• Asian Pacific Journal of Cancer Prevention
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• v.15 no.15
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• pp.6121-6125
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• 2014

Background: Prostate-specific antigen (PSA) is a potential biomarker for early detection of prostate cancer (PCa) but its level is known to be affected by many background factors and roles of ubiquitous toxicants have not been determined. Endocrine disrupting chemicals (EDCs) are ubiquitous reproductive toxicants used in consumer products, which promote tumor formation in some reproductive model systems by binding to AhR, but human data on its expression in prostate cancer as well as its association with PSA levels are not clear. This study aimed to evaluate the expression levels of AhR and its association with serological levels of PSA and to detect possible effects of background factors and EDC exposure history on PSA levels in PCa cases. Materials and Methods: A cross-sectional study was conducted on the tissue levels of AhR and serum levels of PSA in 53 PCa cases from 2008-2011 and associations between each and background and lifestyle related factors were determined. Results: Although the AhR was overexpressed in PCa and correlated with the age of patients, it did not correlate with PSA levels.Of nutritional factors, increased intake of polysaturated fats and fish in the routine regimen of PCa cases increased the PSA levels significantly. Conclusions: AhR overexpression in PCa pontws to roles of EDCs in PCa but without any direct association with PSA levels. However, PSA levels are affected by exposure to possible toxicants in foods whichneed to be assessed as possible risk factors of PCa in future studies.

• Journal of the Korea Society of Computer and Information
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• v.12 no.1 s.45
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• pp.107-116
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• 2007

Is need Remote Access through internet for business of Ubiquitous Computing age, and apply OTP for confidentiality about inputed ID and Password, network security of integrity. Current OTP must be possessing hardware of Token, and there is limitation in security. Install a Snooping tool to OTP network in this treatise, and because using Cain, enforce ARP Cache poisoning attack and confirm limitation by Snooping about user password. Wish to propose new system that can apply Tokenless OTP by new security way, and secure confidentiality and integrity. Do test for access control inflecting Tokenless OTP at Remote Access from outside, and could worm and do interface control with certification system in hundred. Even if encounter hacking at certification process, thing that connection is impossible without pin number that only user knows confirmed. Because becoming defense about outward flow and misuse and hacking of password when apply this result Tokenless OTP, solidify security, and evaluated by security system that heighten safety.

• Journal of the Korean Institute of Intelligent Systems
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• v.16 no.2
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• pp.185-190
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• 2006

Most systems in ubiquitous computing analyze context information of users which have similar propensity with demographics methods and collaborative filtering to provide personalized recommendation services. The systems have mostly used static context information such as sex, age, job, and purchase history. However the systems have limitation to analyze users' propensity accurately and to provide personalized recommendation services in real-time, because they have difficulty in considering users situation as moving path. In this paper we use users' moving path of dynamic context to consider users situation. For the prediction accuracy we complete with a path completion algorithm to moving path which is inputted to RSOM. We train the moving path to be completed by RSOM, analyze users' moving pattern and predict a future moving path. Then we recommend the nearest product on the prediction path with users' high preference in real-time. As the experimental result, MAE is lower than 0.5 averagely and we confirmed our method can predict users moving path correctly.

• Journal of Preventive Medicine and Public Health
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• v.51 no.5
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• pp.242-247
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• 2018

Objectives: To examine survivorship disparities in demographic factors and risk status for non-muscle-invasive bladder cancer (NMIBC), which accounts for more than 75% of all urinary bladder cancers, but is highly curable with early identification and treatment. Methods: We used the US National Cancer Institute's Surveillance, Epidemiology, and End Results registries over a 19-year period (1988-2006) to examine survivorship disparities in age, sex, race/ethnicity, and marital status of patients and risk status classified by histologic grade, stage, size of tumor, and number of multiple primary tumors among NMIBC patients (n=29 326). We applied Kaplan-Meier (K-M) and Cox proportional hazard methods for survival analysis. Results: Among all urinary bladder cancer patients, the majority of NMIBCs were in male (74.1%), non-Latino white (86.7%), married (67.8%), and low-risk (37.6%) to intermediate-risk (44.8%) patients. The mean age was 68 years. Survivorship (in median life years) was highest for non-Latino white (5.4 years), married (5.4 years), and low-risk (5.7 years) patients (K-M analysis, p<0.001). We found significantly lower survivorship for elderly, male (female hazard ratio [HR], 0.96), Latino (HR, 1.20), and unmarried (married HR, 0.93) patients. Conclusions: Survivorship disparities were ubiquitous across age, sex, race/ethnicity, and marital status groups. Non-white, unmarried, and elderly patients had significantly shorter survivorship. The implications of these findings include the need for a heightened focus on health policy and more organized efforts to improve access to care in order to increase the chances of survival for all patients.

• Development and Reproduction
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• v.17 no.3
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• pp.221-229
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• 2013

Cathepsins are members of the multigene family of lysosomal cysteine proteinases and have regulated function in several life processes. The potential role of cathepsin F cysteine gene was expected as protease in the yolk processing mechanism during early developmental stage, but expression analysis was unknown after fertilization. The alignment analysis showed that amino acid sequence of cathepsin F from olive flounder liver expressed sequence tag (EST) homologous to cathepsin F of other known cathepsin F sequences with 87-98% identity. In this study, we examined the gene expression analysis of cathepsin F in various tissues at variety age flounder. Tissue distribution of the cathepsin F mRNA has been shown to be ubiquitous and constitutive pattern regardless of age in each group, although derived from cDNA library using liver sample. The mRNA level of cathepsin F more increased as developmental proceed during embryogenesis and early developmental stage, especially increased in the blastula, hatching stage and 3 days post hatching (dph). As a result, it may suggest that the proteolysis of yolk proteins (YPs) has been implicated as a mechanism for nutrient supply during early larval stages in olive flounder.

• Asian-Australasian Journal of Animal Sciences
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• v.23 no.8
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• pp.1000-1006
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• 2010

Phosducin (PDC) is a photoreceptor cell-specific protein that is phosphorylated by cyclic nucleotide-dependent protein kinase. PDC and PDC-like proteins (PDCL, PDCL2, and PDCL3) are members of a conserved family of small thioredoxin-like proteins that modulate the ${\beta}$- and ${\gamma}$-subunits of G-proteins. In mammals, Pdc, Pdcl, and Pdcl3 genes show ubiquitous expression; however, Pdcl2 gene expression is limited to the testis and ovary. The aim of the present study was to examine the expression patterns of chicken Pdcl2 (cPdcl2) during testicular and ovarian development. Protein sequence comparisons performed using the CLUSTAL X program revealed that the amino acid sequences and potential phosphorylation sites of cPDCL2 and mammalian PDCL2 proteins were highly conserved. Quantitative real-time PCR analysis revealed that cPdcl2 was differentially expressed in the testis and ovary. Specifically, cPdcl2 expression was detected at low levels in the ovary at all time points. In the testis, cPdcl2 expression was detected at low levels until 5 weeks of age. At 8 weeks of age, however, cPdcl2 showed increased expression levels in the testis. Using in situ hybridization, we detected high levels of cPdcl2 expression in the testis, particularly in the spermatocytes and round spermatids. In summary, our data describe expression patterns of germ cell-specific Pdcl2 during testicular and ovarian development in chickens.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.1
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• pp.48.1-48.1
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• 2012

We present the ultraviolet (UV) color-color relation of early-type galaxies (ETGs) in the nearby universe (0.05 < z < 0.12) to investigate the properties of hot stellar populations responsible for the UV excess (UVX). The initial sample of ETGs is selected by the spectroscopic redshift and the morphology parameter from the SDSS DR 7, and then cross-matched with the GALEX far-UV (FUV) and near-UV (NUV) GR6 data. The cross-matched ETG sample is further classified by their emission line characteristics in the optical spectra into quiescent, star-forming, and active galactic nucleus categories. Contaminations from early-type spiral galaxies, mergers, and morphologically disturbed galaxies are removed by visual inspection. By drawing the FUV-NUV (as a measure of UV spectral shape) versus FUV-r (as a measure of UVX strength) diagram for the final sample of -3700 quiescent ETGs, we find that the "old and dead" ETGs consist of a well-defined sequence in UV colors, the "UV red sequence," so that the stronger UVX galaxies should have a harder UV spectral shape systematically. However, the observed UV spectral slope is too steep to be reproduced by the canonical stellar population models in which the UV flux is mainly controlled by age or metallicity parameters. Moreover, 2 mag of color spreads both in FUV-NUV and FUV-r appear to be ubiquitous among any subsets in distance or luminosity. This implies that the UVX in ETGs could be driven by yet another parameter which might be even more influential than age or metallicity.

• Journal of Digital Contents Society
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• v.9 no.1
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• pp.27-31
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• 2008

u-Health is a representative realization method of ubiquitous IT and it is being embossed as an industry that can make our lives abundant. Through the u-Health, the diagnosis will go beyond the restriction of space, which is based on hospital, and be positioned as a universal value in a daily life by combining diagnosis and life naturally. The purpose of this study is to suggest systematic, intelligent, mobile medical information system that has the same effect as the assistant of specialist by providing scientific and objective knowledge, which is suitable for u-Health age. Mobile medical information system can provide user with the opinion of specialist by planting the experience, knowledge and decision making process of specialist that are necessary for solving the problem requiring special medical knowledge and passing through an inference process.

• Journal of Korean Public Health Nursing
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• v.15 no.2
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• pp.387-397
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• 2001

Fatigue is a ubiquitous symptom and is a part of many acute and chronic health conditions. This complex symptom is so prevalence in contemporary society that it motivates a large percentage of the health care-seeking behavior among late-middle aged adults and elders. The purpose of this study was to examine perceptions of fatigue. to identify coping types of fatigue, and to explore factors affected fatigue between middle aged adults and elders who have no critical health problems. The results are as follows: 1. The elderly that manifested high level of fatigue revealed more fatigue than adults. 2. There are three coping types of fatigue. The three types were analyzed by Q-methodology. These three are action-evading, action-limited, and action-oriented. 3. The levels of fatigue manifested by the participants varied significantly according to age, vocation, education, present disease, and income. By identifying the nature of each of the coping types of fatigue, it is recommended to develop an effective nursing interventions for middle aged adults and elders.

• Spatial Information Research
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• v.11 no.4
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• pp.371-389
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• 2003

This study aims at defining the concept of a cyber-geospace and proposing how to establish a cyber-geospace fir the entire country in detail. The study defined the cyber-geospace as 'the dynamic second territory of Korea not only to manage the land systematicality and deal with administrative services for the people in aspect of public sector, but also to contain economic activities of corporations and the citizen's everyday lives in aspect of private sector, in a 3D virtual reality made by digitizing various facilities and buildings as well as the entire toterritory including ground, underground and even sea'. In order to establish such a cyber-geospace, the project should be pursued on the national level fir around ten-year period.