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Discovery of Novel 4${\alpha}$ helix Cytokine by Hidden Markov Model Analysis

  • Du, Chunjuan;Zeng, Yanjun;Zhu, Yunping;He, Fuchu
    • Proceedings of the Korean Society for Bioinformatics Conference
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    • 2005.09a
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    • pp.41-44
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    • 2005
  • Cytokines play a crucial role in the immune and inflammatory responses. But because of the high evolutionary rate of these proteins, the similarity between different members of their family is very low, which makes the identification of novel members of cytokines very difficult. According to this point, a new bioinformatic strategy to identify novel cytokine of the short-chain and long-chain 4${\alpha}$ helix cytokine using hidden markov model (HMM) is proposed in the paper. As a result, two motifs were created on the two train data sets, which were used to search three different databases. In order to improve the result, a strict criterion is established to filter the novel cytokines in the subject proteins. Finally, according to their E-value, scores and the criterion, four subject proteins are predicted to be possible novel cytokines for each family respectively.

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A Study on the Maintenance Policy Considering the Failure Data of the EMU Braking System and the Cost Function (전동차 제동장치의 고장데이터와 비용함수를 고려한 유지보수 정책에 관한 연구)

  • Han, Jae-Hyun;Kim, Jong-Woon;Koo, Jeong-Seo
    • Journal of the Korean Society of Safety
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    • v.30 no.3
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    • pp.13-19
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    • 2015
  • Railway vehicle equipment goes back again to the state just before when failure by the repair. In repairable system, we are interested in the failure interval. As such, a statistical model of the point process, NHPP power law is often used for the reliability analysis of a repairable system. In order to derive a quantitative reliability value of repairable system, we analyze the failure data of the air brake system of the train line 7. The quantitative value is the failure intensity function that was modified, converted into a cost-rate function. Finally we studied the optimal number and optimal interval in which the costs to a minimum consumption point as cost-rate function. The minimum cost point was 194,613 (won/day) during the total life cycle of the braking system, then the optimal interval were 2,251days and the number of optimal preventive maintenance were 7 times. Additionally, we were compared to the cost of a currently fixed interval(4Y) and the optimum interval then the optimal interval is 3,853(won/day) consuming smaller. In addition, judging from the total life, "fixed interval" is smaller than 1,157 days as "optimal interval".

Experimental Study for Influence of Summertime Heat Sources and Basic States on Rossby Wave Propagation (여름철 열원과 기본장이 로스비 파동전파에 미치는 영향에 대한 실험 연구)

  • Kim, Seong-Yeol;Ha, Kyung-Ja;Yun, Kyung-Sook
    • Atmosphere
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    • v.20 no.4
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    • pp.505-518
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    • 2010
  • We investigated the impacts of the diabatic heating location, vertical profile and basic state on the Rossby wave propagation. To examine the dynamical process of individual responses on the regional heat source, a dry version of the linear baroclinic model was used with climatological summertime (JJA) mean basic state and vertical structure of the diabatic heating for 1979-2008. Two sets of diabatic heating were constructed of those positioned in the mid-latitudes (Tibetan Plateau, eastern Mediterranean Sea, and the west-central Asia) and the tropics (the southern India, Bay of Bengal, and western Pacific). It was found that using the principal component analysis, atmospheric response to diabatic heating reaches to the steady state in 19th days in time. The prescribed mid-latitude forcing forms equivalent barotropic Rossby wave propagation along the westerly Asia jets, whereas the tropical forcing generates the Rossby wave train extending from the tropics to mid-latitudes. In relation to the maximum vertical profile, the mid-level forcing reveals a stronger response than the lower-level forcing, which may be caused by more effective Rossby wave response by the upper-level divergent flow. Under the different sub-seasonal mean state, both of the tropical and mid-latitude forcing induce the different sub-seasonal response intensity, due to the different basic-state wind.

Vibration Analysis of Damper System in Torque Converter (토크 컨버터의 댐퍼 진동 특성)

  • Park, Tae-Jun;Kim, Myung-Sik;Jang, Jae-Duk;Joo, In-Sik
    • Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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    • 2007.05a
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    • pp.305-310
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    • 2007
  • This paper presents a damper system design in torque converter to minimize the vibration in powertrain of automatic transmission vehicle. The lock-up clutch in torque converter makes engine and transmission connected directly. When the lock-up clutch is engaged the torque fluctuation of engine is attenuated by the damper system. This function decides the vehicle power-train dynamic characteristics. At first, the dynamic hysteresis effect with any self and surface to surface contact problems of the damper springs in the damper system for torque converter is analyzed by using FEM. It is shown that these simulation results have a good design reference to energy dissipation operating by damper system in torque converter. And, to calculate dynamic characteristics, the vehicle model is structured by using $AMESim^{(R)}$?? that is a common use program. The vehicle model shows the frequency response of vehicle by changing the stiffness of damper spring, and these results lead the most suitable stiffness of spring. Also, new damper system is analyzed resonance frequency variation and is compared with prior damper.

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Training Data Sets Construction from Large Data Set for PCB Character Recognition

  • NDAYISHIMIYE, Fabrice;Gang, Sumyung;Lee, Joon Jae
    • Journal of Multimedia Information System
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    • v.6 no.4
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    • pp.225-234
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    • 2019
  • Deep learning has become increasingly popular in both academic and industrial areas nowadays. Various domains including pattern recognition, Computer vision have witnessed the great power of deep neural networks. However, current studies on deep learning mainly focus on quality data sets with balanced class labels, while training on bad and imbalanced data set have been providing great challenges for classification tasks. We propose in this paper a method of data analysis-based data reduction techniques for selecting good and diversity data samples from a large dataset for a deep learning model. Furthermore, data sampling techniques could be applied to decrease the large size of raw data by retrieving its useful knowledge as representatives. Therefore, instead of dealing with large size of raw data, we can use some data reduction techniques to sample data without losing important information. We group PCB characters in classes and train deep learning on the ResNet56 v2 and SENet model in order to improve the classification performance of optical character recognition (OCR) character classifier.

A Study on the Wear Characteristics of R/S Passing through Curves (곡선부 주행 차량의 마모특성에 관한 연구)

  • Lee, Hi-Sung
    • Journal of the Korean Society for Railway
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    • v.10 no.6
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    • pp.772-778
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    • 2007
  • For the wear characteristics assessment of Saemaul train passing through curves, an analysis model for multi-car system has been developed. By using this model and ADAMS/Rail, sensitivity analyses have been conducted for the wear characteristics by changing the related parameters. At low speed, the wear number and the sliding mean of right wheel showed higher than left wheel, while those of left wheel showed higher than right wheel at high speed. According to the decrease of curve radius, the wear number and the sliding mean were increased. When the length of transition curve was increased, the wear number and the sliding mean was increased. And according to increase of cant, the wear number and the sliding mean were increased.

Analysis of Earthquake Responses of a Floating Offshore Structure Subjected to a Vertical Ground Motion (해저지진의 수직지반운동에 의한 부유식 해양구조물의 지진응답 해석기법 개발)

  • Lee, Jin Ho;Kim, Jae Kwan;Jin, Byeong Moo
    • Journal of the Earthquake Engineering Society of Korea
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    • v.18 no.6
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    • pp.279-289
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    • 2014
  • Considering a rigorously fluid-structure interaction, a method for an earthquake response analysis of a floating offshore structure subjected to vertical ground motion from a seaquake is developed. Mass, damping, stiffness, and hydrostatic stiffness matrices of the floating offshore structure are obtained from a finite-element model. The sea water is assumed to be a compressible, nonviscous, ideal fluid. Hydrodynamic pressure, which is applied to the structure, from the sea water is assessed using its finite elements and transmitting boundary. Considering the fluid-structure interaction, added mass and force from the hydrodynamic pressure is obtained, which will be combined with the numerical model for the structure. Hydrodynamic pressure in a free field subjected to vertical ground motion and due to harmonic vibration of a floating massless rigid circular plate are calculated and compared with analytical solutions for verification. Using the developed method, the earthquake responses of a floating offshore structure subjected to a vertical ground motion from the seaquake is obtained. It is concluded that the earthquake responses of a floating offshore structure to vertical ground motion is severely influenced by the compressibility of sea water.

Sensorless Control of Rotor Field Oriented Induction Motor for Traction Application (견인 유도전동기의 새로운 센서리스 벡터제어)

  • Ryu, Hong-Je;Kim, Jong-Su;Im, Geun-Hui;Won, Chung-Yeon;Dragos, K
    • The Transactions of the Korean Institute of Electrical Engineers B
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    • v.49 no.9
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    • pp.626-634
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    • 2000
  • The paper describes a new and rigorous mathematical model using counter-EMF for the rotor field oriented system with induction motor which uses the estimated speed and rotor flux based on a Model Reference Adaptive System as well as the real-time approach. The estimated speed and rotor flux is used for the speed and flux feedback control. The stability and the convergence of the estimator are improved on the basis of hyperstability theory for non-linear systems. The validity of the proposed method is verified by simulation and also the sensorless control was tested on the propulsion system simulator used for the development of Korean High-Speed Railway Train(KHSRT).

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An analysis of mutual influence between power conversions caused by contact loss during traction of next generation high speed train (차세대 고속전철 주행에 따른 이선현상이 전력변환 상호간에 미치는 영향분석)

  • Kim, Jae-Moon;Chang, Chin-Young;Kim, Yang-Soo;Ahn, Jeong-Joon;Kim, Yeon-Joon
    • Proceedings of the KIEE Conference
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    • 2009.04a
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    • pp.10-12
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    • 2009
  • Electromagnetic Interference(EMI) in electric railway operation has become increasingly important. The components within very high power electronic, and the circuits for treating low-level signals, comprise complex system that must coexist and be highly reliable. To study it, It were included how much the HEMU-400X generates EMI and it has an effect on the power conversion units which resulted from Power Line Disturbance (PLD) phenomenon by contact loss during its running. In this study, the dynamic characteristic of a contact wire and pantograph suppling electrical power to high-speed trains are investigated. The analysis of the loss of contact based on Power Simulator program software is performed to develop power line disturbance model suitable for high speed operation. It is confirmed that a contact wire and pantograph model are necessary for studying the dynamic behavior of the pantograph system.

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A Study on the Vibration/Noise Reduction of a Gear Driving System by Adjusting the Distance between Gear Shafts (기어열의 축간거리 조절을 통한 진동/소음 저감에 대한 연구)

  • Kim, Chea-Sil;Lee, Won-Chang;Lee, Jong-Pan
    • Transactions of the Korean Society for Noise and Vibration Engineering
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    • v.16 no.7 s.112
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    • pp.697-703
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    • 2006
  • This article proposes a new technique for the reduction of vibration and noise in the geared system by adjusting the distance between gear shafts. The vibration and noise may be produced by the abnormal force applied to the tooth face. And the force may be the cause of ununiform velocity in the driven shaft. If the velocity is obtained to be uniform by adjusting the distance between shafts. the vibration and noise may be reduced to some extent. In order to review, a dynamic analysis model for the gear train used in a mill turret and a test rig are developed. The velocities in the driven shaft are calculated by dynamic simulations for the model and noises in the test rig are measured with varying of the distance between shafts. The comparison of simulation and test data shows that the distance between shafts at the most uniform velocity has the lowest level of noise.