• Animal Bioscience
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• 제36권8호
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• pp.1156-1166
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• 2023

Objective: Pork belly is a cut of meat with high worldwide demand. However, although the belly is comprised of multiple muscles and fat, unlike the loin muscle, research on their genetic parameters has yet to focus on a representative cut. To use swine breeding, it is necessary to estimate heritability against pork belly traits. Moreover, estimating genetic correlations is needed to identify genetic relationship among the traditional carcass and meat quality traits. This study sought to estimate the heritability of the carcass, belly, and their component traits, as well as the genetic correlations among them, to confirm whether these traits can be improved. Methods: A total of 543 Yorkshire pigs (406 castrated males and 137 females) from 49 sires and 244 dam were used in this study. To estimate genetic parameters, a total of 12 traits such as lean meat production ability, meat quality and pork belly traits were chosen. The heritabilities were estimated by using genome-wide efficient mixed model association software. The statistical model was selected so that farm, carcass weight, sex, and slaughter season were fixed effects. In addition, its genetic parameters were calculated via MTG2 software. Results: The heritability estimates for the 7th belly slice along the whole plate and its components were low to moderate (0.07±0.07 to 0.33±0.07). Moreover, the genetic correlations among the carcass and belly traits were moderate to high (0.28±0.20 to 0.99±0.31). Particularly, the rectus abdominis muscle exhibited a high absolute genetic correlation with the belly and meat quality (0.73±52 to 0.93±0.43). Conclusion: A moderate to high correlation coefficient was obtained based on the genetic parameters. The belly could be genetically improved to contain a larger proportion of muscle regardless of lean meat production ability.

• 사물인터넷융복합논문지
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• 제9권6호
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• pp.1-9
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• 2023

최근 MS Office 파일 내에 악성 스크립트 등이 은닉된 멀웨어 파일이 발견되고 있다. 이에 본 논문에서는 머신러닝 기법을 적용하여 악성 디지털 파일을 자동으로 검출할 수 있는 시스템을 설계 및 구현하였다. MS Office 파일 내 OLE VBA 매크로 기능을 악용하여 악성 스크립트를 검출하거나, OOXML 구조 분석을 통해 CDH/LFH/ECDH 내부 필드 값에 악성 스크립트를 탐지하고, OOXML 구조에서 참조되지 않는 비정상적인 CDH/LFH 정보를 추가한 경우 이를 검출할 수 있는 메커니즘을 제시하였다. 그리고 VirusTotal 악성 스크립트 판별 기능을 이용하여 MS Office 파일에 대한 악의적 손상 여부 자동 판별하는 기능을 이용하여 머신러닝 기반 통합 소프트웨어를 설계 및 구현하였다. 실험 결과 파일 손상 여부를 자동 판별할 수 있으며 최적의 머신러닝 모델을 이용하여 임의의 MS Office 파일에 대해 향상된 검출 성능을 제공하는 것을 확인하였다.

• The Journal of Advanced Prosthodontics
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• 제16권3호
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• pp.139-150
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• 2024

PURPOSE. The purpose of this diagnostic study was to assess the accuracy and time efficiency of a digital method to draw the denture foundation extension outline on preliminary casts compared with the conventional technique. MATERIALS AND METHODS. A total of 28 preliminary edentulous casts with no anatomical landmarks were digitized using a laboratory scanner. The outlining of the entire basal seat of the denture was performed on preliminary casts and digitized. Casts with no extension outline were digitized and outlines were drawn using software (DWOS, Straumann). The accuracy of the extension outlined between both techniques was evaluated in the software (GOM Inspect; GOM GmbH) by file superimposition. Specificity and sensitivity tests were applied to measure accuracy. The paired t-test (95% CI) was used to compare the mean total area and the working time. RESULTS. The accuracy ranged from 0.57 to 0.92. The buccal and labial frenulum showed a lower value in the maxilla (0.57); while the area between the retromolar pad and buccal frenulum (0.64) showed a lower score in the mandible. The maxillary denture foundation and the working time for both arches were significantly longer for the digital method (P < .001). CONCLUSION. The denture foundation extension outline exhibited a sufficiently excellent accuracy for the digital method, except for the maxillary anterior region. However, the digital method required a longer working time.

• Genomics & Informatics
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• 제8권3호
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• pp.131-137
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• 2010

Genome-wide association studies (GWASs) have greatly contributed to the identification of common variants responsible for numerous complex traits. There are, however, unavoidable limitations in detecting causal and/or rare variants for traits in this approach, which depends on an LD-based tagging SNP microarray chip. In an effort to detect potential casual and/or rare variants for complex traits, such as type 2 diabetes (T2D) and triglycerides (TGs), we conducted a targeted resequencing of loci identified by the Korea Association REsource (KARE) GWAS. The target regions for resequencing comprised whole exons, exon-intron boundaries, and regulatory regions of genes that appeared within 1 Mb of the GWA signal boundary. From 124 individuals selected in population-based cohorts, a total of 0.7 Mb target regions were captured by the NimbleGen sequence capture 385K array. Subsequent sequencing, carried out by the Roche 454 Genome Sequencer FLX, generated about 110,000 sequence reads per individual. Mapping of sequence reads to the human reference genome was performed using the SSAHA2 program. An average of 62.2% of total reads was mapped to targets with an average 22X-fold coverage. A total of 5,983 SNPs (average 846 SNPs per individual) were called and annotated by GATK software, with 96.5% accuracy that was estimated by comparison with Affymetrix 5.0 genotyped data in identical individuals. About 51% of total SNPs were singletons that can be considered possible rare variants in the population. Among SNPs that appeared in exons, which occupies about 20% of total SNPs, 304 nonsynonymous singletons were tested with Polyphen to predict the protein damage caused by mutation. In total, we were able to detect 9 and 6 potentially functional rare SNPs for T2D and triglycerides, respectively, evoking a further step of replication genotyping in independent populations to prove their bona fide relevance to traits.

• 한국추진공학회:학술대회논문집
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• 한국추진공학회 2008년 영문 학술대회
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• pp.130-135
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• 2008

An aerodynamic optimization design process of multistage axial turbine is presented in this article: first, applying quasi-three dimensional(Q3D) design methods to conduct preliminary design and then adopting modern optimization design methods to implement multistage local optimization. Quasi-three dimensional(Q3D) design methods, which mainly refer to S2 flow surface direct problem calculation, adopt the S2 flow surface direct problem calculation program of Harbin Institute of Technology. Multistage local optimization adopts the software of Numeca/Design3D, which jointly adopts genetic algorithm and artificial neural network. The major principle of the methodology is that the successive design evaluation is performed by using an artificial neural network instead of a flow solver and the genetic algorithms may be used in an efficient way. Flow computation applies three-dimensional viscosity Navier Stokes(N-S) equation solver. Such optimization process has three features: (i) local optimization based on aerodynamic performance of every cascade; (ii) several times of optimizations being performed to every cascade; and (iii) alternate use of coarse grid and fine grid. Such process was applied to optimize a three-stage axial turbine. During the optimization, blade shape and meridional channel were respectively optimized. Through optimization, the total efficiency increased 1.3% and total power increased 2.4% while total flow rate only slightly changed. Therefore, the total performance was improved and the design objective was achieved. The preliminary design makes use of quasi-three dimensional(Q3D) design methods to achieve most reasonable parameter distribution so as to preliminarily enhance total performance. Then total performance will be further improved by adopting multistage local optimization design. Thus the design objective will be successfully achieved without huge expenditure of manpower and calculation time. Therefore, such optimization design process may be efficiently applied to the aerodynamic design optimization of multistage axial turbine.

• 융합정보논문지
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• 제11권5호
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• pp.9-16
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• 2021

이진 변조 비직교 다중접속에서 1+1 용량 영역을 달성하는 주제에 대한, 다시 말해, 총 전력은 얼마나 필요한가와 이때 전력은 어떻게 할당해야 되는가에 대한 연구가 다소 미흡하다. 본 논문에서는, 허용 가능한 손실범위 안에서, 2PAM 비직교 다중 접속의 1+1 용량 영역을 달성할 수 있는 평균 총 전송 전력을 고찰한다. 다음으로, 충분한 평균 총 전력을 기반으로 1+1 용량 영역을 달성할 수 있는 전력 할당 계수를 계산한다. 그리고, 수치적 결과를 통해서 0.008 미만의 허용 가능한 손실 범위 안에서, 근접 1+1 용량 영역이 달성됨을 보여준다. 또한, 수치상으로 근접 1+1 용량 영역을 달성하는 양 사용자의 전력 할당 계수를 계산한다. 결론적으로 2PAM 비직교 다중 접속이 근접 1+1 용량 영역에서 동작하기 위해, 적절한 전력 할당과 함께, 적당한 총 전력이 비직교 다중접속 설계에서 계산될 수 있다.

• KSII Transactions on Internet and Information Systems (TIIS)
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• 제11권6호
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• pp.2811-2830
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• 2017

In this paper, we study the problem of mobile data offloading for a network that contains multiple mobile network operators (MNOs), multiple WiFi or femtocell access points (APs) and multiple mobile users (MUs). MNOs offload their subscribed MUs' data traffic by leasing the unused Internet connection bandwidth of third party APs. We propose a combinatorial auction-based two-stage matching mechanism comprised of MU-AP matching and AP-MNO matching. The MU-AP matching is designed to match the MUs to APs in order to maximize the total offloading data traffic and achieve better MU satisfaction. Conversely, for AP-MNO matching, MNOs compete for APs' service using the Nash bargaining solution (NBS) and the Vickrey auction theories and, in turn, APs will receive monetary compensation. We demonstrated that the proposed mechanism converges to a distributed stable matching result. Numerical results demonstrate that the proposed algorithm well capture the tradeoff among the total data traffic, social welfare and the QoS of MUs compared to other schemes. Moreover, the proposed mechanism can considerably offload the total data traffic and improve the network social welfare with less computation complexity and communication overhead.

• 한국CDE학회논문집
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• 제16권5호
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• pp.315-322
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• 2011

The goal of total knee replacement (TKR) surgery is to replace patient's knee joint with artificial implants in order to restore normal knee joint functions. Since mismatched knee implants often cause a critical balancing problem and short durability, designing a well-fitted implant to a patient's knee joint is essential to improve surgical outcomes. We developed a software system that three-dimensionally (3D) simulates TKR surgery based upon 3D knee models reconstructed from computed tomography (CT) imaging. The main task of the system was to extract precise 3D anatomical parameters of a patient's knee that were directly used to determine a custom fit implant and to virtually perform TKR surgery. The virtual surgery was simulated by amputating a 3D knee model and positioning the determined implant components on the amputated knee. The test result shows that it is applicable to derive surgical parameters, determine individualized implant components, rehearse the whole surgical procedure, and train medical staff or students for actual TKR surgery. The feasibility and verification of the proposed system is described with examples.

• 한국작물학회:학술대회논문집
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• 한국작물학회 2017년도 9th Asian Crop Science Association conference
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• pp.122-122
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• 2017

Wheat wild relatives that have never been domesticated contained useful genetic resources such as the resistance to abiotic and biotic stresses. Leymus racemosus is one of the wild species. It can grow in a harsh environment like seaside and distribute by healthy rhizomes. Also, it has a useful genetic resource such as salt tolerance and different diseases resistance. Wheat (Triticum aestivum L. cv. Chinese Spring; CS) was crossed with L. racemosus. Wheat-L. racemosus disomic addition lines were produced. The purpose of this study is to identify protein expression in each disomic addition line compared to CS. We performed two-dimensional electrophoresis. Two-dimensional gels stained with coomassie brilliant blue (CBB), a total of 1566 differentially expressed proteins were identified by Progenesis Same Spots software from the cultivars. However, a total of 90 protein spots were identified to be either present or absent or showing significantly differential expression when the difference threshold was set to more than 1.5 fold. However, out of the 90 differentially protein spots, a total of 74 spots were sorted for mass spectrometry analysis. The identified proteins may provide important clues for better understanding the molecular changes in the chromosomes carrying Leymus racemosus.

• 대한한방내과학회지
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• 제42권3호
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• pp.259-278
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• 2021

Objectives: This study examines the effect of Sagunja-tang on functional dyspepsia (FD) through a systematic review and meta-analysis of a randomized controlled trial (RCT). Methods: A search for RCTs that tested the effect of Sagunja-tang on functional dyspepsia was conducted in Medline, Embase, PubMed, CENTRAL, CiNii, CNKI, NDSL, RISS, OASIS, and KISS databases on November 8, 2020, with no limit on the year of publication. A meta-analysis was performed by synthesizing the findings, including total efficiency, clinical symptom score, myosin light-chain kinase (MLCK) level (pg/mL, and gastric half-emptying time (min). RevMan 5.4.1 software was used for data analysis. The quality of the literature was evaluated using Cochrane's risk of bias (RoB) tool. Results: A total of 14 RCTs met the selection criteria. As a result of the meta-analysis, the treatment group had higher total efficacy and MLCK levels (gastric antrum, jejunum) than the control group, and the clinical symptom score and gastric half-emptying time were lower. However, due to the low quality of the included RCT and the small sample size, the results may be slightly biased.