• International journal of advanced smart convergence
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• 제7권4호
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• pp.57-65
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• 2018

Artificial neural network is inspired by the biological neural network. For simplicity, in computer science, it is represented as a set of layers. Many research has been made in evaluating the number of neurons in the hidden layer but still, none was accurate. Several methods are used until now which do not provide the exact formula for calculating the number of thehidden layer as well as the number of neurons in each hidden layer. In this paper model selection approach was presented. Proposed model is based on geographical analysis of decision boundary. Proposed model selection method is useful when we know the distribution of the training data set. To evaluate the performance of the proposed method we compare it to the traditional architecture on IRIS classification problem. According to the experimental result on Iris data proposed method is turned out to be a powerful one.

• Computers and Concrete
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• 제27권1호
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• pp.41-54
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• 2021

This paper introduced three new strengthening systems for isolated footings: BFRP wrapping system, CFRP wrapping system, and steel jacketing system. The proposed systems are more practical than the current traditional methods, which involves installing many dowel bars and splicing reinforcing steels to join new and old concrete segments. In the proposed three new systems, BFRP wraps, CFRP wraps, or steel jackets are installed on the exterior surface of the enlarged footing, with construction adhesive or a few steel dowels being applied to the contact surfaces. To investigate the effectiveness of three systems, forty-four models were constructed in ABAQUS, with different parameters being considered. All footings investigated failed in punching shear, including original and retrofitted footings. According to FEA results and parametric studies, the three strengthening systems were capable of improving the punching shear resistance of footings. By introducing a new factor η, the punching shear equation in Eurocode 2 was modified to predict the punching shear resistances of the strengthened footings. A linear formula was developed to present the relationship between the new factor η and the investigated parameters.

• 대한한의학원전학회지
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• 제37권1호
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• pp.41-56
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• 2024

Objectives : The purpose of this paper is to model each Xíng(行) of the Yīnyáng Wǔxíng(陰陽五行) theory as a vector, to interpret the Xiāngshēng Xiāngkè(相生相剋) theory as a vector sum, and argue the objectivity and universal applicability of the Xiāngshēng Xiāngkè(相生相剋) theory. Methods : The five xíngs of the Wǔxíng were modeled and expressed as vectors, and the Xiāngshēng Xiāngkè theories were quantitatively explained by vector summation. Results : We calculated the Wǔxíng vectors using the vector sum formula, and found that the Xíng vectors that received mutual support increased in size by about 62%, and the Xíng vectors that received opposition decreased in size by about 38%. Conclusions : This result could be considered as quantitative interpretation of the contents of the Xiāngshēng Xiāngkè(相生相剋) theory which has mostly been explained qualitatively. The results of this study could hopefully provide ideas to quantify various theories based on the Yinyangwuxing theory such as Korean Medicine and other traditional fields in East Asian culture.

• 대한한의학방제학회지
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• 제26권3호
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• pp.183-193
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• 2018

Objectives : In Traditional Korean Medicine, Epimedium koreanum Nakai has diverse pharmacological activities to treat impotence, forgetfulness, cataract and exophthalmos. Present study investigated anti-fibrogenic effects of E. koreanum water extract (EKE) in hepatic stellate cells (HSCs). Methods : To study anti-fibrogenic effects of EKE, LX-2 cells, a human immortalized HSCs, were pre-treated with $3-300{\mu}g/mL$ of EKE, and then subsequently exposed to 5 ng/mL of transforming growth $factor-{\beta}1$ ($TGF-{\beta}1$). Expression level of ${\alpha}-smooth$ muscle actin was determined by immunoblot analysis. Phosphorylation of Smad, transactivation of Smad, and expression of plasminogen activator inhibitor-1 (PAI-1) were monitored to investigate the effect of EKE on $TGF-{\beta}1-mediated$ signaling pathway. Results : Up to $100{\mu}g/mL$, EKE did not show any cytotoxicity on LX-2 cells. Pre-treatment of EKE ($100{\mu}g/mL$) significantly inhibited ${\alpha}-smooth$ muscle actin expression induced by $TGF-{\beta}1$. In addition, EKE significantly decreased Smad2 and Smad3 phosphorylations, Smad binding element-driven luciferase activity and PAI-1 expression by $TGF-{\beta}1$. Of three flavonoid compounds found in EKE, only quercertin ($30{\mu}M$) attenuated $TGF-{\beta}1-mediated$ PAI-1 expression. Conclusion : These results suggest that EKE has an ability to suppress fibrogenic process in HSCs via inhibition of $TGF-{\beta}1/Smad$ signaling pathway.

• 대한한의학방제학회지
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• 제26권3호
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• pp.237-250
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• 2018

Objectives : This study is a pharmacological network approach, aimed to identify the potential active compounds contained in Curcumae Radix, and their associated targets, to predict the various bio-reactions involved, and finally to establish the cornerstone for the deep-depth study of the representative mechanisms. Methods : The active compounds of Curcumae Radix have been identified using Traditional Chinese Medicine System Pharmacology Database and Analysis Platform. The UniProt database was used to collect each of information of all target proteins associated with the active compounds. To find the bio-metabolic processes associated with each target, the DAVID6.8 Gene Functional classifier tool was used. Compound-Target and Target-Pathway networks were analyzed via Cytoscape 3.40. Results : The target information from 32 potential active compounds of Curcumae Radix was collected through TCMSP analysis. The active compounds interact with 133 target genes engaging in total of 885 biological pathways. The most relevant pathway was the lipid-related metabolism, in which 3 representative active compounds were naringenin, oleic acid, and ${\beta}-sitosterol$. The mostly targeted proteins in the lipid pathway were ApoB, AKT1 and PPAR. Conclusions : The pharmacological network analysis is convenient approach to predict the overall metabolic mechanisms in medicinal herb research, which can reduce the processes of various experimental trial and error and provide key clues that can be used to validate and experimentally verify the core compounds.

• 한국지반공학회논문집
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• 제18권4호
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• pp.65-73
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• 2002

본 연구에서는 지중배전선로를 건설함에 있어 전력케이블용 보호관으로 사용되고 있는 PE파형관의 매설깊이별 작용압력-변형률 특성을 분석하기 위해 전산해석 및 실내 모형토조실험을 수행하였으며, 더불어 고전이론에 의한 해석과 비교 분석하여 지중연성관이 어느 매설깊이에서 안전하고 그 때의 거동특성이 어떤 양상을 보이는지 규명하였다. 실내 모형토조실험에 사용된 토조는 현장조건을 정확히 모사하기 위해 대규모로 제작(350$\times$220$\times$300cm)하였으며, 토조의 크기는 전산해석값을 이용하여 벽체에 의한 응력의 반발이 없도록 치수를 결정하였다. 가압장치로는 최대 25ton까지 압력을 가할 수 있는 Actuator시스템을 이용하였다. 각 해석방법에 적용된 매설형태는 A-1급 도로포장 아래 에 PE파형관이 묻히고, 임계하중으로 DB-24차량이 매설관 상단 중앙에 정차했을 때 관이 받는 작용압력-변형률 특성을 분석하였다. 해석결과, KS-C8455에 명시되어 있는 지중연성관의 허용변형률 기준인 3.5%에 만족하는 매설깊이는 약 40cm 이상인 것으로 판명되었고, 실내 모형토조실험 결과값에 대한 회귀분석을 통해 우리나라 지중배전선로의 현장조건에 잘 적용될 수 있는 지중연성관의 매설깊이에 따른 변형률 상관공식을 제안하였다.

• 동의신경정신과학회지
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• 제16권2호
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• pp.135-148
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• 2005

Objective : The purpose of this study is to take around the oriental medical treatment about substance related disorder in china. Method : We review the studies which are published by six different journal in China since 1992 to 2002 involved in substance related disorders. Result 1. The kinds of substance which is the subject of each study. It suggest that the narcotics-withdrawal patients in china take kinds of opium many more than phillopon or barbiturate, cocain etc. especially the heroine takes the most portion in the kinds of opium. 2. The type of chinese medicine demonstration which is about the addiction and withdrawal. There are many symptoms in the each period of withdrawal, According to the each period demonstration, the herbal formula must be different. 3. The formula used in treatment and the substance which is used in common Codonopsis radix is widely used, and pinellia ternata, aractylodes japonica, citrus nobilis, vegetable worms, angelica gigas, zizyphus jujuba, panax ginseng, astragalus membranaceus etc are also used in treatment. 4. The methods of acupunture treatment Hapkok(LI-4), Naegwan(PC6), and Sanyinjiao(SP6) are the widely used acu-points. in addition to these acupoints, there are waegwan(TE5) choksamli(ST36) hanggan(LR2)etc. Conclusion : We expect that this review about substance related disorders in TCM help the clinical study of substance related disorders in Korean medicine.

• 대한한의학방제학회지
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• 제21권2호
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• pp.44-52
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• 2013

Objectives : Samhwangsasim-tang (SST), Hwangryeonhaedok-tang (HHT), Ukgan-san (UGS), Onjunghwadam-hwan (OHH) and Samul-tang (SMT) have been used for the treatment of various diseases. This study was performed to compare the anti-obesity effects of 5 herbal formulas in high fat diet-(HFD) induced obese mice. Methods : The mice were randomly divided into seven groups that were fed a normal diet (ND), a HFD, a HFD plus SST (HFD + SST), a HFD plus HHT (HFD + HHT), a HFD plus UGS (HFD + UGS), a HFD plus OHH (HFD + OHH), or HFD plus SMT (HFD + SMT) at 300 mg/kg/day for 7 weeks. All groups were assayed for body weights, food efficiency ratio (FER), final liver and fat weight and blood biochemical parameters. Results : The increased body weights, food efficiency ratio (FER), and serum total triglyceride were decreased in HFD + OHH group relative to the same measurements in HFD group. Furthermore, the HFD + SST group significantly reduced FER, liver and abdominal subcutaneous fat weight gains, and serum total triglyceride, whereas HDL-cholesterol level was increased compared to HFD group. Conclusions : These results suggested that HFD + OHH and HFD + SST exert anti-obesity effects in HFD-induced obese mice.

• 대한한의학방제학회지
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• 제25권4호
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• pp.449-456
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• 2017

Objective : Coptis rhizoma is traditional herb in Korean medicine, and Pelargonium sidoides extract has been used for relief of acute bronchitis in Western medicine. The present study examined the antibacterial effect of fusion formulation of Coptis rhizoma extract and Pelargonium sidoides extract against bronchial diseases bacteria. Methods : Test sample, fusion formulation of Korean and Western medicine, was prepared by mixing Coptis rhizoma extract and Pelargonium sidoides extract at a ratio of 1:2 (w/w). Antimicrobial properties of test sample were determined by agar diffusion assay and minimum inhibitory concentration (MIC) against bronchus diseases bacteria. Results : In agar diffusion assay, the highest amount of test sample (4 mg/disk) exhibited antibacterial activity against all microorganisms tested. Test sample showed the high activity for S. aureus (19.5 mm), C. diptheriae (16.5 mm), A. fumigatus (19.3 mm), F. nucleatum (22.7 mm) and Mycobactrium sp. (17.3 mm), whereas it showed a low activity for K. pneumonia (9.7 mm). The MIC value was determined as $250{\mu}g/m{\ell}$ against C. diptheriae. Test sample showed better growth inhibitory effects against S. aureus and A. fumigatus with the MIC valus of $125{\mu}g/m{\ell}$. Conclusion : These results suggest the possibility of application to chronic respiratory diseases of fusion formulation of Korean and Western medicine, which was prepared with Coptis rhizoma extract and Pelargonium sidoides extract.

• 대한한의학방제학회지
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• 제28권4호
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• pp.451-458
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• 2020

뇌졸중 후 발생한 뇌전증 환자에서 항경련제와 함께 진간식풍탕가감방(鎭肝熄風湯加減方), 우황청심원(牛黃淸心元)을 위주로 하는 한의 치료를 병행하여 발작 억제 효과를 확인하였다.