• Asian Pacific Journal of Cancer Prevention
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• 제14권7호
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• pp.4289-4294
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• 2013

Background: The purpose of this study was to assess the predictive effect of preoperative CEA and CA 19-9 levels on the prognosis of colorectal and gastric cancer patients. Materials and Methods: CEA and CA 19-9 were evaluated preoperatively in patients undergoing surgery for colorectal cancer (n=116) and gastric cancer (n=49). Patients with CEA levels <5 ng/mL were classified as CEA Group 1, 5-30 ng/mL as CEA Group 2 and >30 ng/mL were classified as CEA Group 3. Similarly the patients with a CA 19-9 level <35 U/mL were classified as CA 19-9 Group 1, with 35-100 U/mL as Group 2 and with >100 U/mL as Group and 3. TNM stages and histologic grades were noted according to histopathological reports. Patients with a TNM grade 0 or 1 were classified as Group A, TNM grade 2 patients constituted Group B and TNM grade 3 and 4 patients constituted Group C. Demographic characteristics, tumor locations and blood types of the patients were all recorded and these data were compared with the preoperative CEA and CA19-9 values. Results: A significant correlation between CA 19-9 levels (>100 U/mL) and TNM stage (in advanced stages) was determined. We also determined a significant correlation between TNM stages and positive vlaues for both CEA and CA 19-9 in colorectal and gastric cancer patients. In comparison between CEA and CA 19-9 levels and age, gender, tumor location, ABO blood group, and tumor histologic grade, no significant correlation was found. Conclusions: Positive levels of both CEA and CA 19-9 can be considered to indicate an advanced stage in colorectal and gastric cancer patients.

• Asian Pacific Journal of Cancer Prevention
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• 제14권2호
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• pp.781-784
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• 2013

Aim: The purpose of this study was to determine whether susceptibility to oral tongue squamous cell carcinoma (OSCC) is related to polymorphisms in the u-PA gene. Methods: We examined the rs2227564 C/T and rs2227562 G/A single nucleotide polymorphisms (SNPs) in 196 OSCC patients and 201 age- and gender-matched controls via direct sequencing and PCR-RFLP methods. Results: Significant differences were found in allelic and genotypic distributions of the rs2227564 and rs2227562 loci when comparing cases and controls. In addition, logistic analyses indicated that the rs2227564 C/T genotype was related to a 1.52-fold increased risk of developing OSCC (adjusted OR=1.521, 95%CI: 1.144~2.022, P=0.004). Linkage disequilibrium analysis was conducted and no association between the two loci was found (D'=0.031, $r^2$=0.000). Conclusions: Our findings provide evidence that the rs2227564 C/T SNP in the u-PA gene is associated with the development of OSCC.

• 대한후두음성언어의학회지
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• 제19권2호
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• pp.133-135
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• 2008

Background and Objectives: The voice changes can occur in peritonsillar abscess and the labeling of this changes as a "muffled voice". The aim of this study was to investigate the changes in acoustic feature of voice before and after treatment in patients with peritonsillar abscess. Materials and Method: 12 patients with peritonsillar abscess were enrolled in the study. Acoustic analysis on sustained Korean vowels /a/, /i/ and /u/ were performed before and after treatment. Results: In patients with peritonsillar abscess, the first formant frequency (F1) and second formant frequency (F2) of /a/ were decreased. There was tendency of articulation of back-low vowel /a/ as back-high vowel /u/. F1 of /i/ and /u/ were increased, while F2 were decreased. There was tendency of articulation of front-high vowel /i/ as back-low vowel /a/. The third, forth, fifth formant frequency (F3, F4, F5) of /a/, /i/ and /u/ were decreased although statistically not significant. Conclusion: The anatomical and functional changes of oropharynx by peritonsillar abscess can cause changes in resonance and speech quality. We suggest that these changes could be the cause of 'muffled voice' in patients of peritonsillar abscess.

• Journal of Chest Surgery
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• 제54권6호
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• pp.554-557
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• 2021

Surgeons are increasingly using the right mini-thoracotomy approach to perform aortic valve surgery. This approach has shown better results in terms of blood loss and length of hospital stay than the sternotomy approach. For selected patients requiring aortic root and ascending aorta surgery, a right mini-thoracotomy approach may prove beneficial. In our technique, we placed a 5-cm horizontal skin incision in the right second intercostal space. Femoro-femoral cardiopulmonary bypass was established. A valved aortic conduit was used for aortic root replacement. The patient's postoperative course was uneventful, with a short hospital stay. This technique offers a minimally invasive approach to aortic root and ascending aorta surgery with easy adaptability and reduced costs.

• 한국인터넷방송통신학회논문지
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• 제9권2호
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• pp.129-135
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• 2009

국내 병원들은 u-Hospital 서비스 구현을 위한 진료예약시스템을 구축, 운영하고 있고, 운영되고 있는 시스템의 대부분은 웹 기반의 방식을 사용하고 있다. 최근 등장하고 있는 Web 2.0 기술은 웹 방식에 있어서 편리한 UI 구조 제공, 빠른 응답서비스 등의 장점을 가지고 웹 영역의 많은 부분을 변화시켜 나가고 있다. 이 기술은 웹 영역을 넘어 모바일 영역에서 일부 응용이 시도되고 있다. 본 논문에서는 Web 2.0 기술을 적용하여 모바일 진료예약 시스템을 구축하였다. 이 시스템은 기존의 모바일 및 웹 기술에 비해 적은 페이지 뷰와 빠른 로딩속도로 인해 사용자의 편리성 및 응답속도를 개선하였고 성능실험을 통해 이를 증명하였다.

• 대한안전경영과학회:학술대회논문집
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• 대한안전경영과학회 2010년도 춘계학술대회
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• pp.127-135
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• 2010

In this paper, the u-Service system that is based on location-aware technology is designed for a silver town. It provides services such as emergency call, intelligent elevator operation, and hands-free door access based on the location of the residents with personal device as called smart tag. It can also be applied to other service areas such as the location-aware u-Service for Hospital, high-rising complex building, APT, etc.

• 대한두개안면성형외과학회지
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• 제21권2호
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• pp.99-105
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• 2020

Background: Due to the different handling properties of unsintered hydroxyapatite particles/poly-L-lactic acid (uHA/PLLA) and polycaprolactone (PCL), we compared the surgical outcomes and the postoperative implantation accuracy between uHA/PLLA and PCL meshes in orbital fracture repair. Methods: Patients undergoing orbital wall reconstruction with PCL and uHA/PLLA mesh, between 2017 and 2019, were investigated retrospectively. The anatomical accuracy of the implant in bony defect replacement and the functional outcomes such as diplopia, ocular motility, and enophthalmos were evaluated. Results: No restriction of eye movement was reported in any patient (n= 30 for each group), 6 months postoperatively. In the PCL group, no patient showed diplopia or enophthalmos, while the uHA/PLLA group showed two patients with diplopia and one with enophthalmos. Excellent anatomical accuracy of implants was observed in 27 and 22 patients of the PCL and uHA/PLLA groups, respectively. However, this study showed that there were neither any significant differences in the surgical outcomes like diplopia and enophthalmos nor any complications with the two well-known implants. Conclusion: PCL implants and uHA/PLLA implants are safe and have similar levels of complications and surgical outcomes in orbital wall reconstruction.

• 보건행정학회지
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• 제14권2호
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• pp.1-16
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• 2004

The study purpose was to find which factors affect selection of hospital network types. This study used the 1998 American Hospital Association Annual Survey Database from Health Forum. Among these U.S. hospitals, the researcher selected hospitals located in Metropolitan Statistical Areas. Therefore the final observation cases for analysis are 1,971 Metropolitan Statistical Area hospitals in the United States. To identify significant variables influencing hospital network types, the study used proportional odds logistics regression model on population size, Health Maintenance Organization penetration rate, and market competition rate of area including a hospital, types of hospital ownership, hospital bed size, proportion of Medicare patients and Medicaid patients in total hospital patients, and occupancy rate. Contrary to conventional wisdom, selection of hospital network types was influenced by population size of area which a hospital located, types of ownership, hospital bed size, and proportion of medicare patients rather than Health Maintenance Organization penetration. Population size 1,000,000-2,499,999 had the highest probability of selecting type IV (clinical-vertical integration) from an independent hospital, and a religious group owned hospitals and for-profit owned hospitals had the highest probability of selecting Type IV (clinical-vertical integration) from an independent hospital. A bed size had positive relation on selecting Type IV (clinical-vertical integration) from an independent hospital. Unlikely general belief that the selecting types of hospital network was determined by the change of health insurance policy such as Health Maintenance Organizations and Preferred Provider Organizations, the types of hospital network were influenced by community characteristics such as population size, and hospital characteristics.

• Asian Pacific Journal of Cancer Prevention
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• 제14권4호
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• pp.2311-2315
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• 2013

Objective: To investigate the expression level of TUG1 and one of its transcript variants (n377360) in osteosarcoma cells and assess the role of TUG1 in proliferation and apoptosis in the U2OS cell line. Methods: TUG1 and n377360 expression levels in patients with osteosarcomas and the U2OS human osteosarcoma cell line were evaluated using real-time quantitative PCR. U2OS cells were transected with TUG1 and n377360 siRNA or non-targeting siRNA. MTS was performed to assess the cell proliferation and flow cytometry was applied to analyze apoptosis. Results: We found significantly higher TUG1 and n377360 expression levels in osteosarcoma tissues compared with matched non-tumorous tissues. In line with this, suppression of TUG1 and n377360 expression by siRNA significantly impaired the cell proliferation potential of osteosarcoma cells. Furthermore, inhibition of TUG1 expression significantly promoted osteosarcoma cell apoptosis. Conclusions: The overexpression of TUG1 and n377360 in osteosarcoma specimens and the functional role of TUG1 and n377360 regarding cell proliferation and apoptosis in an osteosarcoma cell line provided evidence that the use of TUG1 or n377360 may be a viable but an as yet unexplored therapeutic strategy in tumors that over express these factors.

• Archives of Plastic Surgery
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• 제47권5호
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• pp.490-492
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• 2020