• Smart Structures and Systems
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• v.5 no.1
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• pp.69-79
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• 2009

A non-clipped semi-active stochastic optimal control strategy for nonlinear structural systems with MR dampers is developed based on the stochastic averaging method and stochastic dynamical programming principle. A nonlinear stochastic control structure is first modeled as a semi-actively controlled, stochastically excited and dissipated Hamiltonian system. The control force of an MR damper is separated into passive and semi-active parts. The passive control force components, coupled in structural mode space, are incorporated in the drift coefficients by directly using the stochastic averaging method. Then the stochastic dynamical programming principle is applied to establish a dynamical programming equation, from which the semi-active optimal control law is determined and implementable by MR dampers without clipping in terms of the Bingham model. Under the condition on the control performance function given in section 3, the expressions of nonlinear and linear non-clipped semi-active optimal control force components are obtained as well as the non-clipped semi-active LQG control force, and thus the value function and semi-active nonlinear optimal control force are actually existent according to the developed strategy. An example of the controlled stochastic hysteretic column is given to illustrate the application and effectiveness of the developed semi-active optimal control strategy.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.3
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• pp.192-206
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• 2021

The pharmaceutical industry is an industry that provides medicines related to the health and life of the people. The pharmaceutical industry is a traditional regulation industry with the characteristics of R&D(Research and Development), purchasing, manufacturing, distribution and consumption under strict government management. Until now, pharmaceutical companies have continued to make efforts to maintain competitiveness through patent management, new product development, and marketing. However, industries are rapidly changing, including rising costs for developing new products and expanding generic markets. As these changes and uncertainties in the management environment increase, efforts are required to improve the competitiveness of the pharmaceutical industry from a new perspective. In this study, we intend to examine the impact of SCM(Supply Chain Management) dynamic capability of pharmaceutical companies on corporate performance through partnerships to respond to market changes and uncertainties. It was determined that the agility, visibility and flexibility that constitutes the SCM dynamic capabilities would affect the performance of pharmaceutical companies. In this study, the importance of SCM dynamic capabilities and cooperative relationships was identified through surveys by SCM managers of pharmaceutical companies. Consequently, in the pharmaceutical industry, which is a regulatory industry, we have identified that SCM dynamic capabilities and cooperative relationships with partner companies have a significant impact on corporate performance.

• New & Renewable Energy
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• v.17 no.1
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• pp.19-32
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• 2021

Photovoltaic (PV) panels are generally treated as the most dependable components of PV systems; therefore, investigations are necessary to understand and emphasize the degradation of PV cells. In almost all specific deprivation models, humidity and temperature are the two major factors that are responsible for PV module degradation. However, even if the degradation mode of a PV module is determined, it is challenging to research them in practice. Long-term response experiments should thus be conducted to investigate the influences of the incidence, rates of change, and different degradation methods of PV modules on energy production; such models can help avoid lengthy experiments to investigate the degradation of PV panels under actual working conditions. From the review, it was found that the degradation rate of PV modules in climates where the annual average ambient temperature remained low was -1.05% to -1.16% per year, and the degree of deterioration of PV modules in climates with high average annual ambient temperatures was -1.35% to -1.46% per year; however, PV manufacturers currently claim degradation rates of up to -0.5% per year.

• Nuclear Engineering and Technology
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• v.54 no.2
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• pp.423-428
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• 2022

Very low contents (in the range of 10^-9 g/g) of Ir in mantle-derived rock samples (komatiites) were non-destructively determined by INAA coupled with coincidence gamma-ray spectrometry using 16 Ge detectors. Aliquots of the same samples were analyzed by NiS fire-assay ICP-MS for Ir and other platinum group elements. Because the INAA procedure used in this study is non-destructive and is almost free from spectral interference in gamma-ray spectrometry, the INAA values of Ir contents obtained in this study can be highly reliable. Iridium values obtained by ICP-MS were consistent with the INAA values, implying that the ICP-MS values of Ir obtained in this study are equally reliable. Under the present experimental conditions, detection limits were estimated to be 1 pg/g, which corresponds to 0.1 pg for a sample mass of 0.1 g. These levels can be even lowered by an order of magnitude, if necessary, which cannot be achieved by ICP-MS carried out in this study.

• Nuclear Engineering and Technology
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• v.54 no.1
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• pp.386-400
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• 2022

Seismic fragility analysis, a part of seismic probabilistic risk assessment (SPRA), is commonly used to establish the relationship between a representative property of earthquakes and the failure probability of a structure, component, or system. Current guidelines on the SPRA of nuclear power plants (NPPs) used worldwide mainly reflect the earthquake characteristics of the western United States. However, different earthquake characteristics may have a significant impact on the seismic fragility of a structure. Given the concern, this study aimed to investigate the effects of earthquake characteristics on the seismic fragility of concrete containments housing the OPR-1000 reactor. Earthquake time histories were created from 30 ground motions (including those of the 2016 Gyeongju earthquake) by spectral matching to the site-specific response spectrum of Hanbit nuclear power plants in South Korea. Fragility curves of the containment structure were determined under the linear response history analysis using a lumped-mass stick model and 30 ground motions, and were compared in terms of earthquake characteristics. The results showed that the median capacity and high confidence of low probability of failure (HCLPF) tended to highly depend on the sustained maximum acceleration (SMA), and increase when using the time histories which have lower SMA compared with the others.

• BMB Reports
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• v.55 no.1
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• pp.39-47
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• 2022

Adoptive cell transfer (ACT), a form of cell-based immunotherapy that eliminates cancer by restoring and strengthening the body's immune system, has revolutionized cancer treatment. ACT entails intravenous transfer of either tumor-resident or peripheral blood-modified immune cells into cancer patients to mediate anti-tumor response. Although these immune cells control and eradicate cancer via enhanced cytotoxicity against specific tumor antigens, several side effects have been frequently reported in clinical trials. Recently, exosomes, potential cell-free therapeutics, have emerged as an alternative to cell-based immunotherapies, due to their higher stability under same storage condition, lower risk of GvHD and CRS, and higher resistance to immunosuppressive tumor microenvironment. Exosomes, which are nano-sized lipid vesicles, are secreted by living cells, including immune cells. Exosomes contain proteins, lipids, and nucleic acids, and the functional role of each exosome is determined by the specific cargo derived from parental cells. Exosomes derived from cytotoxic effectors including T cells and NK cells exert anti-tumor effects via proteins such as granzyme B and FasL. In this mini-review, we describe the current understanding of the ACT and immune cell-derived exosomes and discuss the limitations of ACT and the opportunities for immune cell-derived exosomes as immune therapies.

• Steel and Composite Structures
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• v.43 no.5
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• pp.553-564
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• 2022

Many existing reinforced concrete (RC) structures need to be strengthening for reason such as poor construction quality, low ductility or designing without considering seismic effects. One of the strengthening methods is strengthening technique with eccentrically braced frames (EBFs). The characteristic element of these systems is the link element and its length is very important in terms of seismic behavior. The link element of Y shaped EBF systems (YEBFs) is designed as a short shear element. Different limits are suggested in the literature for the link length. This study to aim experimentally investigate the effect of the link length for the suggested limits on the behavior of the RC frame system and efficiency of strengthening technique. For this purpose, a total of 5 single story, single span RC frame specimens were produced. The design of the RC frames was made considering seismic design deficiencies. Four of the produced specimens were strengthened and one of them remained as bare specimen. The steel YEBFs were used in strengthening the RC frame and the link was designed as a shear element that have different length with respect to suggested limits in literature. The length of links was determined as 50mm, 100mm, 150mm and 200mm. All of the specimens were tested under cyclic loads. The obtained results show that the strengthening technique improved the energy consumption and lateral load bearing capacities of the bare RC specimen. Moreover, it is concluded that the specimens YB-2 and YB-3 showed better performance than the other specimens, especially in energy consumption and ductility.

• Journal of Microbiology and Biotechnology
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• v.1 no.3
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• pp.157-162
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• 1991

Conditions for glutathione production in E. coli cells which possess pGH501 (2 gshI+gshII) were studied. In terms of ATP supply for the glutathione synthesis, two different systems have been constructed and compared. When the acetate kinase reaction of E. coli was used for ATP generation, 20 mM of L-cysteine was completely converted to glutathione by toluene-treated E. coli cells (100 mg/ml) harboring pGH501 within 2 h at $37^{\circ}C$. However, considering the economical aspects, the glycolytic pathway of yeast was chosen as a better system for ATP generation. The optimal concentrations of reactants for glutathione production were determined to be as follows; 80 mM L-glutamate, 20 mM L-cysteine, 20 mM glycine, 20 mM $MgCl_2$, 50 mM potassium phosphate buffer (pH 7.5), 400 mM glucose, polyoxyethylene stearylamine ($5\;\mul/ml$), toluene-treated E. coli HB101/pGH501 (100 mg/ml), and dried yeast cells (400 mg/ml). The conversion ratio of L-cysteine to glutathione was 80% (about 5 mg/ml) under optimal condition within 6 h at $37^{\circ}C$.

• Journal of Ocean Engineering and Technology
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• v.37 no.4
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• pp.137-144
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• 2023

This study investigates the experimental parameters of particle image velocimetry (PIV) to enhance the measurement technique for turbulent flow fields around a circular cylinder at a Reynolds number (Re) of 1.4×10⁵. At the Korea Research Institute of Ships & Ocean Engineering (KRISO), we utilized the cavitation tunnel and PIV system to capture the instantaneous flow fields and statistically obtained the mean flow fields. An aspect ratio and blockage ratio of 16.7% and 6.0%, respectively, were considered to minimize the tunnel wall effect on the cylinder wakes. The optimal values of the pulse time and the number of flow fields were determined by comparing the contours of mean streamlines, velocities, Reynolds shear stresses, and turbulent kinetic energy under their different values to ensure accurate and converged results. Based on the findings, we recommend a pulse time of 45 ㎲ corresponding to a particle moving time of 3-4 pixels, and at least 3,000 instantaneous flow fields to accurately obtain the mean flow fields. The results of the present study agree well with those of previous studies that examined the end of the subcritical flow regime.

• Smart Structures and Systems
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• v.31 no.5
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• pp.531-543
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• 2023

Base isolation is one of the most widely implemented and well-known technique to reduce structural vibration and damages during an earthquake. However, while the base-isolated structure reduces storey drift significantly, it also increases the base drifts causing many practical problems. This study proposes the use of Shape Memory Alloys (SMA) wires for the reduction in base drift while controlling the overall structure vibrations. A multi-degree-of-freedom (MDOF) structure along with base isolators and Shape-Memory-Alloys (SMA) wires in diagonal is tested experimentally and analytically. The isolation bearing considered in this study consists of laminates of steel and silicon rubber. The performance of the proposed structure is evaluated and studied under different loadings including harmonic loading and seismic excitation. To assess the seismic performance of the proposed structure, shake table tests are conducted on base-isolated MDOF frame structure incorporating SMA wires, which is subjected to incremental harmonic and historic seismic loadings. Root mean square acceleration, displacement and drift are analyzed and discussed in detail for each story. To better understand the structure response, the percentage reduction of displacement is also determined for each story. The result shows that the reduction in the response of the proposed structure is much better than conventional base-isolated structure.