• Journal of Pharmaceutical Investigation
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• 제32권4호
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• pp.259-265
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• 2002

Piroxicam is one of the NSAID, which is used in the systemic and topical treatment of a variety of inflammatory conditions. Conventionally, for topical use, the drug is formulated in gel. We designed an phonophoretic drug delivery system to investigate the piroxicam permeability and the influence of ultrasound application (continuous mode, pulsed mode), frequency (1.0 MHz, 3.0 MHz) and intensity $(1.0\;w/cm^2,\;1.5\;w/cm^2,\;2.0\;w/cm^2)$ with 0.5% piroxicam gel. Per cutaneous absorption studies were performed in vitro models to determine the rate of drug absorption via the skin. Permeation study using hairless mouse skin was performed at $37^{\circ}C$ using buffered saline (pH 7.4, 10% propylene glycol solution) as the receptor solution. Anti-inflammatory activity was determined using carrageenan-induced foot edema model in rat. A pronounced effect of ultrasound on the skin absorption of the piroxicam was observed at all ultrasound energy level studied. Ultrasound was carried out for 10 hr. The highest permeation was observed at intensity of $2.0\;w/cm^2$, frequency of 1.0 MHz and continuous output. The inclusion of phonophoresis was found to improve significantly the skin permeation in vitro and the anti-inflammatory activity in vivo.

• The Journal of Korean Physical Therapy
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• 제13권3호
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• pp.719-726
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• 2001

Transdermal drug delivery offers various advantages over conventional drug delivery systems, such as avoidance gastrointestinal degradation and hepatic first-pass effect. encourages patient compliance. and possible sustained release of drugs. However, transdermal transport of drugs is low permeability of the stratum corneum, the superficial layer of the skin. Many physicochemical and biological factors influencing transdermal transport is described together with the corresponding experimental and clinical results. Phonophoresis is medical treatment with drugs introduced into the skin by ultrasound energy. Enhanced drug penetration is through to result from the biophysical alterations of skin structure by ultrasound waves. The frequency used for phonophoresis is usually from 20 kHz to 15MHz. Phonophoresis can be categorized in to three ranges: low-frequency range(below 1 MHz). therapeutic frequency range(1 to 3MHz), and high-frequency range(above 3 MHz). The depth of penetration of ultrasound into skin is inversely proportional to the frequency. Cavitation may cause mechanical stress. temperature elevation, or enhanced chemical reactivity causing drug transport. One theory is that ultrasound affects the permeation of the stratum corneum lipid structure as the limiting step in permeating through the skin. The range of indications for phonophoresis is wide. Aspecific classification of the range of indications is obtained by classification of pathological conditions. The continuous research is needed for many interesting issucs of phonophoretic transdermal delivory in new future.

• 한국생산제조학회지
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• 제24권5호
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• pp.481-488
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• 2015

It is difficult to see a therapeutic effect from cardiovascular disease treatment methods in the case of a hardened chronic total occlusion (CTO), owing to the calcification of the deposition materials. However, lesion cells, such as CTOs, can be selectively necrotized without affecting the normal tissue using high-intensity ultrasound focused on one point. In this study, a phantom CTO was necrotized by a high-intensity focused ultrasound (HIFU) energy system, and the acoustic characteristics in the focal region were analyzed. An experimental HIFU device was constructed to discover the appropriate conditions for the necrosis of a phantom CTO. The transfer characteristics of the ultrasound changed in the focal region by the density difference of the phantom CTO. These changes were acoustically analyzed to choose the available frequency band for each density. On-off temperature control in the focal region was applied to prevent rapid temperature rises, which would otherwise affect normal tissue.

• Medical Lasers
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• 제9권1호
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• pp.12-24
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• 2020

Human fibroblast-derived multi-peptide factors (MPFs) have been used during treatments with energy-delivering modalities to enhance energy-induced tissue reactions. Human fibroblast-derived MPFs, which include a range of growth factors and chemoattractive factors, activate and recruit fibroblasts and endothelial cells, as well as promote extracellular matrix deposition, all of which are crucial to wound repair. Interestingly, fibroblasts from different species or anatomical sites exhibit distinct transcriptional properties with high heterogeneity. In addition, the patterns of MPF secretion can differ under a range of experimental conditions. Therefore, the use of allogeneic fibroblasts and proper cultivation thereof are necessary to obtain MPFs that can enhance the epithelial-mesenchymal interactions during wound repair. Moreover, energy-delivering devices should be selected according to evidence demonstrating their therapeutic efficacy and safety on a pathological skin condition and the major target skin layers. This paper reviewed the histologic patterns of post-treatment tissue reactions elicited by several energy sources, including non-ablative and ablative fractional lasers, intense focused ultrasound, non-invasive and invasive radiofrequency, picosecond-domain lasers, and argon and nitrogen plasma. The possible role of the immediate application of human fibroblast-derived MPFs during wound repair was proposed.

• 비파괴검사학회지
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• 제18권5호
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• pp.373-380
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• 1998

본 연구에서는 초음파 속도와 광역 감쇠를 이용하여 연골의 강도를 평가하였다. 먼저 60개의 시편을 인체의 연골로부터 얻어서 초음파 속도와 광역 감쇠를 각 시편에 대하여 측정하였다. 시편들은 동일한 두개의 그룹으로 나누어, $0.0004\;s^{-1}$와 $0.08\;s^{-1}$의 변형률에서 압축 하중을 작용시킨 후 각 시편에 대한 최대 압축 강도값을 결정하였다. 그 결과, $0.08\;s^{-1}$에서 측정된 시편들은 $0.0004\;s^{-1}$로 측정된 시편들 보다 63%나 더 높은 평균 강도값을 나타내었다. 초음파 속도와 광역 감쇠는 고변형률 및 저변형률 모두에서 골 강도와 밀접한 연관성을 나타내었다. 또한, 골 강도는 모든 변형률에서 초음파 속도와 광역 감쇠의 선형 조합과도 밀접한 관련성을 보였다 초음파 파라미터의 사용은 여러 가지 골절에 대한 연골의 저항능력을 평가하기 위한 임상진단법으로 훌륭한 수단이 될 수 있을 것이다.

• Journal of Pharmaceutical Investigation
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• 제37권3호
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• pp.149-158
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• 2007

To investigate the permeability of lidocaine, percutaneous absorption studies were performed using excised hairless mouse skin and the penetration of lidocaine via the skin was determined. To increase the skin permeation of lidocine, the effects of $Labrasol^{(R)}$, $Labrafil^{(R)}$, $Labrafac^{(R)}$ and $Transcutol^{(R)}$ were investigated. The skin permeation of lidocaine was increased when $Labrasol^{(R)}$ and $Transcutol^{(R)}$ were used as permeation enhancer. To evaluate the influence of ultrasound, various factors such as application modes (continuous mode and pulsed mode), frequency (1.0 and 3.0 MHz) and intensity (1.0, 1.5 and 2.0 w/$cm^2$) were investigated with lidocaine hydrogel. The pronounced effect of ultrasound on the skin permeation of lidocaine was observed at all ultrasound energy levels. The influence of frequency having an effect on skin permeation rate was higher in the case of using 1 MHz, 2.0 w/$cm^2$ and continuous treatment. As the intensity of ultrasound increased, the permeation of lidocaine was accelerated. The in vivo anesthetic effects were evaluated by two aspects as mechanical threshold and electrical threshold. Six healthy volunteers consented to the randomized, double-blind, and cross-over designed study in each group. In each subject, 3 groups were adapted such as K group (ultrasound with gel base only), L group (lidocaine gel) and B group (ultrasound with lidocaine gel). In conclusion, lidocaine was potent anesthetic which could be block pain threshold effectively. And ultrasound could accelerate the skin penetration of lidocaine. The phonophoretic delivery system could be a good candidate for lidocaine as a local anaesthetic to improve the skin permeation and in vivo anaesthetic effect.

• 한국멀티미디어학회논문지
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• 제20권1호
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• pp.43-50
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• 2017

According to living environment, the number of deaths due to thyroid diseases increased. In this paper, we proposed an algorithm for recognizing a thyroid detection using texture analysis based on shape, gray level co-occurrence matrix and gray level run length matrix. First of all, we segmented the region of interest (ROI) using active contour model algorithm. Then, we applied a total of 18 features (5 first order descriptors, 10 Gray level co-occurrence matrix features(GLCM), 2 Gray level run length matrix features and shape feature) to each thyroid region of interest. The extracted features are used as statistical analysis. Our results show that first order statistics (Skewness, Entropy, Energy, Smoothness), GLCM (Correlation, Contrast, Energy, Entropy, Difference variance, Difference Entropy, Homogeneity, Maximum Probability, Sum average, Sum entropy), GLRLM features and shape feature helped to distinguish thyroid benign and malignant. This algorithm will be helpful to diagnose of thyroid nodule on ultrasound images.

• 한국지반공학회논문집
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• 제20권2호
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• pp.67-73
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• 2004

준설매립 및 연약지반 처리에 있어 압밀촉진 공법들에 대한 연구가 활발하다. 본 연구에서는 초음파를 사용하여 압밀촉진을 유발하고자 하였고 그 영향 정도를 실내실험을 통하여 조사하였다. 실내시험은 특별히 제작된 압밀시험기를 사용하였으며 압밀시험 중 초음파를 시료에 직접 가할수 있도록 고안되었다. 압밀시험 재료로는 원심력 시험기를 사용하여 원하는 조건에 맞는 동질의 시료를 제작하여 사용하였으며 초음파 강도, 처리 시간을 달리하여 시험을 실시하였다. 시험결과 초음파가 압밀에 미치는 영향은 큰 것으로 나타났으며 초음파 처리의 영향에 미치는 정도가 시험조건에 따라 다르게 나타났다. 본 연구의 결과를 이용하여 초음파에 의해 압밀촉진을 위한 공법개발의 가능성을 파악하였다.

• 한국생산제조학회지
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• 제21권1호
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• pp.102-108
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• 2012

A study of terahertz waves (T-ray) was made for the nondestructive evaluation of FRP (Fiber reinforced plastics) composite materials. The to-be-used systems were time domain spectroscopy (TDS) and continuous wave (CW). The composite materials investigated include both turbine blades of wind energy (non-conducting polymeric composites) and conducting carbon fiber composites. Terahertz signals in the TDS mode resembles that of ultrasound; however, unlike ultrasound, a terahertz pulse was not able to detect a material with conductivity. This was demonstrated in CFRP (Carbon fiber reinforced plastics) laminates. Refractive index (n) was defined as one of mechanical properties; so a method was solved in order solve the "n" in the material with the cut parts of the turbine blades of wind energy. The defects and anomalies investigated by terahertz radiation were foreign material inclusions and simulated disband. Especially, it is found that the T-ray went through the turbine blade with greater thickness (about 90mm).

• 한국환경과학회지
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• 제27권9호
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• pp.763-770
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• 2018

Bioremediation in situ is heavily dependent on the oxygenic environment which would privide the dwelling microorganism with sufficient oxygen. The situation could be easily resolved with supply of an Oxygen Releasing Compound (ORC). In this paper we prepared that sort of material out of oyster shell powder (mostly calcium carbonate) that prevails every shore areas of the country. We used two different oxidizing methods in the first step of the whole manufacturing process-conventional heating in a furnace and an ultrasound generator to obtain calcium oxide. Then that calcium oxide was further oxidized into calcium peroxide which may release oxygen under a moisturized condition. The oxygen releasing experiments were run to test the performance of our products, and to determine the gas kinetics during the experiments. Interestingly, calcium peroxide derived from ultrasound treatment was much more energy-effective as ORC than that from furnace heating although the heat derived process was better than that of ultrasound in terms of oxygen content and its releasing rate. We also found that most of the data collected from the gas releasing experiments fairly supported an ordinary $1^{st}$ order kinetics to oxygen concentration, which shaped a sharp discharge of oxygen at the very early moment of each test.