• 대한골관절종양학회지
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• 제6권1호
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• pp.17-21
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• 2000

목적 : 융기성 피부섬유육종은 피부에 생기는 드문 종양으로서 부적절한 절제가 잦은 재발과 예후에 영향을 미치는 것으로 보고되고 있다. 저자들이 경험한 환자를 대상으로 치료와 예후의 관계를 연구하여 적절한 치료법을 제시하고자 하였다. 대상 및 방법 : 1990년 3월부터 본원 정형외과에서 치료한 융기성 피부섬유육종 환자중 추시 기간이 최소 12개월 이상인 14례를 대상으로 치료 방법 및 최종 추시까지의 상태를 점검하였다. 전례 모두 병리학적 진단하에 치료되었으며, 재발 후 전원된 9례를 포함한 13례에서 광범위 절제술이 시행되었다. 1례는 서혜부의 신경, 혈관이 종양과 인접하여 종양내 전절제술을 시행하였고 술후 항암요법을 추가한 경우였다. 결과 : 재발후 전원되었던 9례의 평균 재발 회수는 1.3 (1~2)회였으며, 처음 수술 후 첫번째 재발까지의 기간은 평균 11.8(2~24)개월이었다. 술후 최종 추시까지(평균 추시기간 50.8개월)에서 광범위절제술로 치료한 13례에서는 재발을 볼 수 없었으나, 병소내 전절제술과 항암제치료를 하였던 예에서는 반복된 재발을 보였고, 결국 폐전이로 사망하였다. 결론 : 융기성 피부섬유육종은 반드시 생검을 통한 확진 후 초기에 광범위 절제연 이상으로 절제를 시행하여야 할 것으로 사료된다. 재발은 최소한 2년까지의 추시가 있어야 그 여부를 알 수 있을 것으로 사료된다.

• Journal of Korean Neurosurgical Society
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• 제60권6호
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• pp.667-675
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• 2017

Objective : Total resection without consecutive postoperative whole brain radiation therapy is indicated for patients with a single or two sites of brain metastasis, with close follow-up by serial magnetic resonance imaging (MRI). In this study, we explored the effectiveness, usefulness, and safety of this follow-up regimen. Methods : From January 2006 to December 2015, a total of 109 patients (76 males, 33 females) underwent tumor resection as the first treatment for brain metastases (97 patients with single metastases, 12 with two metastases). The mean age was 59.8 years (range 27-80). The location of the 121 tumors in the 109 patients was supratentorial (n=98) and in the cerebellum (n=23). The origin of the primary cancers was lung (n=45), breast (n=17), gastrointestinal tract (n=18), hepatobiliary system (n=8), kidney (n=7), others (n=11), and unknown origin (n=3). The 121 tumors were totally resected. Follow-up involved regular clinical and MRI assessments. Recurrence-free survival (RFS) and overall survival (OS) after tumor resection were analyzed by Kaplan-Meier methods based on clinical prognostic factors. Results : During the follow-up, MRI scans were done for 85 patients (78%) with 97 tumors. Fifty-six of the 97 tumors showed no recurrence without adjuvant local treatment, representing a numerical tumor recurrence-free rate of 57.7%. Mean and median RFS was 13.6 and 5.3 months, respectively. Kaplan-Meier analysis revealed the cerebellar location of the tumor as the only statistically significant prognostic factor related to RFS (p=0.020). Mean and median OS was 15.2 and 8.1 months, respectively. There were no significant prognostic factors related to OS. The survival rate at one year was 8.2% (9 of 109). Conclusion : With close and regular clinical and image follow-up, initial postoperative observation without prompt postoperative radiation therapy can be applied in patients of brain metastasi(e)s when both the tumor(s) are completely resected.

• 대한골관절종양학회지
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• 제19권1호
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• pp.14-19
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• 2013

목적: 사지에 발생한 염증성 근섬유모세포성 종양의 특성과 치료 결과에 대하여 알아보고자 하였다. 대상 및 방법: 본 연구는 1999년부터 2012년까지 본원 정형외과에서 치료받은 연부조직 종양 환자 중에서 사지에 발생한 염증성 근섬유모세포성 종양으로 병리학적으로 확진된 5명의 환자를 대상으로 하였다. 결과: 남자가 1예, 여자가 4예였으며, 평균 연령은 44세(37-55세)이고, 평균 추시 기간은 34.6개월(8-87개월)이었다. 5명의 환자 모두에서 외과적 절제술을 시행하였으며 이 중 1명의 환자에서만 광범위 절제연을 얻었고, 3명에서는 변연부 절제연을, 다른 1명에서는 병소내 절제연을 얻었다. 광범위 절제연을 얻지 못한 4명의 환자 모두에서 술 후 평균 10.3개월(8-19개월)에 재발이 발생하였으며, 재발한 4명의 환자 중 2명에서 섬유육종으로의 악성 변화가 관찰되었다. 악성 변화를 보인 2명의 환자 중 1명은 폐, 간 및 림프절로의 다발성 원격 전이가 발생하여 추시관찰 37개월에 사망하였다. 5예의 병변 중 3예에서 종양의 경계가 사지의 주요 동맥에 인접한 소견이 관찰되었으며 1예에서는 종양이 좌골 신경을 침범한 소견이 관찰되었다. 결론: 사지에 발생한 염증성 근섬유모세포성 종양은 주요 신경혈관계와 인접하여 발생하는 경향을 나타내었다. 이 종양은 재발을 잘하며 악성 변화의 가능성이 있으므로 광범위 절제술이 적절한 수술적 치료법이 될 것으로 생각된다.

• 대한약침학회지
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• 제16권1호
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• pp.12-20
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• 2013

Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future. Tumor dormancy therapy is a novel therapeutic approach that may improve these shortcomings, promote quality of life, and prolong survival. The aim of this study was to analyze studies on dormancy therapy, especially studies using traditional Oriental herbal medicine, so as to evaluate the efficacy of dormancy therapy with traditional oriental herbal medicine. Methods: We conducted a systematic literature review using Scientific and Technical Information Integration Services (NDSL), PubMed, and RISS. We searched for clinical reports, papers, and books related to tumor metastasis, recurrence, immunotherapy, tumor dormancy, and traditional oriental herbal medicine with anticancer effects. Seventy-nine (79) experimental and clinical articles in both Korean and English were reviewed. This study was conducted from March 1, 2012 to May 31, 2012. Results: This approach, Tumor dormancy therapy, rather than seeking to remove the tumor, includes combination of low-dose chemotherapy, immunotherapy, immunosurveillance, and other methods to stabilize tumor growth and to enhance the host is immunity against disseminated tumor cells and thus to manage cancer as a chronic disease while maintaining quality of life. In particular, integrative use of Oriental herbal medicine has been shown to induce or maintain tumor dormancy, increase the effectiveness of conventional chemotherapy, improve quality of life, and prolong survival. Conclusion: Tumor dormancy therapy is a promising novel therapeutic approach that may be especially effective with Oriental herbal medicine. Further research is needed to determine its potential mechanisms and therapeutic applications.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제36권4호
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• pp.173-177
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• 2014

The present report describe the surgical therapy, clinical course, orthodontic treatment and morphological characteristics of an adenomatoid odontogenic tumor in the maxilla of an 11-year-old patient. The cystic tumor filled the maxillary sinus and involved a tooth. Marsupialization was accompanied by partial enucleation and applied traction to the affected tooth by a fixed orthodontic appliance. Healing was uneventful and no local recurrence was observed during a 1-year period of follow-up control.

• Archives of Plastic Surgery
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• 제43권6호
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• pp.538-543
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• 2016

Background Cutaneous squamous cell carcinoma (SCC), which occurs in keratinocytes of the epidermis and is the second most common skin cancer, has a more invasive growth pattern and higher potential to metastasize than basal cell carcinoma. Total excision of the primary tumor is the treatment of choice. For clear excision of the tumor, invasion depth is one of the most important factors. This study was conducted to clarify the relationship between the size and the invasion depth of cutaneous SCC. Methods Twenty-six cases were collected for this prospective study. Frozen biopsies were examined after complete resection of the tumor, followed by histological confirmation by pathological examination. The major and minor axis lengths of the tumor, the invasion depth, and the level of invasion were measured. Recurrence or metastasis was recorded through regular follow-up. Results The Pearson correlation coefficient was used for statistical analysis. Significant results were observed for the relationship between the major and minor axis lengths and the invasion depth of the tumor (0.747, 0.773). No cases of recurrence or metastasis were observed. Conclusions In head and neck cutaneous SCC, the invasion depth of the tumor is closely related to the major and minor axis lengths of the tumor. Therefore, the invasion depth of the tumor can be estimated by measuring the size of the tumor, and a standard vertical safety margin for head and neck cutaneous SCC can be established, which could be helpful in the development of a preoperative reconstruction plan.

• 대한골관절종양학회지
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• 제11권1호
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• pp.71-81
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• 2005

목적: 근위 대퇴골의 전이성 종양에서 소파술 후 금속 내고정술 또는 고관절 성형술을 시행했던 환자에게서 종양의 국소 재발로 인한 금속 부전을 경험한 저자들은 광범위 절제술 후 재활용 자가골 이식을 이용한 고관절 성형술을 시행하고, 술 후 국소 재발의 유무와 하지의 기능, 합병증의 발생을 통해 전이성 골종양에서 광범위 절제술 후 재활용 자가골을 이용한 재건술의 타당성에 대해 연구하고자 한다. 대상 및 방법: 2000년 5월부터 2003년 5월까지 근위 대퇴골의 전이성 종양 환자 중 광범위 절제술 후 재활용 자가골을 이용한 재건술을 시행한 6례, 5명의 환자를 대상으로 하였다. 환자의 평균 연령은 60.8세, 남녀 비는 3:2였고 술 후 평균 생존 기간은 23.2개월(7~57개월) 이었다. 원발 병소로는 폐암이 2례였고, 위암, 신장암, 다발성 골수종이 각각 1례였다. 수술은 전례에서 광범위 절제술 후 고관절 재건술을 시행하였으며, 재건술로는 체외 방사선 조사 후 자가골 이식술 및 고관절 반치환술을 4례, 저온 처리한 자가골 이식술 및 고관절 전치환술을 2례에서 시행하였다. 술 후 6개월의 Musculoskeletal Tumor Society(MSTS) 기능 평가 지수(1993년) 및 합병증, 생존 기간 동안의 국소 재발의 유무에 대해 조사하였다. 결과: 술 후 6개월에 조사한 MSTS 기능 평가 지수는 63.3%였고, 술 후 합병증으로는 고관절 탈구가 1례에서 발견되었다. 생존 기간 동안 국소 재발의 소견은 관찰되지 않았다. 결론: 술 후 생존 기간이 6개월 이상으로 추정되는 근위 대퇴골의 전이성 종양에서 소파술 후 금속 내고정술이나 고관절 성형술을 시행하는 것보다 광범위 절제술 후 재활용 자가골을 이용한 고관절 재건술을 시행하는 것이 국소 재발을 방지하여, 환자의 생존 기간동안 사지의 기능을 보존하는데 도움이 될 것으로 사료된다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권12호
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• pp.6455-6461
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• 2012

Objective: E-cadherin has been identified as a tumor suppressor in many types of carcinoma. However, some studies recently suggested that the role and expression of E-cadherin might be more complex and diverse. In the present study, we evaluated the prognostic value of E-cadherin expression with reference to levels in membranes and cytoplasm, and the membrane/cytoplasm ratio, in hepatocellular carcinomas (HCCs) after curative hepatectomy. Methods: The expression of E-cadherin was assessed by immunohistochemistry in HCC tissue microarrays from 125 patients, and its prognostic values and other clinicopathlogical data were retrospectively analyzed. Patients were followed for a median period of 43.7 months (range 1 to 126 months). Results: Univariate analysis demonstrated that a high membrane/cytoplasm (M/C) ratio of E-cadherin expression was associated with poor overall survival (OS) (P =0.001) and shorter time to recurrence (TTR) (P=0.038), as well as tumor size, intrahepatic metastasis, and TNM stage. In contrast, neither membrane nor cytoplasmic expression of E-cadherin was related with OS and TTR. Furthermore, multivariate analysis confirmed the M/C ratio to be an independent predictor of OS (P=0.031). ${\chi}^2$ tests additionally showed that the M/C ratio of E-cadherin expression was related with early stage recurrence (P=0.012), rather than later stage recurrence. Conclusion: The M/C ratio of E-cadherin expression is a strong predictor of postoperative survival and is associated with early stage recurrence in patients with HCC.

• Advances in pediatric surgery
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• 제13권2호
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• pp.162-168
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• 2007

Adrenocortical tumors are very rare in children and the clinical course is not clearly understood. The aim of this study is to review the clinical characteristics and courses of pediatric adrenocortical tumors. The medical records of patients who underwent surgery for primary adrenal tumor at the Department of Surgery, Seoul National University hospital, from Jan. 1986 to Feb. 2006 were reviewed. There were 10 adrenocortical tumor patients; 5 had adrenocortical adenoma and 5 adrenocortical carcinoma. All of the adrenocortical adenomas presented as functioning tumors, i.e., Cushing syndrome or virilization. However, only 2 patients had functioning adrenocortical carcinoma. Median size of adenoma was 5 (3.3-6) cm, and carcinoma 12.5 (6.5-13) cm. Adenomas were smaller than 6 cm and carcinomas were larger than 6.5 cm. Surgical resection alone cured all adrenocortical adenoma patients, and they were all alive without recurrence. Three of 5 adrenocortical carcinoma patients died of tumor recurrence despite radical surgery and chemotherapy. There were 2 long-term survivals for adrenocortical carcinoma, one patient survived 10 years without recurrence until he died of newly developed osteosarcoma, and the other patient is alive without recurrence for 20 years. As the prognosis of pediatric adrenocortical carcinoma is poor, peri-operative aggressive chemotherapy is suggested in addition to radical surgery.

• 대한한방내과학회지
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• 제40권4호
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• pp.723-729
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• 2019

Objective: This study was aimed at reporting on a patient with repeated recurrence of metastatic colorectal cancer treated with traditional Korean medicine (TKM) alone after operation and chemotherapy. Method: The patient with metastatic colorectal cancer received tumor resections four times and perioperative chemotherapy for repeated recurrence from February 2013 until March 2015. TKM, which included Gunchil-dan and Haeam-dan, was administered until June 2019 to prevent additional relapses. Results: After 49 months of TKM treatment, there was no tumor recurrence. A no evidence of disease (NED) state was maintained from March 2015 to June 2019. Recurrence-free survival (RFS) was shown for 49 months and overall survival (OS) for 78 months. Serious adverse events evaluated according to the Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 were not identified. This study suggested that TKM with herbal medicine including aRVS might prolong survival and inhibit recurrence of tumors in patients with metastatic colorectal cancer.