• The Korean Journal of Physiology and Pharmacology
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• v.15 no.5
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• pp.259-266
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• 2011

The aim of this study was to evaluate the preventive role of epigallocatechin-3 gallate (EGCG, a derivative of green tea) in ischemia/reperfusion (I/R) injury of isolated rat hearts. It has been suggested that EGCG has beneficial health effects, including prevention of cancer and heart disease, and it is also a potent antioxidant. Rat hearts were subjected to 20 min of normoxia, 20 min of zero-flow ischemia and then 50 min of reperfusion. EGCG was perfused 10 min before ischemia and during the whole reperfusion period. EGCG significantly increased left ventricular developed pressure (LVDP) and increased maximum positive and negative dP/dt (+/-dP/dtmax). EGCG also significantly increased the coronary flow (CF) at baseline before ischemia and at the onset of the reperfusion period. Moreover, EGCG decreased left ventricular end diastolic pressure (LVEDP). This study showed that lipid peroxydation was inhibited and Mn-SOD and catalase expressions were increased in the presence of EGCG. In addition, EGCG increased levels of Bcl-2, Mn-superoxide dismutase (SOD), and catalase expression and decreased levels of Bax and increased the ratio of Bcl-2/Bax in isolated rat hearts. Cleaved caspase-3 was decreased after EGCG treatment. EGCG markedly decreased the infarct size while attenuating the increase in lactate dehydrogenase (LDH) levels in the effluent. In summary, we suggest that EGCG has a protective effect on I/R-associated hemodynamic alteration and injury by acting as an antioxidant and anti-apoptotic agent in one.

• Korean Institute of Interior Design Journal
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• v.21 no.5
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• pp.399-410
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• 2012

Due to development of modern medical services and economics, people raised expectation and demand about medical services from previous disease treatment to comprehensive health care covering prevention and health care. Responses of each medical facility to these social needs and the evolution of concept of medicine rapidly occur. The health examination centers are being operated with the purpose of health examination and this trend is reflected on several aspects such as the size of the facilities, function and configuration of space in health examination centers. Thus, health examination centers consisting of various space systems appear, but this trend and interpretations are lacking. Therefore, the purpose of this study is to draw trends of system through analysis of types and its evolved space systematic analysis and establish it. Analysis targets were classified into small, medium and large groups by sizes based on number of space and a total of 12 health examination centers in four for each category were selected. As research methods, functional relationship of space was examined through analysis of type in which segmentalized type tools were applied in local units. The flow diagram was established based on direction turning point and was classified into sub-flow and main-flow in local units and the systems between local units were derived. Finally, the results of this study can be summarized as the following three results. 1) The space connection system of health examination center showed four systems such as circulation, independence, continuation, and network. 2) Local type indicators and global type indicators which were evolved more from limitation of type analysis tools in existing research were derived so that more systematic analysis could be made. 3) Network system is distributed approach system and space for each function is formed around public space.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.15 no.10
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• pp.6092-6101
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• 2014

This study examined the job experience of visiting supervisors for multicultural families. To achieve the goal of this study, data was collected by in-depth interviews with 7 visiting supervisors for multicultural families. For an analysis of the data, the grounded theory approach by Strauss and Corbin [11] was employed. The results of an analysis of the categories are detailed below. Through an open coding process, a total of 124 concepts, 33 subcategories, and 13 categories were produced. The central phenomenon was 'uncertain employment '. From the axial coding, the causal conditions were 'employment for economic reasons' and 'frequent policy and regulation changes'. The contextual conditions were 'uneasiness about the evaluation result', 'unilateral work instruction system', and 'little improvement of treatment'. Intervention conditions were 'high level of satisfaction with work', 'handy source of income', and 'no other alternative'. Action/interaction strategies were 'efforts for contract extension' and 'receptive attitude'. The consequences were 'hope to retain employment' and 'agonizing over their rights'.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.23 no.7
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• pp.534-538
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• 2010

X-ray systems for medical treatment use noninvasive procedures. Being capable of locally inspecting the inside of the body, X-ray systems are routinely used for basic diagnosis. X-ray systems to be used for medical purposes were originally made with a gas filled tube inside an induction coil in the initial stages of development but with this approach it becomes difficult to take a satisfactory picture through thick body sections, non invasively. However continued development made it possible to take non-invasive pictures of breasts, blood vessels and other body parts through thick body sections. Recently, high-voltage X-ray generators of more compact size, increased generation efficiency, and sophisticated output control have become possible. All of these features are made possible by the use of a high-frequency output from an inverter and a fast switching semiconductor device. In this paper, we describe a new X-ray generator operating with a resonant inverter in order to reduce switching loss and high frequency noise. In addition, in order to identify the differences amongst types of rectification, we have compared output and the quality of X-ray pictures obtained with full-wave rectification and dual-voltage rectification methods.

• International Journal of Highway Engineering
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• v.9 no.4
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• pp.105-116
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• 2007

A ROUNDABOUT is more effective way to improve safety and prevent delays than signal intersection. ROUNDABOUT has been known highly safe treatment that could be used as a method to reduce conflicts between vehicles, to reduce travel speed in inner or approach of intersection, and to have no speed difference between drivers than intersection. In this study, the effective analysis on the installation of ROUNDABOUT was carried out using computer-based simulation tool VISSIM, in order to evaluate performance and safety of ROUNDABOUT and develope a warrant. In conclusion, the results indicated that there was remarkable increase of Y-intersection capacity and decrese of delay, and improvement of traffic safety. Finally, A nice feature of this study is to firstly attempt to use microscopic simulator to evaluate the effectiveness of ROUNDABOUT and suggest a passible operation boundary.

• Archives of Plastic Surgery
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• v.38 no.4
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• pp.512-515
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• 2011

Purpose: Osteoma is one of the common benign tumors of the skull vault and facial skeleton. Although most of the osteomas cause no symptoms, forehead osteomas may lead to facial disfigurement. Osteoma usually happens in solitary lesion and multiple osteomas which don't combine with syndrome are very rare. We report an experience of treatment of non-syndromic multiple osteomas in the skull. Methods: A 54-year-old female patient visited due to the multiple palpable hard masses on her forehead in 2010. In 2002 of her first visit, masses started to appear on her forehead and she was diagnosed as the osteoma by excisional biopsy. She visited again because the mass size and number increased. In preoperative CT scanning, there were above 160 of osteomas, so surgery was planned. Enterogastroduodenoscopy and colonoscopy was conducted to rule out Gardener's syndrome, however there was no abnormality such as multiple polyposis. Results: Under general anesthesia, coronal approach was conducted. There were numerous osteomas in frontal and parietal bone. The multiple osteomas were removed by burring and the patient recovered without any postoperative complications. Conclusion: Multiple osteomas in the skull were rarely reported, although it can accompanied with Gardener's syndrome. We report a case of non-syndromic multiple osteomas in skull vault.

• Tribology and Lubricants
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• v.31 no.6
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• pp.258-263
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• 2015

Biodiesel is an environmentally-friendly fuel with low smoke emission because it contains about 10% oxygen. Biodiesel fuel prepared by transesterification of vegetable oil or animal fats is susceptible to auto-oxidation. The rate of auto-oxidation depends on the number of methylene double bonds contained within the fatty acid methyl or ethyl ester groups. Biodiesel may be easily oxidized under several conditions, i.e., upon exposure to sunlight, temperature, oxygen environment. Maintenance of the fuel quality of biodiesel requires the development of technologies to increase the resistance of biodiesel to oxidation. Treatment with antioxidants is a promising approach for extending the shelf-life or storage time of biodiesel. The chemical properties of various amine-based antioxidants were evaluated after synthesis of the antioxidants by condensation of phenylenediamine with alkylamines at room temperature. In general, the oxidative stability can be assessed based on various experimental parameters. Such parameters may include temperature, pressure, and the flow rate of air through the samples. The Rancimat method (EN14112) was selected because it is a rapid technique that requires very little sample and provides good precision for oxidative degradation analysis. Specifically, the EN 14112 technique provides enhanced efficiency for oxidative stability evaluation when a larger ester head group is utilized. Therefore, this technique was employed for evaluation of the oxidation stability of biodiesel by the Rancimat method (EN14112).

• Journal of Korean Society on Water Environment
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• v.23 no.4
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• pp.490-497
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• 2007

A Combined sewer overflows (CSOs) are themselves a significant source of water pollution. Therefore, the control of urban drainage for CSOs reduction and receiving water quality protection is needed. Examples in combined sewer systems include downstream storage facilities that detain runoff during periods of high flow and allow the detained water to be conveyed by an interceptor sewer to a centralized treatment plant during periods of low flow. The design of such facilities as stormwater detention storage is highly dependant on the temporal variability of storage capacity available (which is influenced by the duration of interevent dry periods) as well as the infiltration capacity of soil and recovery of depression storage. As a result, a continuous approach is required to adequately size such facilities. This study for the continuous long-term analysis of urban drainage system used analytical probabilistic model based on derived probability distribution theory. As an alternative to the modeling of urban drainage system for planning or screening level analysis of runoff control alternatives, this model have evolved that offer much ease and flexibility in terms of computation while considering long-term meteorology. This study presented rainfall and runoff characteristics of the subject area using analytical probabilistic model. This study presented the average annual COSs and number of COSs when the interceptor capacity is in the range $3{\times}DWF$ (dry weather flow). Also, calculated the average annual mass of pollutant lost in CSOs using Event Mean Concentration. Finally, this study presented a decision of storage volume for CSOs reduction and water quality protection.

• The Journal of Internal Korean Medicine
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• v.41 no.3
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• pp.457-466
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• 2020

Introduction: This study aimed to report on the effectiveness of using Korean medicine to improve symptoms of mitral stenosis. While some patients that do not require surgery due to mild mitral stenosis are treated with medication, the medication does not always alleviate the symptoms. Thus, we administered Korean medicine treatments to those patients because there are not many case reports on using this approach to treat symptoms of mitral stenosis. Case Presentation: A 48-year-old male patient with mitral stenosis complained of symptoms, such as palpitation, dyspnea, chest pain, fatigue, and swelling in both legs. To reduce the patient's symptoms, we administered Korean medical treatments, including herbal medicine (Samulanshin-tang-gamibang) and acupuncture. To evaluate the results, we used the numeric rating scale (NRS) and the New York Heart Association (NYHA) functional classification. After 17 days of treatment, the NRS score decreased for palpitation (8→2), dyspnea (8→1), chest pain (5→0), fatigue (96→2), and swelling in both legs (6→2). The NYHA class also changed from Class II to Class I. No adverse reaction was noted. Conclusion: According to the results, Korean medicine treatments can be considered to be effective for mitral stenosis patients. To confirm this finding, a prospective study is needed in the future.

• Biomolecules & Therapeutics
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• v.25 no.2
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• pp.130-139
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• 2017

$CXCR5^+$ T follicular helper (Tfh) cells are associated with aberrant autoantibody production in patients with antibody-mediated autoimmune diseases including lupus. Follicular regulatory T (Tfr) cells expressing CXCR5 and Bcl6 have been recently identified as a specialized subset of $Foxp3^+$ regulatory T (Treg) cells that control germinal center reactions. In this study, we show that retroviral transduction of CXCR5 gene in $Foxp3^+$ Treg cells induced a stable expression of functional CXCR5 on their surface. The Cxcr5-transduced Treg cells maintained the expression of Treg cell signature genes and the suppressive activity. The expression of CXCR5 as well as Foxp3 in the transduced Treg cells appeared to be stable in vivo in an adoptive transfer experiment. Moreover, Cxcr5-transduced Treg cells preferentially migrated toward the CXCL13 gradient, leading to an effective suppression of antibody production from B cells stimulated with Tfh cells. Therefore, our results demonstrate that enforced expression of CXCR5 onto Treg cells efficiently induces Tfr cell-like properties, which might be a promising cellular therapeutic approach for the treatment of antibody-mediated autoimmune diseases.