• Journal of Periodontal and Implant Science
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• 제52권2호
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• pp.127-140
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• 2022

Purpose: In dental avulsion, delayed replantation usually has an uncertain prognosis. After tooth replantation, complex inflammatory responses promote a return to periodontal tissue homeostasis. Various types of cytokines are produced in the inflammatory microenvironment, and these cytokines determine the periodontal tissue response. This study aimed to identify the gene expression profiles of replanted teeth and evaluate the functional differences between immediate and delayed replantation. Methods: Maxillary molars from Sprague-Dawley rats were extracted, exposed to a dry environment, and then replanted. The animals were divided into 2 groups according to the extra-oral time: immediate replantation (dry for 5 minutes) and delayed replantation (dry for 60 minutes). Either 3 or 7 days after replantation, the animals were sacrificed. Periodontal soft tissues were harvested for mRNA sequencing. Hallmark gene set enrichment analysis was performed to predict the function of gene-gene interactions. The normalized enrichment score (NES) was calculated to determine functional differences. Results: The hallmark gene sets enriched in delayed replantation at 3 days were oxidative phosphorylation (NES=2.82, Q<0.001) and tumor necrosis factor-alpha (TNF-α) signaling via the nuclear factor kappa light chain enhancer of activated B cells (NF-κB) pathway (NES=1.52, Q=0.034). At 7 days after delayed replantation, TNF-α signaling via the NF-κB pathway (NES=-1.82, Q=0.002), angiogenesis (NES=-1.66, Q=0.01), and the transforming growth factor-beta signaling pathway (NES=-1.46, Q=0.051) were negatively highlighted. Conclusions: Differentially expressed gene profiles were significantly different between immediate and delayed replantation. TNF-α signaling via the NF-κB pathway was marked during the healing process. However, the enrichment score of this pathway changed in a time-dependent manner between immediate and delayed replantation.

• Journal of East Asia Management
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• 제4권1호
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• pp.53-77
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• 2023

Modern company faces an uncertain future and a competitive environment and are seeking new technologies and creative products to ensure the corporate growth and survival in the market through continuous innovation. "University Industry Cooperation(UIC)" is a point of contact for overcoming the crisis faced by companies and universities in this era and a cooperation platform for mutual prosperity. As a subsidiary of a university, "Technology Holding Company(THC)" is attracting attention as a new window for UIC in Korea. The role of THC is to establish and foster the business opportunities of their subsidiaries and to return investment profits to the university ecosystem again. But recently, the life cycle of technology is getting shorter, and the development cost is steadily increasing. In particular, with the increase of hybrid projects based on convergence and combination, the risk of conducting research(R&D) and new product development(NPD) projects is gradually increasing. A PMO refers to a project management organization that can contribute to improving the success rate of projects with increasing uncertainty by supporting project visibility and appropriate decision-making. The purpose of this study is to raise a research question on whether THC's corporate performance can be improved when "Project Management System(PMO Service)" is introduced into the subsidiary incubation system of THC. This study proposes several research methods to identify the relationship between the introduction of PMO and the corporate performance of THC.

• BMB Reports
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• 제56권4호
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• pp.258-264
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• 2023

As a high-grade soft-tissue sarcoma (STS), undifferentiated pleomorphic sarcoma (UPS) is highly recurrent and malignant. UPS is categorized as a tumor of uncertain differentiation and has few options for treatment due to its lack of targetable genetic alterations. There are also few cell lines that provide a representative model for UPS, leading to a dearth of experimental research. Here, we established and characterized new cell lines derived from two recurrent UPS tissues. Cells were obtained from UPS tissues by mincing, followed by extraction or dissociation using enzymes and culture in a standard culture environment. Cells were maintained for several months without artificial treatment, and some cell clones were found to be tumorigenic in an immunodeficient mouse model. Interestingly, some cells formed tumors in vivo when injected after aggregation in a non-adherent culture system for 24 h. The tissues from in vivo study and tissues from patients shared common histological characteristics. Pathways related to the cell cycle, such as DNA replication, were enriched in both cell clones. Pathways related to cell-cell adhesion and cell-cell signaling were also enriched, suggesting a role of the mesenchymal-to-epithelial transition for tumorigenicity in vivo. These new UPS cell lines may facilitate research to identify therapeutic strategies for UPS.

• Korean Journal of Culture and Social Issue
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• 제16권3호
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• pp.267-287
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• 2010

This study aimed to improve the Traffic Accident Management System's validity and reliability, so the system could help classify and judge the human factors that correlate with traffic accidents. We took traffic accident research and analysis systems of United States and United Kingdom and certain related, former studies into account in building our test system. Next, we used the test system's criteria to re-analyze 502 Gyeonggi province accident records from 2008. We compared the results to existing systems' results to verify the test system's validity and reliability. These results indicated the necessity of removing some uncertain items from the existing systems and adding in some new items from the test system. This should help improve understanding of what happens at traffic accident scenes and of the sources of drivers' abnormal, reckless behavior. We introduce suggestions for improving the Traffic Accident Management System and research concepts for further studies.

• Korean Journal of Environment and Ecology
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• 제27권2호
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• pp.209-218
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• 2013

This study was conducted to analyze the characteristics of odonata communities as habitat types in Wonju City, Korea. The 33 plots were installed at 4 types of biotope like abandoned paddy fields, natural type reservoir, natural type river and forest valley in Wonju city. From the survey, the 9 family and 38 species were identified. As the result of comparative investigation of the species composition of each habitat through TWINSPAN analyzing, the difference of species composition was definite in abandoned paddy field, natural type reservoir and forest valley, however, it was uncertain in natural type river. The dominant species and the subdominant species of each habitat were mainly Sympetrum frequens and Sympetrum infuscatum but the distributions of Paracercion hieroglyphicum, Epophthalmia elegans, and Anax parthenope julius were different as haibtat types. The order of the index of species diversity was not different between abandoned paddy fiedls, natural type reservoir and natural type river, but forest valley was low. The abandoned paddy field was shown the most diverse spawning type of odonata, it is considered that hydrophyten play an important role in the abundant of odonata since the sorts of odonata spawning in plants are majority. As the result of analyzing interspecies relationship, Crocothemis servilia mariannae and Orthetrum albistylum, Crocothemis servilia mariannae-Platycnemis phyllopoda, Lyriothemis pachygastra-Sympetrum parvulum are shown the positive correlation, however, they have a difference in preferred habitat between high correlation species.

• Management & Information Systems Review
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• 제39권2호
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• pp.1-15
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• 2020

Using information and communication technologies, many firms have increased their productivity. In resource based view, practical use of information and communication technologies is a process of increasing competitive advantage in uncertain environment. However, use of new information and communication technologies does not surely improve the productivity and work efficiency, but sometimes could be a factor to hinder firm performance. Technostress means adverse effect occurring in which the user of new information and communication technologies does not adapt to environment of new technologies. That is, Technostress is a negative impact resulted from using information and communication technologies. This study investigated the effect of technostress on counter-productivity. Unlike the previous studies, this study was made with the survey for firm employees of Daegu region, and both counter-productive work behavior and innovation resistance were used in this study. The empirical result means that technostress positively affects both counter-productive work behavior and innovation resistance. Because technostress increases both counter-productive work behavior and innovation resistance, systematic management for firm employees is needed in time adopting information and communication technologies.

• Journal of the Institute of Electronics Engineers of Korea CI
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• 제47권6호
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• pp.93-102
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• 2010

Existing web based information service system solutions show limitations in mobile information services, as well as problems such as uncertain error messages, and difficulty providing swift assistance or real time emergency support. In order to solve these deficiencies, a realtime wireless remote control system has been designed and implemented in this thesis, which is capable of managing and monitoring remote systems using mobile communication devices (Mobile Phone, PDA, Smart Phone) for realtime control. Proposed systems are applied at remote places, for instance 'office building', and a nursery school like 'kindergarten'. In the case of implemented at office building, it can be managing and controlling at real time all sorts of the sensor information that are installed at office building system environment through wire(web environment) or wireless(mobile device). In the other case at kindergarten system that are providing the real-time wireless remote control and monitoring system can be monitoring activity of kindergarten children with a mobile phone of authentication user. The security functions of proposed systems include mobile device user authentication and target system access control. The proposed systems allow real-time user authentication function and system access control function that improve the security of resource administrators and mobile device users, and provides not only uninterrupted services, but also real time mobile service environments.

• Journal of Bio-Environment Control
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• 제13권2호
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• pp.73-80
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• 2004

Two red pepper(Capsicum annuum L.) cultivars, 'Geumtap' and 'Bugang', were cultivated at main producing areas in Korea and harvested four times in 1998 and 1999. Length, weight, dry matter ratio and color of red peppers were measured at each harvest. The relations between external characteristics with regional climatic elements such as total accumulated air temperature, total amount of precipitation and duration of sunshine during the fruit growing periods were compared. Length and fruit weight decreased by delayed harvest. These characteristics were shown significant difference according to cultivars, but not to growing year. Dry matter ratio had a tendency to increase at the 3rd and 4th harvest. The red color as measured a${\times}$L values of pepper powder, increased with being later in harvesting, but the trend was uncertain. In fruit growth, fruit length showed a positive correlation with total accumulated air temperature in later growth period of fruits(from 1st to 20th day before harvesting), and fruit weight had relationships with accumulated air temperature and total amount of precipitation in later growth period of fruit. There was no relation between dry matter ratio and climate elements. The red color was shown high correlations with total amount of precipitation and duration of sunshine. There was highest coefficient of determination($r^2$) in all external characteristics.

• Journal of the Korea Institute of Information and Communication Engineering
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• 제13권6호
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• pp.1167-1174
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• 2009

In the monitoring of a patient in a sickroom, not only the physiologic and environmental data of the patient, which is automatically measured, but also the clinical data(clinical chart)of the patient, which is drew up by a doctor or nurse, are recognized as important data. However, since in the current environment of a sickroom, clinical data is collected being divided from the data that is automatically measured, the two data are used without an effective integration. This is because the integration of the two data is difficult due to their different collection times, which leads the reconstruction of clinical data to be remarkably uncertain. In order to solve these problems, a method to synchronize the continuous environmental data of a sickroom and clinical data is appearing as an important measure. In addition, the increase of use of small machines and the development of solutions based on wireless communications provide a communication platform to the developers of health care. Thus, this paper realizes a remote system for taking care of patients based on a web that uses mobile phones. That is, clinical data made by a nurse or doctor and the environmental data of a sick room comes to be collected by a collection module through a wireless sensor network. An observer can see clinical data and the environmental data of a sickroom through his/her mobile phone, integrating and storing his/her data into the database. Families of a patient can see clinical data made by hospital and the environment of the sick room of the patent through their computers or mobile phones outside the hospital. Through the system,hospital can provide better medical services to patients and their families.

• Archives of Reconstructive Microsurgery
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• 제13권1호
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• pp.43-50
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• 2004

One of the major advantages of microsurgical reconstruction for defects of the hand is that these techniques allow for selection of the most ideal tissue to reconstruct a particular defect, thus optimizing the functional and aesthetic outcome. The dorsalis pedis free flap is an excellent reconstructive tool for various hand reconstructions. It has a reliable vasculature with vessels that are relative large on a long pedicle. It provides thin pliable tissue and be innervated by deep peroneal nerve. Coupled with its thinness and pliability, it is ideal for innervated cover of critically sensitive area, especially such as the hand. Thus it can be used as a cutaneotendinous flap, or an osteocutaneous flap. Otherwise, the major criticism with this flap is related to its uncertain vascularity and the donor defect. It is the purpose of this paper to outline our technique of flap elevation and donor site closure and to indicate our current use of this flap in hand reconstruction. We have treated 10 cases (6 burn scar contracture cases, 4 acute hand trauma cases) of hand reconstruction from Dec. 3, 1997 to Mar. 4, 2004 using dorsalis pedis free flap. The key points for sucess in terms of a viable flap and acceptable donor site are the preservation of the critical dorsalis pedis-first dorsal metatarsal vascular axis and the creation of a viable bed for grafting. In addition, we substituted preserved superficial fat skin graft for split thickness skin graft and wet environment was offered for good graft take. Preserved superficial fat skin is defined as composite graft containing epidermis, dermis and superficial fat layer. With sufficient care in flap elevation and donor site closure, a good graft take of preserved superficial fat skin under wet environment can be achieved with no functional disability and minimal cosmetic deformity in donor site. This flap has proved itself to be a best choice for hand reconstruction.