• 분석과학
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• 제12권6호
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• pp.550-557
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• 1999

본 연구에서는 209종의 PCBs 이성체중 독성등가계수(Toxic Equivalance Factor, TEF)가 제시된 13종의 toxic-PCBs에 대하여 Isotope dilution HRCC/HRMS 방법으로 저니토중의 toxic-PCBs를 분석하였다. 분석결과 surrogate 표준물질의 회수율은 71~99%로 양호하였다. 13종의 toxic-PCBs 농도는 0.84~2.49 ng/g 범위이었으며, 이중 2,2',3,3',4,4',5-HpCB(IUPAC No. 170) 및 2,2',3,4,4',5,5'-HpCB(IUPAC No. 180) 농도가 전체 농도의 50% 정도를 나타내었으며, 2,3,4,4,5-PeCB(IUPAC No. 114)도 10% 정도를 나타내었다. 독성등가계수로 환산한 농도는 0.38~2.63 pg-TEQ/g 범위이었으며, 3,3',4,4',5-PeCB(lUPAC No. 126)가 전체의 50%를 나타내었다.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.131-131
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• 2002

PCBs are wide spread persistent environmental pollutants that exert a broad spectrum of toxic effects. PCBs includes 209 possible congeners differing in extent and position of chlorination of their aromatic rings. In order to understand the toxic mechanism of PCBs, we have tested the effect of PCB on the EROD activity in vivo.(omitted)

• 환경위생공학
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• 제11권3호
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• pp.9-12
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• 1996

Polychlorinated biphenyl (PCBs) is one of major toxic pollutants in marine environments, This artificial chlorinated compound has been found in freshwater, seawater, soil, sediments and organismes living in various environments. Because of its toxicity and degradability, its uses in industrial processes have been banned after 1984 in Korea. Coastal area is an important environment for agriculture, industry, transportation, reduction of pollution loads through biogeochemical processes, cycling of nutrients and recreation. Input of pollutants from land and freshwater has been occurring through runoff, rivers and estuaries. Concentrations of PCBs were determined with GC-ECD. Concentrations of PCBs were in the range of 1.0 - 19.2 ng/g-dry weight of sediment(g-d.w.) at Ulsan, 4.5 -8,2 ng/g-d.w. at Onsan, 2.7 - 33.5 ng/g-d.w. at Masan and 4.0 - 60.7 ng/g-d.w. in Kwangyang, In Inchon area, PCBs were not detected in sediments. In sediments of Nakdong estuary, the distribution of PCBs' concentrations was 0.19 - 303 ng/g-d.w.

• 한국독성학회:학술대회논문집
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• 한국독성학회 2002년도 Current Trends in Toxicological Sciences
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• pp.130-130
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• 2002

Polychlorinated biphenyls (PCBs) are persistent environmental contaminants that elicit a broad spectrum of toxic effects in mammals and other vertebrate species. Because of their lipophilicity, chemical stability and resistance to biodegradation, PCBs tend to accumulate in the human body via food chain and environmental matrices including human adipose tissues, blood and milk.(omitted)

• 청정기술
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• 제11권1호
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• pp.29-39
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• 2005

잔류성 유기오염 물질 (POPs) 중의 하나인polychlorinated biphenyls (PCBs)는 강한 독성 및 난분해성으로 암, 내분기계장애(환경호르몬) 등을 유발할 수 있는데, 대부분의 PCBs는 변압기, 콘덴서 같은 전기 설비의 절연유를 오염시키고 있다. 국내외의 PCBs 관련 오염 현황및 관련 대책을 살펴보고, PCBs를 무해화 분해 처리하기 위한 기술로서 소각, 화학적 탈염소, 광화학, 생물학적 처리를 중심으로 국내외 기술 현황 비교 평가 및 특허 출원 동향을 분석하였다. 이를 바탕으로 향후 국내 PCBs 기술 개발및 대응 방향과 전망을 기술하였다.

• 한국환경생물학회:학술대회논문집
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• 한국환경생물학회 2002년도 학술대회
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• pp.123-126
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• 2002

Pollutants that are persistent, bioaccurnulative, and toxic have been linked to numerous adverse effects in human and animals, PBTs include heavy metals, polychlorinated biphenyls (PCBs), dioxins, polycyclic aromatic compounds (PACs) in addition to pesticides. This study focuses on toxic effects of the PBTs except pesticides on insects. Eight PBTs were selected from subgroups: three heavy metals (Pb, Hg, and Cd), two PCB mixtures (Aroclor mixtures 1 and 2), 2,3,7,8-tetrachlorodibenzo-p-dioxin, two monophenols (4-octylphenol and 4-nonylphenol), and tetrabutyltin, Beet armyworm, Spodoptera exigua, was used as test target insect species. Three physiological markers (metamorphosis, immune reaction, and follicle patency) were assessed in each exposure to different doses of the PCBs. Heat-shock proteins as molecular markers were also analyzed in response to the PCBs. All tested PBTs were toxic to metamorphosis from larvae to pupae when they were applied with diet. Two PCB mixtures were the most toxic compounds in this assay by giving significant toxicity at 0.005 ppm, while others had from 10 to 1000 ppm. Dioxin (0.1 ppb), tetrabutyltin (0.1 ppb), Pb (10 ppb), and Hg (0,01 ppb) were potent to inhibit immune reactions analyzed by inducing phenoloxidase activity and blocked phospholipase $A_2$ enzyme, Tetrabutyltin and dioxin significantly induced follicle cell patency, but their effects were lower than that of endogenous juvenile hormone, Dioxin, Pb, Hg, and Cd could induce the expression of heat shock proteins that were detected by immunoblotting against human HSP70 monoclonal antibody. HSP78 and HSP80 were upregulated in response to the PBTs. This expression was detected from the fat body and epidermis at as fast as 4h after injection. All these results clearly suggest that PBTs give significant ecotoxicity to insects that are valuable organisms in our environment.

• 한국대기환경학회지
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• 제21권3호
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• pp.285-293
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• 2005

This study was aimed at estimation of gas-particle partitioning of polychlorinated biphenyls (PCBs) in ambient air. The samples were collected at urban site in Japan from March 2002 to January 2003. The concentration of total PCBs (from 4 CB to 10 CB) and TEQ (Toxic equivalent) ranged from 62 to $247\;pg/m^3$ and from 2 to $14\;fgTEQ/m^3 $, respectively. The average contribution $(\%)$ of gas phase to total PCBs concentration was above $80\%$, which suggests that in the atmosphere PCBs predominantly existed in the gas phase. The weak correlations between total PCBs concentration and temperature was found. However this result was due to a typhoon during summer and raining during sampling period. The gas-particle partition coefficient (Kp) was obtained as a function of temperature. The partition ratio of gaseous and particulate phase PCBs can be estimated for an arbitrary temperature. The plot of gas/particle partition coefficient (log Kp) vs. sub-cooled liquid vapor pressure $(log\;P_L)$ had reasonable correlations for individual samples but the slope varied among the samples (coefficients of determination for log Kp versus log $P_L$ plot were> 0.76 $(p<0.0001)$, except for 3 samples). As a result, the variations in the slope among the sampling period may be due to change of temperature, raining during sampling period and wind in this study.

• Animal cells and systems
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• 제5권4호
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• pp.327-331
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• 2001

There is a critical developmental period during which brain sexual differentiation proceeds irreversibly under the influence of gonadal hormone. Recently, kinesin superfamily-associated protein 3 (KAP3) gene expressed during the 'critical period' of rat brain differentiation was identified by us (Choi and Lee, 1999). KAP3 functions as a microtubule-based motor that transports membranous organelles anterogradely in cells, including neurons (Yamazaki et al., 1996). mRNA level of KAP3 gene markedly increased before the initiation of puberty. Neonatal treatment of estrogen clearly inhibited the prepubertal increase in KAP3 mRNA level (Choi and Lee, 1999). In the present study, we aimed to investigate the effects of polychlorinated biphenyls (PCBs), as endocrine disruptors (EDs) on the expression of KAP3 gene during the 'critical period' of rat brain development. In our data, PCBs significantly decreased the expression of KAP3 gene in the fetal (day 17) and the neonatal (day 6 after birth in) male and female rat brains. The body weight and the breeding ability were significantly decreased in the PCBs-exposed rats compared with the control. These results showed that PCBs affect the transcriptional level of brain sexual differentiation related gene, KAP3, in the fetal and the neonatal rat brains. The maternal exposure to the PCBs may lead to toxic response in embryonic brain sexual differentiation and breeding ability after sexual maturation. This study indicates that KAP3 gene may be useful as a gene marker to analyze the molecular mechanism of toxic response in the animal brain development and sexual maturation exposed to PCBs.

• Journal of Advanced Marine Engineering and Technology
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• 제30권1호
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• pp.102-108
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• 2006

On the refutation demanded for a control of various toxic substances. PCBs(poly chlorinated biphenyl) has a fatal poisonous matter in the ecosystem and the environmental pollution as it Is a kind of stable chemical substance. Especially, the gross Product of PCBs is estimated at about one million tonnage all over the world. However it is kept on storing in untreated state, then has a deterioration by the Prolonged storage and a risk of overflowing. Therefore, this research examined the fundamental characteristics of combustion and emission for the target of using the IPA (iso-propyl alcohol) solution as a part of PCBs control. IPA was filled to three kinds of Vessel, i.e. Vessel I, II, and III, and then was investigated as follows combustion shape, flame temperature. mass burning velocity, and PM(Particulate matter). A radial thermometer and a C-A thermocouple measured the flame temperature, and the optical extinction method by using He-Ne laser and the filter weight method used in the PM measurement. As a result, with an increasing of L/S ratio, the flame length become shorter and the burning velocity is more rapid, but the particulate matters is higher. It is supposed that the air flow rate is high on Vessel. and then the combustion is Promoted in the surface area of the upstream zone. The future works plan to investigate the characteristics with an using of the mixing of IPA and PCBs

• Bulletin of the Korean Chemical Society
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• 제28권4호
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• pp.520-528
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• 2007

A practical and efficient disposal of PCBs (polychlorinated biphenyls) in waste transformer oil by a chemical dechlorination process has been reported. The transformer oil containing commercial PCB mixtures (Aroclor 1242, 1254 and 1260) was treated by the required amounts of PEG 600 (polyethylene glycol 600), potassium hydroxide (KOH) and aluminum (Al), along with different reaction temperatures and times. The reaction of PEG with PCBs under basic condition produces arylpolyglycols, the products of nucleophilic aromatic substitution. The relative efficiencies of PCB treatment process were assessed in terms of destruction and removal efficiency (DRE, %). Under the experimental conditions of PEG600/KOH/Al/100 oC/2hr, average DRE of PCBs was approximately 78%, showing completely removal of PCBs containing 7-9 chlorines on two rings of biphenyl which appear later than PCB no. 183 (2,2',3,4,4',5',6-heptaCB) in retention time of GC/ECD. However, when increasing the reaction temperature and time to 150 oC and 240 min, average DRE of PCBs including the most toxic PCBs (PCB no. 77, 105, 118, 123 and 169) in PCB family reached 99.99% or better, with the exception of PCB no. 5 and 8 (2,3-diCB and 2,4'-diCB). In studying the reaction of PEG with PCBs, it confirmed that the process led to less chlorinated PCBs through a stepwise process with the successive elimination of chlorines. The process also permits complete recovery of treated transformer oil through simple segregating procedures.