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Clinical Effects of Prothinoamide, Cycloserine, Para-Aminosalicylic Acid, Ofloxasine in Retreatment of Pulmonary Tuberculosis (폐결핵 재치료 환자에서 Prothionamide, Cycloserine, Paraminosalicylic acid, Ofloxasine을 이용한 경구 4제 요법의 임상 효과)

  • Hong, Jae-Rak;Yoo, Min-Kyu;Jeong, Jae-Man;Kim, Young-Jun;Son, Mal-Hyeon
    • Tuberculosis and Respiratory Diseases
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    • v.43 no.5
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    • pp.693-700
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    • 1996
  • Background : Antituberculous therapy is set a short-term therpy used isoniazid(INH), rifampin(RFP), ethambutol(EMB), pyrazinamide(PZA) from 1970s' and treatment rate has been very improved. But drug interruption or irregular medication due to side effects and resistance of drug are serious problem to retreatment cases, specially. Ofloxasine(OFX), developed from Quinolone at 1980's is effective not only other respiratory infectious disease but also pulmonary tube rculosis. And this is useful drug instead of injection agents for retreatment patients who have side effects to other drugs, lived far distance from medical clinics. So, we will evaluate theffectiveness as four oral drugs involving OFX. Method : A retrospective study was made through the regular follow up of smear positive cases,who treated by four drug, namely, prothionamide (PTA) cycloserine(CS), OFX, paraminosalicylic acid(pAS). Results: 1) Out of 66case with positive sputum AFB smear, 42(64%)cases achieved the negative conversion. 2) Considering the negative conversion in all group, 34 case (52%) of sputum conversion occured within first 6 months, on the extent of diease was minimal, moderate, far advanced pulmonary tuberculosis, sputum AFB smear negative response to treatment was 100%, 78%, 46% respectively. 3) The roentgenological improvement occured in 38(58%), extent of diease was minimal, moderately, far advanced pulmonary tuberculosis, Roentgenological improvement to retreatment was 75%, 64%, 46%. 4) When the drnation of patients illness was less than 1 year, 1 to 3 years, 3 10 5 years and more than 5 years, sputum AFB smear negative response to retreatment was 100%, 88%, 80%, 52 %. 5) On side effects, major problems are gastrointestinal troubles, mild liver function abnormality, psychotic problemes, and skin problem(urticaria, itching sensation). Conclusion : The duration & extents of patients illness was shorter & minimal, sputum AFB smear negative response rate was better. Radiologic response is better as shorter duration and minimal extent of diease. But, as diease is longer duration & far advanced, sputum negative conversion & Roentgenological improvement is poor and limited. The adverse reaction was mainly observed gastrointestinal troubles(indigestion, abdominal pain, nausea, vomiting, diarrhea) and are well controled by symptomatic management in most patients, as regard to tolerance to the secondary drugs.

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Impact of Emotional Regulation on the Quality of Life in Elderly People (노인의 감정조절이 삶의 질에 미치는 영향)

  • Yun, EunGyeong;Jo, YeunDuk
    • 한국노년학
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    • v.30 no.4
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    • pp.1429-1444
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    • 2010
  • The purpose of this study was to examine the impact of elderly people's difficulties in emotional regulation on their quality of life and to suggest possible ways of improving their emotional regulation. The subjects in this study were 345 senior citizens who participated in community education programs and used senior centers. A survey was conducted in person, and the instrument used to check their difficulties in emotional regulation was Gratz & Roemer(2004)'s inventory that was rearranged to serve the purpose of this study. When a factor analysis was carried out, their emotional regulation difficulties were categorized into five factors, which were respectively named troubles in emotional response handling, difficulties in accurate emotional awareness, difficulties in emotional coping, and difficulties in emotional reception. The findings of the study were as follows: First, the senior citizens were different from one another in emotional regulation difficulties according to their personal characteristics involving gender, income, financial state, hospitalization experience over the past three months, and presence or absence of disease. Second, their quality of life significantly varied with gender, age, presence or absence of spouse, form of residence, education, income, financial state, hospitalization experience and presence or absence of disease. Third, as a result of investigating the influence of their emotional regulation difficulties on the overall quality of life, a better quality of life was found among those who were male and who had an income and suffered from fewer diseases. And a lower quality of life was found among the senior citizens who faced difficulties in emotional response handling, who had difficulties in emotional control and who lagged behind in terms of emotional coping. Accordingly, the emotional regulation difficulties of the senior citizens could be said to be closely linked to their quality of life. Given the findings of the study, in which way elderly people could be helped to improve their emotional regulation in consideration of their own personal characteristics was discussed, and how to classify their emotional regulation difficulties from various angles to relieve them of the troubles was suggested.

A bibliographic study on medical science ancient period (上古時代) and the era of the old-Korea (古朝鮮時代) (상고시대(上古時代)와 고조선시대(古朝鮮時代)의 의학(醫學)에 관(關)한 문헌적(文獻的) 고찰(考察))

  • Kwon, Hak Cheol;Park, Chan-Guk
    • Journal of Korean Medical classics
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    • v.3
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    • pp.218-247
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    • 1989
  • As mentioned above, I got the next conclusion since I had considered the medical contents of the ancient period(上古時代) and the era of the old-Korea(古朝鮮時代) through several bibliographic records. 1. There were Pung-baeg(風伯), Uh-sa(雨師), Un-sa(雲師) that were the names of the governmental officials during the ancient period of Whan-ung(桓雄). Among them, Uh-sa specially managed the treatment for diseases. When we think of the significance of Pung(風)-which means the winds, Uh(雨)-which means the rain, Un(雲)-which means of clouds, we will find out that the human life will be affected by all kinds of phenomena of the nature. So I can infer that ancestries could prevent and treat diseases with adjusting them tn the changes in the weather. 2. There were five government officials(五事) in the ancient period of Whan-ung(桓雄上古時代). They are Uh-ga(牛加), Ma-ga(馬加), Ku-ga(狗加), Cheo-ga(猪加) and Yang-ga(羊加), and had charges of five important duties. Among them, Cheo-ga was set to a charge of treatment for diseases. So we can notice that there existed people who treated for diseases professionally. When we think of the meanings of Uh(牛)-which intends cows or bulls. Ma(馬)-which intends horses, Ku(狗)-which intends dogs, Cheo(猪)-which intends wild boars and Yang(羊)-which intends sheep, we can see that livestocks would be raised at that time, and they came to have more chances to digest meat. Since the digestion of meat became to be a burden on the stomach and the intestines, it might cause a lot of indigestive troubles. 3. When I compared Tan-gun Pal-ga(檀君八加) with the Oh-ga(五加) in the ancient period of Whan-ung(桓雄上古時代), I could tell that the community of Tan-gun's period is more advanced and specialized than one of Whan-ung's. When I think of the next sentence ; "The Prince Imperial, Bu-u(夫虞) become to be a Ro-ga(鷺加), who treat for diseases professionally.", I am sure that the treatment for diseases was more importment than any other things, because he was the third son of Tan-gun(檀君). 4. According to Tan-gun(檀君) mythology, Whan-ung(桓雄) came down from the heaven of the pure Yang(純陽) to the earth and then changed into a man who had had more Yang(陽) than Yin(陰). And a bear came up from the underground(or the cave) to the ground and then changed into a women who had had more Yin(陰) than Yang(陽). So both of them became to hold together. This story implicated that ancestors had taken a serious view of each of them, namely the ancestors didn't give the ascendance to the one side of them, and made much account of the mutual harmony. So I am sure that this fact coincided with the basic theories of oriental medical science. To refer to two proverbs of Tan-gun mythology that are "Ki-Sam-Chil-Il(忌三七日)" which means caring for twenty one days, and "Pul-Gyon-Il-Gwang-Baeg-Il(不見日光百日)" which means keeping indoors for one hundred days, I can tell you that "twenty-one-day" involves the principle of the birth of life, and "one-hundred-day" contains a preparatory period or the period of death to bear another life. 5. From the medical stuff, such as wormwood(艾), garlic(蒜), or wonder-working herbage(靈草), that had been written at the bibliographic papers of the ancient period(上古時代) and the era of the old-Korea(古朝鮮時代), I consider that many people might get a lot of women's diseases, indigestive troubles, and other diseases that were caused by the weakness, but with using various spices, such as the leaves of water pepper(蔘), they could prevent the occurrance of all kinds of diseases previously. So I regard this treatment as the medicine from food. 6. One of the sayings at Nae-gyong(內經) is that "The stone accupuncture(砭石) came from the orient." We can see both "wonder-wor-king wormwood(靈草)" and "dried wormwood(乾艾)" in the several bibliographic papers of the ancient history of the old-Korea(朝鮮上古史). From these records, I can be convinced that ancestors would utilize the acupuncture(針) and the moxa cautery(灸) to cure a patient of a disease. 7. Even though someone claimed that the book, "medical science and chemistry(醫學化學)" and "medical treatment(醫學大方)" had had been written during the ancient period of the old-Korea(上古朝鮮時代), such a fact can't have been ascertained historical evidence. But it has been handed down that there existed the original phonetic alphabet, such as the "Ka-Im-To alphabet(加臨土文字)" at that time. The terms about the diseases, which had been occurred at the community of the old-Korea(古朝鮮地域), were recorded fragmentarily at other records after that time. The origin of confucianism came from the race of the eastern barbarians, and Tae-Ho-Pok-Hi(太嗅伏義) and the king. Sun(舜) came from the eastern barbarians, too. The divination of tortoise shells at the country of Un(殷) is another from which was developed at the eastern barbarians' fortune-telling of animal bones. From these facts, I can infer that, by all means, they might record the medical knowledge which had been stored for thousands of years while contacting with china directly.

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Structural Performance Evaluation of Floating PV Power Generation Structure System (수상 부유식 태양광발전 구조물의 구조적 성능 평가)

  • Choi, Jin Woo;Seo, Su Hong;Joo, Hyung Joong;Yoon, Soon Jong
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.34 no.5
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    • pp.1353-1362
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    • 2014
  • In recent years, numerous environmental problems associated with the excessive use of fossil fuel are taking place. For an alternative energy resource, the importance of renewable energy and the demands of facilities to generate renewable energy are continuously rising. To satisfy such demands, a large number of photovoltaic energy generation structures are constructed and planned with large scale. However, because these facility zones are mostly constructed on land, some troubles are occurred such as rising of construction cost due to the cost of land use, environmental devastation, etc. To solve such problems, the floating type photovoltaic energy generation system using FRP members have been developed in Korea. FRP members are recently available in civil engineering applications due to many advantages such as high strength, corrosion resistance, light weight, etc. and they are suitable to fabricate the floating structures because of their material properties. In this study, the analytical and experimental investigations to evaluate the structural performance of floating PV generation structure and SMC FRP vertical member which is used to fabricate the structure were conducted. The static and dynamic performances of floating PV generation structure are evaluated through the FE analysis and the experiment, respectively. Moreover, the structural safety evaluation and buckling analysis of SMC FRP vertical compression member are also conducted by the FE analysis, and the structural behavior of SMC FRP member under compression and pullout is investigated by the experiments. From this study, it was found that the structural system composed of pultruded FRP and SMC FRP members are safe enough to resist externally applied loads.

The antioxidative and cytoprotective effect of Lonicerae japonicae Flos water extracts on the ultraviolet(UV)B-induced human HaCaT keratinocytes (금은화 물추출물의 항산화 효과와 Ultraviolet(UV)B로 유도된 사람 각질형성세포 손상에 대한 보호효과)

  • Seo, Seung-Hee;Bae, Gi-Sang;Choi, Sun Bok;Jo, Il-Joo;Kim, Dong-Goo;Shin, Joon-Yeon;Song, Ho-Joon;Park, Sung-Joo;Choi, Mee-Ok
    • The Korea Journal of Herbology
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    • v.29 no.6
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    • pp.63-71
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    • 2014
  • Objectives : Lonicerae japonicae Flos(LJF) has been reported to exhibit anti-oxidant, anti-inflammatory, anti-viral, anti-rheumatoid properties. However, it is still largely unknown whether LJF inhibits the ultraviolet(UV)B-induced oxidative damage in human HaCaT keratinocytes. Therefore in this paper, we investigated the anti-oxidative capacity and protective effect of LJF against UVB-induced oxidative demage in human HaCaT keratinocytes. Methods : To evaluate the anti-oxidative activity of LJF extracts, we measured total phenolic contents, total flavonoid contents, antioxidant capacity, and superoxide scavenging activity. To give an oxidative stress to HaCaT cells, UVB was irradiated with $200mJ/cm^2$ to HaCaT cells. To detect the protective effect of LJF against UVB, we measured cell viability, DNA fragmentation and reactive oxygen species (ROS) production. In addition, we performed high-performance liquid chromatography (HPLC) analysis to find a major component of LJF. Results : LJF contained phenolic and flavonoid contents, and showed the anti-oxidant and superoxide scavenging activity. The UVB-induced oxidative conditions led to the cell death, DNA fragmentation and reactive oxygen species (ROS) production. However, pretreatment with LJF reduced oxidative conditions, including inhibition of cell death, DNA fragmentation and ROS production. In addition, we found out chlorogenic acid as major component of LJF. Conclusions : These results could suggest that LJF contained anti-oxidative contents and exhibited protective effects against UVB on human HaCaT keratinocytes. And the effective compound of LJF which could show protective activities against UVB is chlorogenic acid. Thus, LJF and chlorogenic acid would be useful for the development of drug or cosmetics treating skin troubles.

A Field Survey on the Characteristics of Air Pollutants Emission from Commercial Charcoal Kiln (숯가마에서 발생하는 대기오염물질의 배출특성에 관한 현장조사 연구)

  • Park, Seong-Kyu;Choi, Sang-Jin;Kim, Jin-Yun;Park, Gun-Jin;Hwang, Ui-Hyun;Lee, Jeong-Joo;Kim, Tae-Sik
    • Journal of Korean Society for Atmospheric Environment
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    • v.29 no.5
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    • pp.601-614
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    • 2013
  • The commercial charcoal kiln was projected the largest source of biomass burning sector in Korea. Commercial charcoal kiln was operated to emit air pollutants into the air without any air pollution prevention equipment. The object of this field survey was to understand characteristics of air pollutants concentration and emission factors and to provide preliminary data for effective processor from oak charcoal manufacturing process. As result of field survey, TSP, $PM_{10}$ and $PM_{2.5}$ concentration from charcoal kiln were 400~37,000 $mg/m^3$. These values were over the 100 $mg/m^3$ in TSP, this value was effluent quality standard of Clean Air Conservation Act. The average concentration of CO, $SO_2$ and TVOC were 2~5%. 0~110 ppm and 820~10,000 ppm respectively. The emission factors were 42.4 g-PM/kg-oak in TSP, 40.3 g-PM/kg-oak in $PM_{10}$, 38.2 g-PM/kg-oak in $PM_{2.5}$, 182.5 g-CO/kg-oak, 1.0 g-NO/kg-oak, $SO_2$ 0.2 g-$SO_2/kg$-oak and 104.4 g-TVOC/kg-oak. The part of commercial charcoal kiln had air pollution prevention equipment but it was difficult to work properly. Much wood tar excreted in exhaust emissions from oak charcoal manufacturing process. This wood tar was cause of many troubles sticking in the air pollutant prevention equipment. For handling particulate matters and gaseous air pollutants from oak charcoal manufacturing process in biomass burning, air pollutant prevention equipment design and management needs preprocessor for removal wood tar.

Evaluation on the Performance of Surface Performance Improving Agent for the Deterioration Prevention of Concrete Structures (콘크리트 구조물의 열화방지를 위한 표면 성능 개선제의 성능 평가)

  • Ryu, Gum-Sung;Koh, Kyoung-Taek;Kim, Do-Gyeum;Lee, Jang-Hwa
    • Journal of the Korea institute for structural maintenance and inspection
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    • v.9 no.4
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    • pp.177-186
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    • 2005
  • The latest concrete structure has showed that the deterioration of durability has been increased by the damage from salt, carbonization, freezing & thawing and the others. Therefore, the measures for the concrete which has deteriorated durability have been taken. Among them, it has been often used that surface treatment which cuts off the deterioration factors of durability by protecting the surface of concrete. However, troubles such as fracture and rupture in the repair layer have been reported as time goes by due to the difference between the organic repair material like epoxy and concrete properties. Researchers have been developing the repair material which can cut off the deterioration factors of durability such as $CO_2$ gas, chloride ion and water by making the formation of concrete elaborate through the reaction with calcium ion when the surface improving agent is coated on the concrete. The main ingredient of that is inorganic substance which is the same as the concrete property. This study was evaluated the surface improving agent for permeability, watertightness, air-permeability, chemical resistance and elution resistance. As a result, it has been reported that the surface improving agent improves watertightness and air-permeability by penetration more than 10mm within concrete. Therefore, it is concluded that the surface improving agent developed in this research prevents deterioration of concrete durability when it is coated on the concrete structure.

A Critical Evaluation of George Lindbeck's Cultural-Linguistic Theory of Religion (조지 린드벡의 문화-언어의 종교이론 비평)

  • Je, Haejong
    • The Journal of the Korea Contents Association
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    • v.14 no.4
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    • pp.456-466
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    • 2014
  • This is a study of George Lindbeck's postliberalism that views religion as a cultural-linguistic approach. Knowing that the conceptual-propositional approach of the traditional Christian theology and the experiential-expressive approach of liberalism cannot be a solution for the post-modem religious phenomenon, George Lindbeck proposes an alternative. He proposes a cultural-linguistic approach to overcome the previous approaches. The first insight of Lindbeck's postliberalism is to understand religion as culture or language, because human beings become acquainted with a religion as they learn a language. The second insight comes out of the first, to understand doctrine as grammar. If we understand religion and doctrine this way the troubles and conflicts among religions will be resolved naturally, because each religion can be interpreted in its own system just as a language cannot be said to be good or bad, right or wrong. This approach makes several contributions as follows: it promotes a dialogue among religions, it emphasizes practice; and it preserves the Bible as an authoritative theological text. However it also brings many limitations as follows: it emphasizes the church's interpretation rather than the text's own interpretation; it views the truth simply as coherence; it promotes radical relativism and elitism; and through theological eschatology he makes his theory return to a propositionalism. Accordingly, the researcher concludes that Lindbeck's cultural-linguistic theory of religion is not an alternative that overcomes the limitations of theological conservativism and liberalism.

A Case Study on the Implementation of a River Water Level Monitoring System using PLC(Programmable Logic Controller) and Public Telecommunication Network (PLC(Programmable Logic Controller)와 공중통신망을 이용한 하천수위감시시스템 구축 사례 연구)

  • Kim, Seokju;Kim, Minsoo
    • The Journal of Society for e-Business Studies
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    • v.20 no.4
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    • pp.1-17
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    • 2015
  • A river water level monitoring system which prevents salt water damages and effectively excludes floods has been developed to contribute efficient operation of Nakdong river estuary barrage. The system can be used for monitoring upstream conditions more quickly and do appropriate responses over changes. Telemetry and telecontrols using PLCs have been built at the three sites that directly influence on the operation of barrage gates, and are linked to Nakdong river estuary barrage's IOS (Integrated Operation System) through public communication networks. By using PLC, the system can achieve even higher reliability and versatility than before as well as easy management. By power control devices, we can remotely control the power of PLCs to treat the minor troubles instantly without going on-sites. The power control devices also save data in preparation for the cases of communication failures. The system uses ADSL (FTTH) as a main network between SCADA server and PLCs, and CDMA (M2M) as a secondary network. In order to compensate security vulnerabilities of public communication network, we have installed the VPNs for secure communication between center and the observation stations, just like a dedicated network. Generally, river water level observations have been used custom-manufactured remote terminals to suit their special goals. However, in this case, we have established a system with open architecture considering the interface between different systems, the ease of use and maintenance, security, price, etc.

Geospatial analysis of terrorist bombing attacks in Afghanistan (아프가니스탄 폭탄테러공격에 관한 지리-공간 분석)

  • Yun, Min-Woo
    • Korean Security Journal
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    • no.33
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    • pp.261-290
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    • 2012
  • Since the launch of Operation Enduring Freedom in 2001, Afghanistan has been a critical battle ground for war against global terrorism. For the last 10 years, the U.S. government and its allies and the Afghan government have put a considerable effort to crush terrorists and insurgents and at the same time to construct nationwide governance system. Yet, the noble mission still seems far from complete. Terrorist or insurgent operations in Afghanistan are still active and troublesome. Thus this subject continues to draw a considerable attention of research or investigative reports to grasp an insightful knowledge or intelligence that may allow a better handling of terrorist troubles in this war-torn nation. This study hopes to serve this purpose by providing analyzed information on terrorist bombings in Afghanistan occurred between 2004 and 2007. It adopts GIS (Geographic information System) analysis technique to uncover spatially patterned aspects of terrorist bombing attacks in Afghanistan. The specific focus of this study is to examine whether terrorists behave rationally when they decide which targets to attack. For analysis, this study will focus on examining whether characteristics of localities have certain impact on the risk of being targets of terrorist bombing attacks. To examine the hypothesis of this study, it will explore how the spatial risk of becoming targets of terrorist bombing attack interacts with cost necessary for executing a ttack paid b y terrorists; 1) by demonstrating the spatial distribution of bombing attacks in Afghanistan and 2) by estimating the distance between headquarters (or home base) of terrorists groups and the bombed target area.

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