• Quality Improvement in Health Care
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• v.1 no.1
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• pp.56-65
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• 1994

Total quality management has been a focus of concern in recent years since some dissatisfaction with the results from implementation of quality assurance programs in the U.S. Many managerial methodologies and innovation guidelines from academic disciplines have been applied to promote TQM programs in the health field. This paper consists of two folds of aspects: firstly to examine TQM's managerial philosophy by comparing with the newly introduced managerial concepts in Business Reengineering; and then to introduce a method for an integrative way of process analysis, Entity Life-Cycle Diagram (ELCD) modeling. The analysis method was compared with Process Map, which is a well-known method for BR applications. To show effectiveness of ELCD modeling, a case of application was introduced using 'drug' as a target entity. With having TQM issues in mind, the result was reflected in designing Entity Relation Diagrams. The results of ELCD modeling turn out to be helpful in designing database related to quality monitoring, in that many monitoring check points can be identified in a systematic way and that queries cross-sectional over organizational boundaries can be generated with a consistent view focusing on the drug use as a single process. Full evaluation of the analysis method remains to be studied until the completion of the information system under construction. But as long as TQM is based on a process-oriented view and needs supports from information system, ELCD can be one of the appropriate choice as a tool for the process analysis.

• Journal of Korean Society for Atmospheric Environment
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• v.27 no.5
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• pp.580-602
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• 2011

Volatile organic compound (VOC) emissions in the 2007 CAPSS (Clean Air Protection Supporting System) emissions inventory are chemically speciated for the SAPRC99 (Statewide Air Pollution Research Center 99) mechanism, following the Source Classification Code (SCC) matching method to borrow the U.S.EPA's chemical speciation profiles. CMAQ simulations with High-order Direct Decoupled Method (HDDM) are in turn applied to evaluate uncertainty in the method by comparing the simulated model VOC species to the observations in the Seoul Metropolitan Area (SMA) for a 2007 June episode. Simulations under-predicted ALK1 to ALK4 in SAPRC99 by a factor of 2 to 5 and over-predicted ALK5 by a factor of 7.5 while ARO1, ARO2, OLE1, and ethylene (ETH) are comparable to the observations, showing relative difference by 10 to 30%. OLE2 emissions are roughly 4 times overestimated. Emission rates for individual VOC model species are revised referring to the ratio of simulated to observed concentrations. Impact of the VOC emission changes on the overall ozone prediction was insignificant for the days of which 1-hr maximum ozone are lower than 100 ppb. However, simulations showed ozone difference by 5 to 10 ppb when high ozone above 120 ppb was observed in the vicinity of Seoul. This result suggests that evaluations on individual model VOC emissions be necessary to lead ozone control plans to the right direction. Moreover, the simulated ratios of ARO1 and ARO2 to $NO_x$ are roughly 50% lower than the observed ones, which imply that adjustment in $NO_x$ and VOC emission rates may be required to mimic the real VOC/$NO_x$ condition over the area.

• Wind and Structures
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• v.20 no.2
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• pp.349-361
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• 2015

Higher-mode vertical vortex-induced vibrations (VIV) have been observed on several steel box-girder suspension bridges where different vertical modes are selectively excited in turn with wind velocity in accordance with the Strouhal law. Understanding the relationship of VIV amplitudes for different modes of vibration is very important for wind-resistant design of long-span box-girder suspension bridges. In this study, the basic rectangular cross-section with side ratio of B/D=6 is used to investigate the effect of different modes on VIV amplitudes by section model tests. The section model is flexibly mounted in wind tunnel with a variety of spring constants for simulating different modes of vibration and the non-dimensional vertical amplitudes are determined as a function of reduced velocity U/fD. Two 'lock-in' ranges are observed at the same onset reduced velocities of approximately 4.8 and 9.4 for all cases. The second 'lock-in' range, which is induced by the conventional vortex shedding, consistently gives larger responses than the first one and the Sc-normalized maximum non-dimensional responses are almost the same for different spring constants. The first 'lock-in' range where the vibration frequency is approximately two times the vortex shedding frequency is probably a result of super-harmonic resonance or the "frequency demultiplication". The main conclusion drawn from the section model study, central to the higher-mode VIV of suspension bridges, is that the VIV amplitude for different modes is the same provided that the Sc number for these modes is identical.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.17 no.11
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• pp.2575-2580
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• 2013

In this paper, we watch out key measure of the level of transportation service about travel time and delay time. And we measured vehicle traffic by moving vehicle method using CCTV which is one of the travel time measure. We should be measured in place of continuous traffic flow characteristics with wide traffic light interval. In addition, traffic flow on the other side of the interval must be sufficiently identifiable and at the end of this section must be possible U-turn. This method it requires only the driver of the vehicle because of the CCTV measure. In addition, We cannot require time, distance, and traffic equipment that can be recorded. Because equipped with the software to do that. In addition to traffic, average travel time, average space speed, traffic density are also available.

• 한국정보디스플레이학회:학술대회논문집
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• 2005.07b
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• pp.1343-1346
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• 2005

Self assembled monolayers (SAM) are generally used at the anode/organic interface to enhance the carrier injection in organic light emitting devices, which improves the electroluminescence performance of organic devices. This paper reports the use of SAM of 1-decanethiol (H-S(CH2)9CH3) at the cathode/organic interface to enhance the electron injection process for organic light emitting devices. Aluminum (Al), tris-(8-hydroxyquionoline) aluminum (Alq3), N,N'-diphenyl-N,N'-bis(3 -methylphenyl)-1,1'- diphenyl-4,4'-diamine (TPD) and indium-tin-oxide (ITO) were used as bottom cathode, an emitting layer (EML), a hole-transporting layer (HTL) and a top anode, respectively. The results of the capacitancevoltage (C-V), current density -voltage (J-V) and brightness-voltage (B-V), luminance and quantum efficiency measurements show a considerable improvement of the device performance. The dipole moment associated with the SAM layer decreases the electron schottky barrier between the Al and the organic interface, which enhances the electron injection into the organic layer from Al cathode and a considerable improvement of the device performance is observed. The turn-on voltage of the fabricated device with SAM layer was reduced by 6V, the brightness of the device was increased by 5 times and the external quantum efficiency is increased by 0.051%.

• Korean Journal of Health Education and Promotion
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• v.20 no.3
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• pp.91-108
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• 2003

Psychological stress is a growing issue in work stress research because work stressors are closely related to depression； and depression, in turn, decreases organizational effectiveness. Considering such causal relationships of work stress, a comprehensive source to control work stress is needed for worksite mental well-being. This study was conducted to identify how social support at work controlled work stress and which characteristics of social support were effective on work stress reduction. The study participants were 240 workers employed in a public hospital in Georgia, U.S.A self-administered survey was given to employees with their pay slips, and followed by a hospital wide voice reminder for 7 days. Surveys were conducted over a 20-day period. The questionnaires asked about job demands, job control, social support at work, depression, job performance, absenteeism, and demographics. The social support construct was structured on the source of support at work and the kinds of support were provided. Statistical analyses were conducted in the structural equation modeling approach. Social support at work was directly related to high job control, low depression, and high job performance. High score of social support at work were significantly associated with high job control, low depressive symptoms, and high job performance. By source of support, only organizational support was positively related to high job control. Organizational support was more effective than supervisor and coworker support. Any stressors and their outcomes were not differenciated by the kinds of support. This result indicated that job control was influenced more by the source of support than the kinds of support provided at work； and the most efficient source of support was the organization. Organizational support was a strong factor in improving workers" perceived controllability of their jobs from a work stress reduction perspective.tive.

• Proceedings of the Korean Society of Applied Pharmacology
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• 1995.10a
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• pp.107-113
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• 1995

Basement membrane laminin is a multidomain glycoprotein that interacts with itself, heparin and cells. The distal long arm plays major cell and heparin interactive roles. The long arm consists of three subunits (A, B1, B2) joined in a coiled-coil rod attached to a terminal A chain globule (G). The globule is in turn subdivided into five subdomains (Gl-5). In order to analyze the functions of this region, recombinant G domains (rG, rAiG, rG5, rGΔ2980-3028) were expressed in Sf9 insect cells using a baculovirus expression vector. A hybrid molecule (B-rAiG), consisting of recombinant A chain(rAiG) and the authentic B chains (E8-B)was assembled in vitro. The intercalation of rAiG into E8-B chains suppressed a heparin binding activity identified in subdomain Gl-2. By the peptide napping and ligand blotting, the relative affinity of each subeomain to heparin was assigned as Gl> G2= G4> G5> G3, such that G1 bound strongly and G3 not at all. The active heparin binding site of G domain in intact laminin appears to be located in G4 and proximal G5. Cell binding was examined using fibrosarcoma Cells. Cells adhered to E8, B-rAiG, rAiG and rG, did not bind on denatured substrates, poorly bound to the mixture of E8-B and rG. Anti-${\alpha}$6 and anti-${\beta}$1 integrin subunit separately blocked cell adhesion on E8 and B-rAiG, but not on rAiG. Heparin inhibited cell adhesion on rAiG, partially on B-rAiG, and not on E8. In conclusion, 1) There are active and cryptic cell and heparin binding activities in G domain. 2) Triple-helix assembly inactivates cell and heparin binding activities and restores u6131 dependent cell binding activities.

• Transactions of the Korean hydrogen and new energy society
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• v.21 no.1
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• pp.1-11
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• 2010

Current distribution measurement technique based on a segmented bipolar plate (BP) has been widely adopted to visualize the distribution of current density in a polymer electrolyte membrane. However, a concern is raised how closely the current density of a segmented BP can approach that of a corresponding non-segmented membrane. Therefore, in this paper, the accuracy of the measurement technique is numerically evaluated by applying a three-dimensional, two-phase fuel cell model to a $100\;cm^2$ area fuel cell geometry in which segmented BPs and non-segmented membrane are combined together. The simulation results reveal that the errors between the current densities of the segmented BPs and non-segmented membrane indeed exist, predicting the maximum relative error of 33% near the U-turn regions of the flow-field. The numerical study further illustrates that the erroneous result originates from the BPs segmented non-symmetrically based on the flow channels that allows some currents bypassing flow channels to flow into its neighboring segment. Finally, this paper suggests the optimal way for bipolar plate segmentation that can minimize the deviation of current measured in a segmented BP from that of a corresponding membrane region.

• Biotechnology and Bioprocess Engineering:BBE
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• v.7 no.1
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• pp.43-51
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• 2002

The cloning and expression of $\beta-glucosidase$ II, encoded by the gene ${\beta}glu2$, from thermotolerant yeast Pichia etchellsii into Escherichia coli is described. Cloning of the 7.3 kb BamHI/SalI yeast insert containing ${\beta}glu2$ in pUC18, which allowed for reverse orientation of the insert, resulted in better enzyme expression. Transformation of this plasmid into E. coli JM109 resulted in accumulation of the enzyme in periplasmic space. At $50^{\circ}C$, the highest hydrolytic activity of 1686 IU/g protein was obtained on sophorose. Batch and fed-batch techniques were employed for enzyme production in a 14 L bioreactor. Exponential feeding rates were determined from mass balance equations and these were employed to control specific growth rate and in turn maximize cell growth and enzyme production. Media optimization coupled with this strategy resulted in increased enzyme units of 1.2 kU/L at a stabilized growth rate of $0.14\;h^{-l}$. Increased enzyme production in bioreactor was accompanied by formation of inclusion bodies.

• Nuclear Engineering and Technology
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• v.46 no.6
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• pp.803-816
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• 2014

Defense-in-depth is a fundamental safety principle for the design and operation of nuclear power plants. Despite its general appeal, defense-in-depth is not without its drawbacks, which include its potential for concealing the occurrence of hazardous states in a system, and more generally rendering the latter more opaque for its operators and managers, thus resulting in safety blind spots. This in turn translates into a shrinking of the time window available for operators to identify an unfolding hazardous condition or situation and intervene to abate it. To prevent this drawback from materializing, we propose in this work a novel safety principle termed "observability-in-depth". We characterize it as the set of provisions technical, operational, and organizational designed to enable the monitoring and identification of emerging hazardous conditions and accident pathogens in real-time and over different time-scales. Observability-in-depth also requires the monitoring of conditions of all safety barriers that implement defense-in-depth; and in so doing it supports sensemaking of identified hazardous conditions, and the understanding of potential accident sequences that might follow (how they can propagate). Observability-in-depth is thus an information-centric principle, and its importance in accident prevention is in the value of the information it provides and actions or safety interventions it spurs. We examine several "event reports" from the U.S. Nuclear Regulatory Commission database, which illustrate specific instances of violation of the observability-in-depth safety principle and the consequences that followed (e.g., unmonitored releases and loss of containments). We also revisit the Three Mile Island accident in light of the proposed principle, and identify causes and consequences of the lack of observability-in-depth related to this accident sequence. We illustrate both the benefits of adopting the observability-in-depth safety principle and the adverse consequences when this principle is violated or not implemented. This work constitutes a first step in the development of the observability-in-depth safety principle, and we hope this effort invites other researchers and safety professionals to further explore and develop this principle and its implementation.