• 제목/요약/키워드: toxic substance

검색결과 233건 처리시간 0.026초

흡음재의 연소 생성물이 인체에 미치는 영향에 대한 실험적 연구 및 법률 개정 제언 (Experimental Study on the Effects of Combustion Products on the Human Body and Suggestion of Law Revision)

  • 강정기;최돈묵
    • 한국화재소방학회논문지
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    • 제33권4호
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    • pp.28-34
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    • 2019
  • 점화원이 무엇이든 화염의 확산과 인체에 영향을 미치는 직접적인 요소는 가연물이다. 음악학원, 노래방 등에서 사용하고 있는 마감재인 흡음재는 폴리우레탄으로 구성되며 연소 시 다량의 유독가스를 발생한다는 것은 알려진 사실이다. 그럼에도 현행법은 학원의 경우 수용인원 100명 미만의 경우 난연 마감재를 사용해야 한다는 강행규정이 없다. 본 연구에서는 실제 음악학원에 설치된 흡음재를 수거하여 실화재 연소실험을 통해 화염확산 속도를 측정하였으며, MultiRaelite 복합가스 측정기(타겟물질 VOC, HCHO, SO2, CO2, CO, HCN, NO2)를 이용하여 유독가스를 측정한 결과 Time weighted average (TWA)와 Short term exposure limit (STEL)의 허용농도를 초과하여 기기한계값이 측정되었다. 또한 시중에 판매중인 난연 흡음재와 비난연 흡음재를 비교 연소 실험한 결과, 착화 및 확산에 있어 현격한 차이를 보였다. 따라서 실험결과를 바탕으로 수용인원 100명 미만의 학원에도 난연 마감재 사용을 강제할 필요가 있음을 제언하고자 한다.

급성 중독으로 응급실에 내원하여 사망한 환자의 원인물질 및 시간 분포 (Causative Substance and Time of Mortality Presented to Emergency Department Following Acute Poisoning: 2014-2018 National Emergency Department Information System (NEDIS))

  • 이현재;좌민홍;한은아;고동률;고재욱;공태영;조준호;정성필
    • 대한임상독성학회지
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    • 제19권2호
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    • pp.65-71
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    • 2021
  • Purpose: The purpose of this study was to investigate the cause of acute fatal poisoning and the time of death by analyzing the National Emergency Department Information System (NEDIS) of South Korea. Methods: The NEDIS data from 2014 to 2018 excluding non-medical visits were used for this study. The patients with acute poisoning were extracted using diagnostic codes. The toxic substances were classified into pharmaceuticals, pesticides, gases, artificial poisonous substances, and natural toxic substances. Patients were classified according to the time of death, place of death, and region. In each case, the most causative substances of poisoning were identified. Results: There were 380,531 patients including poisoning-related diagnoses, of which 4,148 (1.1%) died, and the WHO age-standardized mortality rate was 4.8 per 100,000. Analysis of 2,702 death patients whose primary diagnosis was acute poisoning, the most common cause of poisoning death was pesticides (62%), followed by therapeutic drugs, gas, and artificial toxic substances. Herbicides were the most common pesticides at 64.5%. The proportion of mortality by time, hyperacute (<6 h) 27.9%, acute (6-24 h) 32.6%, subacute (1-7 d) 29.7%, and delayed period (>7 d) were 9.8%. Conclusion: This study suggests that the most common cause of poisoning death was pesticides, and 60% of deaths occurred within 24 hours. The 71% of mortality from pesticides occurred within 6-24 hours, but mortality from gas was mostly within 6 hours. According to the geographic region, the primary cause of poisoning death was varied to pesticides or pharmaceuticals.

화평법에 따른 급성 수생독성 예측을 위한 QSAR 모델의 활용 가능성 연구 (Applicability of QSAR Models for Acute Aquatic Toxicity under the Act on Registration, Evaluation, etc. of Chemicals in the Republic of Korea)

  • 강동진;장석원;이시원;이재현;이상희;김필제;정현미;성창호
    • 한국환경보건학회지
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    • 제48권3호
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    • pp.159-166
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    • 2022
  • Background: A quantitative structure-activity relationship (QSAR) model was adopted in the Registration, Evaluation, Authorization, and Restriction of Chemicals (REACH, EU) regulations as well as the Act on Registration, Evaluation, etc. of Chemicals (AREC, Republic of Korea). It has been previously used in the registration of chemicals. Objectives: In this study, we investigated the correlation between the predicted data provided by three prediction programs using a QSAR model and actual experimental results (acute fish, daphnia magna toxicity). Through this approach, we aimed to effectively conjecture on the performance and determine the most applicable programs when designating toxic substances through the AREC. Methods: Chemicals that had been registered and evaluated in the Toxic Chemicals Control Act (TCCA, Republic of Korea) were selected for this study. Two prediction programs developed and operated by the U.S. EPA - the Ecological Structure-Activity Relationship (ECOSAR) and Toxicity Estimation Software Tool (T.E.S.T.) models - were utilized along with the TOPKAT (Toxicity Prediction by Komputer Assisted Technology) commercial program. The applicability of these three programs was evaluated according to three parameters: accuracy, sensitivity, and specificity. Results: The prediction analysis on fish and daphnia magna in the three programs showed that the TOPKAT program had better sensitivity than the others. Conclusions: Although the predictive performance of the TOPKAT program when using a single predictive program was found to perform well in toxic substance designation, using a single program involves many restrictions. It is necessary to validate the reliability of predictions by utilizing multiple methods when applying the prediction program to the regulation of chemicals.

유기질계 토양개량재를 이용한 절토비탈면 녹화공법 적용시험 연구 (A Study on Application Test of Cut-slope Revegetation Measures with Organic Soil Amendment Materials)

  • 전기성;우경진
    • 한국환경복원기술학회지
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    • 제8권3호
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    • pp.13-20
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    • 2005
  • This study was conducted to suggest the ecological restoration methods of the decomposed granite cut-slope by organic soil amendment materials. Field test carried out for the cut-slope with organic soil amendment materials method and other three revegetation methods in Cheongwon. Test revegetation plants were Festuca arundinacea, Lolium perenne, Dactylis glomerata, Lespedeza cyrtobotrya, and Arundinella hirta. The result of this study can be summarized as follows; 1. The soil hardness, the soil acidity, and the soil humidity of organic soil amendment materials method were at a suitable value for plants growth. And it was better as compared with other three revegetation methods of cutting-rock slopes. 2. The result of toxic substance investigation, all items were at a suitable for standard law. 3. During one year after seeding, most plants germinated and especially Festuca arundinacea and Dactylis glomerata grows well. Seedling numbers were 336.7 per $m^2$(after 6 months), 183.3 per $m^2$(after 10 months), and 353.3 per $m^2$(after 6 months). Ten months later after seeding, plants showed 80% ground coverage. Visual rate, plant height, and growth rate were excellence, Also, high plant growth in spring better than autumn.

주거용 건축물의 실내 라돈농도 경감방안에 관한 연구(I) -Test Cell Study (A Study on Mitigation Methods of Indoor Radon Concentration in Residential Buildings(I) - Test Cell Study)

  • 차동원
    • KIEAE Journal
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    • 제1권2호
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    • pp.21-28
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    • 2001
  • Naturally-ocurring short-lived decay products of radon gas in indoor air are the dominant source of ionizing radiation exposure to the general public. It is written in BEIR VI Report(l999l the radon progeny were identified as the second cause of lung cancer next to cigarette or 10 % to 14 %(15,400 to 21,800 persons p.a.) of all lung cancer deaths in USA. Indoor radon concentrations in houses typically result from radon gaining access to houses mainly from the underlying soil. In the States, they have "Indoor Radon Abatement Act" which was converted from "Toxic Substance Control Act" in 1988 to establish the national long-term goal that indoor air should be as free of radon as the ambient air outside of buildings. To review and study techniques for controlling radon, two test cells were constructed for a series of tests and are under measuring indoor and soil gas (underneath of floor slab)radon concentrations according to EPA's measurement protocol. In this paper, important theoretical studies are previewed and the following paper will explain the test results and confirm the theories reviewed to find out suitable coefficients. On the basis of test analysis, it will be described and evaluated various techniques that can be used to mitigate elevated indoor concentration of radon including the control of radon and its decay products.

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실험실 내에서 배양된 편평상피암 세포주에 대한 염화불소의 효과 (THE EFFECTS OF SODIUM FLUORIDE ON SQUAMOUS CELL CARCINOMA CELL LINE CULTURED IN VITRO)

  • 박노부
    • Maxillofacial Plastic and Reconstructive Surgery
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    • 제18권2호
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    • pp.316-322
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    • 1996
  • 불소의 유전물질에 대한 독성효과는 현재까지 논란의 대상이되고 있으며, 서로 상반된 연구 결과들이 보고되고 있다. 저자는 불소의 세포 유전학적 효과를 규명하고자 실험실 내에서 배양된 편평상피암 세포주에 염화불소를 처리하여 세포독성 검사와 염색체이상 검사를 시행하여 다음과 같은 결론을 얻었다. 1. 염화불소의 농도와 처리시간에 비례하여 세포성장이 현저히 감소하므로 염화불소는 편평상피암 세포주에 독성을 가진다. 2. 염화불소의 농도가 증가할수록 염색체이상 발현빈도가 현저히 높게 나타나므로 염화불소는 편평상피암 세포주에서 DNA 손상을 야기할 수 있다. 염색체 이상의 형태는 chromatid break가 가장 많이 나타났다.

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Pool Combustion of Iso-Propanol Fuel including IPA and PCBs in different Type Vessels

  • An Suk-Heon
    • Journal of Advanced Marine Engineering and Technology
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    • 제30권1호
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    • pp.102-108
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    • 2006
  • On the refutation demanded for a control of various toxic substances. PCBs(poly chlorinated biphenyl) has a fatal poisonous matter in the ecosystem and the environmental pollution as it Is a kind of stable chemical substance. Especially, the gross Product of PCBs is estimated at about one million tonnage all over the world. However it is kept on storing in untreated state, then has a deterioration by the Prolonged storage and a risk of overflowing. Therefore, this research examined the fundamental characteristics of combustion and emission for the target of using the IPA (iso-propyl alcohol) solution as a part of PCBs control. IPA was filled to three kinds of Vessel, i.e. Vessel I, II, and III, and then was investigated as follows combustion shape, flame temperature. mass burning velocity, and PM(Particulate matter). A radial thermometer and a C-A thermocouple measured the flame temperature, and the optical extinction method by using He-Ne laser and the filter weight method used in the PM measurement. As a result, with an increasing of L/S ratio, the flame length become shorter and the burning velocity is more rapid, but the particulate matters is higher. It is supposed that the air flow rate is high on Vessel. and then the combustion is Promoted in the surface area of the upstream zone. The future works plan to investigate the characteristics with an using of the mixing of IPA and PCBs

도시유역의 부유고형물 유출평가를 위한 쓸림모형 개발 (A Development of Washoff Model for Suspended Solids in Urban Areas)

  • 주진걸;정동휘;김중훈;박무종
    • 한국물환경학회지
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    • 제26권5호
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    • pp.789-795
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    • 2010
  • Suspended Solid (SS) is one of the main pollutants and discharges with attached other pollutants such as heavy metal and toxic substance. It is very important to estimate and forecast the release characteristics of SS for water quality improvement. The current studies assumed that SS release rate is proportional to the rain intensity and suggested exponential washoff models. These models related to the shear force of flow. In this study, a new washoff model is suggested based on relation with SS release rate and mean flow rate of the basin surface which is closely related to the shear force. The proposed model is applied to the Goonja drainage district in Seoul, Korea. The new washoff model simulates the SS discharge more accurately in the various rainfall types. The model can be widely applied to the real problems such as the management of non-point source pollutant and the design of treatment facilities.

Photodynamic Action by Endogenous Non-Chlorophyll Sensitizer As a Cause of Photoinhibition

  • Suh, Hwa-Jin;Kim, Chang-Sook;Jin Jung
    • Journal of Photoscience
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    • 제7권3호
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    • pp.87-95
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    • 2000
  • As sunlight not always optimized for every terrestrial plant in terms of light quality, quantity and duration, some plants suffer detrimental effects of sunlight exposure under certain conditions. Photoinhibition of photosynthesis is a typical phenomenon representing harmful light effects, commonly observed in many photosynthetic organisms. It is generally accepted that functional, structural loss of photosystem II complex(PSII) is the primary event of photoinhibition. Accumulating data also suggest that singlet oxygen($^1$O$_2$) is the main toxic species directly involved in it. There are two different views on the specific site and mechanism of $^1$O$_2$ production in the photosynthetic membrane. One of them favors the PSII reaction center, where the primary charge pairs recombination occurs as a prerequisite for the generation of $^1$O$_2$, and the other inclines to photosensitized $^1$O$_2$ formation by a substance located outside PSII. This article describes how we, as the advocators of the latter concept, have arrived at the conclusion that $^1$O$_2$ immediately involved in PSII photodamage is largely generated from the Rieske center of the cytochrome b$_{6}$/f complex and diffuses into PSII, attacking the reaction center subunits.s.

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Inhibitory Effects of Acinetobacter sp. KTB3 on Infection of Tobacco mosaic virus in Tobacco Plants

  • Kim, Young-Sook;Hwang, Eui-ll;O, Jeong-Hun;Kim, Kab-Sig;Ryu, Myong-Hyun
    • The Plant Pathology Journal
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    • 제20권4호
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    • pp.293-296
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    • 2004
  • During the screening of antiviral substances having inhibitory effects on Tobacco mosaic virus (TMV) infection on tobacco plants, we found a bacterial isolate KTB3, and identified it as Acinetobacter sp. which strongly inhibited the infection of TMV When the culture filtrate from KTB3 was applied on the upper surface of the Xanthi-nc tobacco leaves at the same time, or 24 hours before TMV inoculation, almost complete inhibition was achieved. Likewise, 86% inhibition was achieved, when the culture filtrate was applied on the underside of the leaves. In field trials, transmission of TMV from diseased seedlings to healthy ones during transplanting work was reduced by 92%, when the culture filtrate was sprayed onto the tobacco seedlings, cv. NC82, 24 hours before transplanting. No toxic effect was observed on the tobacco plants. Antiviral substance from the culture filtrate was purified by ethanol precipitation, dialysis, DEAE-cellulose, and Sephadex G75 gel column chromatography. The partially purified active material which showed positive color reaction to sugar and protein inhibited TMV infection by 60% at 1 ${\mu}$g/ml.