed to follow the virial relation $M=k_e{\sigma}^2R_e/G$, with M being the mass, σ_* being the stellar velocity dispersion, R_e being the effective radius, G being Newton's constant, and k_e being the virial factor, a geometry factor of order unity. Applying this relation to (a) the ATLAS^3D sample of Cappellari et al. (2013) and (b) the sample of Saglia et al. (2016) gives ensemble-averaged factors 〈k_e〉 = 5.15 ± 0.09 and 〈k_e〉 = 4.01 ± 0.18, respectively, with the difference arising from different definitions of effective velocity dispersions. The two datasets reveal a statistically significant tilt of the empirical relation relative to the theoretical virial relation such that $M{\propto}({\sigma}^2_*R_e)^{0.92}$. This tilt disappears when replacing R_e with the semi-major axis of the projected half-light ellipse, a. All best-fit scaling relations show zero intrinsic scatter, implying that the mass plane of ETGs is fully determined by the virial relation. Whenever a comparison is possible, my results are consistent with, and confirm, the results by Cappellari et al. (2013). The difference between the relations using either a or R_e arises from a known lack of highly elliptical high-mass galaxies; this leads to a scaling (1 - ϵ ) ∝ M^0.12, with ϵ being the ellipticity and $R_e=a\sqrt[]{1-{\epsilon}}$. Accordingly, a, not R_e, is the correct proxy for the scale radius of ETGs. By geometry, this implies that early-type galaxies are axisymmetric and oblate in general, in agreement with published results from modeling based on kinematics and light distributions.

• The Korea Journal of Herbology
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• v.23 no.3
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• pp.27-32
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• 2008

Objectives : In this paper, we describe that $^1H-NMR$ spectroscopy may be superior to the conventional HPLC for the quantitative analysis of hesperidin from Citrus unshiu. Methods : $^1H-NMR$ spectra (400 MHz) were recorded in $DMSO-d_6$ using a Varian UNITY Inova AS 400 FT NMR spectrometer. One hundred milligram of powdered Citrus unshiu was weighed out and mixed with 1 ml of $DMSO-d_6$ with sonication for 30 min (room temperature). The extracts were filtrated through a 0.45 ${\mu}m$ PVDF filter and 0.5 ml of filtrated extract used for quantitative $^1H-NMR$ measurement (added 1 mg of dimethyl terephthalate as internal standard). The quantity of hesperidin was calculated by the ratio of the intensity of the compound to the known amount of internal standard. For HPLC analysis, the half gram of plant material was extracted with 60 ml of MeOH for 2 hours. The extracts were made 100 ml volume and analyzed by a Waters HPLC system using a YMC ODS column. The total flow rate was 1.0 ml/min with a sample volume 10 ${\mu}l$ and UV detection at 280nm. Results : The contents of hesperidin in Citrus unshiu was determined $5.33{\pm}0.06$% in the quantitative $^1H-NMR$ method and $5.15{\pm}0.12%$ in HPLC method. Using the quantitative $^1H-NMR$ the contents of hesperidin can be determined in much shorter time than the conventional HPLC measurements. Conclusions : From those results, the advantages of quantitative $^1H-NMR$ analysis are that can be analyzed to identify and quantify, and no reference compounds required for calibration curve. Besides, it allows rapid and simple quantification for hesperidin with an analysis time for only 10 min without any pre-purification steps.

• Proceedings of the KIPE Conference
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• 2004.07a
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• pp.77-81
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• 2004

In this paper a novel line interactive UPS (Uninterruptible Power Supply) using the two 4-leg VSCs and AC line reactor is proposed. The 4-leg Voltage Source Converter(VSC) can use the DC link voltage effectively by the 3-D SVPWM method. Hence the DC battery voltage can be reduced by $15\%$ in comparison to that of the conventional line-interactive UPS system. One VSC is in parallel with the AC line reactor of the power source side, and the other is in series with the load. The parallel 4-leg voltage source inverter controls three-phase line voltage independently in order to control the line reactor current indirectly. It eliminates the neutral line current and the active ripple power of the source side using the pqr theory so that unity power factor and the sinusoidal source current can be achieved even though both the source and the load voltages have zero sequence components. The series 4-leg voltage source inverter compensates the line voltage and allows the load voltage to be balanced and harmonic-free. Both of parallel and series 4-leg voltage source inverters always act as independently controllable voltage sources, so that three-phase output voltage shows a seamless transition to the backup mode. The feasibility of the proposed UPS system has been investigated and verified through computer simulation results.

• International Journal of Computer Science & Network Security
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• v.22 no.7
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• pp.451-458
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• 2022

This article is devoted to the problem of national and patriotic education of young students by means of digital technologies in the conditions of distance learning environment. It is emphasized that national and patriotic education is a powerful means of strengthening the unity and integrity of Ukraine. It is proved that national and patriotic education will be effective under the condition of systematic and purposeful activity on formation of patriotic consciousness in youth, sense of national dignity, necessity of service of ideals and values of the country. Various forms of educational work of national and patriotic orientation at Pavlo Tychyna Uman State Pedagogical University, which were conducted by digital technologies: online thematic lectures, educational classes, round tables, workshops, guest online meetings with famous researchers of historical heritage of Ukraine, online tours of historical places, virtual exhibitions of art, participation in the national-patriotic student camp "Diia" (Action) and etc. The activity of the University Library and V. O. Sukhomlinsky State Scientific and Pedagogical Library of Ukraine of the National Academy of Pedagogical Sciences of Ukraine, which has a significant impact on the formation of national consciousness and social and political activity of students by modern means of information and communication technologies. It is determined that the project "Inclusive 3D map" helps to broaden the horizons and deepen the knowledge of young students, education of a true citizen, the formation of cognitive interest in the subjects studied, motivation to study, raising awareness of Ukrainians on historical and cultural heritage. The study showed that young students take an active social attitude: they speak Ukrainian, want to live and work in Ukraine, respect their homeland, its traditions, cultural and historical past, love to travel and they are tolerant of people with special needs. Promising areas of educational work with students based on the use of a wide range of information and communication technologies, namely 3D games, TV tandems, podcasts, social networks, video resources in national and patriotic education of youth.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1994.04a
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• pp.290-290
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• 1994

The binding characteristic of oxomemazine to muscarinic receptor in the cerebrum, heart, and ileum were compared to those of pirenzepine to investigate whether oxomemazine could classify the muscarinic receptor subtypes. 〔$^3$H〕Quinucl idinyl benzilate(QNB) identified a single class of muscarinic receptors with apparent K$\sub$D/ value of about 60 pM in three tissues. Analysis of the pirenzepine inhibition curve of 〔$^3$H〕QNB binding to cerebral microsome indicated the presence of two receptor subtypes with high (Ki=16 nM, M$_1$-receptor) and low (Ki=400 nM, M$_2$-receptor) affinity for pirenzepine. Oxomemazine also identified two receptor subtypes with high (Ki=84 nM, On-receptor) and low (Ki=1 4 ${\mu}$M, O$\sub$L/-receptor) affinity in rat cerebral microsome, The percentage population of the M$_1$-and M$_2$-receptors to the total receptors were 61 : 39, and those of the O$\^$H/- and O$\sub$L/-receptors 39 : 61, respectively, However, the Hill coefficients of these two drugs for the inhibition of 〔$^3$H〕QNB binding to the heart and ileum were close to unity which indicated that these drugs bound to a uniform population of receptors in these two tissues. The Ki values for the low affinity sites of pirenzepine and oxomemazine in the cerebrum were similar to those of these drugs in the heart ileum. Both pirenzepine and oxomemazine increased K$\sub$D/ value for 〔$^3$H〕QNB without affecting the binding sites concentration and Hill coefficient for the 〔$^3$H〕QNB binding. Oxomemazine had a 10-fold lower affinity at Ma-receptors than at M$_1$-receptors, and pirenzepine a 8-fold lower affinity at O$\sub$L/-receptors than OH-receptors. Analysis of the shal low competition curves of oxomemazine for the H$_1$ receptors and pirenzepine for the O$\sub$L/-receptors yielded that 69% of the M$_1$-receptors were of the O$\sub$H/-receptors and the remaining 31% of the O$\sub$L/-receptors, and that 29% of the O$\sub$L/-receptors were of the M$_1$-receptors and 71% of the M$_2$-receptors. However, M$_2$ for oxomemazine and O$\sub$H/ for pirenzepine were composed of a uniform population. These results suggest that oxomemazine could discriminatethe muscarnic receptor subtypes and may subclassify the M$_1$-receptors into two subtypes.

• Journal of Technology Innovation
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• v.17 no.1
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• pp.1-48
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• 2009

Recently we have found some symptoms that R&D fiscal incentives might not work well what it has intended through the analysis of current statistics of firm's R&D data. Firstly, we found that the growth rate of R&D investment in private sector during the recent decade has been slowdown. The average of growth rate (real value) of R&D investment is 7.1% from 1998 to 2005, while it was 13.9% from 1980 to 1997. Secondly, the relative share of R&D investment of SME has been decreased to 21%('05) from 29%('01), even though the tax credit for SME has been more beneficial than large size firm, Thirdly, The R&D expenditure of large size firms (besides 3 leading firms) has not been increased since late of 1990s. We need to find some evidence whether fiscal incentives are effective in increasing firm's R&D investment. To analyse econometric model we use firm level unbalanced panel data for 4 years (from 2002 to 2005) derived from MOST database compiled from the annual survey, "Report on the Survey of Research and Development in Science and Technology". Also we use fixed effect model (Hausman test results accept fixed effect model with 1% of significant level) and estimate the model for all firms, large firms and SME respectively. We have following results from the analysis of econometric model. For large firm: i ) R&D investment responds elastically (1.20) to sales volume. ii) government R&D subsidy induces R&D investment (0.03) not so effectively. iii) Tax price elasticity is almost unity (-0.99). iv) For large firm tax incentive is more effective than R&D subsidy For SME: i ) Sales volume increase R&D investment of SME (0.043) not so effectively. ii ) government R&D subsidy is crowding out R&D investment of SME not seriously (-0.0079) iii) Tax price elasticity is very inelastic (-0.054) To compare with other studies, Koga(2003) has a similar result of tax price elasticity for Japanese firm (-1.0036), Hall((l992) has a unit tax price elasticity, Bloom et al. (2002) has $-0.354{\sim}-0.124$ in the short run. From the results of our analysis we recommend that government R&D subsidy has to focus on such an areas like basic research and public sector (defense, energy, health etc.) not overlapped private R&D sector. For SME government has to focus on establishing R&D infrastructure. To promote tax incentive policy, we need to strengthen the tax incentive scheme for large size firm's R&D investment. We recommend tax credit for large size film be extended to total volume of R&D investment.

• Journal of the Korean Institute of Traditional Landscape Architecture
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• v.36 no.2
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• pp.30-37
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• 2018

The uniformed regulations for control of the height of buildings owned by individuals to protect landscape of cultural properties are causing serious social conflicts by limiting the development of landowners. It is urgent need of introducing indicators that can resolve such conflicts and evaluate the regulations of buildings, which can satisfy urban development as well as landscape management of cultural properties. Therefore, the purpose of this study is to simulate landscape changes according to the Cultural Heritage Protection Act and National Land Planning and Utilization Act by using Unity3D in the Pungnammun Gate(Treasure No. 308) of Jeonju and its surroundings, where architectural cultural property forms the symbolic landscape of the city. Then some items such as view points, target points were introduced and the quantitative evaluation of landscapes was attempted by applying the indicator of 3D Visual Exposure. As a result, the viewing opportunity and viewing area of Pungnammun Gate were not significantly influenced by changes in landscape according to the two laws. However, the change of the height of buildings by the National Land Planning and Utilization Act, which has the greatest development capacity, confirmed the possibility of weakening the identification of the Pungnammun Gate by increasing 3D Visual Exposure of the background buildings more than two times. Finally, it was confirmed that the skyline of Pungnammun Gate was clearly infringed upon development under the National Land Planning and Utilization Act, but the skyline was maintained similar to the current situation in the regulation by the Cultural Heritage Protection Act. Thus, this study is meaningful in that the application of 3D Visual Exposure showed the possibility of utilization as an indicator for quantitatively evaluating the protection of view on cultural property and skyline according to the changes of building heights.