• Nutritional Sciences
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• v.5 no.1
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• pp.13-19
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• 2002

A mutation in the promoter region of uncoupling protein 3 (UCF3), specifically the -55C longrightarrow T transition, may influence an individual's energy metabolism and body weight. The objective of this study was to investigate the effect of a weight reduction program on endocrine functions and body fat distribution, related to UCP3 promoter genotype. Ninety overweight pre-menopausal female subjects participated in the weight reduction program at Yonsei University Hospital, and were placed on a calorie-restricted diet (300 kcal less than their daily requirements) for 12 weeks. After 12 weeks, all subjects on the program lost approximately 5% of their initial body weights and had lower Body Mass Index (BMI) values. Among the 90 women, 56 had a normal (without mutation) UCP3 genotype, while 34 women had mutations in the promoter region of UCP3. Despite similar weight reductions in both groups, a significantly higher decrease in abdominal adipose tissue was observed in the normal UCP3 genotype group, compared to the group with mutations. In particular, there was a significant reduction of fat at the lumbar 1 (Ll) level in the without-mutation group. Serum levels of total cholesterol, apolipoprotein Al were significantly decreased in the without-mutation group, by 4.4% and 5.7% respectively. Serum levels of hormones were not significantly changed in both groups artier the intervention. However, in the group without the mutations, the leptin level significantly reduced by 23.4% (p<0.001). Serum free fatty acid (FFA) concentration was significantly increased in the group with mutation following the weight reduction program. On the other hand, FFA responses were shown similar increases in both groups. In conclusion, although no difference was found in the magnitude of weight reduction in both groups, there were significant differences in body fat distribution and in endocrine function between the groups.

• Journal of Ocean Engineering and Technology
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• v.31 no.2
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• pp.81-90
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• 2017

The 1MW OTEC (Ocean Thermal Energy Conversion) platform was designed for application in equatorial seas. In this study, the OTEC platform was investigated using numerical and experimental methods. An octagon-shaped OTEC platform was investigated using the Ocean Engineering Basin of KRISO. These experiments included various tests of regular waves, irregular waves and irregular waves with current (wave+current). The responses of the platform in regular waves showed good agreement between the numerical and experimental results, including the motion RAO, wave run up, and mean drift force. The peak period of heave and pitch motions were observed around 0.5 rad/s, and the effect of the total reflection was found under short wave conditions. The standard deviation (STD) of the platform motion was checked in irregular waves of equatorial and Hawaiian seas. The STD of the pitch was less than $4^{\circ}$ different from the operability requirement under equatorial conditions and the surge STD of the wave frequency showed good agreement between the numerical and experimental results. The STD values of the surge and pitch were increased 66.6% and 92.8% by the current effects in irregular waves, but the pitch STD was less than $4^{\circ}$ under equatorial conditions. This study showed that the STD of the surge was affected by spring effects. Thus, the watch circle of the platform and tension of the mooring lines must be evaluated for a specific design in the future.

• Steel and Composite Structures
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• v.35 no.2
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• pp.261-278
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• 2020

In steel-concrete composite beams, to improve the cracking resistance of the concrete slab in the hogging moment region, a new type of connector in the interface, named uplift-restricted and slip-permitted screw-type (URSP-S) connector has been proposed. This paper focuses on the behavior of steel-concrete composite beams with URSP-S connectors. A total of three beam specimens including a simply supported beam with URSP-S connectors and two continuous composite beams with different connectors arrangements were designed and tested. More specifically, one continuous composite beam was equipped with URSP-S connectors in negative moment region and traditional shear studs in other regions. For comparison, the other one was designed with only traditional shear studs. The failure modes, crack evolution process, ultimate capacities, strain responses at different locations as well as the interface slip of the three tested specimens were measured and evaluated in-depth. Based on the experimental study, the research findings indicate that the larger slip deformation is allowed while using URSP-S connectors. Meanwhile, the tensile stress reduces and the cracking resistance of the concrete slab improves accordingly. In addition, the overall stiffness and strength of the composite beam become slightly lower than those of the composite beam using traditional shear studs. Moreover, the arrangement suggestion of URSP-S connectors in the composite beam is discussed in this paper for its practical design and application.

• Steel and Composite Structures
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• v.36 no.1
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• pp.1-16
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• 2020

In steel-concrete composite beams, to improve the cracking resistance of the concrete slab in the hogging moment region, a new type of connector in the interface, named uplift-restricted and slip-permitted screw-type (URSP-S) connector has been proposed. This paper focuses on the behavior of steel-concrete composite beams with URSP-S connectors. A total of three beam specimens including a simply supported beam with URSP-S connectors and two continuous composite beams with different connectors arrangements were designed and tested. More specifically, one continuous composite beam was equipped with URSP-S connectors in negative moment region and traditional shear studs in other regions. For comparison, the other one was designed with only traditional shear studs. The failure modes, crack evolution process, ultimate capacities, strain responses at different locations as well as the interface slip of the three tested specimens were measured and evaluated in-depth. Based on the experimental study, the research findings indicate that the larger slip deformation is allowed while using URSP-S connectors. Meanwhile, the tensile stress reduces and the cracking resistance of the concrete slab improves accordingly. In addition, the overall stiffness and strength of the composite beam become slightly lower than those of the composite beam using traditional shear studs. Moreover, the arrangement suggestion of URSP-S connectors in the composite beam is discussed in this paper for its practical design and application.

• Journal of Radiation Industry
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• v.6 no.3
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• pp.281-287
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• 2012

The model plant, Arabidopsis thaliana is the subject of an international genome research project. Massive doses of ionizing radiation have been shown to induce physiological changes in plants. The wild-type (Ler) Arabidopsis plants were irradiated with 100 Gy and 800 Gy of gamma-ray. Gibberellin (GA) affects developmental processes and responses according to the various environment conditions in diverse plant. The 13 GA isomers were analyzed at vegetative (VE) and reproductive (RE) stages by HPLC. Total GA contents were reduced with the increase in radiation doses at VE and RE stages. Specifically, levels of GA3, GA4, GA12, and GA34 were significantly reduced with the increase of radiation doses. Oligonucleotide microarrays analysis was performed with Arabidopsis plants at different developmental stages and doses of gamma-ray. Through the microarray data, we isolated 41 genes related to GA biosynthesis and signaling transduction. Expression of these genes was also decreased as the reduction of GA contents. Interestingly, in GA signaling related gene expression, gibberellin-responsive protein, putative (At2g18420) was down-regulated at VE and RE stages. Myb21 (At3g27810), Myb24 (At5g40350), and Myb57 (At3g01530) was down-regulated at RE stage. In GA biosynthesis related gene expression, YAP169 (At5g07200) and GA20ox2 (At5g51810) were down-regulated at 100 Gy treatment of VE stage and 800 Gy treatment of RE stage in cytoplasm, respectively. However, exceptively, GA3ox2 (At1g80340) was up-regulated at 100 Gy treatment of RE stage in cytoplasm. In this study, the wild type (Ler) Arabidopsis plants showed differences in response with development stage at the various doses of gamma-rays. GA contents change was reported in gamma irradiated plant.

• Journal of the Korean Society of Child Welfare
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• no.40
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• pp.9-39
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• 2012

The study aims to examine how exposure to phonography on the internet affects adolescents' behaviour toward sexual assault and the sex trade industry based on the social learning theory. A nationwide survey was conducted on adolescents between the ages of 14 to 19. Responses from a total of 2,829 adolescents were obtained and utilized in the analysis. The analytic findings showed that Korean adolescents are heavily exposed to phonography on the internet. Students use the internet to search for pornographic web sites, and they periodically look for updated materials. The study showed that between 1.8% to 16.5% of adolescents, who were exposed to or watched pornographic materials, committed sexual assault and were guilty of sexually harassing others. 3.5%(95) of those who were surveyed experienced sex trade. Internet chat rooms are considered to be a contributing factor. The results show that adolescents who were exposed to phonography are more prone to committing the acts of sexual assault and sexual harrassment, and tend to be more influenced toward sexual violence.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.6
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• pp.536-544
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• 2019

Purpose: Proper nutrition is essential for brain development during infancy, contributing to the continued development of cognitive, motor, and socio-emotional skills throughout life. Considering the insufficient published data in the Middle East and North Africa, experts drafted a questionnaire to assess the opinions and knowledge of physicians on the impact of nutrition on brain development and cognition in early life. Methods: The questionnaire consisted of two parts: The first focused on the responders' demographic and professional characteristics and the second questioned the role of nutrition in brain development and cognition. Descriptive statistics were used to summarize respondents' characteristics and their responses to questions. Results: A total of 1,500 questionnaires were distributed; 994 physicians responded. The majority of the surveyed physicians (64.4%) felt that nutrition impacts brain development in early childhood (0-4 years), with almost 90% of physicians agreeing/strongly agreeing that preventing iron, zinc, and iodine deficiency would improve global intelligence quotient. The majority of physicians (83%) agreed that head circumference was the most important measure of brain development. The majority of physicians (68.9%) responded that the period from the last trimester until 18 months postdelivery was crucial for brain growth and neurodevelopment, with 76.8% believing that infants breast-fed by vegan mothers have an increased risk of impaired brain development. Conclusion: The results of this study show that practicing physicians significantly agree that nutrition plays an important role in brain and cognitive development and function in early childhood, particularly during the last trimester until 18 months postdelivery.

• Journal of the Korean Dietetic Association
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• v.25 no.4
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• pp.295-309
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• 2019

The purpose of this study were to identify the dietary practices of vulnerable older adults and to assess the foodservice and food provision service programs perceived by the health and welfare service providers in the community. A survey was conducted on health and welfare service providers working in outreach community centers and community health centers in Seoul. A total of 260 nurses and social workers participated in the survey and 224 responses were used for data analysis after excluding significant missing data. The respondents consisted of nurses (58.5%) and social workers (41.5%). In terms of the dietary life of the vulnerable older adults, they perceived that the food cost was burdensome to the older adults and poor dental conditions prohibited them from eating various foods. The health and welfare service providers rated highly for 'home-delivered meal and side dish services are effective for checking older adults' conditions' but rated low for availability of menu choices. In targeting vulnerable older adults for food and nutrition service programs, the home-delivered meal service was found to be suitable for older adults living alone, those over age of 80 years, those with mobility difficulties, and those with economic difficulties. The food provision service was appropriate for older adults living with their spouse or other family members. Vulnerable older adults are a heterogeneous population with diverse needs related to food and nutrition. Home-delivered meal/side dish service and food provision services will achieve their goals when they reach the correct targets with a customized service.

• Journal of Fashion Business
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• v.23 no.5
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• pp.137-150
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• 2019

This study aimed to provide consumer perception and evaluation of natural Cynanchi Atrium Fermented Original Cosmetics for Skin Whitening that can improve skin by using oriental medicinal ingredients. The product was applied three times a day for two weeks by a total of 60 users who agreed to participate in a clinical trial assessing the usability and skin sensitivity to extracts that had already completed component safety testing. This study subjects reported which images were most reminiscent of Korea. They preferred products that bore Korean images because they felt trust and recognized that the quality of the cosmetics was excellent. The responses also showed that many consumers were willing to buy a product, even though it was luxurious, elegant, and expensive. The cognitive evaluation of Original Cosmetics was high and showed that the quality was likely to be good. The usability and CMF(Color, Material, Finishing) evaluation of Original Cosmetics showed good product the product is long-lasting and tightened and moisturized skin naturally. They are think about that this product it has moisturizing effects and good application for use, so it is light and soft to use. And had a whitening effect. It was intended to assist in the development of products that meet consumers' desires and expectations for safe, healthy, and beautiful skin by developing a skin whitening Original Cosmetics prototype that can inhibit the production of melanin and tyrosinase activity safely and effectively.

• Development and Reproduction
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• v.23 no.2
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• pp.139-148
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• 2019

Rising of water temperature due to global warming is a great concern to aquaculturists and fishery biologists. Hence, the present study aimed to investigate the effects of high water temperature on juvenile red spotted grouper, Epinephelus akaara based on the evaluation of stress responses in blood. E. akaara juveniles were exposed to different thermal conditions ($25^{\circ}C$, $28^{\circ}C$, $31^{\circ}C$, and $34^{\circ}C$) for 6 weeks following 2 weeks of acclimation at $25^{\circ}C$. Blood cell morphology and number were examined at three sampling points (2, 7, and 42 days) from a total of 180 fish. Major erythrocytic cellular abnormalities (ECA) observed in blood smears of thermally stressed groups ($31^{\circ}C$ and $34^{\circ}C$) after 6 weeks were echinocytes, teardrop-like cells, swollen cells and vacuolated cells. Both red and white blood cell number (RBC and WBC) were significantly (p<0.05) elevated in $31^{\circ}C$ and $34^{\circ}C$ group after 6 weeks thermal exposure. Differential leucocytes number showed significant increases in neutrophil (N) and decreases in lymphocytes (L) in the highest temperature ($34^{\circ}C$). Different N:L ratio was observed at different thermal conditions which can be used as a reliable alternative to measure stress response. Taken together, these results suggest that higher temperature ($31^{\circ}C$ and $34^{\circ}C$) can interfere the immune system of red spotted grouper by altering the blood cell morphology and number.