• The KIPS Transactions:PartA
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• v.9A no.3
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• pp.295-300
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• 2002

In this paper, we apply the 3-dimension algorithm to the random interleaver and s-random interleaver and analyze the performance of the turbo code system with random interleaver (or s-random interleaver). In general, the performance of interleaver is determined by minimum distance between neighbor data, thus we could improve the performance of interleaver by increasing the distance of the nearest data. The interleaver using 3-dimension algorithm has longer minimum distance and average distance compared to existing random-interleaver (s-random interleaver) because the output data is generated randomly from 3-dimension storage. To verify and compare the performance of our proposed system, the computer simulations have been performed in turbo code system under gaussian noise environment.

• Biomolecules & Therapeutics
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• v.18 no.1
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• pp.106-110
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• 2010

The pharmacokinetics and bioavailability of ambroxol, an expectoration improver and mucolytic agent, were studied to determine the feasibility of enhanced transdermal delivery of ambroxol from the ethylene-vinyl acetate (EVA) matrix system containing polyoxyethylene-2-oleyl ether as an enhancer in rats. The ambroxol-010 matrix system (15 mg/kg) was applied to abdominal skin of rats. Blood samples were collected via the femoral artery for 28 hrs and the plasma concentrations of ambroxol were determined by HPLC. Pharmacokinetic parameters were calculated using Lagran method computer program. The area under the curve (AUC) was significantly higher in the enhancer group ($1,678{\pm}1,413.3\;ng/ml{\cdot}hr$) than that in the control group $1,112{\pm}279\;ng/ml{\cdot}hr$), that is treated transdermally without enhancer, showing about 151% increased bioavailability (p<0.05). The average $C_{max}$ was increased in the enhancer group ($86.0{\pm}21.5\;ng$/ml) compared with the control group ($59.0{\pm}14.8\;ng$/ml). The absolute bioavailability was 13.9% in the transdermal control group, 21.1% in the transdermal enhancer group and 18.1% in the oral administration group compared with the IV group. The $T_{max}$, $K_a$, MRT and $t_{1/2}$ of ambroxol in transdermal enhancer group were increased significantly (p<0.01) compared to those of oral administration. As the ambroxol-EVA matrix containing polyoxyethylene-2-oleyl ether and tributyl citrate was administered to rats via the transdermal routes, the relative bioavailability increased about 1.51-fold compared to the control group, showing a relatively constant, sustained blood concentration. The results of this study show that ambroxol-EVA matrix could be developed as a transdermal delivery system providing sustained plasma concentration.

• Journal of Korean Society for Atmospheric Environment
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• v.30 no.2
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• pp.95-109
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• 2014

In this study, the concentration of odorants released from albumin (EA) and yolk (EY) portions of boiled egg samples were determined as a function of storage time. The concentrations were measured at storage days of 0, 1, 3, 6, and 9 under room temperature. As such, odorants produced during both fresh and decay conditions were measured through time. A total of 19 compounds were selected as the main target odorants along with 12 reference compounds. GC-MS (for VOC) and GC-PFPD system (for sulfur gases) equipped with thermal desorption (TD) system were employed for odorant analysis in this work. The initial concentrations measured from the chamber system were converted into flux terms ($ng{\cdot}g^{-1}{\cdot}min^{-1}$). The EA showed the highest concentration of $H_2S$ (234 $ng{\cdot}g^{-1}{\cdot}min^{-1}$) at EA-0, and the concentrations of AT (Acetone) was also seen clearly in the range of 11.7 (EA-0) to 58.6 $ng{\cdot}g^{-1}{\cdot}min^{-1}$ (EA-9). The EY showed similar patterns. EtAl (Ethyl alcohol) increased 9.47 (EA-1) to 96.7 $ng{\cdot}g^{-1}{\cdot}min^{-1}$ (EA-9) in EA samples. Ketone, alcohol, sulfur groups generally exhibited high concentrations compared to other odorants. These data were also compared in relation to olfactometry related dilution-to-threshold (D/T) ratio by air dilution sensory (ADS) test and sum of odor intensity (SOI).

• Korean Journal of Microbiology
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• v.31 no.4
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• pp.274-278
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• 1993

Overproduced proteins in many cases result in forming insoluble inclusion bodies, and their formation might be due to high concentration of protein. To investigate how proteins become insoluble, chloramphenicol acetyltransferase (CAT) and .betha.-lactamase were overproduced, and their solubilities and activities were determined. CAT was accumulated from 9 to 45% of total cellular protein in a fully soluble form without inclusion body formation. CAT specific activity was shown to be proportional to the amount of the protein produced. Moderately produced .betha.-lactamase by the phase T7 expression system at 30.deg.C comprised only mature forms in a soluble form. However, overproduced .betha.-lactamase at 37.deg.C became insoluble. Most precursor forms of .betha.-lactamase in the cytoplasm were insoluble, whereas majority of the mature forms in the periplasm space were soluble. Also, chaperone GroE proteins which assist proper protein folding and translocation did not increase .betha.-lactamase solubility significantly under the experimental condition. It seems that the formation of inclusion bodies in the cell is related to the nature of protein itself rather than just to high concentration of protein.

• Proceedings of the Korean Society of Surveying, Geodesy, Photogrammetry, and Cartography Conference
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• 2004.11a
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• pp.405-410
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• 2004

In mid-90's, the Korean government introduced the GIS(Geographic Information System) to digitalize every topography of national land and thereby, index locations and attributes of various urban facilities to construct a system whereby every information could be managed and operated in an integrated way, but the reliability of such geographic information has yet to be tested, much less its modification, complementation and maintenance. Under such circumstances, this study was aimed at constructing a reference point infrastructure for Seoul and Kyonggi area and comparing the data obtained from the GPS operation and various facility location data with the existing GIS data to address the problems of GIS operation and suggest their solutions. As a result of calculating the GPS reference point data and analyzing the deviations of the unknown point data in comparison with the fixed point ones, it was found that the horizontal location values were reliable within +/- 5cm, but that the above-sea level values varied as much as 1.4m depending on the deployment of pre-set fixed points determined by the direct level gauging. In addition, as a result of directly surveying major facilities around the roads based on the coordinates of the urban reference points networked with such a reference point system to check their conformity to existing data, it was confirmed that the difference was as wide as 2m. Such differences may be attributable to the fact that the data with their geographic information not confirmed are used as basic data for GIS. Hence, this study suggests the ways to set the absolute geographic data based on reference points and test the reliability of existing data and thereby, suggests a methods to solve the problems.

• Polymer(Korea)
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• v.25 no.2
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• pp.177-185
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• 2001

In this work, the cure kinetics and rheological properties of difunctional epoxy(diglycidylether of bisphenol A, DGEBA)/polysulfone (PSF) blends were investigated using differential scanning calorimeter and rheometer. From the DSC results of the blends, the temperature of the exothermic peak and cure activation energy (E) using a half-width method were increased with increasing the PSF content to neat epoxy resin up to 30 wt%. However, a marginal decrease in the blend system was shown in E. The conversion ($\alpha$) and conversion rate (d$\alpha$/dt) were decreased as the content of PSF increases. Rheological properties of the blend system were investigated under isothermal condition using a rheometer. Cross-linking activation energy (E$_{c}$) was determined from the Arrhenius equation based on gel time and curing temperature. As a result, the E$_{c}$ showed a similar behavior with E which could be resulted from high viscosity of PSF and the phase separation between DGEBA and PSF.PSF.f PSF and the phase separation between DGEBA and PSF.PSF.

• YAKHAK HOEJI
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• v.55 no.1
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• pp.1-10
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• 2011

Mastic is a bleed resin formed in pistacia lentiscus tree extract form the anacatdiaceae family. Mastic is used as a food ingredient in the Mediteraanean resin, and has been used by local inhabitants as a traditional medicine for relief of upper abdominal discomfort, dyspepsiaand peptic ulcer. Clinically, mastic has been effective in the treatment of benign gastric and duodenal, ulcers, giving symptomatic relief and endoscopically proven healing. In this study, to enhance activiteies of poorly water soluble Mastic with oils, surfactants and cosurfactants and then the mixure was microemulsified in aqueous media under condition of gentle agitation and digestive motility that would be encountered in the gastrointestinal tract. Formulation development and screening were based on phase diagrams and characteristics of resultant microemulsion. For optimum mastic formulation, microemulsions with various ratio (w/w%) of mastics, oils, surfactants and cosurfactants were prepared and their solubility was evaluated by monitoring particles size in their buffer through visual asessment and electrophoretic light scattering spectrophotomerter (ELS). In vitro activity of self microemulsified mastic (SME mastic) was determined by minimum ingibition concentration (MIC) test against a panel of Helicobacter pylori (H. pylori) clinical strains. Additionally, in vivo activity of SME masitc was investigated us mouse infected by CH275 of H. pylori. The mean diameter of SME mastic was less then 100 nm in water and SME mastic was showed similar antiboisis effect compared to tometronidazole, clarithromycin and omeproazole. Consequently, SME mastic would be effective system to exterminate H. pylori. If mastic were dose with combined treatment, mastic might augur well for effect of H. pylori eradication as good remedy.

• Korean Journal of Microbiology
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• v.36 no.2
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• pp.84-90
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• 2000

Biodegradation of vanous medium-chain-length polyhydroxyalkanoates (MCL-PHAs) by an extracellular depolymerase system from Pseudomonas sp. RY-1 was investigated under laboratoly conditions. The degradation rate of the polymers was determined by quantitative clem zone technique, enzyme (turbidity) assay, and respirometry assay. Although the enzyme system secreted by Pscudomor~as sp. RY-1 was capable of degrading all MCL-PHAs tested. its secretion was influenced by the availability of secondary carbon sources. The rate of enzymatic degradation of MCL-PHAs was dependent upou the monomeric composition of the polyesters and reduced as the chain lengths of the monomer m t s in the polyesters increased. MCL-PHAs containing C-even monomer units showed faster degradation rate than MCL-PHAs containing C-odd monomer units. Respiration rates of MCL-PHAs with C-even monomer uuts were also much faster than those of MCL-PHAs with C-odd monomer units. The degmdation rate of MCL-PHAs bearing unsaturated substituents was faster than that of mcl-PHAs without functional substituents, which is suggesting the correlation between the degradation rate and the crystallinity of MCL-PHAs.

• Journal of the Earthquake Engineering Society of Korea
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• v.18 no.2
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• pp.89-94
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• 2014

Spatial variations of a seismic wave are mainly wave passage and wave scattering. Wave passage effect is produced by changed characteristics of exciting seismic input motions applied to the bedrock. Modified input motions travel horizontally with time differences determined by apparent shear wave velocity of the bedrock. In this study, wave passage effect on the seismic response of a structure-soil system is investigated by modifying the finite element software of P3DASS (Pseudo 3-Dimensional Dynamic Analysis of a Structure-soil System) to apply inconsistent (time-delayed) seismic input motions along the soft soil-bedrock interface. Study results show that foundation size affected on the seismic response of a structure excited with inconsistent input motions in the lower period range below 0.5 seconds, and seismic responses of a structure were decreased considerably in the lower period range around 0.05 seconds due to the wave passage. Also, shear wave velocity of the bedrock affected on the seismic response of a structure in the lower period range below 0.3 seconds, with significant reduction of the seismic response for smaller shear wave velocity of the bedrock reaching approximately 20% for an apparent shear wave velocity of 1000m/s at a period of 0.05 seconds. Finally, it is concluded that wave passage effect reduces the seismic response of a structure in the lower period range when the bedrock under a soft soil is soft or the bedrock is located very deeply, and wave passage is beneficial for the seismic design of a short period structure like a nuclear container building or a stiff low-rise building.

• The Journal of the Acoustical Society of Korea
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• v.38 no.5
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• pp.522-533
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• 2019

The compressive sensing model for range-Doppler estimation can be expressed as an under-determined linear system y = Ax. To find the solution of the linear system with the compressive sensing method, matrix A should be sufficiently incoherent and x to be sparse. In this paper, we propose a transmission waveform design method that maintains the bandwidth required by the sonar system while lowering the mutual coherence of the matrix A so that the matrix A is incoherent. The proposed method combines two methods of optimizing the sensing matrix with the alternating projection and suppressing unwanted frequency bands using the DFT (Discrete Fourier Transform) matrix. We compare range-Doppler estimation performance of existing waveform LFM(Linear Frequency Modulated) and designed waveform using the matched filter and the compressive sensing method. Simulation shows that the designed transmission waveform has better detection performance than the existing waveform LFM.