• 제목/요약/키워드: transformed

검색결과 6,492건 처리시간 0.037초

Fluorine Labeling in Biosynthetic Studies (I) : Synthesis of Fluorfarnesols

  • Park, O-Sook
    • Archives of Pharmacal Research
    • /
    • 제9권4호
    • /
    • pp.237-242
    • /
    • 1986
  • The Synthesis of E, E, E-12-fluorofarnesol and E, Z-6-fluorofarnesol which are key intermediates for the study of biosynthesis of some sesquiterpenes, is described. E, E-Farnesyl acetate is treated with selenium dioxide to give E, E, E-12-hydroxy farnesyl acetate, whih is transformed by DAST into E, E, E-12-hydroxy farnesyl acetate, which is transformed by DAST into E, E, E,-12-fluorofarnesylacetate. The latter compound is hydrolyzed to E, E, E,-12-fluorofarnesol. The reformatsky reaction of 6-methyl-5-hepten-2-one with ethyl bromofluoroacetate affords ethyl 2-fluoro-3-hydroxy-3, 7 dimethyl-6-octanoate. This ester is acetylated and eliminated to give ethyl (Z)-2-fluoro-3, 7-dimethylocta-2, 6-dienoate, which is transformed to allyl bromide via allylic alcohol. The allyl bromide is treated with dianion of methyl acetate to give-keto ester. The $\beta$-keto ester is converted to diethyl phosphoryloxy compound. The conjugate addition of lithium dimethylcuprate to the latter compound gives fluoro ester, which is treated with DIBAL to afford E, Z-6-fluorofarnesol.

  • PDF

임펠러 마모 상태 진단 (Diagnosis of Impeller Wear Conditions)

  • 이도환;이선기;정래혁;조민호
    • 한국소음진동공학회:학술대회논문집
    • /
    • 한국소음진동공학회 2010년도 추계학술대회 논문집
    • /
    • pp.236-241
    • /
    • 2010
  • This paper presents a wear diagnosis method for centrifugal impellers by using an accelerometer. The features are calculated from raw and wavelet transformed signals with several statistical methods applied in time or frequency domains. From the effectiveness coefficient test, it is shown that 7th level of wavelet transformed signal is suitable for wear classification problems. A neural network with 5 feature sets is applied to diagnose the wear magnitude of pump impellers. The verification result reveals that high accuracy for the wear diagnosis of impellers can be obtained by using wavelet features transformed from acceleration signals.

  • PDF

불확실 선형 시스템을 위한 적분 가변구조 지점에서 지점으로 레귤레이션 제어기 (A Variable Structure Point-to-Point Regulation Controller for Uncertain General Linear Systems)

  • 이정훈
    • 전기학회논문지
    • /
    • 제63권4호
    • /
    • pp.519-525
    • /
    • 2014
  • In this paper, an alternative variable structure controller is designed for the point-to-point regulation control of uncertain general linear plants so that the output of plants can be controlled from an arbitrarily given initial point to an arbitrarily given reference point in the state space. By using the error between the steady state value of the output and an arbitrarily given reference point and those integral, a transformed integral sliding surface is defined, in advance, as the surface from an initial state to an arbitrarily given reference point without the reaching phase problems. A corresponding control input is suggested to satisfy the existence condition of the sliding mode on the preselected transformed integral sliding surface against matched uncertainties and disturbances. Therefore, the output controlled by the proposed controller is completely robust and identical to that of the preselected transformed integral sliding surface. Through an example, the effectiveness of the suggested controller is verified.

오미자의 형질전환된 근으로부터 리그난 화합물의 검출 (Detection of Lignans from Transformed Root Cultures of Schisandra chinensis Baillon)

  • 황성진;표병식;황백
    • 한국약용작물학회지
    • /
    • 제12권6호
    • /
    • pp.448-453
    • /
    • 2004
  • Transformed roots of Schisandra chinensis were obtained following co-cultivation of in vitro cultivated plantlet segments with Agrobaterium rhizogens ATCC15834. This root was examined for its growth and gomisin J contents under various culture conditions. Among the six basal culture media tested, WPM (Lloyd & McCown, 1980) medium supplemented with 5% sucrose was the best roots growth 6.2 (g D.W/flask) and gomisin J accumulation 1.56 $(X10^{-3}\;ug/g\;D.W)$. Initial inoculum size correlated with the yield of biomass while gomisin J contents was not affect. Gomisin J production was influenced by the initial sucrose concentration and the highest production yield was achieved at the concentration of 7%. The optimal shaking speeds for roots growth and gomisin J production was 120 and 140 rpm, respectively.

Biotransformation of Ginseng Extract to Cytotoxic Compound K and Ginsenoside $Rh_2$ by Human Intestinal Bacteria

  • Bae, Eun-Ah;Choo, Min-Kyung;Lee, Young-Churl;Kim, Dong-Hyun
    • Natural Product Sciences
    • /
    • 제10권6호
    • /
    • pp.347-352
    • /
    • 2004
  • When saponin extracts of dried ginseng and red ginseng were anaerobically incubated with human intestinal microflora, these extracts were metabolized to compound K and ginsenoside $Rh_2$, respectively. However, when these extracts were incubated with commercial lactic acid bacteria, these did not metabolize these ginsenosides to compound K or ginsenoside $Rh_2$. Among some intestinal bacteria isolated from human feces, Bacteroides C-35 and C-36 transformed these saponin extracts to compound K and ginsenoside $Rh_2$, respectively. These bacteria also transformed water extracts of dried ginseng and red ginseng to compound K and ginsenoside $Rh_2$, respectively, similarly with that of the saponin extracts. Among transformed ginsenosides, compound K and 20(S)-ginsenoside $Rh_2$ exhibited the most potent cyotoxicity against tumor cells.

Expression of Modified Green Fluorescent Protein in Suspension Culture of Taxus cuspidata

  • Kim, Chang-Heon;Kim, Kyung-Il;Chung, In-Sik
    • Journal of Microbiology and Biotechnology
    • /
    • 제10권1호
    • /
    • pp.91-94
    • /
    • 2000
  • The suspension cells of Taxus cuspidata were transformed with Agrobacterium tumefaciens harboring binary vector pCAMBIE1302 encoding mgfp. Transient transfection efficiency was compared by using the fluoremetric measurement. The transient transfection efficiency was improved by transformation with DMSO and/or sonication treatment. Optimum conditions for DMSO and sonication treatment were 3% and 30sec, respectively. selection and maintenance of transformed cells were continued for 3 months. An insertion of the mgfp gene in transformed cells was detected by PCR and an expression of GFP confirmed by the western blot analysis.

  • PDF

Fuzzy modeling using transformed input space partitioning

  • You, Je-Young;Lee, Sang-Chul;Won, Sang-Chul
    • 제어로봇시스템학회:학술대회논문집
    • /
    • 제어로봇시스템학회 1996년도 한국자동제어학술회의논문집(국내학술편); 포항공과대학교, 포항; 24-26 Oct. 1996
    • /
    • pp.494-498
    • /
    • 1996
  • Three fuzzy input space partitoining methods, which are grid, tree, and scatter method, are mainly used until now. These partition methods represent good performance in the modeling of the linear system and nonlinear system with independent modeling variables. But in the case of the nonlinear system with the coupled modeling variables, there should be many fuzzy rules for acquiring the exact fuzzy model. In this paper, it shows that the fuzzy model is acquired using transformed modeling vector by linear transformation of the modeling vector.

  • PDF

Statistical Analysis of Effective Components for Aroma of Sigumjang

  • Choi, Ung-Kyu;Park, June-Hong
    • Food Science and Biotechnology
    • /
    • 제14권2호
    • /
    • pp.249-254
    • /
    • 2005
  • The relationship between Sigumjang gas chromatographic patterns precisely analyzed with capillary column and ranked order in sensory analysis was investigated by stepwise multiple regression analysis. Highly predictable multiple regression models were obtained in the analysis. Ninety percent of the Sigumjang aroma was explained by the regression models at step 15 in four transformation except for absolute value transformed with root square and relative value transformed with logarithm. The aroma of Sigumjang was most affected by 2,3-dimethylpyrazine at absolute value and absolute value transformed with logarithm and by 2-furancarboxaldehyde in other transformation. The quality of sigumjang was highly affected by ${\beta}$-phallendrenal, methylpyrazine, tetramethylpyrazine, 5-methyl-2-furancarboxaldehyde, unknown 2, octanoic acid, 4-ethylphenol, methyl 10,13-octadecanoate and ethyl linoleate.

파이프 내부의 유동소음에 관한 연구 (A study on the fluid noise in the pipe)

  • 황기수;최명진
    • 대한설비공학회:학술대회논문집
    • /
    • 대한설비공학회 2009년도 하계학술발표대회 논문집
    • /
    • pp.1435-1439
    • /
    • 2009
  • Drainage noise with making think about what they do disturbs neighborhoods live under source of noise. elbow pipe built in the house. the general elbow pipe has a rectangular elbow because of easiness when the plan set up or executing. therefore, free falling fluid impacts on the wall of the elbow pipe almost at one point. in this paper, to disperse the potential energy, the shock decentralizes from tiny area to large area. And It is considered how the characteristics change according to the noise of transformed shape of pipe, then researched the effectiveness of transformed pipe configuration.

  • PDF

Possible Involvement of 15-Deoxy-$\Delta^{12,14}$ prostaglandin $\textrm{J}_2$ in ET-18-O-$\textrm{CH}_3$-Induced Apoptosis in H-Ras Transformed Human Breast Epithelial (MCF10A-ras) Cells

  • Na, Hye-Kyung;Surh, Young-Joon
    • 한국독성학회:학술대회논문집
    • /
    • 한국독성학회 2003년도 춘계학술대회 논문집
    • /
    • pp.100-101
    • /
    • 2003
  • It has been known that elevated levels of COX-2 is associated with resistance to apoptosis in cancerous or transformed cells. However, recent studies have shown that up-regulation of COX-2 may be implicated in induction of apoptosis. Previous studies from this laboratory have shown that a novel alkylphospholipid type antitumor agent ET-18-O-$CH_3$ (l-O-octadecyl-2-0-methyl-glycero-3-phosphocholine) induces COX-2 expression in H-ras transformed human breast epithelial cells (MCF10A-ras) while it causes apoptosis in the same concentration range.(omitted)

  • PDF