• Korean Chemical Engineering Research
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• v.51 no.5
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• pp.597-601
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• 2013

In this study, we present simple microfluidic approach for the synthesis of monodisperse microcapsules by using droplet-based system. We generate double emulsion through single step in the microfluidic device having single junction while conventional approaches are limited in surface treatment for the generation of double emulsion. First, we have injected disperse fluid containing FC-77 oil and photocurable ethoxylated trimethylolpropane triacrylate (ETPTA) and water containing 3 wt% poly(vinyl alcohol) (PVA) as continuous phase into microfluidic device. Under the condition, we easily generate double emulsion with high monodispersity by using flow focusing. The double emulsion droplets are transformed into microcapsules under the UV irradiation via photopolymerization. In addition, we control thickness of double emulsion's shell by controlling flow rate of ETPTA. We also show that the size of double emulsions can be controlled by manipulation of flow rate of continuous phase. Furthermore, we synthesize microcapsules encapsulating various materials for the application of drug delivery systems.

• Genomics & Informatics
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• v.12 no.4
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• pp.283-288
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• 2014

Among all serious diseases globally, diabetes (type 1 and type 2) still poses a major challenge to the world population. Several target proteins have been identified, and the etiology causing diabetes has been reasonably well studied. But, there is still a gap in deciding on the choice of a drug, especially when the target is mutated. Mutations in the KCNJ11 gene, encoding the kir6.2 channel, are reported to be associated with congenital hyperinsulinism, having a major impact in causing type 1 diabetes, and due to the lack of its 3D structure, an attempt has been made to predict the structure of kir6.2, applying fold recognition methods. The current work is intended to investigate the affinity of four phytochemicals namely, curcumin (Curcuma longa), genistein (Genista tinctoria), piperine (Piper nigrum), and pterostilbene (Vitis vinifera) in a normal as well as in a mutant kir6.2 model by adopting a molecular docking methodology. The phytochemicals were docked in both wild and mutated kir6.2 models in two rounds: blind docking followed by ATP-binding pocket-specific docking. From the binding pockets, the common interacting amino acid residues participating strongly within the binding pocket were identified and compared. From the study, we conclude that these phytochemicals have strong affinity in both the normal and mutant kir6.2 model. This work would be helpful for further study of the phytochemicals above for the treatment of type 1 diabetes by targeting the kir6.2 channel.

• Journal of Digital Convergence
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• v.11 no.7
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• pp.59-66
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• 2013

Insurance has been preferential treatment than other financial products for risk ensure as a original function in tax law. However, the recent insurance products is being released in a variety of ways combined with investment and savings, as well as risk ensure. In addition, as the insurer's sales approach including to tax avoidance, tax saving strategies, tax policy associated with the tax-free savings-type insurance has been criticized. The government amended Article 25 of the Enforcement Decree of the Income Tax Act 2013 in order to prevent tax avoidance and equity among other financial instruments, but there are still many problems exist. this study looks for the validity of the tax policies of savings-type insurance In terms of the Enforcement Decree of the Income Tax Act as amended in 2013, and derived for ways to improve.

• Spatial Information Research
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• v.9 no.2
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• pp.227-238
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• 2001

As society progresses and becomes more complicated, improvements and demanded in the quality of life according to various interest groups. In relation to environment concerns, waste landfill sites in particular have been of concern. Conflicts involving treatment of such sites and decision making policies have been a point of contention between local governments, residents, and concerned organizations. To resolve these conflicts, this study developed the Multi-Criteria Spatial Decision Support System (MC-SDSS). The results of the case study revealed several conclusions; first, the approach used in this study can help to yield a better consensus for deciding upon waste landfill sites; next, by conducing sensitivity analysis, technical errors which can occur during the decision making process can be minimized; and finally, resistance from specific opposition groups can be effectively dealt with by using MC-SDSS.

• Women's Health Nursing
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• v.10 no.1
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• pp.32-41
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• 2004

Purpose: The purpose of this study was to explore and describe the process of life adaptation in women with cervical cancer. Method: A grounded theory method with guided data collection and analysis was used. Fifteen women with cervical cancer who had some kind of treatment at the hospital were asked open-ended and descriptive questions with a guideline. All interviews were tape-recorded and transcribed verbatim. Result: The core category that emerged from the comparative analysis was "overcoming cancer" named as a process of life adaptation in the participants. The process of overcoming cancer evolved three stages - "admitting reality", "attempting health-care" and "continuing health-care". Depending on the paradigm model, the central phenomena of the experiences was "powerlessness". The internal factors motivating women to overcome cancer were "denial of cancer" and "desire for life". Strategies of overcoming cancer included "living as a cancer patient," "selective food eating," "steady exercising," "getting rid of stress," and "preparing for death". The intervening conditions, "supportive system," "forms of life," and "burden on family," influenced overcoming cancer. Conclusion: The results of this study could help clinical nurses to understand life adaptation in cervical cancer patients and establish efficient coping strategies in dealing with the problems they face.

• YAKHAK HOEJI
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• v.41 no.6
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• pp.749-755
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• 1997

It has been reported that dose-dependent $Ca^{2+}$ increase by menadione in platelets could be measured by fluorescent dye, quin-2. The problems will be described here rel ating to measuring $Ca^{2+}$ in menadione-exposed platelets using fura-2 and fluo-3, widely used fluorescent indicators. Additions of menadione to fura-2 loaded platelets and their lysates resulted in marked reduction in fluorescence intensity at both 340nm ($Ca^{2+}$-unbound form) 380nm ($Ca^{2+}$-undbound form) excitation wavelengths. Fura-2 excitation spectra were overlapped with UV-visible absorption spectra of menadione, suggesting that light absorption by menadione itself could quench fluorescence generated by fura-2. Next approach was to use fluo-3 which has the higher wavelength (490nm) of excitation. Previous work demonstrated that treatment with probenecid to platelets was required to prevent fluo-3 dye leakage. However, probenecid itself was proven to be inadequate to measure the concentration of intracellular $Ca^{2+}$; by reducing menadione-induced cytotoxicity in platelets. Our results suggest that it is not feasible to measure $Ca^{2+}$ in platelets by using fura-2 and fluo-3 in the presence of probenecid, and cautions should be taken to measure changes of intracellular $Ca^{2+}$ levels by fluorescent dyes following chemical exposure.

• The Journal of Information Systems
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• v.29 no.2
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• pp.265-286
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• 2020

Purpose Among various psychosocial factors, negative social comparison, attention blocking to stimuli, and cognitive interference via information overload are considered most critical in hindering the effective performance improvement of computer-based idea generation. Given that the effect of negative social comparison along with a plausible solution based on the notion of performance feedback and goal setting has been successfully addressed, this study focused on the remaining issues of "attention blocking to stimuli and cognitive interference via information overload" and attempted to find a way to alleviate the effect of such process losses on performance. Design/methodology/approach A 2 × 4 between-subjects design was used, crossing cognitive ability (high and low) and personality (extroversion and introversion). Five subjects per each treatment were randomly selected to make the sample size equal. The group simulator was used to measure individual-level performance. The dependent variables were the quantity of and quality score of ideas. The manner by which these performance measures were operationalized was consistent with prior studies. An additional analysis using the number of diverse ideas was also conducted. Findings Three arguments were made in this study: (1) high cognitive individuals would perform better than low cognitive individuals, (2) extraverted individuals would perform better than introverted individuals, and (3) cognitive ability and personality would interact such that individuals in Q1 would have the highest performance. Cognitive ability had an effect on quality not quantity. Personality had an effect on both quantity and quality. An interaction between cognitive ability and personality was not found due to small sample size despite the use of the group simulator.

• Journal of Acupuncture Research
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• v.25 no.5
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• pp.117-125
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• 2008

Objectives : In these days Low back pain is most common, and the weakness of muscle strength is important factor. The aim of this study is to prove the influence of the exercise therapy on pain control and muscle strength in acute low back pain patient. Methods : Subjects of this research were 30 inpatients with acute low back pain from 2008. 3. 20 to 2008. 6. 20. 15 patients in each, 2 groups; Non exercise therapy, exercise therapy were divided and the conclusions for treatment are as follows. Results : 1. Regarding alleviation of pain by VAS, both non exercise therapy Group I and exercise therapy Group II showed significant decrease of VAS. 2. Muscle strengthening by extension and flexion peak torque, the exercise therapy Group II showed higher rate of improvement than the non exercise therapy Group I in extension peak torque. 3. Muscle strengthening by extension and flexion peak torque ratio, the exercise therapy Group II showed higher rate of improvement and distribution approach to normal ratio than the non exercise therapy Group I. Conclusions : Exercise therapy was effective in muscle strengthening of acute low back pain.

• Maxillofacial Plastic and Reconstructive Surgery
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• v.40
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• pp.19.1-19.6
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• 2018

Background: Calcium pyrophosphate dihydrate deposition disease (CPDD) is a rare disease in the temporomandibular joint (TMJ) space. It forms a calcified crystal mass and induces a limitation of joint movement. Case presentation: The calcified mass in our case was occupied in the left TMJ area and extended to the infratemporal and middle cranial fossa. For a complete excision of this mass, we performed a vertical ramus osteotomy and resected the mass around the mandibular condyle. The calcified mass in the infratemporal fossa was carefully excised, and the segmented mandible was anatomically repositioned. Scanning electronic microscopy (SEM)/energy-dispersive X-ray spectroscopy (EDS) microanalysis was performed to evaluate the calcified mass. The result of SEM/EDS showed that the crystal mass was completely composed of calcium pyrophosphate dihydrate. This result strongly suggested that the calcified mass was CPDD in the TMJ area. Conclusions: CPDD in the TMJ is a rare disease and is difficult to differentially diagnose from other neoplasms. A histological examination and quantitative microanalysis are required to confirm the diagnosis. In our patient, CPDD in the TMJ was successfully removed via the extracorporeal approach. SEM/EDS microanalysis was used for the differential diagnosis.

• The korean journal of orthodontics
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• v.41 no.5
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• pp.361-370
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• 2011

Objective: Speedy surgical orthodontics (SSO), an innovative orthodontic treatment, involves the application of orthopedic forces against temporary skeletal anchorage devices following perisegmental corticotomy to induce movement of specific dental segments. Herein, we report the biological effects of SSO on the teeth and periodontal structures. Methods: Five beagle dogs were divided into 2 groups and their 6 maxillary incisors were retracted $en$ $masse$ by applying 500 g orthopedic force against a single palatal mini-plate. Retraction was performed without and with perisegmental corticotomy in groups I and II, respectively. All animals were killed on the 70th day, and their periodontal structures were processed for histologic analyses and scanning electronic microscopy (SEM). The linear distance between the third maxillary incisor and canine was used as a benchmark to quantify the retraction amount. Results: Retraction was markedly faster and retraction amount greater in group II than in Group I. Surprisingly, Group II did not show any root resorption despite extensive retraction, while Group I showed prominent root surface irregularities. Similarly, SEM showed multiple resorption lacunae in Group I, but not in Group II. Conclusions: SSO is an effective and favorable orthodontic approach for major en masse retraction of the maxillary anterior teeth.