• Research in Community and Public Health Nursing
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• 제13권4호
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• pp.629-638
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• 2002

The impact of chronic diseases on patients and their families depends on how well the family members cope with it. Therefore, research on strategies for facilitating the coping of the families in a desirable manner is very important. Dementia management strategies refer to specific means families of dementia patients use to cope with dementing illness of their family members. This study was designed to examine type of dementia management strategies utilized by families and to identify factors influencing them. The subjects in this study were 103 conveniently selected demented patients and their primary caregivers who were registered to a public health center located in Chungcheong Province. The subjects were visited by 20 home visiting nurses, and the data were collected using a structured questionnaire. The data were collected form May 2, 2001 to June 2, 2001. The findings of this study were as follows. 1. The most frequently used types of dementia management strategies were active management (M=3.36, S.D=.96), and encouragement (M=2.94, S.D=.99). Criticism was least used type of dementia management strategy (M=2.71, S.D=.99). 2. The factors influencing each management strategy were as follows; 1) The criticism management strategy was most frequently used by the primary caregivers who graduated elementary school (F=3.21, p<.05). 2) The encouragement strategy was most frequently used by the primary caregivers in a case when the patients were in the mild stage of dementia (F=2.76, p<.05), when the patients never had any treatment experiences (F=2.01, p<.05), when the family could afford the provision of treatment for the patients (F=-2.44, p<.050), and when the primary caregiver had a job (t=2.90, p<.01). 3) The active management strategy was most widely used by the primary caregivers who could afford the provision of treatment for the patients (F=-2.31, p<.05) and were in their 70s (F=3.04, p<.05). This type of management strategy was significantly more used by those who discussed the difficulties of caring with their family members (F=3.46, p<.05). 3. The use of criticism management strategies was significantly correlated with the total level of burden of the primary caregivers. But the types of encouragement and active management strategies had negative correlations with the caregivers' burden although they were not significant. Since the findings of this study showed that the criticism management strategy had a significant positive relationship with caregivers' burden, those who are more likely to use the negative management strategy should be identified in future studies. The primary caregivers who are more likely to use negative strategy should be more closely monitored and be focused as the group who should be intervened in future studies.

• Journal of Korean Neuropsychiatric Association
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• 제57권3호
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• pp.230-234
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• 2018

A large proportion of patients with schizophrenia show a poor response to first-line antipsychotic drugs, which is termed treatment-resistant schizophrenia. Previous studies found that a different neurobiology might underlie treatment-resistant schizophrenia, which necessitates the development of different therapeutic approaches for treating treatment-resistant schizophrenia. This study reviewed previous studies on the pathophysiology of treatment-resistant schizophrenia and the pharmacological intervention, and forthcoming investigations of treatment-resistant schizophrenia are suggested.

• Journal of Society of Preventive Korean Medicine
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• 제25권3호
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• pp.39-55
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• 2021

Objective : To investigate specific prescriptions, herbal medicines and treatment strategy, this study systematically reviewed case studies on traditional Chinese medicine (TCM) treatment for childhood cancer. Method : Literature searches were performed on database of China National Knowledge Infrastructure (CNKI). Studies published before December 2020 were categorized and analyzed according to the treatment strategy and we also investigated Chinese herbs used in the prescriptions. Results : Twenty-five studies including 17 case series and 8 single case reports were included in our review. Of the total 439 patients, 379 (85.7%) had leukemia and other myeloplastic disease. Conventional western medicine (CWM) treatment was also used with TCM based on the syndrome identification. Most studies reported favorable effect of combination treatment with CWM and TCM. Among 266 herbs in the studies, reinforcing herbs were more frequently used than anti-cancer herbs. Conclusion : Traditional herbal treatment for childhood cancer should be performed considering the syndrome identification as well as stage of CWM. Reinforcing herbs should be more focused because of the fragility and growth of the childhood.

• Journal of Korean Neurosurgical Society
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• 제62권2호
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• pp.201-208
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• 2019

Objective : In patients with internal carotid artery (ICA) occlusion, collateral middle cerebral artery (MCA) flow has a protective role against ischemia. However, some of these patients may experience initial major neurological deficits and major worsening on following days. Thus, we investigated the safety and efficacy of endovascular treatment (EVT) for ICA occlusion with collateral MCA flow by comparing clinical outcomes of medical treatment versus EVT. Methods : The inclusion criteria were as follows : 1) acute ischemic stroke with ICA occlusion and presence of collateral MCA flow on transfemoral cerebral angiography (TFCA) and 2) hospital arrival within 12 hours from symptom onset. The treatment strategy was made by the attending physician based on the patient's clinical status and results of TFCA. Results : Eighty-one patients were included (30 medical treatment, 51 EVT). The EVT group revealed a high incidence of intracranial ICA occlusion, longer ipsilesional MCA contrast filling time, and a similar rate of favorable clinical outcome despite a higher mean baseline the National Institutes of Health Stroke Scale (NIHSS) score. By binary logistic regression analysis, intravenous recombinant tissue plasminogen activator and EVT were independent predictors of favorable clinical outcome. In subgroup analysis based on stroke etiology, the non-atherosclerotic group showed a higher baseline NIHSS score, higher incidence of EVT, and a higher rate of distal embolization during EVT in comparison with the atherosclerotic group. Conclusion : In patients with ICA occlusion and collateral MCA flow, decisions regarding treatment strategy based on TFCA can help achieve favorable clinical outcomes. EVT strategy with respect to etiology of ICA occlusion might help achieve better angiographic outcomes.

• Journal of Aquaculture
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• 제20권1호
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• pp.56-59
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• 2007

Effect of dietary nutrient composition on growth and body composition of juvenile olive flounder Paralichthys olivaceus with different feeding strategy was determined. Twenty-five fish averaging 16 g were randomly distributed into 12, 180 L flow-through tank each. Four treatments in triplicates were prepared: fish were fed to satiation twice daily by the control diet for 8 weeks as the control group (Con) and fish were fed to satiation twice daily by the control and high nutrient diets for 6 weeks after 2-week fasting (2WS-6WFC, 2WS-6WFHN, respectively) and finally, fish were fed to satiation twice daily by the high nutrient diet for the consecutive 3 days after 4-day fasting for 8 weeks (4DS-3DFHN). No significant difference was found in either survival or weight gain of flounder among treatments. Feed efficiency ratio (FER) for fish in the 2WS-6WFHN treatment was significantly higher than that for fish in the Con and 2WS-6WFC treatments. Protein efficiency ratio (PER) of fish in the 2WS-6WFHN and 4DS-3DFHN treatments was significantly higher than that of fish in the 2WS-6WFC treatment. In conclusion, manipulation of dietary nutrient composition and/or feeding strategy can effectively improve growth of juvenile olive flounder without growth retardation at restricted feeding regime.

• ETRI Journal
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• 제30권1호
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• pp.81-88
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• 2008

The security threat posed by worms has steadily increased in recent years. This paper discusses the application of the optimal and sub-optimal Internet worm control via Pontryagin's maximum principle. To this end, a control variable representing the optimal treatment strategy for infectious hosts is introduced into the two-factor worm model. The numerical optimal control laws are implemented by the multiple shooting method and the sub-optimal solution is computed using genetic algorithms. Simulation results demonstrate the effectiveness of the proposed optimal and sub-optimal strategies. It also provides a theoretical interpretation of the practical experience that the maximum implementation of treatment in the early stage is critically important in controlling outbreaks of Internet worms. Furthermore, our results show that the proposed sub-optimal control can lead to performance close to the optimal control, but with much simpler strategies for long periods of time in practical use.

• The Journal of Korean Physical Therapy
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• 제15권4호
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• pp.180-189
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• 2003

The purpose of this study was to emphasize the strategy of the home visiting physical therapy for elderly patients who have joint and musculoskeletal problems, disabled person who staying in home and early discharged person who staying in home with replacement of artificial hip joint and central nerve system problems with CP, CVA, SCI etc. Home visiting physical therapist can provide evaluation and diagnosis, treatment with their special knowledge and techniques, treatment council and education for the patients and family member and refer the patients to other specialist. Home visiting physical therapy can expects that patients will have better treatment with emotionally, economically and for long term care patients.

• Journal of applied mathematics & informatics
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• 제39권5_6호
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• pp.895-918
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• 2021

Human African Trypanosomiasis (HAT) also known as sleeping sickness, is a neglected tropical vector borne disease caused by trypanosome protozoa transmitted by bites of infected tsetse fly. The basic reproduction number, R₀ derived using the next generation matrix method which shows that the disease persists in the population if the value of R₀ > 1. The numerical simulations of optimal control model carried out to determine the control strategy that can combat HAT under the minimum cost. The results indicate that, the use of both education campaign, treatment and insecticides are more efficient and effective to eliminate HAT in African community but too costly. Furthermore, the cost-effectiveness of the control measures (education campaign, treatment and insecticides) were determined using incremental cost-effectiveness ratio (ICER) approach and the results show that, the use of education and treatment of infected people as the best cost effective strategy compared to other strategies.

• Journal of Genetic Medicine
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• 제19권2호
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• pp.49-56
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• 2022

Mitophagy, the selective degradation of damaged or surplus mitochondria using core autophagy machinery, plays an essential role in maintaining cellular mitochondrial function. Impaired mitophagy is closely linked to various human diseases, including neurodegenerative diseases, cardiovascular diseases, cancers and kidney disease. Defective mitophagy induces the accumulation of damaged mitochondria and thereby results in a decline in cellular survival and tissue function. Accordingly, enhancement of mitophagy has been proposed as a novel strategy for the treatment of human diseases closely linked to mitochondrial dysfunction. Recent studies showing that the stimulation of mitophagy has a therapeutic effect on several disease models highlight the possibility of disease treatment using mitophagy. The development of mitophagy inducers with toxicity and the identification of molecular mechanisms will enable the clinical application of mitophagy-based treatments.

• Journal of Environmental Science International
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• 제27권6호
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• pp.447-456
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• 2018

In this research, the target process was a modified type of a conventional aeration tank with four different influent feeding points and alternated aeration to obtain nitrogen removal. For more accurate switching of influent feeding, the process was operated under a designed control strategy based on monitoring of $NH_4-N$ and $NO_X-N$ concentrations in the tank. However, the strategy did have some limitations. For example, it was not sensitive to detecting the end of each reaction when losing the balance between nitrification and denitrification of each opposite part of biological tank. To overcome the limitations of the existing control strategy, a diagnosis-based control strategy was suggested in this research using the diagnosis results classified as normal (N), ammonia accumulation (AA) and nitrate accumulation (NA). Using the pre-designed rules for control actions, the aeration and volume of the aerated part of the reactor could be increased or decreased at a fixed mode time. In simulations of the suggested diagnosis-based control strategy, the $NH_4-N$ and $NO_X-N$ removal rates in the reactor were maintained at higher levels than those of the existing control strategy.