• Molecular & Cellular Toxicology
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• 제3권sup4호
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• pp.34.4-34.4
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• 2007

• Molecular & Cellular Toxicology
• /
• 제5권4호
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• pp.323-327
• /
• 2009

• Molecular & Cellular Toxicology
• /
• 제3권sup4호
• /
• pp.35.2-35.2
• /
• 2007

• Molecular & Cellular Toxicology
• /
• 제3권sup4호
• /
• pp.37.5-37.5
• /
• 2007

• Molecular & Cellular Toxicology
• /
• 제3권sup4호
• /
• pp.37.3-37.3
• /
• 2007

• Molecular & Cellular Toxicology
• /
• 제3권4호
• /
• pp.299-305
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• 2007

The endocrine disrupting chemical, di (2-ethylhexyl) phthalate (DEHP) is a plasticizer used in polyvinyl chloride products ubiquitous in our daily lives. DEHP has potentially adverse effects on the liver, kidney, lung, heart, reproductive organs and endocrine systems. Many toxicological data on the DEHP toxicity have been stated, but complete protein profiles have not yet been reported. In this study, DEHP-induced oxidative DNA damage in rat lymphocyte was evaluated by Comet assay (single-cell gel electrophoresis) for the first time. Moreover, DEHP-induced protein profile alterations were examined in rat liver by using toxicoproteomic tools. 34 protein spots in the liver were identified to be significantly deregulated by DEHP on the 2-dimensional gel. Among them, 20 spots were up-regulated and 14 spots down-regulated by DEHP.

• Molecular & Cellular Toxicology
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• 제1권1호
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• pp.26-31
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• 2005

The detection and the regulation of man-made synthetic chemicals and the establishment of toxicity that may pose a genetic hazard in our environment are subjects of great concern because of its close correlation between environmental contamination and human health. Since the tens of thousands of man-made chemicals that have been introduced into the environment in the last few decades must also be tested for their damaging effect on DNA, the agents that cause this damage must be identified.

• Molecular & Cellular Toxicology
• /
• 제3권sup4호
• /
• pp.34.1-34.1
• /
• 2007

• Molecular & Cellular Toxicology
• /
• 제3권sup4호
• /
• pp.38-38
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• 2007

• Molecular & Cellular Toxicology
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• 제1권3호
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• pp.143-148
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• 2005

This review aims to show that industrial sustainable chemistry, minimizing or reducing the ecological impacts by the chemicals, is not an emerging trend, but is already a reality through the application of 'White Biotechnology' such as 'green' chemistry and engineering expertise. A large number of current industrial case studies are presented, as well as new developments from the chemical industry. The case studies cover new chemistry, new process design and new equipment. By articulating the requirements for industrial application of sustainable chemistry, this review also seeks to bridge any existing gap between academia and industry regarding the R & D and engineering challenges needed to ensure green chemistry research enables a more sustainable future chemical industry considering eco-toxicological impacts.