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The Effects of Cognitive Therapy in Major Depressive Disorder (주요우울장애에 대한 인지치료의 효과)

  • Lee, Kang-Joon
    • Korean Journal of Biological Psychiatry
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    • v.13 no.3
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    • pp.144-151
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    • 2006
  • Objectives : Cognitive therapy is the most extensively researched psychological treatment for nonpsychotic unipolar outpatient depressive disorders. This review focused on the utility of this approach in severe or chronic depressive disorders, in relapse prevention and also on the potential benefits of combining cognitive therapy with medication. Methods : The author reviewed original studies and quantitative analyses on the effects of cognitive therapy, predictors of response, and neuroimaging studies of cognitive therapy in major depressive disorder. The sources used for the literature search were data bases : PubMed, EMBASE, CDSR on the internet, references in papers or books. Results : This review suggests that cognitive therapy is as effective as antidepressant medication in severe depressive disorders. And cognitive therapy can be an effective alternative to antidepressant medication. Patients benefited significantly more from combined cognitive therapy and antidepressant treatment than from either treatment alone. Most importantly, the addition of cognitive therapy to usual treatment appears to protect against future relapse in individuals known to be at high risk of repeated episodes of depression. In addition, subjects who received cognitive therapy showed significantly greater improvements in chronic depression than receiving antidepressant medication. Pooled data suggests that there is a significant relationship between the therapist's level of training or experience, the type of therapy used and patient outcome. Recent functional imaging studies examining brain changes following cognitive therapy report a variety of regional effects, but there is no consistent pattern across the few published studies. Conclusion : Cognitive therapy has proved beneficial in treating depressive patients. Despite empirical data supporting its efficacy, there are still problems in gaining access to cognitive therapy in clinical practice.

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A Study on the Speech Recognition Performance of the Multilayered Recurrent Prediction Neural Network (다층회귀예측신경망의 음성인식성능에 관한 연구)

  • 안점영
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.3 no.2
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    • pp.313-319
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    • 1999
  • We devise the 3 models of Multilayered Recurrent Prediction Neural Network(MLRPNN), which are obtained by modifying the Multilayered Perceptron(MLP) with 4 layers. We experimentally study the speech recognition performance of 3 models by a comparative method, according to the variation of the prediction order, the number of neurons in two hidden layers, initial values of connecting weights and transfer function, respectively. By the experiment, the recognition performance of each MLRPNN is better than that of MLP. At the model that returns the output of the upper hidden layer to the lower hidden layer, the recognition performance shows the best value. All MLRPNNs, which have 10 or 15 neurons in the upper and lower hidden layer and is predicted by 3rd or 4th order, show the improved speech recognition rate. On learning, these MLRPNNs have a better recognition rate when we set the initial weights between -0.5 and 0.5, and use the unipolar sigmoid transfer function in the lower hidden layer.

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A Single-Phase Embedded Z-Source DC-AC Inverter by Asymmetric Voltage Control (비대칭 전압 제어를 이용한 단상 임베디드 Z-소스 DC-AC 인버터)

  • Oh, Seung-Yeol;Kim, Se-Jin;Jung, Young-Gook;Lim, Young-Cheol
    • The Transactions of the Korean Institute of Power Electronics
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    • v.17 no.4
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    • pp.306-314
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    • 2012
  • In case of the conventional DC-AC inverter using two DC-DC converters with unipolar output capacitor voltages, for generating the AC output voltage, the output capacitor voltages of its each DC-DC converter must be higher than the DC input voltage. To solve this problem, this paper proposes a single-phase DC-AC inverter using two embedded Z-source converters with bipolar output capacitor voltages. The proposed inverter is composed of two embedded Z-source converters with common DC source and output AC load. The AC output voltage is obtained by the difference of the output capacitor voltages of each converter. Though the output capacitor voltage of converter is relatively low compared to the conventional method, it can be obtained the same AC output voltage. Moreover, by controlling asymmetrically the output capacitor voltage, the AC output voltage of the proposed system is higher than the DC input voltage. To verify the validity of the proposed system, a DSP(TMS320F28335) based single-phase embedded Z-source DC-AC inverter was made and the PSIM simulation was performed under the condition of the DC source 38V. As controlled symmetrically and asymmetrically the output capacitor voltages of each converter, the proposed inverter could produce the AC output voltage with sinusoidal waveform. Particularly, in case of asymmetric control, a higher AC output voltage was obtained. Finally, the efficiency of the proposed system was measured as 95% and 97% respectively in case of symmetric and asymmetric control.

Implementation of DS-UWB Impulse Generator with Suppression of Frequency Band for WLAN (WLAN 주파수 대역이 억제된 DS-UWB 임펄스 생성기 구현)

  • Park, Chong-Dae;Kim, Bum-Joo;Kim, Dong-Ho
    • Journal of Advanced Navigation Technology
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    • v.10 no.1
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    • pp.13-19
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    • 2006
  • In this paper, Gaussian impulse generator for DS-UWB was proposed and fabricated so that the frequency band allocated to WLAN, around 5 GHz, was suppressed in accordance with the regulation of radiation spectrum limitation defined by FCC. In order to transform an unipolar rectangular signal to a Gaussian impulse, the proposed impulse generator consists of two stage impulse generation parts; the first stage using dual SRD and the second stage using gain switching of semiconductor laser diode. The result shows a gaussian impulse as narrow as 180 psec in width. In addition, high order derivative Gaussian filter with a structure of 4 stage ring resonators was designed and fabricated so that DS-UWB impulse generator could reduce the frequency spectrum of WLAN by 25 dB compared to the spectral power of th adjacent UWB band.

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Treatment Stimulator's Pulse of Transcranial Magnetic Stimulation (경두개 자기자극장치의 치료자극 펄스)

  • Kim, Whi-Young
    • The Journal of the Korea Contents Association
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    • v.9 no.11
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    • pp.289-296
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    • 2009
  • In this study, I presented power control unit with potential use in the magnetic stimulation of biological systems. The effect of the magnetic stimulation depends on the geometry and orientation of the induced electric field as well as on the current pulse waveform delivered by the stimulator coil. TMS is achieved from the outside of the head using pulses of electromagnetic field that induce an electric field in the brain. There are numerous possibities in the applications TMS, such as diagnosis and therapy through the brain stimulation. These factors are very important to define the equipment requirements and characteristics in that the topology of the power supply and the size and geometry of the coil. The proposed solution is the generation of current pulses with variable amplitude and duration, according to a user defined input. Another solution is the topology that uses elements to store and transfer energy from the power source to the load. In addition to proposed topology, an adequate control strategy and right set of the power circuit parameters made possible to obtain unipolar waves and bipolar waves.

A Study on the PEM Electrolysis Characteristics Using Ti Mesh Coated with Electrocatalysts (Ti Mesh 처리 촉매전극을 이용한 고체고분자 전해질 전기분해 특성연구)

  • Sim, Kyu-Sung;Kim, Youn-Soon;Kim, Jong-Won;Han, Sang-Do
    • Transactions of the Korean hydrogen and new energy society
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    • v.7 no.1
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    • pp.29-37
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    • 1996
  • Alkaline water electrolysis has been commercialized as the only large-scale method for a long time to produce hydrogen and the technology is superior to other methods such as photochemical, thermochemical water splitting, and thermal decomposition method in view of efficiency and related technical problem. However, such conventional electrolyzer do not have high electric efficiency and productivity to apply to large scale hydrogen production for energy or chemical feedstocks. Solid polymer electrolyte water electrolysis using a perfluorocation exchange membrane as an $H^+$ ion conductor is considered to be a promising method, because of capability for operating at high current densities and low cell voltages. So, this is a good technology for the storage of electricity generated by photovoltaic power plants, wind generators and other energy conversion systems. One of the most important R&D topics in electrolyser is how to minimize cell voltage and maximize current density in order to increase the productivity of the electrolyzer. A commercialized technology is the hot press method which the film type electrocatalyst is hot-pressed to soild polymer membrane in order to eliminate the contact resistance. Various technologies, electrocatalyst formed over Nafion membrane surface by means of nonelectrolytic plating process, porous sintered metal(titanium powder) or titanium mesh coated with electrocatalyst, have been studied for preparation of membrane-electrocatalyst composites. In this study some experiments have been conducted at a solid polymer electrolyte water electrolyzer, which consisted of single cell stack with an electrode area of $25cm^2$ in a unipolar arrangement using titanium mesh coated with electrocatalyst.

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Electroencephalographic Alpha Asymmetry in Major Depressive Disorder Patients With Anxiety Symptoms (불안을 동반한 주요우울장애 환자에 대한 뇌파 알파 비대칭의 특성 연구)

  • Lee, Jun-Seok;Yang, Byung-Hwan;Lee, So Hee;Lee, Seung-Min
    • Korean Journal of Biological Psychiatry
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    • v.14 no.1
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    • pp.42-47
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    • 2007
  • Objectives : Studies have reported differences between depressed adults and controls in quantitative measures of EEG alpha asymmetry, but, there are few using Korean subjects. So, the present study compared EEG regional alpha asymmetries of patients having major depressive disorder(MDD) and normal controls. Methods : The subjects in this study were 11 unmedicated unipolar depressed patients and 11 non-depressed, age matched controls. Resting EEG(eyes closed and eyes open) was recorded from each participant using 8 scalp electrodes. Beck Depression Inventory(BDI), 17-item Hamilton Depression Rating Scale(HDRS), Zung's Self-Rating Depression Scale(SDS) and Spielberger's State-Trait Anxiety Inventory(STAI) were used to evaluate depression and anxiety symptoms. Results : The severities of depression measured by self-report questionnaires were positively associated with those of anxiety(state and trait) ; The subjects were both anxious and depressed. Anxious-depressed patients differed from controls in alpha asymmetry at T4 channels. They showed evidence of greater activation over right than left temporal site. Conclusion : These findings are consistent with the previousely reported alpha asymmetry of depressed patients with an anxiety disorder. The failure to find the evidence of reduced right parietal activity in depression is presumed to be due to opposing effects of comorbid anxiety on parietotemporal activity.

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The Effects of Wnt Signaling on Neural Crest Lineage Segregation and Specification (Wnt signaling이 neural crest lineage segregation과 specification에 미치는 영향)

  • Song, Jin-Su;Jin, Eun-Jung
    • Journal of Life Science
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    • v.19 no.10
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    • pp.1346-1351
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    • 2009
  • Recent evidence has shown that many pluripotetic neural crest cells are fate-restricted and that different fate-restricted crest cells emigrate from the neural tube at different times. Jin et al. (2001) identified the expression patterns of Wnts and its antagonists at the time that neural crest cells were being specified and suggested that Wnt signaling was involved in the segregation/differentiation of neural crest cells in the trunk in vitro. In this study, we evaluated the effects of Wnt signaling in avian neural crest lineage segregation. To accomplish this, Wnt signaling was disturbed at the time of neural crest segregation and differentiation by grafting Wnt-3a expressing cells and conducting dominant negative glycogen synthase kinase (dnGSK) electroporation. Stimulation of Wnt signaling induced neural crest lineage segregation and melanoblast specification, and increased the expression levels of genes known to be involved in neural crest development such as cadherin 7 and Slug, which suggests that they are involved in Wnt-induced neural crest lineage differentiation into melanoblasts.

The composition control of ITO/PET by Plasma Emission Monitors (PEM을 이용한 ITO/PET film 조성 제어)

  • 한세진;김용한;김영환;이택동
    • Proceedings of the Korean Vacuum Society Conference
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    • 1999.07a
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    • pp.213-213
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    • 1999
  • 현재 LCD용 기판재료는 ITO/glass를 전극으로 사용하고 있다. 그러나 유리기판은 무겁고 깨지기 쉽기 때문에 사용상 곤란한 점이 많다. 최근 flexible하고 가공성 및 생산성이 우수한 플라스틱한 ITO를 성막하여 EL용, Touch panel, plastic LCD용 사용하려는 시도로, roll-to-roll 연속 스퍼터링에 의한 ITO성막공정에 대한 연구가 최근 활발하게 이루어지고 있다. 폴리머는 유리에 비해 Tg 온도가 낮고, 기판으로부터의 수분 및 여러 종류의 가스방출이 심하기 때문에 유리와는 달리 ITO막의 제조에 있어 큰 차이점이 있다. 따라서, 폴리머에 반응성 스퍼터링을 하기 위해서는 표면처리가 중요한 변수가 되며, roll to roll sputter로 ITO 필름을 얻기 위해서는 폭과 길이 방향으로 균일한 막을 얻는 것이 중요하다. 두께 75$\mu\textrm{m}$, 폭 190mm, 길이 400m로 권취된 광학용 Polyethylene terephthalate(PET:Tg:8$0^{\circ}C$)위에 In-10%Sn의 합금타겟과 Unipolar pulsed DC power supply를 사용하여 반응성 마그네트론 스퍼터링 방법으로 0.2m/min의 속도로 연속 스퍼터링 하였다. PET를 Ar/O2 혼합가스로 플라즈마 전처리를 한 후, AFM, XPS를 이용하여 효과를 분석을 하였고, 성막전에 가스방출을 막기 위해 TiO를 코팅하였다. Pilot 연속 생산공정에서 재현성을 위해 PEM(Plasma Emission Monitor)의 optical emission spectroscopy를 이용, 금속과 산화물의 천이구역에서 sprtter된 I/Sn 이온과 산소 이온의 반응에 의한 최적의 플라즈마의 강도값을 입력하여 플라즈마의 radiation을 검출하고, 스퍼터링 공정중 실질적인 in-situ 정보로 이용하였다. PEM을 통하여 In/Sn의 플라즈마 강도변화를 조사하였다. 초기 In/Sn의 플라즈마 강도(intensity)는 강도를 100하여, 산소를 주입한 결과, plasma intensity가 35 줄어들었고, 이때 우수한 ITO 박막을 얻을 수 있었다. Pulsed DC power를 사용하여 아크 현상을 방지하였다. PET 상에 coating 된 ITO 박막의 표면저항과 광투과도는 4-point prove와 spectrophotometer를 이용하여 분석하였고, AES로 박막의 두께에 따른 성분비를 확인하였다. ITO 박막의 광투과도는 산소의 유량과 sputter 된 In/Sn ion의 plasma emission peak에 따라 72%-92%까지 변화하였으며, 저항은 37$\Omega$/$\square$ 이상을 나타내었다. 박막의 Sn/In atomic ratio는 0.12, O/In의 비율은 In2O3의 화학양론적 비율인 1.5보다 작은 1.3을 나타내었다.

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Position Controller for Clutch Drive System of PHEV(Plug in Hybrid Electric Vehicle) (PHEV(Plug in Hybrid Electric Vehicle)의 클러치 구동 시스템을 위한 BLDC 모터의 위치제어기)

  • Jin, Yong-Sin;Shin, Hee-Keun;Kim, Hag-Wone;Mok, Hyung-Soo;Cho, Kwan-Yuhl
    • The Transactions of the Korean Institute of Power Electronics
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    • v.17 no.2
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    • pp.166-173
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    • 2012
  • Plug-in Hybrid Electric Vehicle is driven by the engine, the primary traction motor, and the secondary auxiliary motor generating the electric power for battery charging. Secondary auxiliary motor should be connected to the engine or separated from the engine by the clutch system. This paper presents the position controller of the BLDC motor for the clutch system of Plug-in Hybrid Electric Vehicle. The BLDC motor can be applied to the clutch system in spite of it's low accuracy of the position control due to high gear ratio between the clutch and the motor. Since the attachment and the detachment between the motor and the engine should be carried out within 0.3 seconds, the position controller with fast acceleration and deceleration is implemented. For the torque control with braking operation for the BLDC motor, the modified bipolar PWM method with low current ripple compared to the conventional unipolar PWM is presented. The position control performance of the BLDC motor for the clutch system is verified through the simulation and experiments.