• Proceedings of the Korean Society of Embryo Transfer Conference
• /
• 2004.10a
• /
• pp.59-59
• /
• 2004

• Proceedings of the Zoological Society Korea Conference
• /
• 2005.08a
• /
• pp.19-19
• /
• 2005

• Journal of Biomedical Engineering Research
• /
• v.9 no.2
• /
• pp.251-252
• /
• 1988

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength.

• Proceedings of the Korean Society of Veterinary Clinics Conference
• /
• 2006.05a
• /
• pp.204-204
• /
• 2006

• 대한생식의학회:학술대회논문집
• /
• 2007.11a
• /
• pp.111-111
• /
• 2007

• 대한생식의학회:학술대회논문집
• /
• 2007.11a
• /
• pp.112.1-112.1
• /
• 2007

• Proceedings of the Korean Society of Developmental Biology Conference
• /
• 2004.07a
• /
• pp.23-23
• /
• 2004

• 대한예방의학회:학술대회논문집
• /
• 1996.10a
• /
• pp.279-280
• /
• 1996

• Journal of Biomedical Engineering Research
• /
• v.10 no.2
• /
• pp.89-90
• /
• 1989

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased.

• Journal of Biomedical Engineering Research
• /
• v.15 no.3
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• pp.341-346
• /
• 1994

To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atel- ocollagen was produced. The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength.