• Title/Summary/Keyword: traditional knowledge data

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Recent advances in microfluidic technologies for biochemistry and molecular biology

  • Cho, Soong-Won;Kang, Dong-Ku;Choo, Jae-Bum;Demllo, Andrew J.;Chang, Soo-Ik
    • BMB Reports
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    • v.44 no.11
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    • pp.705-712
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    • 2011
  • Advances in the fields of proteomics and genomics have necessitated the development of high-throughput screening methods (HTS) for the systematic transformation of large amounts of biological/chemical data into an organized database of knowledge. Microfluidic systems are ideally suited for high-throughput biochemical experimentation since they offer high analytical throughput, consume minute quantities of expensive biological reagents, exhibit superior sensitivity and functionality compared to traditional micro-array techniques and can be integrated within complex experimental work flows. A range of basic biochemical and molecular biological operations have been transferred to chip-based microfluidic formats over the last decade, including gene sequencing, emulsion PCR, immunoassays, electrophoresis, cell-based assays, expression cloning and macromolecule blotting. In this review, we highlight some of the recent advances in the application of microfluidics to biochemistry and molecular biology.

『Aheuichaulyo』-Restoration of the lost medical book in ancient Korea (고려(高麗) 의서(醫書) 『어의촬요(御醫撮要)』의 복원)

  • Ahn, Sang-Woo
    • The Journal of Korean Medical History
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    • v.14 no.2
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    • pp.83-107
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    • 2001
  • "Aheuichaulyo御醫撮要" was known to be published by Choi Jong-jun崔宗峻 in Korea高麗 Dynasty(A.D.1226), however its original copy is not available at the present. It was thought that Korean folk medicine and the remedies were recorded in this book, and these were recorded in "Euibangyoochui醫方類聚" published in Chosun朝鮮 dynasty(1445). "Euibangyoochui" is called a treasure-house of the knowledge of traditional oriental medicine which contains over 50,000 prescriptions and enormous amount of medical information. The restoration of "Aheuichaulyo" was possible during the process of establishment of data base work of "Euibangyoochui". "Aheuichaulyo" was restored as 132 chapters mainly from the related con tents of "Euibangyoochui" and partially from the contents of "Hyangyakjipsungbang鄕藥集成方" and "Boonmoononyukyihaebang分門瘟疫易解方" for the supplement.

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Chemical Constituents from Non-polar Fraction of the Fruiting Bodies of Hericium erinaceum (노루궁뎅이 버섯 자실체의 비극성 분획에서 분리된 성분들)

  • Li, Wei;Shim, Sang Hee;Kim, Young Ho
    • Korean Journal of Pharmacognosy
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    • v.48 no.4
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    • pp.280-284
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    • 2017
  • Lion's Mane Mushroom, Hericium erinaceum, is a traditional edible mushroom widely used in culinary applications. It has been also used as a medicine in East Asian countries due to its various biological activities. Chemical investigation of fruiting bodies of this mushroom afforded many aromatic compounds, which were mostly isolated from polar fraction of its extracts. Herein we tried to investigate non-polar compounds from the extracts of this mushroom. $CHCl_3$-soluble fraction of the extracts was subjected to chemical investigation, which resulted in isolation of four compounds. Their chemical structures were elucidated as ircicerebroside (1), cortenuamide A (2), 1-D-arabinitol-monolinoleate (3), and cinnamic acid (4) on the basis of spectroscopic data. To the best of our knowledge, this is the first report of compounds 1, 2, and 4 from Hericium erinaceum.

Narcolepsy : Clinical Feature, Diagnosis and Treatment (기면증 : 임상 양상, 진단 그리고 치료)

  • Shin, Hong-Beom
    • Sleep Medicine and Psychophysiology
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    • v.17 no.2
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    • pp.63-68
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    • 2010
  • Narcolepsy is a central neurologic system disease. It begins early in life with disabling symptoms including excessive daytime sleepiness, cataplexy, sleep paralysis, hypnagogic hallucination and nocturnal sleep fragmentation. Patient with typical symptoms of narcolepsy is diagnosed by objective data from nocturnal polysomnography and multiple sleep latency tests. Narcolepsy is controlled with various medications. Nowadays, modafinil with favorable side effects profiles compared with traditional stimulant is mainly used. Gamma hydroxyl butyrate is effective in cataplexy. Cataplexy is also controlled with antidepressant such as Venlafaxine, SSRI, and TCA. As the knowledge of pathophysiology of narcolepsy expands, new treatment including immunological method, application of hypocretin and histamine systems have been tried.

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An overview of Korean Medicine for burn injury (화상에 대한 최근 한의학적 연구 동향)

  • Kwon, Ho-Young;Kim, Jeong-Hwan
    • Korean Journal of Acupuncture
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    • v.26 no.4
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    • pp.157-172
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    • 2009
  • Objective : The purpose of this study is to review and summarize the research on a burn. Methods : We reviewed 16 studies about burn which were relative to oriental medicine. We selected those studies from Korean studies Information Service System and Korean Traditional Knowledge Portal. Result : Selected 16 studies were divided into 12 trial articles, 3 case reports and 1 review article. Most of studies reported that oriental medical treatment of burn were effective. Conclusion : Further studies needed for burn and more clinical data would be needed to prove the effects of oriental medical treatment in burn.

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Learning and Classification in the Extensional Object Model (확장개체모델에서의 학습과 계층파악)

  • Kim, Yong-Jae;An, Joon-M.;Lee, Seok-Jun
    • Asia pacific journal of information systems
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    • v.17 no.1
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    • pp.33-58
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    • 2007
  • Quiet often, an organization tries to grapple with inconsistent and partial information to generate relevant information to support decision making and action. As such, an organization scans the environment interprets scanned data, executes actions, and learns from feedback of actions, which boils down to computational interpretations and learning in terms of machine learning, statistics, and database. The ExOM proposed in this paper is geared to facilitate such knowledge discovery found in large databases in a most flexible manner. It supports a broad range of learning and classification styles and integrates them with traditional database functions. The learning and classification components of the ExOM are tightly integrated so that learning and classification of objects is less burdensome to ordinary users. A brief sketch of a strategy as to the expressiveness of terminological language is followed by a description of prototype implementation of the learning and classification components of the ExOM.

Proposed approach for determination of tributary areas for scattered pressure taps

  • Aly, Aly Mousaad
    • Wind and Structures
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    • v.16 no.6
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    • pp.617-627
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    • 2013
  • In wind load calculations based on pressure measurements, the concept of 'tributary area' is usually used. The literature has less guidance for a systematic computational methodology for calculating tributary areas, in general, and for scattered pressure taps, in particular. To the best of the author's knowledge, there is no generic mathematical equation that helps calculate the tributary areas for irregular pressure taps. Traditionally, the drawing of tributary boundaries for scattered and intensively distributed taps may not be feasible (a time and resource consuming task). To alleviate this problem, this paper presents a proposed numerical approach for tributary area calculations on rectangular surfaces. The approach makes use of the available coordinates of the pressure taps and the dimensions of the surface. The proposed technique is illustrated by two application examples: first, quasi-regularly distributed pressure taps, and second, taps that have scattered distribution on a rectangular surface. The accuracy and the efficacy of the approach are assessed, and a comparison with a traditional method is presented.

Chemical Profile and Cytotoxicity Activity of Stem-bark of Anacardium occidentale

  • Shehu, Abdullahi;Ponnapalli, Mangala Gowri;Mahboob, Mohd;Prabhakar, Pitta Venkata;Olatunji, Gabriel Ademola
    • Natural Product Sciences
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    • v.28 no.2
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    • pp.62-67
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    • 2022
  • Column chromatographic fractionation of the methanol and ethyl acetate extracts of the stem-bark of Anacardium occidentale led to the isolation of five compounds (1-5). Their structures were determined by spectroscopic means by comparing spectral data to be β-sitosterol (1), 2,4-dihydroxy acetophenone (2), 1-monolinolein (3), ethyl oleate (4) and β-sitosterol-3-O-β-D-glucopyranoside (5). These compounds were evaluated for cytotoxicity against human cancer cell lines: A549, SCOV3 and rat normal cell line NRK49f. Compounds 2-5 were for the first time isolated from A. occidentale.

Diet-Cancer Related Nutrition Knowledge, Beliefs, and Attitudes of Korean Adults (한국 성인의 식습관-암과 관련된 영양 지식, 믿음, 태도에 관한 연구)

  • Jin, Young-Hee
    • Journal of the Korean Society of Food Culture
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    • v.15 no.2
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    • pp.111-121
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    • 2000
  • This study was to investigate the nutrition and cancer prevention knowledge, beliefs, attitudes, and self-reported dietary changes. Data were collected from 903 parents whose children were attending an elementary school, a middle school, a high school, or a junior college in Kimcheon. Thirty-seven percent of the subjects reported that they had made dietary changes for their health. Respondents reported eating more vegetables(33.1%), fruit(24.1%), whole grains(19.9%), and lower-fat meats(14.5%) and less alcohol(17.2%), high-fat meat(16.4%), fats(13.8%), smoked foods(13.8%), snacks/cake/sweets(11.7%), salty foods(9.6%), and refined grain products(6.1%). Those who did not make any dietary changes most often said the reason was that they thought their diets were already healthful and therefore there was no reason to make a change. Eighty-nine percent of the subjects agreed that diet and disease were related and 89.5% knew that diet and cancer were related, yet 8% believed there was nothing a person could do to reduce the risk of getting cancer. In response to open-ended questions about foods that either increase or decrease cancer risk, vegetables, fruit, traditional fermented foods, etceteras, and whole grains were thought to decrease risk, and burned foods, salty foods, additives, high-fat meats/fats, and alcohol were thought to increase cancer risk. In this study, education levels to be the major demographic variable and residential district had an impact on cancer prevention knowledge and attitudes. People at lower educational levels and rural residents should be targeted for education about cancer risk reduction.

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Using US Patent Analysis to Monitor the Technological Trend in the Field of Gastrointestinal Microbiome - Implications on Korean Medicine Research and Development - (미국 특허분석으로 보는 장내 미생물 기술 발전 현황 - 한의학 연구 및 한의약 기술 발전에 주는 시사점 -)

  • Geoncheol Jo;Sejun Yoon;Jeong Woon ,Bae;Byung Joo Kim
    • The Journal of Korean Medicine
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    • v.44 no.1
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    • pp.38-55
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    • 2023
  • Objectives: The purpose of this study was to provide direction for future research in the field of Korean medicine by analyzing microbiome based technologies emerging as a new diagnostic and treatment paradigm. Methods: To achieve the purpose of the study intellectual property data was used. After establishing citation network from registered microbiome-related US patents, citation network was analyzed by knowledge persistence-based main path approach to understanding technological trajectories. Furthermore, community detection algorithms were used to quantitatively identifying specific technological domain in a particular time period. Results: Results shows that early technologies in livestock industry contribute most to the recent patents. Knowledge in the patents flow through the path of food and beverage technological domain, and finally are inherited to the recent development of diagnosis, treatment and prevention technic. Conclusions: This study indicate that developing diagnostic tools which can link the composition of microbiome to specific diseases should be given high priority. Researches should lead to novel therapeutic strategies. Specifically, improving reliability of pattern identification and finding effective therapeutic compositions based on principles of Korean medicine is necessary.