• Title/Summary/Keyword: triple difference model

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Outcomes of Triple-Negative Versus Non-Triple-Negative Breast Cancers Managed with Breast-Conserving Therapy

  • Bhatti, Abu Bakar Hafeez;Khan, Amina Iqbal;Siddiqui, Neelam;Muzaffar, Nargis;Syed, Aamir Ali;Shah, Mazhar Ali;Jamshed, Arif
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2577-2581
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    • 2014
  • Background: Triple negative breast cancer is associated with aggressive behavior and high risk of local and regional failure. Aggressive surgical intervention is considered suitable. This makes role of breast conserving therapy (BCT) debatable in these patients. The objective of this study was to compare outcome of BCT for triple negative versus non-triple negative breast cancer. Materials and Methods: Medical records of patients who underwent breast conserving therapy from 1999 to 2009 at Shaukat Khanum Cancer Hospital and had complete receptor status information were extracted. Patients were divided into triple negative breast cancer (TNBC) and non-TNBC. Patient characteristics, medical treatment modalities and adverse events were compared. Expected five year locoregional recurrence free, disease free and overall survival was calculated. The Cox proportional hazard model was used to identify independent predictors of outcome. Results: A total of 194 patients with TNBC and 443 with non-TNBC were compared. Significant difference was present for age at presentation (p<0.0001), family history (p=0.005), grade (p<0.0001) and use of hormonal therapy (p<0.0001). The number of locoregional failures, distant failures and mortalities were not significantly different. No significant difference was present in 5 year locoregional recurrence free (96% vs 92%, p=0.3), disease free (75% vs 74%, p=0.7) and overall survival (78% vs 83%, p=0.2). On multivariate analysis, tumor size, nodal involvement and hormonal treatment were independent predictors of negative events. Conclusions: Breast conserving therapy has comparable outcomes for triple negative and non-triple negative breast cancers.

Marginal and internal fit of all ceramic crown using the replica technique and the triple-scan protocol (Replica technique과 Triple-scan protocol을 이용한 지르코니아 전부도재관의 변연 및 내면 적합도에 관한 비교 연구)

  • Shin, Mi-Sun;Lee, Jang-Hoon
    • The Journal of Korean Academy of Prosthodontics
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    • v.55 no.4
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    • pp.372-380
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    • 2017
  • This study was conducted to compare the marginal and internal fit of all ceramic crown using the replica technique and the triple-scan protocol. Materials and methods: Twenty zirconia ceramic crowns were fabricated using titanium abutment model. All crowns were divided into two groups of 10 each, depending on the replica technique and the triple-scan protocol. The internal and marginal fit of 10 zirconia ceramic crowns were measured at 17 points for each specimen using the replica technique. The other 10 ceramic crowns were measured using the triple-scan protocol. Statistical analysis was performed by t-test (${\alpha}=.05$). Results: The mean and standard deviation of marginal and internal fit were significantly different between the replica technique ($49.86{\pm}29.69{\mu}m$) and triple-scan protocol ($75.35{\pm}64.73{\mu}m$, P<.001). The mean and standard deviation of internal fit except marginal fit were $58.38{\pm}31.77{\mu}m$ and $64.00{\pm}46.43{\mu}m$, respectively (P>.343). Conclusion: There was a statistically significant difference in the marginal fit measured by the two methods. However, there was no statistically significant difference in the internal fit between the two methods.

Site-response effects on RC buildings isolated by triple concave friction pendulum bearings

  • Ates, Sevket;Yurdakul, Muhammet
    • Computers and Concrete
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    • v.8 no.6
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    • pp.693-715
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    • 2011
  • The main object of this study is to evaluate the seismic response effects on a reinforced concrete building isolated by triple concave friction pendulum (TCFP) bearings. The site-response effects arise from the difference in the local soil conditions at the support points of the buildings. The local soil conditions are, therefore, considered as soft, medium and firm; separately. The results on the responses of the isolated building are compared with those of the non-isolated. The building model used in the time history analysis, which is a two-dimensional and eight-storey reinforced concrete building with and without the seismic isolation bearings and/or the local soil conditions, is composed of two-dimensional moment resisting frames for superstructure and of plane elements featuring plane-stress for substructure. The TCFP bearings for isolating the building are modelled as of a series arrangement of the three single concave friction pendulum (SCFP) bearings. In order to investigate the efficiency of both the seismic isolation bearings and the site-response effects on the buildings, the time history analyses are elaborately conducted. It is noted that the site-response effects are important for the isolated building constructed on soft, medium or firm type local foundation soil. The results of the analysis demonstrate that the site-response has significant effects on the response values of the structure-seismic isolation-foundation soil system.

The Impacts of the 40 Hour Work Week Standard on Actual Working Hours, Wages and Employment (주 40시간 근무제의 도입이 근로시간, 임금 및 고용에 미치는 영향)

  • Kim, Hyungrak;Lee, Jungmin
    • Journal of Labour Economics
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    • v.35 no.3
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    • pp.83-100
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    • 2012
  • This paper estimates the impacts of introducing the 40 hour work week standard in South Korea on actual working hours, wages and employment. We exploit variation in timing of implementing the 40 hour work week standard across industries and establishment size and estimate the causal effects by a triple difference model. Our results show that the 40 hour work week standard decreased actual working hours by about 43 minutes while it increased hourly wage rate by 6.6%. The probability of new hires decreased by about 2.3% points.

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Development of Red Pepper Dryer -Simulation and Optimization- (고추 건조기(乾燥機)의 개발(開發)에 관한 연구(硏究) -시뮬레이션 및 최적화-)

  • Keum, D.H.;Choi, C.H.;Kim, S.Y.
    • Journal of Biosystems Engineering
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    • v.16 no.3
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    • pp.248-262
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    • 1991
  • Simulation model was developed to analyze drying process for tray type red pepper dryer and validated by experiments. This model could predict satisfactorily temperatures and moisture contents of red pepper and temperatures of drying air during drying. Optimize algorithm was developed to search control valiables (drying air temperature, air recycle ratio and air flow rate) of red pepper dryer based on a criterion of minimizing energy consumption under the constraint conditions that statisfied carotenoid retension of at least 210mg per 100g dry matter, the moisture content of bottom layer of 15% (d.b) and drying time of less than 35 hours. Step changes in drying air temperature and air recycle ratio were considered in the optimization. In single step in control variables, the difference of the moisture content between top layer and bottom layer was great and more fan power was required. As the drying trays were exchanged when the moisture content of bottom layer reached to 100% (d.b), fifty percent of energy was saved and the difference of moisture content was little. In double step changes in control variables, optimal conditions were found by changing the step when the moisture content of bottom layer reached to 100% (d.b) (about 19.8 hours from starting drying). Optimum air flow rate was $18.1cmm/m^2$. Optimum drying air temperature and air recycle ratio in the first step was $55.8^{\circ}C$ and 0.80, and in the second step $65.6^{\circ}C$ and 0.88, respectively. In triple step changes in control variables, the optimal conditions were found by changing the steps when the moisture content of bottom layer reached to 250% (d.b) and 150% (d.b). Optimal air temperatures were $66.2^{\circ}C$, $58.4^{\circ}C$ and $66.9^{\circ}C$, and optimal air recycle ratios were 0.778, 0.785, 0.862 at each step, respectively. Optimal air flow rate was $18.9cmm/m^2$. The best operating mode was triple step mode considering energy consumption, drying time, fan power, and quality of dried red pepper. When the triple step mode was used to dry the red pepper, the energy consumption was about 16.5%~57.2% less than that of the single step mode and the drying time was 6.6 hours shorter than that of the double step mode.

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Effect of additional firing process after sintering of monolithic zirconia crown on marginal and internal fitness (단일구조 지르코니아 크라운의 소결 후 추가 소성 과정이 변연 및 내면 적합도에 미치는 영향)

  • Shin, Mi-Sun;Lee, Hyeonjong
    • The Journal of Korean Academy of Prosthodontics
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    • v.57 no.4
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    • pp.321-327
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    • 2019
  • Purpose: To evaluate an effect of additional firing process after sintering of monolithic zirconia crown on marginal and internal fit through three-dimensional analysis. Materials and methods: Ten monolithic zirconia crowns were fabricated using titanium abutment model. Monolithic zirconia crowns were designed, milled, and sintered as a control group, and additional firing with coloring was performed as a test group. Three dimensional analysis were performed by using triple-scan protocol, and cross-section analysis on mesio-distal and disto-lingual section was evaluated to measure marginal and internal fitness. Then, three-dimensional surface difference on between two groups was evaluated (${\alpha}=.05$). Results: There was statistically significant difference between the control group ($32.0{\pm}24.3{\mu}m$) and the test group ($17.0{\pm}10.8{\mu}m$) in the mesial axial wall (P < .02) and the control group ($60.2{\pm}24.3{\mu}m$) and the test group ($71.8{\pm}21.5{\mu}m$) in the distal axial wall (P < .01). There was no statistically significant difference at the remaining point. Conclusion: There was no statistical significance on the deviation of inner surface of crown according to firing number, and the results of both group were considered clinically acceptable.

Numerical study on pressure drop with moving contact lines of dry slug flow in a hydrophobic minichannel (소수성 미니채널 내 움직이는 접촉선을 가진 액체슬러그의 압력 강하에 대한 수치해석)

  • Jeon, Jun Ho;Park, Su Chung;Yu, Dong In;Kim, Tae Hun;Lee, Yeon Won
    • Journal of the Korean Society of Visualization
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    • v.18 no.3
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    • pp.116-121
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    • 2020
  • In this study, a single-phase analysis of droplet slug with different contact angles was performed based on the visualization of experimental results. Droplet slug - flowing between gases in a hydrophobic mini channel - moves with a triple contact line without a gas liquid film on the wall. The results show that the rotational flow inside the droplet occurred; this was compared and verified with the results of two-phase analysis. The pressure field shows pressure rise at the front and rear ends. The effective length - the section that satisfies the laminar flow condition - became shorter as the droplet velocity increased. The Choi's correlation for the effective length agrees with this analysis results with a slight difference. This difference is judged as the difference in the contact angle of the slug model.

Marginal and internal discrepancy of 3-unit fixed dental prostheses fabricated by subtractive and additive manufacturing (절삭 및 적층 가공법으로 제작된 3본 고정성 국소의치의 변연 및 내면 적합도에 관한 연구)

  • Choi, Jae-Won
    • The Journal of Korean Academy of Prosthodontics
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    • v.58 no.1
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    • pp.7-13
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    • 2020
  • Purpose: This study was to evaluate marginal and internal discrepancy of 3-unit fixed dental prostheses (FDP) fabricated by subtractive manufacturing and additive manufacturing. Materials and methods: 3-unit bridge abutments without the maxillary left second premolar were prepared (reference model) and the reference model scan data was obtained using an intraoral scanner. 3-unit fixed dental prostheses were fabricated in the following three ways: Milled 3-unit FDP (MIL), digital light processing (DLP) 3D printed 3-unit FDP (D3P), stereolithography apparatus (SLA) 3D printed 3-unit FDP (S3P). To evaluate the marginal/internal discrepancy and precision of the prosthesis, scan data were superimposed by the triple-scan protocol and the combinations calculator, respectively. Quantitative and qualitative analysis was performed using root mean square (RMS) value and color difference map in 3D analysis program (Geomagic control X). Statistical analysis was performed using the Kruskal-Wallis test (α=.05), MannWhitney U test and Bonferroni correction (α=.05/3=.017). Results: The marginal discrepancy of S3P group was superior to MIL and D3P groups, and MIL and D3P groups were similar. The D3P and S3P groups showed better internal discrepancy than the MIL group, and there was no significant difference between the D3P and S3P groups. The precision was excellent in the order of MIL, S3P, and D3P groups. Conclusion: Within the limitation of this study, the 3-unit fixed dental prostheses fabricated by additive manufacturing showed better marginal and internal discrepancy than the those of fabricated by subtractive manufacturing, but the precision was poor.

The Application of Customer Relationship Management for the Effective Prenatal Care (효과적인 산전관리를 위한 고객관계관리(CRM)의 도입)

  • Shin, Sook;Paik, Soo-Kyung;Kang, Sung-Hong;Kim, Yu-Mi
    • Korea Journal of Hospital Management
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    • v.10 no.1
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    • pp.93-114
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    • 2005
  • The prenatal care is the preventive medical service to help the pregnant mother deliver the healthy baby. It's regular examines give some chances to check-up the healthy conditions. This thesis concentrates on the CRM system to support an effective prenatal care system and prove the effectiveness of it. As CRM is the adapted management related to the customer's own information, it is important to develop the CRM model classified by the patients characteristics. A general hospital in Busan operated the CRM system to carry out the effective prenatal care and there is an analysis to ensure the effectiveness of CRM system for the pregnant women in our maternity ward. The results can be summarized as follows: 1) According to the comparisons with the CRM system, we can conclude the system is desirable. (1) Maternal Age : In the age distribution, the prenatal visit frequency, triple marker freqency, oral GTT and targeted ultrasonography in the experimental group in 30 to 34 years old is higher on the whole. For over 35 years old group, the higher frequency comes out in the oral GTT and targeted ultrasonography and for 25 to 29 years old group the different figure shows just in the targeted ultrasonography. (2) Area of residence: There is a clear difference in all the items in Busan and near area but no sign of difference in prenatal visits and oral GTT in other residencial area. Especially in the targeted ultrasonography the higher figure shows in the experimental group located in the both areas. The targeted ultrasonography is known as the specific examination which should be examined by the specialists, on the contrary the other examinations can be operated in the small clinic. So the public information and seminars related with ultrasonography increases the check-up frequency. The clinic requests some ultrasonographical examinations to the specialists in general hospital. (3) Parity: The clear difference shows that the CRM system causes the prenatal visit frequency to become higher in experimental group. The figure is 9.7 times and 8.6 times each. This is opposite that the past study said multiparity reduced the average prenatal visits. But the result of CRM is considered as the method to help the multiparity understand the importance of the prenatal care. (4) Obstetrical history: In the experimental group of the spontaneous delivery group, the figure is higher in the prenatal visit frequency, triple marker, oral GTT and targeted ultrasonography but the Caesarean section delivery group has higher figure in targeted ultrasonography. (5) In the first check-up, the rate of targeted ultrasonography in under 16 week pregnancy, in the 16 week pregnancy to 32 week pregnancy and the over 32 week pregnancy in the experimental group is upper than the compared one. For the oral GTT, there is a difference in under 16 week pregnancy but no difference in prenatal visits and triple marker. 2) The analysis of characteristics of prenatal care through the decision tree resulted in the fact that the most important variable is the residential area. After the delivery frequency is following, the obstetrical history and maternal age are in order. It is the same result in the triple marker and oral GTT. Consequently it is the same order of important variables in CRM system. The effectiveness of CRM system is proved in this study. The CRM system is a marketing method to control and lead the customers through the segmentation of customer data. It increases the new customer aquisition, maintenance of loyal customers, augmentation of customers value, activation of potential customers and creation of life time customers. So eventually it can enlarge the customers value. The medical institution should make efforts to establish the data base enforced by the customer's information on the underlying ordinary data system to carry out the CRM system effectively. In addition, it should develop the a variety of marketing strategy in order to set up one to one marketing satisfying the needs of individual patients.

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Image segmentation Using Hybrid Level Set (하이브리드 레벨 셋을 이용한 이미지 분할)

  • Joo Ki-See;Kim Eun-Seok
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.8 no.7
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    • pp.1453-1463
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    • 2004
  • The conventional image segmentation method using level set has been disadvantage since level set function in the gradient-based model evolves depending on the local profile of the edge. In this paper, a new model is introduced by hybridizing level set formulation and complementary smooth function in order to smooth the driving force. We consider an alternative way of getting the complementary function(CF) which is much easier to simulate and makes sense for most cases having no triple junctions. The rule of thumb is that CF must be computed such that the difference between their average and the original CF function should be able to introduce a reliable driving force for the evolution of the level set function. This proposed hybrid method tries to minimize drawbacks the conventional level set method.