• Korean Journal of Microbiology
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• v.46 no.2
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• pp.122-126
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• 2010

RAD53 functions as an effector kinase of checkpoint pathways in Saccharomyces cerevisiae, which plays a central role to regulate many downstream cellular processes in response to DNA damage. It also involves in transcriptional activation of various genes including RNR genes which encode the key enzyme required for dNTP synthesis. In this study, we identified CYC8 as a suppressor for the hydroxyurea sensitivity of $rad53{\Delta}$ mutation. $Rad53{\Delta}$ mutant transformed with a multi-copy plasmid containing CYC8 showed increased hydroxyurea resistance. In contrast, TUP1 which forms a complex with CYC8 did not function as a suppressor. In the case of mutations, both $cyc8{\Delta}$ and $tup1{\Delta}$ suppressed hydroxyurea sensitivity of $rad53{\Delta}$. Since CYC8 can propagate as a prion in yeast, overexpression of CYC8 induced misfolding of the normal CYC8 proteins, resulting in dominant cyc8-phenotype. Therefore, it is suggested that CYC8 can act as a multi-copy suppressor due to its prion property. It was observed that the levels of RNR transcription were increased in the yeast strains containing either multi-copies of CYC8 gene or $cyc8{\Delta}$ mutation, suggesting that the increased level of RNR will elevate the intracellular pools of dNTPs, which, in turn, suppress the phenotype of $rad53{\Delta}$ mutation.

• Journal of Korean Society of Forest Science
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• v.104 no.2
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• pp.221-229
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• 2015

The purpose of study was to broaden our knowledge on the productivity and cost of thinning operations which has become increasingly practiced in Korea. The thinning operations were conducted in a 40-year old larch (Larix leptolepis) stand, including chainsaw felling and processing at the stump, followed by yarding tree-length logs using a Koller K301-4 tower yarder. The logs were further processed and sorted into 1.8 m and 3.6 m log piles at the landing. We used a standard time study method to evaluate key variables that affect the productivity of thinning operations. The total stump-to-pile operational cost was $41,707won/m^3$. The highest cost activity was the yarding phase which cost $20,083won/m^3$ (48.2% of the total cost), followed by the costs of processing treelength materials into marketable log lengths ($12,143won/m^3$; 29.1%), and then by the costs of sorting/piling the processed logs ($5,039won/m^3$; 12.1%). It was interesting to see that felling and processing trees at the stump had low costs at $1,315won/m^3$ (3.2%) and $3,127won/m^3$ (7.5%), respectively. We used the detailed time study data to develop regression equations which were to predict yarding productivity. Our analysis showed that harvesting system cost was highly sensitive to the number of logs, yarding distance and lateral distance per turn, respectively.

• Korean journal of communication and information
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• v.22
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• pp.77-106
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• 2003

As globalization of communication is going on and as the media have become increasingly central to the world economy, media policy matters have become the province of world economic organizations like the IMF and the WTO. The WTO service negotiation is focused primarily on the discriminatory and quantitative barriers associated with the trade of audiovisual services. Domestic measures such as subsidization, content regulation including quotas, and licensing requirements and restrictions on foreign ownership and control are at issues here. These measures have been successfully implemented by countries wishing to withstand competition from the American audiovisual industry. The debate about trade in audiovisual services is permeated by the unstated assumption that these programs are pure commodities whose production, distribution, exhibition and in turn, values are solely determined by the market forces. It is therefore presumed that liberalization of trade in audiovisual services will benefit all, serving cultural pluralism and diversity as well as economic efficiency. However, this assumption is not shared by developing countries, the recipients of U.S. television material. They argue audiovisual sector requires a social and cultural approach, since it plays a key role in the preservation of people's identity and social bonds. They claim that it is the each state's right to define its media policy and to implement it through the means it considers fit. These clashing views over the nature of the audiovisual material and the ways in which protect cultural pluralism and diversity do not confine to be the realm of theoretical debate. Each state's interest and motivation to protect its local industry and to have a competitive advantage in the international market is working in this battle. Consolidation with the countries like Australia, Canada, and EU nations, in favour of cultural exemption, seems to be the best policy for us. However, we are not entirely free from the WTO pressures, considering relation to the U. S. This study analyzes Korean Broadcasting Law compared with those of other OECD countries and tries to propose some strategical guidelines facing WTO service negotiation in the area of broadcasting.

• Journal of Science and Technology Studies
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• v.12 no.1
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• pp.1-43
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• 2012

This paper examines the American Civil Liberties Union(ACLU)'s recent legal challenge on patents held by Myriad Genetics on two genes (BRCA1 and BRCA2) associated with a high risk of breast and ovarian cancer. Instead of analyzing the ACLU's objections to the BRCA patents in terms of its legal technicalities and normative ethical principles, this paper seeks to situate this legal case in the broader historical context of the shifting understanding of the relationship between private ownership, economic development, and the public interest in academic sciences. This paper first briefly chronicles a series of scientific developments and key legal decisions involving patenting of life forms, including genetically engineered micro-organisms animals and biological materials of human origins like cell cultures and genes, that led to the US Patent and Trademark Office(USPTO)'s official guidelines on human gene patenting in 2001. At another level, this paper analyzes the expansion of the scope of intellectual property rights in the life sciences in terms of shifting economic and legal assumptions about public knowledge and its role for economic development in the 1970s. I then show how these economic, legal, and ethical ideas that linked private ownership and the public interest have been challenged from the 1990s, calling for revisions in intellectual property laws regarding a wide array of life forms. The tragedy of the anticommons in human gene patenting, according to ACLU, has severely undermined creative scientific activities, medical innovations, access to health care and rights to life among cancer patient groups. ACLU's objection to human gene patenting on several US-constitutional grounds in turn suggests issues regarding intellectual property are critically linked to vital issues pertinent to the creative communities in arts and sciences, such as free exchange of ideas, censorship and monopoly, and free expression and piracy etc.

• Journal of the KSME
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• v.21 no.1
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• pp.21-31
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• 1981

원자력발전소의 원자로냉각재 압력경계의 건전성과 안정성을 확보하기 위하여 법적 요구조건을 설정함에 있어 파괴역학이 어떻게 적용되었는 가를 설명하였다. 이를 요약하면 다음과 같다. 1) 압력경계에 사용되는 재료의 $RT_{NDT}$를 정의하였다. 이는 무연성천이온도와 같은 개 념의 것으로, 앞으로 재료의 파괴인성은 이 $RT_{NDT}$에 대한 상대온도의 함수로 주어진다. 2)비연성파괴를 방지하기 위한 설계조건으로서 선형탄성 파괴역학에 근거한 조건식을 인용하였다. 여기서 조건식이란 능력확대계수의 합계가 어떠한 조건에서도 이러한 조건식을 만족한다는 것을 해석적으로 확인하고 규제당국의 승인을 받아야 한다. 3) 가동중검사에 발견된 결함으로 합격수준을 초과하는 것은 파괴역학적으로 해석하여 구조적 으로 안전하다는 것은 파괴역학적으로 해석하여 구조적으로 안전하다는 것을 입증하여야 한다. 이때 결함은 원자로의 가동과 더불어 성장하므로 수명기간중 피로파괴에 이를 것인지의 여부도 평가하여야 한다. 이때의 대조균열성장률은 Paris의 power law에 따른다. 4) 고속중성자 (E>1. 0MeV)에 의한 조사취화를 감시하기 위하여 감시시험계획을 사전에 수립 하고 이에 따라 감시시험을 수행하여 조사에 수립하고 이에 따라 감시시험을 수행하여 조사에 의한 원자로용기 재료의 파괴인성의 저하를 평가하여 이를 고려한 충분한 안전여유를 갖는 운 전조건 즉, 압력-온도 한계곡선을 산출하여야 한다. 이때의 취화 정도는 DELTA. $RT_{NDT}$ 와 Upper Shelf Energy의 감소로 나타낸다. 또한, 압력-온도 한계곡선은 선형관성 파괴역학에 입각한 조건식을 이용하여 해당 온도에서의 압력을 산출한다. System을 개발 사용하기 위하여 기존 전자계산소를 이용하는 방법이 바람직하며 System의 도입은 자체운영을 결정하기 전에 경제적인 여건 등 여러가지 문제를 검토하여야 한다. 특히 Turn Key Base로 System를 도입할 경우에는 System의 도입목 적과 사용빈도, 앞으로의 확장성 현재 설계및 생산 과정과의 마찰가능성, 유지보수문제 등을 신 중히 검토하여야 한다. 이제 기계공업도 전자계산기를 이해하고 사용하므로 서 발전할 수 있는 단계가 되었다. 예로부터 좋은 공구를 개발하여 적절히 사용하는 것이 기계공업 발전의 첩경이 었다. 전자계산기는 현대 기술이 개발한 가장 강력하고 사용하기 좋은 공구이다.점에서 피로구열의 안정성장을 논하고, 과거 10여년간의 피로 crack문제에 대한 연구방법, 실험방법 등을 소개하는 방향으로 고 를 진행시켜 나가겠다.에 그 효과가 증대됨을 알 수 있었다.적용한 임상실험이 수행되어야 할 것이다. 또한 위치결정에서 획득한 좌표값의 정확성을 알아보기 위해서 팬톰을 이용한 방사선조사 실험이 추후에 실행되어져야 할 것이다. 그리고 제작된 프레임에 Rotating X선 시스템과 내부 장기의 움직임을 계량화하고 PTV에서의 최적 여유폭을 설정함으로써 정위 방사선수술 및 3 차원 업체 방사선치료에 대한 병소 위치측정과 환자의 자세에 대한 setup 오차측정 결정에 도움이 될 수 있을 것이라고 사료된다. 상대적으로 우수한 것으로 나타났으며, 혼합충전재는 암모니아의 경우 코코넛과 펄라이트의 비율이 7：3인 혼합 재료 3번과 소나무수피와 펄라이트의 비율이 7：3인 혼합 재료 6번에서 다른 혼합 재료에 비하여 우수한 것으로 나타났다. 4. 코코넛과 소나무수피의 경우 암모니아 가스에 대한 흡착 능력은 거의 비슷한 것으로 사료되며,

• Journal of Distribution Science
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• v.12 no.8
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• pp.31-42
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• 2014

Purpose - Recently, a variety of activities for practicing the continuing management of domestic and foreign companies have been conducted and further, corporate social responsibility for maximizing the value of stakeholders such as customers, cooperative companies, and the local community emerges as a key business strategy. Accordingly, the issue of whether corporate image and customer value through corporate social responsibility activities positively affect customer loyalty and customer attitude is investigated in this study. Research design, data, and methodology - Corporate social responsibility activities are classified into legal and moral activities, environmental protection activities, economic activities, and community service activities; further, customer values are classified into emotional value, functional value, and social value, to determine the parameters. In addition, the strategic approach direction of social responsibility activities is justified as a strategy for effectively achieving the expected results that corporations seek by proving the effect of these parameters on customer loyalty. Results - The study results can be summarized as follows. First, legal and moral activities, environmental protection activities, economic activities, and community service activities are four types of CSR activities affecting meaningful improvements in corporate image. Second, legal and moral activities affect factors that meaningfully improve customer value, including factors such as emotional value, functional value, and social value, while environmental protection activities affect improvements in the factor of social value only. Third, corporate image affects meaningful improvements in customer value. Fourth, corporate image affects improvements in customer loyalty positively. Fifth, the three factors of customer value, that is, emotional value, functional value, and social value affect meaningful improvements in customer loyalty. Sixth, customer value acts to partly mediate the effect of companies' CSR activities on customer loyalty. As shown in the study results above, it was verified that CSR activities affect meaningful improvements in corporate image and customer value and, in turn, corporate image and customer value affect meaningful improvements in customer loyalty. In addition, it was verified that customer value acts to partly mediate the effects of companies' CSR activities on customer value. Conclusions - Accordingly, the results of this study suggests as follows. First, it was clearly verified that customers' recognition of CSR efforts has a positive effect on corporate image, customer value, and loyalty because CSR activities improve the relationships between customers and corporations by providing customers with value. Second, it was suggested that corporations implement social contribution activities strategically according to the theory that the higher the rate of CSR activities, the better the corporate image and repurchase intention would be, which is a theory verified through practical analysis. Corporations should do this by constructing positive relationships from the value perceived by customers. To summarize the study results in a brief manner, it is suggested by the results of the study that a corporation should conduct CSR more actively to make customers recognize the positive image of their products and services.

• Journal of Digital Convergence
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• v.19 no.9
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• pp.105-114
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• 2021

The paper investigates a mediating effect of job embeddedness in the influence of positive psychological capital on organizational citizenship behavior(OCB) for members of medical institutions. The members include medical doctors, nurses, medical technicians, health administrative staffs, and other medical service staffs of hospitals in Daejeon City, Chungcheongnam-do, Chungcheongbuk-do, and Sejong City. Using 453 questionnaires for hypothesis tests, the main results are as follows. Firstly, positive psychological capital exerts a significantly positive effect on OCB. Secondly, the fit and links of job embeddedness turn out to have a significant and positive effect on OCB, whereas the sacrifice does not have statistically significant effect on it. Thirdly, while the fit and links of job embeddedness appear to have mediating effects between positive psychological capital and OCB, the sacrifice of it does not exert a mediating effect. The findings thus suggest that we need a new approach to the role of job embeddedness in the positive impacts of positive psychological capital on OCB through the fit and links of job embeddedness. Furthermore, organizations need to focus on key elements in the application of job embeddedness.

• 한국사회정책
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• v.25 no.2
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• pp.191-217
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• 2018

At the turn of the century, social policy in both developed and developing countries confronts new challenges and risks caused by the multiple crises in finance, food, energy and climate change. Changes in the structures of risks are particularly significant. In addition, the global economic crisis starting in 2008 has provided a new context of the global political economy. Both developed and developing countries have responded to these new challenges and risks differently. What risks do these responses aim to address? How can these responses address these risks? Can these diverse responses offer lessons for lower income economies attempting to address social development challenges alongside economic growth in the globalised and increasingly uncertain 21st century context? This paper aims to provide a critical review of the new trends, phenomena or directions of social policy discourse and practice to respond to the new risks in the context of development. Explaining the nature and forms of new challenges and risks and pointing out the potentials and limitations of social policy discourse, it introduces the key points of the previous research we have to keep in mind in formulating alternative social policy approaches. General principles and core elements of social policy in addressing new challenges and risks in the $21^{st}$ century, which are particularly visible in social policy reforms in emerging economies, are highlighted as a conclusion.

• Journal of Technology Innovation
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• v.26 no.4
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• pp.146-172
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• 2018

In the Small and Medium Enterprises(SMEs) sector, research has shown an increasing trend due to changes in industrial society and policy. Therefore, the interrelationship between academic research and policy is relatively high. In this study, we analyzed the trends of academic research related to SMEs innovation policy. Moreover, we examined the interrelationships. By using text mining techniques, we have identified key themes and changes in domestic policy papers published since the announcement of the "Five-Year Plan for Innovation of SMEs". Also, we compared them with "Five-Year Plan for Innovation of SMEs" of each period. The result shows that the gap between academic research and policy has been closing over time. This study shows that there is an increasing number of research studies that verify policies at the relevant time from an academic point of view, and that policy issues are in turn influencing academic research due to government-driven policies. Also, it was confirmed that there was a time gap between academic research and policy. Academic research tended to increase compared to the previous year's level, when the policy had been implemented. The results of this study are expected to contribute to the establishment of the "2019~2023 five-year plan for Small and Medium Enterprises" which will be announced in the future, and this study will demonstrate the possibility of devising evidence-based policy.

• Korean Journal of Heritage: History & Science
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• v.51 no.4
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• pp.234-253
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• 2018

Within the Gyeongju Basin lies the central an ancient tombs (Wolseongbuk tombs), which are seen to be the core tombs of the Silla ruling class. An accurate understanding of the location of the ancient tombs, commonly known as a flatland area, provides a clue to understanding the contrast process and direction of the ancient tombs. This in turn requires an accurate understanding of the surrounding landscape, including where the ancient tombs are located. In other words, it must be possible to restore as much of the highland area as possible within the basin in which the ancient tombs are located. All data were analyzed as deeply as possible in order to identify the topographical features of the ancient tombs. As a result, it appears that the ancient tombs are located at the end of a fan or at the end of the line, and a large number of springs and wetlands are distributed around the area. This area is relatively low and unsuitable for generating high levels of moisture on the ground. These topographical features are directly related with the distribution of polymers, and solids were completely formed to avoid wetlands. Meanwhile, the ancient tombs are divided into several zones by springs and wetlands, and each area also has the characteristics of large groups where the boundaries are protruding and isolated. Also, this aspect was found to be true for the Oreung around Namcheon. After all, the location and distribution of Silla in the Daerungwon area are the result of the reflection of the fine geographical features of the Gyeongju basin, which are the key factors of springwater and wetlands.