• Preventive Nutrition and Food Science
• /
• 제10권3호
• /
• pp.279-284
• /
• 2005

Uncoupling protein-1 (UCP-1) plays a major role in thermogenesis, and has been implicated in the pathogenesis of obesity and metabolic disorders. The aim of this study was to estimate the effects of A-3826G polymorphism of UCP-1 gene on body fat distribution. Two hundred forty eight Korean female overweight subjects with BMI more than 25 kgfm2 participated in this study. The areas of abdominal subcutaneous and visceral fat of all subjects were measured from computed tomography cross sectional pictures of the umbilical region. Subcutaneous fat areas of upper and lower thigh were also measured. Body composition was measured by bio-impedance analysis, and serum concentrations of biochemical parameters, such as glucose, triglyceride, cholesterol etc, were also measured. Genotype of UCP-1 was analyzed by polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP) method. The frequencies of UCP-1 genotypes were AA type; $27.8\%,\;AG\;type;\;51.2\%\;and\;GG\;type;\;21.0\%,$ and the frequency of G allele was 0.47. Body weight, BMI, WHR, SBP, DBP and body compositions were not significantly different by UCP-1 genotype. Abdominal visceral fat area was significantly higher in AG and GG type compared with AA type (p=0.009), but subcutaneous fat areas were not significantly different by UCP-1 genotype. Among biochemical parameters, LDL cholesterol level was significantly higher in GG type compared with AA and AG types (p=0.033). Among all subjects, 121 subjects finished 1 month weight loss program containing hypocaloric diet and exercise. The reduction of body weight and BMI were lower in GG type compared with AA/AG type even though statistical significances were not found (p > 0.05). These results suggest that UCP-1 genotype has a significant effect on visceral fat accumulation among Korean female overweight subjects with BMI more than $25\;kg/m^2$.

• 한국식품영양과학회지
• /
• 제19권5호
• /
• pp.381-386
• /
• 1990

This study was investigated the effects of water soluble extract of Ganoderma lucidum kale juice and soidium dextrothyroxine on lipid components in serum of hypercholesterolmemic rats in vivo in order to prevent in cardiovascular disease. Total cholesterol concentrations in serum were significantly increased after feeding cholesterol diet group compared with control group and were significantly increased after feeding cholesterol diet group compared with control group and were lower in Ganoderma lucidum kale juice and sodium dextrothyrioxine diet groups than in control group. Ratio of high density lipoprotein cholesterol concentration to total cholesterol were significantly highest in sodium dextrothyroxine fed groups among diet groups and were higher in Ganodrma lucidum and kale juice fed group than in control group. Phospholipid concentrations in seurm were significantly lower in Ganoderma lucidum kale juice and sodium dextrothyroxine(1.25mg/kg diet) fed groups than in control group and triglyceride concentra-tions were lower in Ganderma lucidum sodium dextrothyroxine fed groups than in other groups. Triiodothyronine concentration in serum were lower in Ganoerma lucdum and kale juice fed groups than in the other groups while it was higher in sodium dextrothyroxine diet group than in other groups. Tetraiodothyronine concentrations is serum were remakably higher in sodium dextrothyroxine fed group than in other groups. Blood glucose concentration was lower in cholesterol diet group than in other groups but was higher in sodium dextrothyroxine diet group than in other groups.

• 한국식품과학회지
• /
• 제17권3호
• /
• pp.175-179
• /
• 1985

알칼리 처리와 글리세린으로 에스테르화 반응을 시킨 탈산공정에 의하여 정제한 각 미강유의 이화학적 항수 및 지방질 조성을 비교하였다. 비중 및 굴절율은 글리세린처리미강유가 알칼리정제미강유보다 높았고, 색도는 글리세린처리미강유가 알칼리정제미강유보다 훨씬 진한 황색도를 나타내었으며, 발연점은 알칼리정제미강유가 글리세린처리미강유보다 60${\sim}80^{\circ}C$높았다. 유리지방산의 함량은 알칼리정제미강유(0.05%)보다 글리세린처리미강유(0.88${\sim}$1.36%)가 높았으며, 왁스는 알칼리정제미강유에서는 검출되지 않았으나 글리세린처리미강유에서는 soft wax가 0.600${\sim}$0.871%, hard wax가 0.035%${\sim}$0.486% 함유되어 있었다. 알칼리 정제미강유와 글리세린처리미강유의 중성지방질, 당지방질 및 인 지방질의 함량은 큰 차이가 없었다. 중성지방질중의 TG 함량은 알칼리정제미강유(96.3%)가 글리세린처리미강유(93.0${\sim}$94.1%)보다 많았으며 MG함량은 알칼리정제미강유(0.11%)가 글리세린처리미강유(0.39${\sim}$0.69%)보다 낮았다. 알칼리 정제미강유와 글리세린처리미강유의 주요지방산은 올레산, 리놀레산, 팔미트산 이었으며 처리방법에 따라 큰 차이가 없었다.

• 한국축산식품학회지
• /
• 제26권1호
• /
• pp.78-84
• /
• 2006

본 연구는 어유 1%와 쑥 펠렛 사료의 첨가수준(0, 1, 3, 5%)에 따라 돼지고기의 품질을 검토하고자 돼지 40두를 공시하여 사용하였다. 돼지의 증체량은 유의성이 없었다. 어유와 쑥 펠렛 사료의 급여 수준에 따른 돈육의 일반성분 중 조지방은 감소하는 경향이었고(p<0.05), 수분과 조단백질 및 조회분은 유의성이 없었다. 총콜레스테롤, HDL-C, 중성지방은 처리구에서 높았고, LDL-C은 대조구보다 처리구에서 낮았다(p<0.05). pH, 보수성 그리고 전단력은 대조구보다 처리구에서 높았으며, 특히 T3구에서 가장 높았다. 육색은 처리구에서 대조구보다 $L^*$값이 높아 밝은 색을 유지하였다. 관능평가 결과 어유와 쑥 펠렛의 급여구에서 연도와 풍미가 높은 점수를 나타내었고 특히 T2와 T3구에서 유의적인 결과를 보였다(p<0.05).

• 한국산학기술학회논문지
• /
• 제14권4호
• /
• pp.1737-1746
• /
• 2013

본 연구는 농촌지역 중 노년기 여성을 대상으로 건강교육과 운동프로그램을 실시하여 체성분과 혈중지질, 골밀도 및 건강행태에 미치는 영향을 확인하기 위하여 시도하였다. 중 노년기 여성 33명을 대상으로 2012년 3월 5일부터 2012년 5월 31일까지 12주간 건강교육과 운동프로그램을 실시하였으며, 체성분과 혈중지질, 골밀도 및 건강행태에 미치는 효과를 확인하기 위해 단일군 전후설계로 paired t-test, ANCOVA를 실시하였다. 프로그램 적용 후, 평균체중과 BMI, 체지방량, 총콜레스테롤, 중성지방, LDL콜레스테롤, 골밀도, 운동과 음주 및 흡연에 대한 건강행태에서 유의한 변화가 있었다. 따라서 3개월 이상의 강도 높은 유산소운동과 개인별 맞춤 근력운동을 적절하게 병행한 운동프로그램의 기획 및 제공이 필요할 것으로 판단되며, 개인별 건강행태변화를 위해서 대상자에게 초점을 맞춘 건강교육을 횟수를 늘려 제공하는 등 기존의 프로그램을 보완한 체계적인 관리가 지역사회에서 실천되도록 해야 할 것이다.

• 한국식생활문화학회지
• /
• 제19권4호
• /
• pp.429-434
• /
• 2004

대두 탈취부산물(scum)로부터 분리 정제한 식물성스테롤 처리 식이를 휜쥐에게 4주간 공급하며 혈장지질, 포도당 농도 및 혈장, 췌장, 근육조직의 인슐린 함량에 미치는 영향을 조사하였다. 대두 탈취부산물로부터 분리 정제한 식물성스테롤 성분의 순도는 68.3%였으며, 그 조성은 campesterol 21.4%, ${\beta}$-stigmasterol 62.3%, sitosterol 11.0% 및 미확인물질 5.8%였다. 식물성스테롤 처리량의 증가에 따라 $0{\sim}3%(w/w)$ 처리군 에서의 중성지질, 총 콜레스테롤 및 인지질 함량의 감소는 비례관계가 성립하였으나 그 이상의 처리는 큰 차이가 없었다. 따라서 식물성 스테롤 처리가 혈장지질 농도와 밀접한 상관관계가 있으며, 식물성 스테롤의 적정 처리량은 3%(w/w)내외인 것으로 밝혀졌다. 한편 혈장, 근육조직의 인슐린 함량변화 등의 탄수화물 관련 조직에는 거의 영향을 미치지 않는 것으로 밝혀졌다.

• 대한한방부인과학회지
• /
• 제31권3호
• /
• pp.33-49
• /
• 2018

Objectives: The purpose of this study was to investigate the correlation between Pattern identification instrument and biomarkers in polycystic ovary syndrome patients. Methods: Pattern identification instrument questionnaire, Sasang constitutional test, body composition test, pulse analyzing test, laboratory test were performed and the results were analyzed. Correlation analysis was performed between pattern identification and laboratory test results. Results: Testosterone, SHBG, $17{\alpha}$-OH-progesterone, AMH were highest in the Kidney-Yang Deficiency (腎陽虛) group. LH, FSH, LH/FSH ratio were the highest in the Endogenous Heat due to Yin Deficiency (陰虛內熱) group. DHEA-S was the highest in the Dampness-Heat in Liver Meridian (肝經濕熱) group. E2, Prolactin, Cholesterol, Triglyceride, HDL-Cholesterol, LDL-Cholesterol, Glucose (FBS), Insulin, HOMA-IR ratio, HbA1c were the highest in the Phlegm-Dampness (痰濕) group. Conclusions: In this study, we obtained basic data analyzing the correlation between pattern identification instrument and biomarkers in polycystic ovary syndrome patients. If further studies are performed, we expect to be able to obtain clues to study the mechanism of polycystic ovary syndrome.

• 대한수의학회지
• /
• 제45권3호
• /
• pp.429-438
• /
• 2005

The purpose of this study was to examine whether conjugated linoleic acid and selenium supplementation in broiler chicken diets would be effective, enhance indices of immune status and body weight, and modulate serum lipid concentration. Forty Hyline brown chickens, 1 weeks of age, were divided into 5 groups of 8 chickens. Chickens were fed the experimental diets supplemented with 1% CLA (conjugated linoleic acid; Group 1), 1% CLA + selenium (Group 2), 1% safflower-seed-oil as LA (Group 3), 1% safflower-seed-oil as LA + selenium (Group 4) or nothing (Control) for 4 weeks. After 4 weeks, serum, liver, spleen and abdominal fat were taken. Measurement of total immunoglobulin were executed using sandwich ELISA. Weight ratio of liver to body showed that the group fed with CLA were significantly higher than the group fed with CLA + selenium. Weight ratios of spleen and fat to body showed no significantly differences. In concentrations of serum total cholesterol and HDL-cholesterol, the group fed with CLA showed significantly higher values than that fed with CLA + selenium. In concentrations of serum triglyceride and LDL-cholesterol there were no significantly differences between the treatment groups. In conclusion, supplementation of CLA with selenium protected hepatomegaly and reduced level of serum total cholesterol and HDL-cholestererol in chickens.

• 동아시아식생활학회지
• /
• 제14권5호
• /
• pp.418-424
• /
• 2004

In this study, we investigated the effects of ostrich extract combined with Korean herb medicine(OEKHM) on the serum parameters in carageenan induced paw edema in rats. Carageenan causes enhanced edema formation which contributes to the pathophysiology of inflammation. Male Sprague-Dawley rats were used. There were four groups of treatments: OEKHMs and the control. After treatment with oral doses of 3 mL/180 g BW. 3 kinds of OEKHMs were processed which were ostrich bone with flesh meat with herb medicine(BFH), ostrich bone with flesh meat(BF), and ostrich bone with internal organs(BI). The contents of crude fat of the BFH was lower, but crude protein and crude ash of the BFH were significantly higher than those of the BF and the BI. In case of the levels of minerals(Ca, P, Mg, Fe, Cu and Zn ) of the BFH were significantly higher than those of BF and BI. And the heavy metals(Pb and Cd) were not detected in the OEKHM. The serum level of triglyceride in the BFH treated group decreased compared to that of the edema induced group. The serum levels of HDL-cholesterol concentration in the BFH supplemented group increased compared to that of the other groups. The serum levels of minerals(Ca, Mg, Fe, Cu and Zn) of the BFH treated group significantly increased than those of other groups(p<0.05).

• 한방재활의학과학회지
• /
• 제30권4호
• /
• pp.41-53
• /
• 2020

Objectives The purpose of this study was to investigate the effects of Silbi-san on the antioxidant and fat accumulation inhibition and to analyze the anti-obesity effect by analyzing the changes in serum lipid composition in obese mice. Methods We compared contents of phytochemicals like total polyphenols and total flavonoid and antioxidant activities such as 2,2-dipheny-1-picrylhydrazyl and 2.2'-azino-bis (3-ethylbenzothiazoline-6-sulphonic acid) radical scavenging activity. After Silbi-san in 3T3-L1 cells in vitro and mouse adipose tissue ex vivo, we quantified intracellular triglyceride accumulation and lipolysis. Moreover, the anti-obesity activity though inhibiting pancreatic lipase were analyzed. In 3T3-L1 cells, morphological changes showed that control cells had many lipid while cells treated with Silbi-san had less lipid accumulation. 30% EtOH Silbi-san treatment also suppressed the fat absorption by inhibiting the activity of pancreatic lipase and led to high lipolysis through promoting glycerol release. The experimental group was divided into four groups: Normal group fed normal feed, Control group fed 60% high fat diet (HFD) and distilled water, drug group fed 60% high fat diet and 200 mg/kg of Silbi-san water extract, drug group fed 60% HFD and 200 mg/kg of Silbi-san 30% ethanol extract. Results Serum total cholesterol content and serum low density lipoprotein-cholesterol content were significantly decreased in the Silbi-san extract group compared to the control group, serum high density lipoprotein-cholesterol content was significantly increased in Silbi-san extract group. Conclusions In this study, the antioxidant and fat accumulation inhibitory effects of Silbi-san were confirmed.