• Clinical and Experimental Reproductive Medicine
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• 제18권1호
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• pp.63-71
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• 1991

To establish the normal fertile range in the results of the sperm zona-free hamster ova penetration assay (SPA) in Korean male, SPA using the low temperature ($4^{\circ}C$) capacitation in TEST-yolk buffer (TYB) was performed in 67 fertile and 26 infertile men. Sperm parameters in routine semen analysis were also checked and compared with the results of SPA. Sperm concentration, motility and motility index (MI) were significantly higher in fertile group compared with infertile group: $96.0{\pm}46.6$ vs $43.6{\pm}31.9{\times}10^6/ml$, $65.5{\pm}14.8%$ vs $45.8{\pm}23.6%$ and $46.31{\pm}13.29$ vs 27.40{\pm}17.98$, respectively. In fertile group, the hamster ova penetration rate (PR) was $98.5{\pm}5.0%$ (80%-100%), and the penetration index (mean penetrations per ovum, PI) was $9.59{\pm}6.35$(3.1-29.0). All the fertile men showed PI>3.0. In infertile group, PR was $24.6{\pm}24.8%$ (0%-70%), and PI was $0.40{\pm}0.42$ (0-1.3). Both PR and PI were significantly lower in infertile group. There was a significant correlation beween PI and sperm motility or MI, respectively, in fertile group whereas there was no correlation in infertile group. These data suggest that SPA using the low temperature capacitation in TYB can be a valuable diagnostic tool for the assessment of male fertility in vitro and provide an important supplement to the traditional tests of sperm quality.

• Nuclear Engineering and Technology
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• 제52권7호
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• pp.1565-1570
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• 2020

Photons with the energy of 60 keV are regularly used for some kinds of bone density examination devices, like the single photon absorptiometry (SPA). This article reports a flexible and lightweight rare earth/polymer composite for enhancing shielding efficiency against photon radiation with the energy of 60 keV. Lead oxide (PbO) and several rare earth element oxides (La₂O₃, Ce₂O₃, Nd₂O₃) were dispersed into natural rubber (NR) and the photon radiation shielding performance of the composites were assessed using monte carlo simulation method. For 60 keV photons, the shielding efficiency of rare earthbased composites were found to be much higher than that of the traditional lead-based composite, which has bad absorbing ability for photons with energies between 40 keV and 88 keV. In comparison with the lead oxide based composite, Nd₂O₃-NR composite with the same protection standard (the lead equivalent is 0.25 mmPb, 0.35 mmPb and 0.5 mmPb, respectively), can reduce the thickness by 35.29%, 37.5% and 38.24%, and reduce the weight by 38.91%, 40.99% and 41.69%, respectively. Thus, a flexible, lightweight and lead-free rare earth/NR composite could be designed, offering efficient photon radiation protection for the users of the single photon absorptiometry (SPA) with certain energy of 60 keV.

• Genomics & Informatics
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• 제19권3호
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• pp.21.1-21.5
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• 2021

The use of social media data, like Twitter, for biomedical research has been gradually increasing over the years. With the coronavirus disease 2019 (COVID-19) pandemic, researchers have turned to more non-traditional sources of clinical data to characterize the disease in near-real time, study the societal implications of interventions, as well as the sequelae that recovered COVID-19 cases present. However, manually curated social media datasets are difficult to come by due to the expensive costs of manual annotation and the efforts needed to identify the correct texts. When datasets are available, they are usually very small and their annotations don't generalize well over time or to larger sets of documents. As part of the 2021 Biomedical Linked Annotation Hackathon, we release our dataset of over 120 million automatically annotated tweets for biomedical research purposes. Incorporating best-practices, we identify tweets with potentially high clinical relevance. We evaluated our work by comparing several SpaCy-based annotation frameworks against a manually annotated gold-standard dataset. Selecting the best method to use for automatic annotation, we then annotated 120 million tweets and released them publicly for future downstream usage within the biomedical domain.

• 사상체질의학회지
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• 제19권3호
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• pp.62-74
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• 2007

1. Objectives This study is a pilot study to investigate the Mongolian's morphologic characteristics of face according to Sasang Constitution. 2. Methods We had collected 100 cases of Mongolian and took pictures their frontal view, lateral view of face and measured height, breaths and projected length of face with Face Features Measurement Program(FFMP) and analyzed shape differences of face according to Sasang constitution. 3. Results and Conclusions (1) In the frontal view of female, there were 11 items(total 322 items) significantly different among three constitutions, and in lateral view 13 items(total 191 items). (2) In the frontal view of male, there were 88 items(total 322 items) significantly different among three constitutions, and in lateral view 46 items(total 191 items).

• 한국미생물·생명공학회지
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• 제47권1호
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• pp.25-33
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• 2019

Lactobacillus rhamnosus BFE5264, isolated from a Maasai fermented milk product ("kule naoto"), was previously shown to exhibit bile acid resistance, cholesterol assimilation, and adhesion to HT29-MTX cells in vitro. In this study, we re-annotated and analyzed the previously reported complete genome sequence of strain BFE5264. The genome consists of a circular chromosome of 3,086,152 bp and a putative plasmid, which is the largest one identified among L. rhamnosus strains. Among the 2,883 predicted protein-coding genes, those with carbohydrate-related functions were the most abundant. Genome analysis of strain BFE5264 revealed two consecutive CRISPR regions and no known virulence factors or antimicrobial resistance genes. In addition, previously known highly variable regions in the genomes of L. rhamnosus strains were also evident in strain BFE5264. Pairwise comparison with the most studied probiotic strain L. rhamnosus GG revealed strain BFE5264-specific deletions, probably due to insertion sequence-mediated recombination. The latter was associated with loss of the spaCBA pilin gene cluster and exopolysaccharide biosynthetic genes. Comparative genomic analysis of the sequences from all available L. rhamnosus strains revealed that they were clustered into two groups, being within the same species boundary based on the average nucleotide identities. Strain BFE5264 had a sister group relationship with the group that contained strain GG, but neither ANI-based hierarchical clustering nor core-gene-based phylogenetic tree construction showed a clear distinctive pattern associated with the isolation source, implying that the genotype alone cannot account for their ecological niches. These results provide insights into the probiotic mechanisms of strain BFE5264 at the genomic level.

• 사상체질의학회지
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• 제19권3호
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• pp.99-125
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• 2007

1. Objectives This study focuses on the Revision and Translation of the Mongolian's Sasang constitution Diagnosis Questionnaire (SDQ-M) 2. Methods 03'SDQ's questionnaire analysis study have been performed based on the absolutely diagnosed group of 423 cases who have respond to the Sasang constitution Diagnosis Questionnaire (SDQ) from June to November, 2003. 3. Results and Conclusions Revised 05'SDQ-M's traits, which result from on the basis of 03'SDQ's questionnaire analysis study results and socio-cultural understanding via Mongolian physical constitution diagnosis as well as Mongolian translators' interchange, are as follows. (1) 05'SDQ-M is mainly adjusted in terms of external appearances and the nature of illness symptoms. (2) 05'SDQ-M's physical constitution questionnaires are equally adjusted. (3) 05'SDQ-M is re-used, deleted, or created on the basis of 03'SDQ's questionnaire analysis results. (4) 05'SDQ-M is translated to be easy for Mongolians.

• 한국경제지리학회지
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• 제1권1호
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• pp.173-191
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• 1998

본 연구는 정부의 무안 국제공항 건설 결정과 관련하여 특색 있는 무안지역의 관광개발 방안을 제시하는 데 그 목적을 두고 있다. 현재 각 지방자치단체가 추진하고 있는 천편일률적인 위락공간 조성 위주의 관광개발을 지양하고 관광의 본질에 충실한 관광개발을 위해 다음과 같은 세 가지 근본적인 질문을 제기하였다. 관광의 본질은 무엇인가\ulcorner 누구를 위한 관광개발인가\ulcorner 무엇을 위한 관광개발인가\ulcorner 여기에서 얻어진 결론은 극히 원론적인 것임에도 불구하고 실제에 있어서 잘 지켜지지 않고 있는 것으로 다음과 같이 요약할 수 있다. 첫째, 관광개발은 해당 지역에 자연적.역사적으로 주어진 관광소재의 특성을 최대한 강화할 수 있도록 수행되어야 한다. 둘째, 관광개발 과정에 지역주민의 참여를 유도하고, 개발의 내용이 지역산업의 발전과 주민의 소득증대로 이어져야 한다. 셋째, 관광개발은 경제적 이익만을 추구하기보다는 지역주민과 관광객의 삶의 질을 종합적으로 향상시킬 수 있도록 추진되어야 한다. 본 연구에서는 특색 있는 무안군의 관광개발 방안으로 공항 연계도로지 꽃길 조성, 회산 연꽃 방죽의 불교 관광지 및 전통 요양 단지로의 개발, 일제시대 군용 비행장의 역사 문화 관광지화. 해수 목욕(해수찜) 단지 조성, 그리고 공항입지의 이점을 살린 관광농업의 활성화를 지적하였다.

• 한국컴퓨터정보학회논문지
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• 제11권3호
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• pp.117-124
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• 2006

본 논문에서는 자율적인 작업 처리 능력을 가진 이동 에이전트의 효율적인 이주를 위해 네트워크 트래픽 감지를 이용한 최적의 이주 노드 경로 탐색 및 최적 노드로의 경로조정 기법과 노드 재지정 기법을 제시한다. 기존의 이동 에이전트는 사용자로부터 다양한 작업을 부여받거나 혹은 에이전트의 작업 처리 결과 량이 매우 많을 경우, 에이전트의 크기 증가로 인해 네트워크 과부하 및 트래픽을 가중시킬 수 있다. 또한, 많은 네트워크 트래픽이 발생한 시점에서 사용자가 지정한 라우팅 스케줄(Routing Schedule)에 따라 이주를 수행하면 많은 노드 순회 시간 비용이 소요됨은 물론 통신망 결손 및 노드 장애와 같은 특정한 상황에 능동적으로 대처할 수 없다. 따라서 본 논문에서는 많은 네트워크 트래픽 발생 경로나 시점에서의 에이전트 이주 시 사용자에 의한 수동적 라우팅 스케줄 지정 방식에서 탈피하여 네트워크 트래픽 감지를 이용한 목적노드까지의 최적 경로 탐색을 통해 자동적인 경로 조정을 수행하는 에이전트의 이주 기법을 제시한다. 최적 이주 경로 탐색 및 조정 기법은 네트워크 트래픽 경로를 회피하는 방식으로 이동 에이전트의 순회 작업 처리 시간을 단축시키고 분산 노드에 대한 이주 신뢰성을 보장해준다.