• Clinical and Experimental Reproductive Medicine
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• 제9권1_2호
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• pp.29-41
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• 1982

This retrospective clinical study was done based under the delivery records of 146 cases of twin pregnancies in Yonsei University, Severance Hospital and Wonju Christian Hospital from 1977 through 1980 with particular interest in the second twins. Clinical factors, Apgar scores related to neonatal prognosis, and perinatal mortality rate were statistically analyzed and the following results were obtained. The mean - birthweight for A (first) twins was 2,377 grams and for B (second) twins 2,296 grams. In comparison of the percentage of low-birth-weight (less than 2,500 grams) infants, there were more small B twins, but the difference was statistically not significant. Because there were no significant statistical differences in birth weight-grouping between A and B twins, they could be compared with the comprehensive Apgar scores, but this method was also shown to be statistically not significant. In comparison of the percentage of breech deliveries in A and B twins, the percentage was more than three times in B twin (A twin, 7.5 per cent; B twin, 24.0 per cent), and the difference was statistically very significant (p < 0.0005). There were no significant statistical differences between the Apgar scores of A and B twins in reference to the manner of delivery. According to the manner of delivery of B twins, spontaneous vertex delivery and total breech extraction revealed higher infant mortality rate than others. B twins presented by the vertex in 88 cases (61.0 per cent), by the breech in 55 cases (37.0 per cent), and by the shoulder in 3 cases (2.0 per cent). And this therefore disclosed no significant statistical differences in Apgar scores in relation to the presentation. The duration of labor appeared to have no clear correlation with the Apgar scores and the perinatal mortality of A and B twins. The delivery interval between A and B twins was 11.9 minutes on an. averge, varying from 3 to 65 minutes. The length of this interval was not found to have any significant effect on the Apgar scores and the perinatal mortality rate of B twin.

• Advances in pediatric surgery
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• 제15권2호
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• pp.157-160
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• 2009

Although the incidence of esophageal atresia (EA) is higher in twins than in singletons by two to three times, EA usually affects only one member of twins. We report one pair of twins concordant for EA. A 31-year-old healthy woman bore monozygotic female twins at 36 weeks of gestation. They weighed 2,216 and 2,480 g, respectively. They had EA with distal tracheoesophageal fistula and underwent primary esophageal anastomosis on the birth day and the $2^{nd}$ day of life, respectively. Twin A also had suspicious antral obstruction and pyloroplasty was done simultaneously with esophageal repair. She needed antral web excision for continued gastric stasis one month after $1^{st}$ operation and three balloon dilatations of the esophagus. Twin B recovered uneventfully.

• Journal of Yeungnam Medical Science
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• 제5권2호
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• pp.255-261
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• 1988

저자들은 본원에서 제왕절개술에 의해 태어난 후 약 3시간만에 사망한 dicephalus type의 conjoined twins를 1례 경험하였기에 문헌 고찰과 함께 보고하는 바이다.

• 품질경영학회지
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• 제45권4호
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• pp.601-610
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• 2017

Purpose: Authors observe the digital twin enabled smart factory and/or digital manufacturing processes where Industry 4.0 technologies and quality management principles intersect. In this regard, this study reviews existing research regarding digital twins from the perspective of quality management. Methods: Initially, attention was given to how digital twins are manifested in the Industry 4.0 environment. Then, authors identify quality management elements amongst digital twin models, to align the concept of quality with the functional purpose of digital twins. After introducing specific examples of quality management tools applied to digital twins, the authors extend the domain of quality management into the analysis of multimedia format quality data obtained through machine vision. Results: Inspired by cases on the quality management application to digital twins, the authors suggest a framework for Industry 4.0 quality management. The envisioned suggested framework encompasses 4 dimensions, namely, 4M&1E, an application time window, new methodologies, and enabling technologies. Conclusion: Finally, the authors unfold the emerging trend of digital twin enabled smart factories, while emphasizing the necessity of quality management in conjunction with the introduction of digital twins.

• International journal of advanced smart convergence
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• 제10권4호
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• pp.84-97
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• 2021

Digital twins are one of the promising digital technologies used to facilitate digital transformation. Therefore, it needs to continually be developed remain relevant in industry and academia. Consolidation of research is required to create a common understanding of the topic and to ensure that future research is built upon a solid foundation. Based on a bibliometric review and a thematic analysis of 217 publications on digital twins from the past two decades, this paper creates and analyzes a visual knowledge map and proposes areas for further research. To comprehensively analyze the development trends and research trends of digital twins, we performed statistical analysis of the relevant literature on digital twins within the core collection database of Web of Science. Through our research, we have shown that the current situation, trends, and hotspots of digital twin research were analyzed via CiteSpace. This study demonstrates that research on digital twins is rapidly growing in popularity, that the output of the research depends largely on the core group of authors conducting it, and that digital twins warrant cross-domain and cross-disciplinary research pathways.

• Childhood Kidney Diseases
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• 제25권1호
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• pp.35-39
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• 2021

Bartter syndrome is an autosomal recessive hypokalemic salt-losing tubulopathy, and classic Bartter syndrome is associated with mutations in the CLCNKB gene. While chronic hypokalemia is known to induce renal cyst formation in different renal diseases, renal cyst formation in Bartter syndrome is rarely reported. Russian six-year-old identical male twins were referred to our hospital for the evaluation of renal cysts, which were incidentally detected on abdominal sonography due to diarrhea. Both twins had shown symptoms of polydipsia, polyuria, and nocturia since they were one year olds. Vital signs including blood pressure were normal in both twins. Renal sonography revealed nephromegaly, increased echogenicity of renal cortex, and various sized multiple cysts in both kidneys for both twins. Laboratory findings included hyponatremia, hypokalemia, hypochloremia, and metabolic alkalosis. Bartter syndrome with renal cysts were suspected. Genetic analysis for both twins confirmed a homozygous c.1614delC deletion on exon 15 of the CLCNKB gene, which was confirmed as a previously unreported variant to the best of our knowledge. They were managed with potassium chloride, nonsteroidal anti-inflammatory drugs, and angiotensin-converting-enzyme inhibitors. Metabolic alkalosis, hypokalemia, hypochloremia, and polyuria partially improved during the short course of treatment. This is the first report of a homozygous mutation in the CLCNKB gene in an identical twin, presenting with renal cysts.

• Neonatal Medicine
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• 제18권2호
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• pp.197-203
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• 2011

목적: 35세 이상 산모에서 체외 수정 시술을 통해 출생한 쌍생아와 자연 임신 쌍생아의 임상 양상을 비교하여 35세 이상 산모와 체외 수정 시술로 출생한 신생아 관리에 기초 자료 제공을 위하여 실시하였다. 방법: 2001년 1월 1일부터 2010년 12월 31일 사이 분당차병원에서 출생한 쌍생아 중 산모의 나이가 35세 이상인 신생아 508례를 대상으로 하여, 체외 수정 시술을 시행 받은 288례와 자연 임신군 220례 사이의 주산기 특성과 합병증 및 신생아기 질환발생의 차이를 의무 기록을 통해 후향적으로 조사하였다. 결과: 체외 수정 시술군과 자연 수정군 사이의 산모 연령은 (36.7${\pm}$2.07세 vs. 36.8${\pm}$2.18세, P=0.57)로 통계적 차이는 보이지 않았다. 재태 연령($36^{+0}{\pm}1^{+5}$주 vs. $36^{+0}{\pm}2^{+0}$주, P=0.95), 출생체중(2,420${\pm}$440 g vs. 2,480${\pm}$460 g, P=0.14) 역시 차이는 보이지 않았다. 1분 아프가 점수(7.37${\pm}$1.19 vs. 7.09${\pm}$1.46, P=0.019)와 5분 아프가 점수(8.67${\pm}$0.84 vs. 8.51${\pm}$0.96, P=0.045)는 모두 체외 수정 시술군에서 높았다. 임신성 당뇨, 임신성 고혈압, 전치태반, 조기 양막 파수, 제왕 절개술, 부당 경량아의 빈도는 두 군간의 차이가 없었다. 조발형 패혈증의 빈도는 체외 수정 시술군에서 자연 수정군보다 낮았다(2.4% vs. 6.4%, P=0.02). 그밖에 신생아 호흡 곤란 증후군, 기관지 폐 형성이상, 동맥관 개존증, 신생아 괴사 장염, 뇌실 내 출혈의 발생 빈도는 모두 두 군 간에 차이가 없었다. 결론: 본 기관에서 지난 10년간 고연령 산모에서 체외 수정 시술로 태어난 쌍생아의 임상 양상을 조사하여 자연 수정으로 출생한 쌍생아와 비교하였을 때, 체외 수정 시술로 인하여 주산기 합병증과 신생아기 질환의 발생 빈도가 높아지지는 않았다.

• 자원환경지질
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• 제40권4호
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• pp.461-471
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• 2007

고응력사의 지시자로서 방해석 쌍정 분석법을 이용하여 방해석내 쌍정이 생성될 당시의 변형온도와 고응력장의 상태 및 방향 등을 살펴보았다. 연구는 한반도 남부지역에 소규모로 불규칙하게 분포하고 있는 석회질 암석을 대상으로 수행되었다. 분석 결과에서 쌍정의 형태(한 방향 또는 두 방향의 얇고 두꺼운 직선형 쌍정), 변형률(1.235-7.453%), 두께($0.77-1.94{\mu}m$), 치밀도(25.26-41.99 twins/mm) 등을 고려하여 추정한 연구지역에서의 방해석 쌍정에 의한 변형온도는 약 $150^{\circ}-200^{\circ}C$ 이하로 나타났다. 주변형률의 크기와 방향에서 최대수축변형률($e_3\leftrightarrow{\sigma}_1$)의 방향은 경상분지 남부에 해당하는 GS-1와 영남육괴 남부에 해당하는 BS-1 지역에서 N-S, 그리고 옥천습곡대 서남부에 해당하는 NR-1 지역에서는 E-W 방향을 보였다. 최대인장변형률($e_1\leftrightarrow{\sigma}_3$)의 경우 GS-1과 BS-1 지역은 $NWW-SEE{\sim}NNE-SSW$ 그리고 NR-1 지역은 N-S 방향으로 나타났다. 즉, 연구지역에는 방해석 쌍정의 생성과 관련된 서로 다른 고응력장이 최소한 두 번 이상 작용했을 가능성을 시사한다.

• 한국보육지원학회지
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• 제9권6호
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• pp.267-288
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• 2013

본 연구는 쌍둥이 출산이 증가하는 시대의 흐름에 따라 쌍둥이 자녀를 양육하는 어머니의 육아고충과 어려움에 대한 심층적인 이해를 도모하고, 이에 따른 적절한 지원책을 모색하고자 하는데 목적이 있다. 이를 위해 P시에 거주하며 영아 쌍둥이를 양육하는 어머니 6명을 대상으로, 2012년 12월부터 2013년 8월까지 두 차례의 심층면담을 실시하였다. 연구결과 첫째, 영아 쌍둥이 육아경험에서 어머니가 인식하는 자녀가 겪는 어려움으로는 욕심도 사랑도 나누어야 하는 아이들, 환경의 제약을 받는 아이들, 태생 자체가 약한 아이들로 나타났다. 둘째, 영아 쌍둥이 육아경험에서 어머니가 인식하는 본인의 어려움은 아플 시간도 없는 엄마, 몸도 마음도 쓸쓸한 엄마, 경제적 부담을 힘들어 하는 엄마로 나타났다. 이를 위해 쌍둥이에 대한 사회적 인식의 변화와 정서적, 경제적 지원 시스템이 구축되어야 할 것을 제안한다. 본 연구의 결과는 향후 쌍둥이 육아지원의 활성화를 돕는 기초자료가 될 수 있을 것이다.

• 한국수산과학회지
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• 제30권6호
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• pp.1058-1059
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• 1997