• 제목/요약/키워드: u-health

검색결과 2,353건 처리시간 0.035초

Tristetraprolin Inhibits the Growth of Human Glioma Cells through Downregulation of Urokinase Plasminogen Activator/Urokinase Plasminogen Activator Receptor mRNAs

  • Ryu, Jinhyun;Yoon, Nal Ae;Lee, Yeon Kyung;Jeong, Joo Yeon;Kang, Seokmin;Seong, Hyemin;Choi, Jungil;Park, Nammi;Kim, Nayoung;Cho, Wha Ja;Paek, Sun Ha;Cho, Gyeong Jae;Choi, Wan Sung;Park, Jae-Yong;Park, Jeong Woo;Kang, Sang Soo
    • Molecules and Cells
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    • 제38권2호
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    • pp.156-162
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    • 2015
  • Urokinase plasminogen activator (uPA) and urokinase plasminogen activator receptor (uPAR) play a major role in the infiltrative growth of glioblastoma. Downregulatoion of the uPA and uPAR has been reported to inhibit the growth glioblastoma. Here, we demonstrate that tristetraprolin (TTP) inhibits the growth of U87MG human glioma cells through downregulation of uPA and uPAR. Our results show that expression level of TTP is inversely correlated with those of uPA and uPAR in human glioma cells and tissues. TTP binds to the AU-rich elements within the 3' untranslated regions of uPA and uPAR and overexpression of TTP decreased the expression of uPA and uPAR through enhancing the degradation of their mRNAs. In addition, overexpression of TTP inhibited the growth and invasion of U87MG cells. Our findings implicate that TTP can be used as a promising therapeutic target to treat human glioma.

유헬스케어(U-health Care)에서 양도락의 활용 방안 (The Application of Ryodoraku in the U-health Care System)

  • 송호섭
    • Journal of Acupuncture Research
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    • 제27권6호
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    • pp.115-122
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    • 2010
  • Objectives : The purpose of this study was to propose the utilization plan of Ryodoraku in the U-health care systems. Methods : Computerized literature searches were performed for Ryodoraku related articles using the following databases: KISS, RISS, DBPIA, NDSL from 1990 to Oct 2010. Search terms were '양도락' or 'Ryodoraku' or 'U-health'. Due to Ryodoraku coming from Japan, additional literature review(articles published by 2008) on Japanese journal of Ryodoraku medicine was done for compensation. Results : 1. Introduction of U-health : As rapid progress of population aging and strong interest in health, the demand for the traditional Korean medical service is increasing. Until now healthcare service has provided post treatment by face-to-face manner. But according to related researches, proactive treatment is resulted to be more effective for preventing diseases. Particularly, the existing healthcare services have limitations in preventing and managing chronic geriatric degenrative diseases such as metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis, etc., because the cause of the above is complex and even related to life habit. As the advent of ubiquitous technology, patients with the chronic geriatric degenrative diseases can improve life habit such as poor eating habits and physical inactivity without the constraints of time and space through u-healthcare service. Therefor, lots of researches for u-healthcare service focus on providing the personalized healthcare service for preventing and managing that. To cope with this situations, The concept of u-healthcare service should be adopted in the traditional korean medicine and diagnostic devices suitable for it should be also devised and developed based on traditonal korean medine. 2. Review of existing Ryodoraku related articles for applying to U-health : articles investigating feasibility applying Ryodoraku to meridian diagnosis and raising problems of it, articles providing recent research trends of Ryodoraku, Ryodoraku related articles considering usefulness for U-health, and articles confirming the repeatability and reproducity of Ryodoraku were included. Based on the review of the above Ryodoraku related articles, several application of Ryodoraku in the U-health care system. Conclusions : To make preparations for the increasing need of traditional Korean medicine due to rising morbidity rate of chronic geriatric degenerative diseases, it is necessary to appropriately apply Ryodoraku to the U-health care system. The application of Ryodoraku is as follows. 1. To use Ryodoraku additionally to the established diagnostic device of metabolic syndrome, CVA, coronary heart diseases, parkinson's diseases, degenerative joint disease, spondylosis. 2. To apply Ryodoraku to the symptoms or diseases having a tendency to be diagnosed by correlation between the affected meridian and the lesion such as headache, nuchal pain, shoulder pain, low back pain, sciatica, HNP, etc. 3. To secure the repeatability and reproducity of Ryodoraku. 4. To devise and develop Ryodoraku appliance in order to overcome the known drawbacks and to improve error of measurement.

건강정보 교환 표준에 기반한 유비쿼터스 헬스케어 시스템 개발 (Development of an Ubiquitous Healthcare System based on Health Information Exchange Standards)

  • 이인근;김화선;조훈
    • 한국지능시스템학회논문지
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    • 제22권3호
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    • pp.273-280
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    • 2012
  • 의료 환경의 변화로 인해 개인의 건강관리를 위한 유비쿼터스 헬스케어(u-헬스케어) 서비스 및 시스템에 관한 관심이 증대되고 있다. u-헬스케어 시스템은 기본적으로 생체신호를 측정하기 위한 개인건강기기, 무선통신을 통해 개인건강기기로부터 전송되는 정보를 수집하는 정보수집기, 그리고 정보수집기로부터 전송되는 개인건강정보를 저장하고 관리하기 위한 건강정보시스템 등과 같은 다양한 기기와 시스템이 결합된 복합적인 환경으로 구성되어 있다. 이러한 기기 및 시스템 사이의 상호운용성을 위해 국제적으로 IEEE 11073이나 HL7과 같은 건강정보 교환 표준들이 발표되었으나, 국내에서는 이러한 표준을 적용한 u-헬스케어 시스템의 개발하여 실제 환경에 적용한 연구가 많지 않다. 따라서 본 논문에서는 건강정보 교환을 위한 국제 표준에 기반하여 혈당, 혈압, 체성분과 같은 건강정보를 관리할 수 있는 u-헬스케어 시스템을 개발한다. 또한 경북대학교병원 내분비계 질환자 대상의 임상시험을 통해 개발한 시스템의 안정성을 검증하고, 운영 과정에서의 문제점 및 개선 방안을 찾는다.

u-아동 신체 & 정선 건강 Wellness Care Service 설계 및 구현 (u-Children's Physical and Mental Health Wellness Care Service Design and Implementation)

  • 신유민;박범
    • 산업경영시스템학회지
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    • 제33권4호
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    • pp.28-37
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    • 2010
  • In this study, services for promoting health were provided to kindergarten children. As u-Health services for children, services centered of positioning of children are provided. However, since problems related with obesity and mental health are increasing day by day due to westernized eating habits, the necessity of physical and mental health care for children is on the rise. Considering this state, in this study, experiments of u-Health services under the concept of wellness were conducted on kindergarten children. For physical health, the children's obesity was controlled and for mental health, services of diagnosing hyperactivity disorder which is a sub symptom of ADHD were provided. Based on the results, it could be identified that parents' satisfaction and children's health conditions were improved.

u-Health 생활지원시스템 시범 서비스 (u-Health Life Support System Trial Service)

  • 김선칠;박기현
    • 대한디지털의료영상학회논문지
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    • 제11권2호
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    • pp.79-84
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    • 2009
  • Recently, there has been a rapid increase of interest in u-Health systems or instruments. The importance of testbeds has been discussed deeply also. However, beyond laboratory or ward environments, testbeds covering metropolitan area cannot be found easily. Moreover, there has been few papers which discuss the results of testbed operations for various instruments in different age groups. In this paper, the results of testbed which operated in Daegu metropolitan area are discussed and improvement directions to strengthen the competitiveness are proposed using user analysis. In particular, the results of trial services using the u-Life support instruments (medication reminder, falling safety phone, bio-patch and shirts, etc) for super aging societies in the near future are discussed.

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미국에서의 침술과 카이로프랙틱 건강보험 급여 현황 (A Study on Current Status of Acupuncture and Chiropractic Health Insurance in the United States)

  • 김주철;이은경;김동수
    • 대한예방한의학회지
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    • 제23권1호
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    • pp.1-13
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    • 2019
  • Backgrounds : The market of Complementary Alternative Medicine(CAM) in the United State(U.S.) accounts for a large proportion of the global CAM market and has a high growth rate. The recent introduction of Obama Care has brought the change in the health insurance system for CAM, and we need to analyze it for its implication to Korean system. Objectives : The purpose of this study is to investigate the current status of acupuncture and chiropractic health insurance in the U.S., and to draw implications for expanding the health insurance coverage for Korean traditional medicine through the comparison between the U.S. and Korean health insurance systems. Methods : We examined the data through the literature search and from the websites of both U.S. government departments and related organizations for the health insurance policy. Based on the collected data, we analyzed its CAM health insurance system in Korea. Results : The acupuncture covered by public health insurance in the U.S. has a limit in the number of treatments and a range of applied diseases compared with Korea. In addition, the practice of acupuncture is not subdivided. However, the chiropractic in the U.S. which also has a limited number of coverage and only three categories of practices are similar to that of Korea. Conclusions : Although the use of CAM by public health insurance is not active in the U.S., but the organizations such as Veterans Health Administration in Vermont is already discussing the use of acupuncture to solve the problem of opioid overuse. Thus Korea also needs to discuss to promote the expansion of the insurance system for CAM.

u-Health System을 위한 생체신호 모니터링에 관한 연구 (A Study on Monitoring of Bio-Signal for u-Health System)

  • 한영환
    • 한국컴퓨터정보학회논문지
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    • 제16권3호
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    • pp.9-15
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    • 2011
  • u-healthcare 시스템은 센서 네트워크로부터 수집된 대량의 생체신호를 신속히 처리 분석하여 의료진에게 전달함으로써 시간과 장소에 관계없이 환자에게 적절한 의료 서비스를 제공할 수 있다. 현존하는 u-healthcare 시스템들은 단지 환자의 건강 상태만을 모니터링 한다. 본 논문에서는 무선 센서네트워크에 기반한 u-health 모니터링의 프로토타입을 구현하고 검증하였다. 이 시스템은 수집된 생체 신호를 신속히 분석하여 의학적으로 의미 있는 결과를 도출하는 것이 용이하다. 이 모니터링 시스템은 피검자의 이상 데이터 수집 시에만 서비스 제공자에게 데이터를 전송한다. 이러한 방법은 모니터링부와 서비스 제공자사이의 무선 데이터 패킷의 부하를 줄일 수 있다. 실시간 생체 신호 모니터링 시스템을 구현함으로 유-헬스 서비스가 가능하게 되고 의료서비스의 효율성을 향상시킨다.

USN 기술을 이용한 건강정보 관리 시스템 설계 (Design of a Management System of Health Information based on USN)

  • 임영문;김남돈
    • 대한안전경영과학회:학술대회논문집
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    • 대한안전경영과학회 2009년도 춘계학술대회
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    • pp.439-444
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    • 2009
  • Recently ubiquitous sensor network(USN) technique has been applied into various industrial fields such as construction of u-city, civil and architectural engineering, medical areas. The main objective of this paper is to design a u-health system based on USN. Compared to the previous researches, the proposed system in this paper was designed to activate with collected information about health in outdoor environment.

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U-Health 관리를 위한 케어모델 구현 (Implementation of Care Model for Management of U-Health)

  • 홍진근;손동철;김기홍
    • 한국산학기술학회:학술대회논문집
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    • 한국산학기술학회 2006년도 춘계학술발표논문집
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    • pp.498-501
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    • 2006
  • 본 논문에서는 고령화 사회로 진입되고 있는 우리 사회에서 더 한층 관심이 고조되고 있는 의료 서비스를 목표로 하는 U-Health 케어 시스템의 선진국의 사례와 함께 적용 가능한 U-Health 케어 시스템 모델을 제시하였다.

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