• Title/Summary/Keyword: toxic effects

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Effects of diesel exhaust and it′s particles on respiratory and reproductive Systems in mice

  • Sagai, Masaru
    • Proceedings of the Korea Air Pollution Research Association Conference
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    • 1999.10a
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    • pp.289-292
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    • 1999

  • In recent year, there has been a progressive increase in urban air pollution that is Characterized by high concentrations of atmospheric particulate matter (PM10), resulting primarily from increase of automobils, especially diesel engine powered cars. Although the mechanisms of underling respiratory morbidity due to PM10 are not nuclear, it is thought that the fine particles (PM2.5) are of gratest concern to health since they can be breathed most deeply into the lung, where they are likely to be more toxic than the larger particles.(omitted)

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Reduction of Dioxin-Induced Expression of cyplal Gene through Repression of AhR/Arnt DNA Binding by Mek-1 inhibitor PD98059

  • Park, Hyunsung
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2002.11b
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    • pp.60-66
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    • 2002

  • Aryl hydrocarbons, environmental contaminants accumulate in tissue and pose potential risk in human health. 2,3,7,8-Tertachlorodibenzo-p-dioxin (TCDD) is known as a most potent toxicant among aryl hydrocarbons. TCDD elicits numerous toxic responses in experimental animals and human, including hepatic carcinoma, pulmonary and skin tumor in adult rodents, craniofacial abnormality during mouse embryogenesis, chloracne, reproductive abnormality, immunotoxicity, endocrine effects in exposed humans.(omitted)

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Application of Calux Bioassay for Determining Dioxin Toxicity Equivalents

  • Joung, Ki-Eun;An, Jin-Young;Sheen, Yhun-Yhong
    • Proceedings of the Korean Society of Toxicology Conference
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    • 2003.10b
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    • pp.172-173
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    • 2003

  • There are growing concerns about human health effects of dioxin and dioxin like compounds such as polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs), and polychlorinated biphenyls (PCBs). Earlier studies recognized that 2.3.7.8-tetrachloro dibenzo-p-dioxin (TCDD) and structually related dioxin like compounds invoke a number of common toxic responses that are mediated through a high-affinity cytosolic receptor protein, the AhR.(omitted)

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Characterization of Single Channel Properties of Cardiac $Ca^{2+}$ Release Channel in Rats Treated with the Immunosuppressant Drug, Cyclosporin A

  • Lee, Eun-Hui;Park, Chul-Seung;Kim, Do-Han
    • Proceedings of the Korean Biophysical Society Conference
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    • 1997.07a
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    • pp.29-29
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    • 1997

  • Cyclosporin A (CsA) is widely used to suppress rejection in rcipients of solid organ or bone marrow transplants. A variety .of toxic side effects of this agent such as cardiotoxicity have been reported. However the underlying molecular mechanisms for the cardiotoxicity are not well resolved.(omitted)

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Pharmacological Evaluation of the Glycosidated Phenylpropanoids Containing Fraction from Orobanche crenata

  • El-Shabrawy, O.A.;Melek, F.R.;Ibrahim, M.;Radwan, A.S.
    • Archives of Pharmacal Research
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    • v.12 no.1
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    • pp.22-25
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    • 1989

  • Ethylacetate fraction from Orobanche crenata, contained two phenylpropanoid glycosides, exhibited some pharmacological properties. It was found to be non-toxic to rats in oral doses up to 500mg/100gm body weight. In large doses, it lowered the arterial blood pressure of anaethetised rats, and produced significant analgesic effect in mice and diuretic effect in rats. It further showed smooth muscle relaxant and antispasmodic effects in the isolated rabbit intestine and guinea-pig ileum respectively.

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