• 환경정책연구
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• 제3권2호
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• pp.113-137
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• 2004

The objective of this study is to introduce the definitions and classification methods of wastes in international agreements and legislations, examine the concept of wastes and their classification systems in Korea, and finally analyze and compare the concept of wastes in different countries for finding better solutions and suggestions. The study summarizes the concept of wastes as introduced in the Basel Convention, OECD, EU, US, and UK. First, each of the member countries adapt to the same concepts of wastes as defined in their international agreements; second, the intention of the wastes holder and the conditions of the wastes are considered at the same time when defining the concepts. Upon close examination of the classification of wastes systems as introduced in the Basel Convention, OECD, EU, US, and UK, the wastes are classified into toxic and non-toxic wastes according to the existence of poisonous substances. Therefore, it is classified as a toxic waste when any toxic substance on its list is included in the waste, while others are considered as a non-toxic waste if they don't contain poisonous substances. Secondly, in the UK, the matter of toxic or non-toxic wastes are classified, not according to the existence of the poisonous substances, but based on the generation of sources. In Korea, the concepts of wastes are divided into the two categories - a concept as defined in actual legislations and a concept in its translation. The Korean classification of the wastes include Wastes Management Act, amended in 1995, which stipulates that toxic substances should be managed in a special way as the designated wastes. It appears that the Act utilizes the classification method that classifies the wastes according to the existence of poisonous substance. Korea's concepts of wastes should be changed after recognition of the concepts in international agreement (Basel Convention, EU) and other foreign laws(US, UK) that consider subjective and objective standards at the same time when they define the concepts. Also, the development of technology in recycling and reuse of the wastes can remove the current absolute notion of the wastes so that it also should not be passed over. Also, because a classification structure of wastes has a close relationship with a disposal structure, its classification system should be fixed gradually to come up with the development of wastes disposal technology and its policy.

• 한국컴퓨터그래픽스학회논문지
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• 제25권5호
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• pp.1-9
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• 2019

본 논문에서는 강우시 빗방울로 인해 왜곡된 연안 파랑 비디오 영상에서 빗방울 제거와 제거된 영역에 대한 배경 정보를 복원하기 위한 적대적생성신경망을 이용한 영상 강화 방법을 제안하고자 한다. 영상 변환에 널리 사용되는 Pix2Pix 네트워크와 현재 단일 이미지에 대한 빗방울 제거에 좋은 성능을 보여주고 있는 Attentive GAN을 실험 대상 모델로 구현하고, 빗방울 제거를 위한 공개 데이터 셋을 이용하여 두 모델을 학습한 후 빗방울 왜곡 연안 파랑 영상의 빗방울 제거 및 배경 정보 복원 성능을 평가하였다. 연안 파랑 비디오에 영상에 대한 빗방울 왜곡 보정 성능을 향상시키기 위해 실제 연안에서 빗방울 유무가 짝을 이룬 데이터 셋을 직접 획득한 후 사전 학습된 모델에 대하여 전이 학습에 사용하여 빗방울 왜곡 보정에 대한 성능 향상을 확인하였다. 모델의 성능은 빗방울 왜곡 영상으로부터 파랑 정보 복원 성능을 최대 신호 대 잡음비와 구조적 유사도를 이용하여 평가하였으며, 전이 학습을 통해 파인 튜닝된 Pix2Pix 모델이 연안 파랑 비디오 영상의 빗방울 왜곡에 대한 가장 우수한 복원 성능을 보였다.

• 대한간호학회지
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• 제4권1호
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• pp.38-49
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• 1974

Presently, the performance level of the college student has received a great deal of attention, particularly in the area of professional education. The problem of under achievement, especially in areas dealing with science and technology, has gone through considerable investigation by numerous Psychologists and Educators. Thus for, however, they have not been successful in determining conclusively the non-intellectual factors involved. The maladjustment problem of these students has been a thorn in the side of nursing education for some time. This topic has been discussed among nursing educators without any tangible results. Furthermore, the fact that the number of students who withdraw from nursing education programs before graduation has increased. This represents a major problem for nursing education. This problem area had increased attention drawn to it on October 1957, when Russia successfully launched to first satellite "Sputnik" into space. Various studies seem to indicate that factors related to over achievement and under.achievement can be found in the motivation of the students. This study is aimed at testing 3 hypotheses which hopefully will lead to a better understanding of the learning activities of nursing students and to determine some of their nonintellectually personality traits. Hypothesis I: learning activities in nursing students and persona1ity are correlated, there will be significant differences in personality need structures between 4 classes of nursing collegiate students. Sub-hypothesis: There will also be significant differences in the degree of student satisfaction in her major subject. Hypothesis I: If there is a special personality need structure which is required for the clinical learning activity in general, then there will be significant differences between the personality need structures of under-achievers and overachiever. Hypothesis II : If each clinical nursing subject requires different personality need structures, then there will be differences in personality need structure between the different clinical groups Methodology: 1. Tool: A Korean translation and correction of the Edwards Personal Preference Schedule of U.S.A. was used. 2. Subject and Test Method: Subjects were nursing students at Yonsei University, who enrolled for Fall semester of 1971. The Researcher herself executed the test for the test for the class as a group, and the absent students were tested indidually. Out of 307 students, 293 students (95.4%) were reported. 3. Statistical treatment: The mean and standard deviation for each of the 15 personality need variables were computed and the value of T-test was obtained to determine the differences in the personality need structures between each group. Results: 1, For the first hypothesis, the personality need structures between each of the 4 classes and the reported degree of satisfaction in major subject showed significant differences. Therefore the hypothesis I was accepted. 2. The comparison of personality need structure of under-achievers and over-achievers in clinical fields showed significant differences. Thus hypothesis II was accepted. 3. Personality need structure between clinical subject groups showed significant differences therefore the 3rd hypothesis was accepted.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.24-24
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• 2017

Heavy metals at toxic levels have the capability to interact with several vital cellular biomolecules such as nuclear proteins and DNA, leading to oxidative stress in plants. The present study was performed to explore the metal tolerance mechanism in Sorghum seedling. Morpho-physiological and metal ions uptake changes were observed prominently in the seedlings when the plants were subjected to different concentrations of $CuSO_4$ and $CdCl_2$. The observed morphological changes revealed that the plants treated with Cu and Cd displayed dramatically altered shoot lengths, fresh weights, and relative water content. In addition, the concentration of Cu and Cd was markedly increased by treatment with Cu and Cd, and the amount of interacting ions taken up by the shoots and roots was significantly and directly correlated with the applied level of Cu and Cd. Using the 2-DE method, a total of 24 and 21 differentially expressed protein spots from sorghum leaves and roots respectively, 33 protein spots from sorghum leaves under Cd stress were analyzed using MALDI-TOF/TOF MS. However, the over-expression of GAPDH plays a significant role in assisting Sorghum bicolor to attenuate the adverse effects of oxidative stress caused by Cu, and the proteins involved in resistance to stress helped the sorghum plants to tolerate high levels of Cu. Significant changes were absorbed in the levels of proteins known to be involved in carbohydrate metabolism, transcriptional regulation, translation and stress responses. In addition, the up-regulation of glutathione S-transferase and cytochrome P450 may play a significant role in Cd-related toxicity and stress responses. The results obtained from the present study may provide insights into the tolerance mechanism of seedling leaves and roots in Sorghum under heavy metal stress.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.124-124
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• 2017

Cadmium (Cd) is of particular concern because of its widespread occurrence and high toxicity and may cause serious morpho-physiological and molecular abnormalities in in plants. The present study was performed to explore Cd-induced morpho-physiological alterations and their potentiality associated mechanisms in Sorghum bicolor leaves at the protein level. Ten-day-old sorghum seedlings were exposed to different concentrations (0, 100, and $150{\mu}M$) of $CdCl_2$, and different morpho-physiological responses were recorded. The effects of Cd exposure on protein expression patterns in S. bicolor were investigated using two-dimensional gel electrophoresis (2-DE) in samples derived from the leaves of both control and Cd-treated seedlings. The observed morphological changes revealed that the plants treated with Cd displayed dramatically altered shoot lengths, fresh weights, and relative water content. In addition, the concentration of Cd was markedly increased by treatment with Cd, and the amount of Cd taken up by the shoots was significantly and directly correlated with the applied level of Cd. Using the 2-DE method, a total of 33 differentially expressed protein spots were analyzed using MALDI-TOF/TOF MS. Of these, treatment with Cd resulted in significant increases in 15 proteins and decreases in 18 proteins. Significant changes were absorbed in the levels of proteins known to be involved in carbohydrate metabolism, transcriptional regulation, translation and stress responses. Proteomic results revealed that Cd stress had an inhibitory effect on carbon fixation, ATP production and the regulation of protein synthesis. In addition, the up-regulation of glutathione S-transferase and cytochrome P450 may play a significant role in Cd-related toxicity and stress responses. Our study provides insights into the integrated molecular mechanisms involved in response to Cd and the effects of Cd on the growth and physiological characteristics of sorghum seedlings. The upregulation of these stress-related genes may be candidates for further research and use in genetic manipulation of sorghum tolerance to Cd stress.

• 한국환경농학회지
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• 제36권4호
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• pp.241-248
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• 2017

본 연구는 최근 RNAi 기반 LMO의 연구 개발이 활발히 진행됨에 따라 향후 이러한 기술을 이용한 LMO의 유해성 및 자연생태계 위해성평가가 필요할 때 실험실 수준에서 dsRNA를 대량으로 발현시키는 시스템을 확립하고, 수분(화분)매개 곤충인 꿀벌을 대상으로 유해성평가 시험을 수행하는 방법을 제시하고자 하였다. L4440 vector에 Snf7과 GFP 유전자를 클로닝한 plasmid를 HT115 (DE3) 대장균에 형질 전환한 후 온도, 배양시간, IPTG 농도를 각기 다르게 하여 최적의 발현조건을 탐색한 결과 $37^{\circ}C$, 0.4 mM IPTG, 4시간의 배양시간에서 가장 많은 양의 dsRNA가 발현됨을 확인하였다. 국내 외 제시된 꿀벌 위해성평가 가이드라인을 바탕으로 대장균에서 분리한 dsRNA를 꿀벌 성충에 급성섭식으로 처리한 결과 생사율과 일반중독증상에서 차이를 보이지 않는 것으로 보아 대장균으로부터 분리한 Snf7 dsRNA와 GFP dsRNA는 꿀벌 성충에 유해하지 않음을 알 수 있었다. 본 연구를 통해 dsRNA 물질의 유해성평가 및 자연생태계 위해성 평가를 위한 대량 추출 방법과 위해성평가 대상종의 사육 및 물질 처리 방법을 확립하여 향후 이뤄질 dsRNA의 꿀벌 위해성평가에 활용될 것으로 사료된다.

• 동국한의학연구소논문집
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• 제7권1호
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• pp.1-32
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• 1998

청말 중서의회통파인 장석순의 의학사상을 "의학충중참서록"를 중심으로 정리하였다. 고전을 철처히 이해하여 동양의학의 이론을 바탕으로 서양의학을 접목시켜 장점을 취하고 단점을 보완하려고 노력하였다. 그의 의학적인 이론으로는 대기론, 기화론, 간병론, 화어법 등이 있고, 상한론과 온병학의 통합을 주장하고 내과병증에 다양한 방법을 제시하였다.

• 대한의용생체공학회:의공학회지
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• 제25권1호
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• pp.71-76
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• 2004

척추 측만증 교정 시 유합 범위에 따른 수술 후 의 효과를 분석하기 위하여 King-Moe type II 형태의 척추 측만증 환자를 대상으로 이에 대한 수학적 유한 요소 모델을 개발하였다. 유한 요소 모델을 이용하여 척추경 나사못을 이용한 고정 및 강봉 감염술 형태의 수술모사를 수행하였으며, 유합 범위를 각기 달리하여 수술 시뮬레이션 후의 척추계의 변화 즉 Cobb 각도, 첨추체 축회전, 흉추 후만각 그리고 늑골고의 변화를 정량적으로 계산하였다. 해석 결과 강봉 감염술의 경우에서 보다 강봉을 척추경 나사못에 연결시키는 과정에서 훨씬 더 많은 Cobb각도의 변화를 얻을 수 있었다. 강봉 감염술 과정에서는 약간의 Cobb각도 감소를 유발시킬 수 있었으나 오히려 척추체 축회전과 늑골 돌출고의 증가를 나타내었다 아울러 강봉과 척추경 나사못의 체결 과정이 척추 후만각 유지에도 큰 역할을 하고 있음을 알 수 있었다. 유합 범위를 변곡 발생 추체의 위치 보다 한 단계씩 길게(T4-12) 하여 60o의 강봉 감염술을 시행하였을 경우 Cobb 각도를 두 배 감소시킬 수 있었으나 급격한 늑골고와 첨추체 축회전량의 증가가 유발되었다. 해석 결과 유합 범위는 만곡 흠추체에서 변곡이 발생되는 위치 보다 한 레벨씩 작게 선정하는 것이 최적의 유합 범위임을 알 수 있었다.

• 사상체질의학회지
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• 제11권2호
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• pp.283-299
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• 1999

1. 연구목적 kainic acid를 실험동물에 주입할 경우 간질발작을 일으키고 변연계 특히 해마체 부위에서 조직의 손상이 일어나게 되는데 이는 사람에 있어 측두엽성 간질에서 보이는 구조적 변화와 유사한 것이다. 본 실험은 신경독성 물질인 kainic acid로 마우스의 해마체에 손상을 유발하고 이 경우에 열다한소탕이 신경보호효과가 있는지의 여부를 알고자한 것이다. 2. 연구방법 kainic acid를 경구투여하고 열다한소탕을 3주일간 복용시키면서 각각 1, 2, 3일과 1주, 3주에 조직을 관찰하였다. 조직손상은 해마체의 CA1, CA3과 thalamus, amygdala 등에서 c-fos 와 DNA fragmentation의 출현 율로 지표를 삼았으며 광학현미경하에서 육안적 관찰을 병행하였다. 3. 결과 및 결론 kainic acid만을 투여한 대조 군에서는 실험 3주째에도 손상지표인 c-fos 와 DNA fragmentation이 발견되었으나 열다한소탕을 투여한 실험 군에서는 실험 약 3일 째부터 손상지표의 발현이 줄어 7일째에는 나타나지 않음을 알 수 있었다. 또한 현미경 하의 육안적 관찰에서도 실험초기 많은 손상을 보였던 신경세포가 2주일 후 어느 정도 회복되는 것을 볼 수 있었다. 이로써 열다한소탕이 kainic acid로 유발된 실험동물의 해마체손상에 대하여 신경세포 보호 효과 및 손상 억제 효과가 있음을 알 수 있었다.

• The Korean Journal of Physiology and Pharmacology
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• 제16권6호
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• pp.393-398
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• 2012

Mast cells are involved in allergic responses, protection against pathogens and autoimmune diseases. Dexamethasone (Dex) and other glucocorticoids suppress $Fc{\varepsilon}RI$-mediated release of inflammatory mediators from mast cells. The inhibition mechanisms were mainly investigated on the downstream signaling of Fc receptor activations. Here, we addressed the effects of Dex on Fc receptor expressions in rat mast cell line RBL-2H3. We measured mRNA levels of Fc receptors by real-time PCR. As expected, Dex decreased the mRNA levels of activating Fc receptor for IgE ($Fc{\varepsilon}R$) I and increased the mRNA levels of the inhibitory Fc receptor for IgG $Fc{\gamma}RIIb$. Interestingly, Dex stimulated transcriptions of other activating receptors such as Fc receptors for IgG ($Fc{\gamma}R$) I and $Fc{\gamma}RIII$. To investigate the mechanisms underlying transcriptional regulation, we employed a transcription inhibitor actinomycin D and a translation inhibitor cycloheximide. The inhibition of protein synthesis without Dex treatment enhanced $Fc{\gamma}RI$ and $Fc{\gamma}RIII$ mRNA levels potently, while $Fc{\varepsilon}RI$ and $Fc{\gamma}RIIb$ were minimally affected. Next, we examined expressions of the Fc receptors on cell surfaces by the flow cytometric method. Only $Fc{\gamma}RIIb$ protein expression was significantly enhanced by Dex treatment, while $Fc{\gamma}RI$, $Fc{\gamma}RIII$ and $Fc{\varepsilon}RI$ expression levels were marginally changed. Our data showed, for the first time, that Dex regulates Fc receptor expressions resulting in augmentation of the inhibitory receptor $Fc{\gamma}RIIb$.