• Archives of Plastic Surgery
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• 제37권1호
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• pp.79-82
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• 2010

Purpose: Carcinosarcomas are rare neoplasms in which both malignant epithelial and mesenchymal elements are identified. We have found only twenty one cases of primary cutaneous carcinosarcoma in the English language literature. Therefore it has been difficult to diagnosis because its unclear etiology and low frequency. Methods: A 31-year-old young man with a protruding mass on his ankle dorsum was examined. The tumor was $7{\times}6{\times}3\;cm$ sized and arose from a burn scar. The mass was wide excised and applied split thickness skin graft. Characteristic pathologic finding was a mixture of squamous cell carcinoma and malignant fibrous histiocytoma. Results: Three months after the operation, the patient died of multiple metastasis to the liver, lung and finally of sepsis despite adjuvant chemotherapy and adjuvant radiotherapy. Conclusion: If a metastatic cutaneous carcinosarcoma is diagnosed, wide excision is required. There should be more aggressive management to minimize the risk of recurrence. Further research into the etiology and pathophysiology of the disease and a more careful differential diagnosis may allow improvement in treatment.

• Archives of Plastic Surgery
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• 제36권5호
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• pp.548-554
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• 2009

Purpose: To evaluate clinical efficacy and safety of hyaluronic acid based autologous dermal fibroblasts (Hyalograft 3D) in the treatment of diabetic foot ulcers. Methods: A total of 28 patients with diabetic ulcers were randomized to either the control group with nonadherent foam dressings(n=14) or the treatment group with autologous tissue - engineered grafts(n=14). Weekly assessment contained vital sign checks, ulcer size measurements, and wound photos. At 12th week, percentages of complete wound healing and mean healing times were compared. Safety was also monitored by adverse events. Results: Complete wound healing was achieved in 84.6% of the treatment group and 23.1% of the control group (p<0.005). The mean times of closures for the treatment versus control groups were 6.1 weeks and 10.9 weeks, respectively. No adverse events related to the study treatment occurred. Conclusion: The use of hyaluronic acid based autologous fibroblast grafts was found to be a safe and effective treatment for diabetic foot ulcers.

• Advances in Traditional Medicine
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• 제6권1호
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• pp.53-57
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• 2006

The plant Indigofera aspalathoides is used by a large number of tribes in India for the treatment of various hepatic disorders and abscesses. The methanol extract of Indigofera aspalathoides (MEIA) was evaluated for its protective effects on gastric mucosal lesion in Wister albino rats against indomethacin, histamine and ethanol induced gastric mucosal damage. The response to MEIA was assessed using the ulcer index, thiobarbituric acid reactive substance (TBARS), and glutahione level. MEIA pretreatment showed protection against chemical induced gastric mucosal damage, a significant reduction in the ulcer index and TBARS activity and increase glutathione level as compared with that of standard drugs.

• 한방안이비인후피부과학회지
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• 제18권3호
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• pp.108-113
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• 2005

Objective: The purpose of this case study is to show a case of ulcer due to Buerger's disease improved by conservative oriental medical therapy. Method: The patient was treated from 31 March, 2004 to 1 June, 2004 by acupuncture, herb, dressing Results: We evaluated through X-ray, picture of patient's foot and measuring of infect size. Conclusion: We suggest to treat ulcer resulting from Buerger's disease with oriental medical therapy and would like to research oriental medical treatment plan for the further treatment.

• Archives of Pharmacal Research
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• 제24권6호
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• pp.485-498
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• 2001

Helicobacter pylori is one of the most commonly encountered human pathogens. It has been shown to be closely associated with peptic ulcer disease (PUD), gastric adenocarcinoma, and the gastric mucosa-associated lymphoid tissue (MALT) that may lead to gastric lymphoma. The current diagnostic methods include histology, microbiological culture, classic serology unease activity detection, polymerase chain reaction (PCR) and stool antigen detection. Its treatment modality options are multiple; however, a triple regimen consisting of a proton pump inhibitor (PPI), and two antibiotics for 10 to 14 days is preferred. Drug resistance is a growing problem in this organism and new therapeutic options are currently limited .

• Parasites, Hosts and Diseases
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• 제30권3호
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• pp.231-234
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• 1992

조경사업 인부로 일하던 58세 만성 알폴성 환자가 2년 전부터 심와부 불쾌감, 오심, 무른변을 자주 보는 등의 증상을 느꺼오던 중 3개일 전부터 증상이 심해지면서 4 kg의 체중 감소가 있어 내원하였다. 입원 후 시행한 내시 경정사상 십이지 장궤양이 관찰되었고, 대 변검사에서는 분선충(Strongyloides stertoralis)의 rhabditoid 유충이 발견되어, 십이지장궤양 및 분선충증으로 진단되었다. 대변 배양검사에서는 분선충의 filari(orts 유충이 화인되었다. 환자는 분선충증에 대하여 albendazole을 14일간 투여받은 후 하루 4∼5회씩 있던 무른 대변이 정상 대변으로 돌아왔고, 대변 검사 및 대변 배양검사에서 분선충이 더 이상 관찰되지 않았다. 십이지장궤양에 대해서는 colloidal bismuth sulfate로 6주간 치료받은 후, 역시 내시경상 완치되었음이 확인되었고, 건강한 상태로 퇴원하였다. 이 증례는 분선충증이 십이지장궤양과 인과관계가 있을 것임을 시사하는 흥미있는 1례로 생각되었다.

• 디지털융복합연구
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• 제19권12호
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• pp.649-660
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• 2021

본 연구의 목적은 중환자실 환자를 대상으로 케어비데로봇을 이용한 배설간호가 실금관련 피부염, 욕창위험도, 생리적 지표(혈청 알부민, 단백질, 헤모글로빈, 림프구 변화)에 미치는 효과를 확인하기 위해 시행되었다. 연구대상은 종합병원 중환자실에 입실한 환자들을 대상으로 케어비데로봇 ((주)큐라코)을 이용하여 실험군에게는 케어비데로봇을 1인당 1대씩 장착하고 실금이 발생 될 시 작동하게 하여 건조 완료하였으며, 대조군에게는 실금이 발생될 시 물티슈로 닦고 자연 건조를 시키는 방법으로 1주간 진행하였다. 수집된 자료는 기술통계, t-test, repeated measured ANONA로 분석하였다. 연구결과 실금 관련 피부염, 욕창 위험도, 알부민, 림프구는 집단간에 통계적으로 유의한 차이가 있었다. 본 연구는 케어비데로봇을 이용한 배설간호가 피부 점막에 미치는 효과를 과학적 근거인 생리적 지표로 검증하였다는 점에서 의의가 있으며, 대상자 확대를 통한 추후 연구가 더욱 필요하다.

• 대한핵의학회:학술대회논문집
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• 대한핵의학회 1988년도 제27차 춘계학술대회
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• pp.127.1-127.1
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• 1988

• Archives of Plastic Surgery
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• 제34권5호
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• pp.543-550
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• 2007

Purpose: Diabetic foot ulcer is a representative disease of chronic would with multiple defects of wound healing factors. Many nutrition factors have been known to be essential for wound healing, but objective data are lacking. The purpose of this study is to determine those factors essential for wound healing, and to find out which of those factors are lacking in diabetic foot ulcer patients through this pilot study. Methods: We studied 100 patients who visited our clinic from March 2005 to February 2006 for treatment of diabetic foot ulcers with a duration of more than 6 weeks. We checked serum levels of protein, albumin, vitamin A, C, E, iron, magnesium, zinc, copper and hemoglobin by drawing 23cc blood after 8 hours of fasting. Protein, albumin, iron, magnesium levels were measured by colorimetry; hemoglobin levels were measured by auto analysis. Vitamin levels were measured by high performance liquid chromatography (HPLC), copper and zinc levels were measured by Inductively coupled plasma (ICP). They were compared with normal values. The patients were divided by transcutaneous oxygen pressure levels, age and sex to study the effects of these parameters. Results: 76% and 61% of patients had within-normal range serum protein and albumin levels, respectively. Among vitamins, only the level of vitamin C was low in 55% of the patients. Levels of vitamin A, E were normal or high in 93% and 100% of patients. As for trace elements, levels of iron and zinc were low in 63% and 60% of patients, but levels of magnesium and copper were usually normal or high. Levels of vitamin C, iron and zinc were lower in the low-transcutaneous oxygen pressure group. There were no definite differences according to age and sex. Conclusion: Serum levels of Hb, vitamin C, iron, zinc were low in most diabetic foot ulcer patients. The deficit was very severe in the low-transcutaneous oxygen pressure group.

• 대한본초학회지
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• 제33권4호
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• pp.9-18
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• 2018

Objectives : This study aimed to investigate the anti-ulcer effect of an standardized herbal extracts mixture of Inulae Flos and Paeoniae Radix (HT074) on acidified ethanol induced gastric injury and its potential mechanisms. Methods : Antioxidant activities of HT074 and its constituents were measured by DPPH (2,2-Diphenyl-1-picrylhydrazyl) and ABTS (2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging capacity. After the oral administration of HT074 at doses of 100, 300 mg/kg twice per day for 14 days, Gastric lesions were induced by oral administration of acidified ethanol in Sprague Dawley rats. Oxidative stress markers, such as super oxide dismutase (SOD) activity, concentrations of catalase (CAT) and glutathione (GSH) were measured in gastric mucosal tissues. Additionally, the expression of human mucin gene, Mucin 5AC (MUC5AC) mRNA in gastric mucosal tissues was measured. Results : HT074 showed dose dependent radical scavenging activities against DPPH and ABTS radicals. Oral administration of HT074 300 mg/kg for 14 consecutive days significantly decreased gastric lesions and histological damages induced by HCl/EtOH in rats. HT074 treatment significantly increased the activity of SOD (300 mg/kg) and concentration of GSH (100 and 300 mg/kg), however catalase concentration was not significantly increased. MUC5AC mRNA expression was significantly increased by HT074 100, 300 mg/kg treatment. Conclusions : HT074 protects the gastric mucosa from oxidative stress caused by acidified ethanol by increasing the activity of SOD, concentration of GSH and mucin biosynthesis. These findings suggest that HT074 could be an effective candidate for prevention and treatment of gastritis and gastric ulcer.